Research Topics
Genomes and GenesSpecies | M BahraSummaryAffiliation: Humboldt University Country: Germany Publications
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Detail Information
Publications
Surgical strategies and predictors of outcome for malignant neuroendocrine tumors of the pancreasMarcus Bahra
General, Visceral and Transplantation Surgery Clinic, Charite, Campus Virchow Hospital, Humboldt University, Berlin, Germany
J Gastroenterol Hepatol 22:930-5. 2007..The aim of this study was to retrospectively review all patients who underwent pancreatic resection for malignant neuroendocrine tumor of the pancreas at the one department from 1989 to 2003...
Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomasMarcus Bahra
Department of General, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Berlin, Germany
Pancreas 41:222-9. 2012..Activation of the hedgehog signal transduction pathway, triggered by hedgehog binding to the transmembrane receptor patched 1 (PTCH1) or by mutations in the PTCH1 gene, plays an important role in the development of various tumors...
Surgical strategies for treatment of malignant pancreatic tumors: extended, standard or local surgery?Matthias Glanemann
Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Germany
World J Surg Oncol 6:123. 2008..Due to the development of modern instruments, laparoscopic operations became more and more successful, even in malignant pancreatic diseases. This review summarizes the recent literature on the above mentioned topics...
High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivoAnnika Lehmann
Institute of Pathology, Charite University Hospital, Berlin, Germany
BMC Cancer 9:395. 2009..The strong association between aberrant HDAC activity and the occurrence of cancer has led to the development of a variety of HDAC inhibitors (HDIs), which emerge as promising new targeted anticancer therapeutics...
Repeated steroid pulse therapies in HCV-positive liver recipients: significant risk factor for HCV-related graft lossM Bahra
Department of Surgery, Charite Campus Virchow Klinikum, Humboldt University, Berlin, Germany
Transplant Proc 37:1700-2. 2005..We retrospectively analyzed 232 patients after orthotopic liver transplantation (OLT) for HCV cirrhosis to determine the influence of methylprednisolone pulse therapy on long-term outcome after OLT...
Outcome after liver re-transplantation in patients with recurrent chronic hepatitis CMarcus Bahra
Klinik fUr Allgemein, Viszeral, und Transplantationschirurgie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
Transpl Int 20:771-8. 2007..This observational study may help select patients and identify the optimal time-point of liver retransplantation in ''Hepatitis C'' virus positive patients in the future...
Fibrosis progression in hepatitis C positive liver recipients after sustained virologic response to antiviral combination therapy (interferon-ribavirin therapy)Marcus Bahra
Klinik fUr Allgemein, Viszeral, und Transplantationschirurgie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
Transplantation 83:351-3. 2007..Sustained virologic response is associated with a deceleration of fibrosis progression and might therefore play a major role in prevention of graft cirrhosis in hepatitis C virus-infected liver graft recipients...
Influence of donor histology on outcome in patients undergoing transplantation for hepatitis CMarcus Bahra
Klinik fUr Allgemein, Viszeral, und Transplantationschirurgie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
Transplantation 84:144-8. 2007..Donor age was defined as one of the most important predictors of outcome in these patients; however, the mechanism leading to more severe recurrent hepatitis has not yet been investigated...
[Metastatic lesions to the pancreas. When is resection reasonable?]M Bahra
Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin
Chirurg 79:241-8. 2008..The significance of pancreatic resection for pancreatic metastatic lesions has not yet been sufficiently investigated. A retrospective analysis of patients undergoing pancreatic resections for pancreatic metastases was conducted...
MMF and calcineurin taper in recurrent hepatitis C after liver transplantation: impact on histological courseMarcus Bahra
Medizinischa Klinik mit Schwerpunht, Hepatologie, Gastroentorologie, Universitätsklinikum Charité and Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
Am J Transplant 5:406-11. 2005..MMF in combination with CNI taper showed a positive effect on fibrosis progression, graft inflammation and ALT levels and may improve the clinical course of HCV after OLT, however, the antiviral properties of MMF are still unconfirmed...
Significance of mycophenolate mofetil treatment in patients with HCV reinfection after liver transplantation: impact on clinical course and histologic damageM Bahra
Department of Surgery, , Humboldt-University, Berlin, Germany
Transplant Proc 34:2934-5. 2002
[Second-look operation in pancreatic carcinoma previously assessed as unresectable]P Warnick
Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Augustenburger Platz 1, 13353 Berlin, Deutschland
Zentralbl Chir 135:70-4. 2010..Preoperative diagnostic investigations may help, however, the definite decision on tumour resectability can only be made intraoperatively during explorative laparotomy...
