Christoph Arenz

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650
    Marlen Hesse
    Humboldt Universitat zu Berlin, Institute of Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Expert Opin Ther Pat 24:1271-6. 2014
  2. pmc TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells
    Susann Voigt
    Institut fur Immunologie, Christian Albrechts Universitat, Michaelisstrasse 5, 24105 Kiel, Germany
    BMC Cancer 14:74. 2014
  3. pmc Potent inhibition of Acid ceramidase by novel B-13 analogues
    Denny Proksch
    Institut fur Chemie, Humboldt Universitat zu Berlin, Brook Taylor Str 2, 12489 Berlin, Germany
    J Lipids 2011:971618. 2011
  4. doi request reprint Rolling-circle amplification: unshared advantages in miRNA detection
    Saskia Neubacher
    Humboldt Universitat zu Berlin, Institut fur Chemie, Brook Taylor Strasse 2, 12489 Berlin, Germany
    Chembiochem 10:1289-91. 2009
  5. doi request reprint Small molecule inhibitors of acid sphingomyelinase
    Christoph Arenz
    Institut fur Chemie, Humboldt Universitat zu Berlin, Berlin, Germany
    Cell Physiol Biochem 26:1-8. 2010
  6. doi request reprint Development of a novel FRET probe for the real-time determination of ceramidase activity
    Krishna P Bhabak
    Department of Organic and Bioorganic Chemistry, Humboldt Universitat zu Berlin, Institute for Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Chembiochem 14:1049-52. 2013
  7. doi request reprint Assaying Dicer-mediated miRNA maturation by means of fluorescent substrates
    Marlen Hesse
    Institute for Chemistry, Humboldt Universitat zu Berlin, Berlin, Germany
    Methods Mol Biol 1095:95-102. 2014
  8. doi request reprint Detection of microRNA maturation using unmodified pre-microRNA and branched rolling circle amplification
    Saskia Neubacher
    Institute for Chemistry, Humboldt Universitat zu Berlin, Berlin, Germany
    Methods Mol Biol 1095:109-19. 2014
  9. ncbi request reprint MicroRNAs--future drug targets?
    Christoph Arenz
    Institut fur Chemie, Humboldt Universitat zu Berlin, Brook Taylor Strasse 2, 12489 Berlin, Germany
    Angew Chem Int Ed Engl 45:5048-50. 2006
  10. doi request reprint A chemo-enzymatic approach to specifically click-modified RNA
    Claudine M Dojahn
    Humboldt Universitat zu Berlin, Institute for Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Chem Commun (Camb) 49:3128-30. 2013

Collaborators

  • Krishna P Bhabak
  • Marlen Hesse
  • Saskia Neubacher
  • Brian P Davies
  • Sebastian Banhart
  • Claudine M Dojahn
  • Denny Proksch
  • Susanne Redmer
  • Susann Voigt
  • Dagmar Heuer
  • Christiane Schöniger
  • Anke G Roth
  • Anke Gundula Roth
  • Andrea Martini
  • Essa M Saied
  • Christian Roder
  • Lukas Aeberhard
  • Holger Kalthoff
  • Sophia Koch
  • Parvin Davarnia
  • Supandi Winoto-Morbach
  • Dieter Adam
  • Stephan Philipp
  • Anna Trauzold
  • Dieter Kabelitz
  • Kazimierz Madela
  • Stefan Schütze
  • Burkhard Kleuser
  • Andrea Huwiler
  • Anett Hauser
  • Jan Jasper Klein
  • S Redmer