[Liver transplantation for primary biliary cirrhosis: retrospective analysis of results at a single center]D A Jacob
Charite Campus Virchow, Universitatsmedizin Berlin, Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Berlin
Dtsch Med Wochenschr 131:2327-32. 2006..It was the aim of this study to analyse survival and complication rates after LTx among 100 patients in a long-term follow-up of up to 17 years...
Liver transplantation for primary biliary cirrhosis: influence of primary immunosuppression on survivalD A Jacob
Department of General, Visceral, and Transplantation Surgery, Humboldt University of Berlin, Charite Virchow Clinic, Berlin, Germany
Transplant Proc 37:1691-2. 2005..Liver transplantation is the only established curative therapy for end-stage primary biliary cirrhosis (PBC). However, the influence of primary immunosuppression on long-term patient and graft survival is still controversial...
Role of mannose-binding lectin-2 polymorphism in the development of acute cellular rejection after transplantation for hepatitis C virus-induced liver diseaseD Eurich
Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow, Berlin, Germany
Transpl Infect Dis 14:488-95. 2012....
[Pylorus-preserving pancreatic head resection: a new standard for tumors]M Glanemann
Klinik fUr Allgemein, Visceral und Transplantationschirurgie, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Deutschland
Chirurg 79:1107-14. 2008..Patients can benefit fundamentally from this procedure if it is carried out at a specialized center...
Viscoelasticity-based magnetic resonance elastography for the assessment of liver fibrosis in hepatitis C patients after liver transplantationC Kamphues
Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite, Campus Virchow Klinikum, Berlin, Germany
Rofo 184:1013-9. 2012..The aim of this study was to prospectively assess the diagnostic accuracy of viscoelasticity-based magnetic resonance (MR) elastography for the assessment of liver fibrosis in HCV patients after liver transplantation...
[Reconstruction of visceral arteries with homografts in excision of the pancreas]U Settmacher
Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Campus Virchow Klinikum, Charite, Humboldt Universitat, Berlin
Chirurg 75:1199-206. 2004..Whether this provides clinical benefit remains uncertain...
Donor age does not influence 12-month outcome after orthotopic liver transplantationW Faber
Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Klinikum, Humboldt University, Berlin, Germany
Transplant Proc 43:3789-95. 2011..Due to this, an expansion of the donor pool is necessary, for example, by accepting donor grafts from elderly donors. The aim of this study was to investigate the outcome after OLT depending on donor age...
High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosisW Weichert
Institute of Pathology, Charite University Hospital, Berlin, Germany
Br J Cancer 97:523-30. 2007..Based on our findings, this subgroup could be identified by applying simple immunohistochemical techniques...
Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growthG Schumacher
Department of General, Visceral, and Transplantation Surgery, , Augustenburger Platz 1, 13353 Berlin, Germany
Transplant Proc 34:1392-3. 2002
Surgical palliation of advanced pancreatic cancerM Bahra
Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Klinik fUr Allgemein, Visceral und Transplantationschirurgie, Germany
Recent Results Cancer Res 177:111-20. 2008..However, beyond controlled randomized studies, a palliative pancreaticoduodenectomy in patients with advanced pancreatic carcinoma cannot be recommended at this time...
Surgical techniques for resectable pancreatic cancerM Bahra
Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Klinik fUr Allgemein, Visceral und Transplantationschirurgie, Germany
Recent Results Cancer Res 177:29-38. 2008..An extended lymphadenectomy showed no benefit in several trials. Despite the encouraging advances in surgical treatment, actuarial 5-year survival rates after pancreatic resection are only at about 20%...
[Adenoviral vector expressing the TRAIL gene driven by the hTERT promoter]D Jacob
Klinik für Transplantations, Viszeral und Allgemeinchirurgie, Charite Campus Virchow, Humboldt Universitat zu Berlin, Deutschland
Z Gastroenterol 42:1363-70. 2004....
Relationship between the interleukin-28b gene polymorphism and the histological severity of hepatitis C virus-induced graft inflammation and the response to antiviral therapy after liver transplantationDennis Eurich
Department of General, Visceral, and Transplant Surgery, Charite, Campus Virchow, Berlin, Germany
Liver Transpl 17:289-98. 2011..G-allele might serve as a marker for graft inflammation and as a predictor for unfavorable antiviral therapy outcome in HCV-re-infected LT-population...
Transforming growth factor β1 polymorphisms and progression of graft fibrosis after liver transplantation for hepatitis C virus--induced liver diseaseDennis Eurich
Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Berlin, Germany
Liver Transpl 17:279-88. 2011....
Peroxisome proliferator-activated receptor gamma is highly expressed in pancreatic cancer and is associated with shorter overall survival timesGlen Kristiansen
Institute of Pathology and Department of Surgery, Charite University Hospital, Berlin, Germany
Clin Cancer Res 12:6444-51. 2006..We aimed to clarify the expression patterns of PPARgamma in pancreatic ductal carcinomas and to correlate these to clinicopathologic variables, including patient survival...
Nonresponse to pre-operative chemotherapy does not preclude long-term survival after liver resection in patients with colorectal liver metastasesUlf P Neumann
Department of General, Visceral, and Transplantation Surgery, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
Surgery 146:52-9. 2009..The aim of the study was to identify risk factors for poor outcome in patients with pre-operative chemotherapy of CRM...
Peginterferon alfa-2b plus ribavirin for the treatment of hepatitis C recurrence following combined liver and kidney transplantationVolker Schmitz
Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow, Berlin, Germany
Ann Transplant 12:22-7. 2007....
Primary radical surgery in elderly patients with epithelial ovarian cancer: analysis of surgical outcome and long-term survivalChristina Fotopoulou
Department of Gynecology and Obstetrics, Campus Virchow Clinic, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
Int J Gynecol Cancer 20:34-40. 2010..The aim of our study was to determine the impact of radical cytoreductive surgery, the cornerstone of clinical management in primary EOC, in this population with special regard to the associated morbidity...
Mayo risk score for primary biliary cirrhosis: a useful tool for the prediction of course after liver transplantation?Dietmar A Jacob
Department of General, Visceral and Transplantation Surgery, Humboldt University of Berlin, Charite Virchow Clinic, Berlin, Germany
Ann Transplant 13:35-42. 2008..Therefore, this study was designed to investigate the association of the MRS score with postoperative survival and complications...
Antiviral treatment of patients with recurrent hepatitis C after liver transplantation with pegylated interferonSven C Schmidt
Klinik fUr Allgemein, Viszeral, und Transplantationschirurgie, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
Dig Dis Sci 55:2063-9. 2010..The recurrence of hepatitis C virus (HCV) after liver transplantation (OLT) leads to recurrent cirrhosis in up to 40% of patients...
Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypesGuido Schumacher
Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Berlin, Germany
J Gastroenterol Hepatol 22:1469-73. 2007..2-Methoxyestradiol (2-ME2) has been shown to inhibit tumor growth. The aim was to examine the efficacy of 2-ME2 on multidrug-resistant human cells from pancreatic and gastric cancer...
Long-term outcome of liver transplants for chronic hepatitis C: a 10-year follow-upUlf P Neumann
Klinik fUr Allgemein, Viszeral, und Transplantationschirurgie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
Transplantation 77:226-31. 2004..However, there are still no clear predictors for severe recurrence. The aim of this study was to examine the 10-year outcome and risk factors for graft failure caused by HCV recurrence...
Gene therapy in colon cancer cells with a fiber-modified adenovector expressing the TRAIL gene driven by the hTERT promoterDietmar Jacob
Department of General, Visceral and Transplantation Surgery, Humboldt University of Berlin, Charite Campus Virchow, Berlin, Germany
Anticancer Res 24:3075-9. 2004....
Fibrosis progression after liver transplantation in patients with recurrent hepatitis CUlf P Neumann
Klinik fUr Allgemein, Viszeral, und Transplantationschirurgie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, D 13353 Berlin, Germany
J Hepatol 41:830-6. 2004....
Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growthGuido Schumacher
Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, Berlin 13353, Germany
World J Gastroenterol 11:1420-5. 2005..The purpose is to assess the effect on tumor growth of the immuno-suppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma...
Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cellsDietmar Jacob
Department of General, Visceral and Transplantation Surgery, Humboldt University of Berlin, CharitA Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
World J Gastroenterol 11:2552-6. 2005....
Overexpression of Polo-like kinase 1 is a common and early event in pancreatic cancerWilko Weichert
Institute of Pathology, Charite University Hospital, Berlin, Germany
Pancreatology 5:259-65. 2005..Therefore, PLK1 has been proposed as a new target for antineoplastic treatment strategies...
Prospective randomized comparison between a new mattress technique and Cattell (duct-to-mucosa) pancreaticojejunostomy for pancreatic resectionJan M Langrehr
Department of General, Visceral and Transplanation Surgery, Charité Campus Vichow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
World J Surg 29:1111-9, discussion 1120-1. 2005..Therefore the mattress technique for pancreatojejunostomy seems to be safe and is, in our opinion, well suitable for training schedules in pancreatic surgery...
Influence of donor/recipient HLA-matching on outcome and recurrence of hepatitis C after liver transplantationJan Michael Langrehr
Department of Surgery, Charite, Campus Virchow Clinic, Humboldt University, Berlin, Germany
Liver Transpl 12:644-51. 2006....
Long-term follow-up after recurrence of primary biliary cirrhosis after liver transplantation in 100 patientsDietmar A Jacob
Department of General, Visceral and Transplantation Surgery, Humboldt University of Berlin, Charite Virchow Clinic, Berlin, Germany
Clin Transplant 20:211-20. 2006..Tac-treated patients showed more frequently and also earlier histologically proven PBC recurrence; however, in our population we could not observe an impact on graft dysfunction and patient's survival...
Neuroendocrine tumor of the pancreas and bilateral adrenal pheochromocytomas. A rare manifestation of von Hippel-Lindau disease in childhoodJan M Langrehr
Department for General, Visceral and Transplantation Surgery, Charite, Campus Virchow Clinic, 13353 Berlin, Germany
J Pediatr Surg 42:1291-4. 2007..This is the first report on the combination of a neuroendocrine pancreatic tumor with adrenal pheochromocytoma in a pediatric patient with von Hippel-Lindau (VHL) disease...
Hepatitis C recurrence and fibrosis progression are not increased after living donor liver transplantation: a single-center study of 289 patientsMaximilian Schmeding
Department of General and Transplantation Surgery, Charite Campus Virchow Klinikum, Berlin, Germany
Liver Transpl 13:687-92. 2007..Patient and organ survival were similar when patients with large HCC and early tumor recurrence were excluded from analysis. LDLT can therefore be advocated for HCV patients...
Combination therapy of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cellsDietmar A Jacob
Department of General, Visceral and Transplant Surgery, Charite Campus Virchow Clinic, Humboldt University of Berlin, Berlin, Germany
J Gastroenterol Hepatol 22:738-48. 2007..The aim of this study was to test an approach combining the PARP inhibitor 3-ABA with standard gemcitabine therapy in human pancreatic cancer cells...
Jejunal loop drainage versus direct pancreatic duct drainage after pancreatic head resectionDietmar A Jacob
Department of General, Visceral, and Transplant Surgery, , Campus Virchow-Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
Surg Today 36:898-907. 2006..CONCLUSION: The choice of drainage system did not impact on the number or severity of postoperative complications or survival, indicating that loop drainage is as safe and effective as direct pancreatic duct drainage...
Treatment of patients with recurrent hepatitis C after liver transplantation with peginterferon alfa-2B plus ribavirinUlf Neumann
Klinik fUr Allgemein, Viszeral, und Transplantationschirurgie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
Transplantation 82:43-7. 2006....
Long-term results of mycophenolate mofetil as part of immunosuppressive induction therapy after liver transplantationJan M Langrehr
Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Germany
Clin Transplant 20:272-83. 2006..In our study, we report on the long-term results of triple induction therapy after orthotopic liver transplantation (OLT), consisting of MMF and low-dose corticosteroids, in combination with either tacrolimus or cyclosporine...
The impact of simultaneous liver resection for occult liver metastases of pancreatic adenocarcinomaF Klein
Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Gastroenterol Res Pract 2012:939350. 2012..However, a potential benefit of this radical surgical approach with regard to overall survival and/or quality of life remains to be proven...
Morphological analysis and differentiation of benign cystic neoplasms of the pancreas using computed tomography and magnetic resonance imagingC Grieser
Klinik für Radiologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin
Rofo 185:219-27. 2013....
Carcinoma of the distal and middle bile duct: surgical results, prognostic factors, and long-term follow-upMarcus Bahra
Chirurgische Klinik und Poliklinik, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, Berlin, Germany
J Hepatobiliary Pancreat Surg 15:501-7. 2008..Carcinoma of the distal bile duct is associated with poor prognosis. Surgical resection remains the only potentially curative treatment. We conducted a retrospective study to identify prognostic factors determining longterm survival...
Role of secondary cytoreductive surgery in ovarian cancer relapse: who will benefit? A systematic analysis of 240 consecutive patientsJalid Sehouli
Department of Gynecology, Charite University Medical Center Berlin, Berlin, Germany
J Surg Oncol 102:656-62. 2010..In contrast to primary ovarian cancer, the value of surgery in relapsed-OC (ROC) remains unclear. We evaluated surgical and clinical outcome of secondary cytoreduction in ROC...