Detail Information

Publications22

  1. doi request reprint miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650
    Marlen Hesse
    Humboldt Universitat zu Berlin, Institute of Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Expert Opin Ther Pat 24:1271-6. 2014
    ..Since microRNAs (miRNAs) are important components of the gene regulatory networks in neurodegenerative diseases, there is huge effort to find correlation between expression patterns of miRNAs and disease...
  2. pmc TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells
    Susann Voigt
    Institut fur Immunologie, Christian Albrechts Universitat, Michaelisstrasse 5, 24105 Kiel, Germany
    BMC Cancer 14:74. 2014
    ..The potential of TRAIL-induced programmed necrosis in tumor therapy is, however, almost completely uncharacterized. We therefore investigated its impact on a panel of tumor cell lines of wide-ranging origin...
  3. pmc Potent inhibition of Acid ceramidase by novel B-13 analogues
    Denny Proksch
    Institut fur Chemie, Humboldt Universitat zu Berlin, Brook Taylor Str 2, 12489 Berlin, Germany
    J Lipids 2011:971618. 2011
    ..Furthermore, we provide hints for an introduction of basic functional groups at an alternative site of the B-13 scaffold that do not interfere with acid ceramidase inhibition in vitro...
  4. doi request reprint Rolling-circle amplification: unshared advantages in miRNA detection
    Saskia Neubacher
    Humboldt Universitat zu Berlin, Institut fur Chemie, Brook Taylor Strasse 2, 12489 Berlin, Germany
    Chembiochem 10:1289-91. 2009
    ..The use of T4 RNA ligase 2 (T4 RnL2) at elevated temperatures enables very good discrimination of miRNAs differing by a single nucleotide...
  5. doi request reprint Small molecule inhibitors of acid sphingomyelinase
    Christoph Arenz
    Institut fur Chemie, Humboldt Universitat zu Berlin, Berlin, Germany
    Cell Physiol Biochem 26:1-8. 2010
    ..Very recently, some new and promising inhibitors from different substance classes have been developed. In this review, previous and current developments in the field are summarized...
  6. doi request reprint Development of a novel FRET probe for the real-time determination of ceramidase activity
    Krishna P Bhabak
    Department of Organic and Bioorganic Chemistry, Humboldt Universitat zu Berlin, Institute for Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Chembiochem 14:1049-52. 2013
    ..We present a fluorescent sphingolipid FRET probe that allows homogeneous ratiometric determination of enzyme activity in real-time...
  7. doi request reprint Assaying Dicer-mediated miRNA maturation by means of fluorescent substrates
    Marlen Hesse
    Institute for Chemistry, Humboldt Universitat zu Berlin, Berlin, Germany
    Methods Mol Biol 1095:95-102. 2014
    ..Dicer or miRNA maturation assays can be easily performed in a 384-well plate format, consuming less than 1 pmol of RNA beacon per reaction. ..
  8. doi request reprint Detection of microRNA maturation using unmodified pre-microRNA and branched rolling circle amplification
    Saskia Neubacher
    Institute for Chemistry, Humboldt Universitat zu Berlin, Berlin, Germany
    Methods Mol Biol 1095:109-19. 2014
    ..Here we describe the in vitro detection of the Dicer-mediated miRNA maturation step using unmodified pre-miRNA and branched rolling circle amplification. ..
  9. ncbi request reprint MicroRNAs--future drug targets?
    Christoph Arenz
    Institut fur Chemie, Humboldt Universitat zu Berlin, Brook Taylor Strasse 2, 12489 Berlin, Germany
    Angew Chem Int Ed Engl 45:5048-50. 2006
  10. doi request reprint A chemo-enzymatic approach to specifically click-modified RNA
    Claudine M Dojahn
    Humboldt Universitat zu Berlin, Institute for Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Chem Commun (Camb) 49:3128-30. 2013
    ..Herein we describe an easy and versatile chemo-enzymatic approach to label RNA at its termini or defined internal positions via click-chemistry...
  11. doi request reprint Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues
    Krishna P Bhabak
    Humboldt Universitat zu Berlin, Institute for Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Bioorg Med Chem 21:874-82. 2013
    ....
  12. pmc Improved plaque assay identifies a novel anti-Chlamydia ceramide derivative with altered intracellular localization
    Sebastian Banhart
    Junior Research Group Sexually Transmitted Bacterial Pathogens NG 5, Robert Koch Institute, Berlin, Germany
    Antimicrob Agents Chemother 58:5537-46. 2014
    ..Thereby, 1-O-methyl-NBD-ceramide-C16 represents a lead compound for the development of novel anti-Chlamydia drugs and furthermore constitutes an agent to illuminate sphingolipid trafficking pathways in Chlamydia infections. ..
  13. doi request reprint Novel amide- and sulfonamide-based aromatic ethanolamines: effects of various substituents on the inhibition of acid and neutral ceramidases
    Krishna P Bhabak
    Humboldt Universitat zu Berlin, Institute for Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Bioorg Med Chem 20:6162-70. 2012
    ..However, the hydrophobicity and the steric effects of longer alkyl chains (n-Pr, n-Bu or t-Bu groups) at the phenyl ring were found to be important for an enhanced selectivity towards aCDase over nCDase...
  14. doi request reprint MicroRNA maturation and human disease
    Marlen Hesse
    Institute for Chemistry, Humboldt Universitat zu Berlin, Berlin, Germany
    Methods Mol Biol 1095:11-25. 2014
    ..Herein, we review the current knowledge of how miRNAs are linked to human disease and which parts of the miRNA maturation machinery could serve as future drug targets. ..
  15. doi request reprint A rapid assay for miRNA maturation by using unmodified pre-miRNA
    Saskia Neubacher
    Institut fur Chemie, Humboldt Universitat zu Berlin, Brook Taylor Strasse 2, 12489 Berlin, Germany
    Chembiochem 12:2302-5. 2011
    ..The assay depends on the cleavage of unmodified pre-miRNAs and the subsequent amplification of the mature miRNA by rolling circle amplification (see accompanying scheme)...
  16. doi request reprint Perspectives in targeting miRNA function
    Christiane Schöniger
    Humboldt Universitat zu Berlin, Institute for Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Bioorg Med Chem 21:6115-8. 2013
    ..In this perspectives article, we provide a short overview on recent developments in this field. ..
  17. doi request reprint Novel fluorescent ceramide derivatives for probing ceramidase substrate specificity
    Krishna P Bhabak
    Humboldt Universitat zu Berlin, Institute for Chemistry, Brook Taylor Str 2, 12489 Berlin, Germany
    Bioorg Med Chem 20:6154-61. 2012
    ....
  18. doi request reprint Novel drugs targeting sphingolipid metabolism
    Krishna P Bhabak
    Institut fur Chemie, Humboldt Universitat zu Berlin, Brook Taylor Str 2, Berlin, 12489, Germany
    Handb Exp Pharmacol 215:187-96. 2013
    ..Ceramide is in the center of sphingolipid metabolism. We describe the most important and most recent inhibitors for enzymes controlling cellular ceramide levels...
  19. ncbi request reprint A fluorescence probe for assaying micro RNA maturation
    Brian P Davies
    Humboldt Universitat zu Berlin, Institut fur Chemie, Brook Taylor Strasse 2, 12489 Berlin, Germany
    Bioorg Med Chem 16:49-55. 2008
    ..We have developed a fluorescence beacon with which to study the maturation of miRNAs. Details are provided of a homogeneous assay for detecting potential inhibitors of miRNA maturation in a high-throughput format...
  20. ncbi request reprint A homogenous assay for micro RNA maturation
    Brian P Davies
    Humboldt Universitat zu Berlin, Institut fur Chemie, Brook Taylor Strasse 2, 12489 Berlin, Germany
    Angew Chem Int Ed Engl 45:5550-2. 2006
  21. doi request reprint Development of carbohydrate-derived inhibitors of acid sphingomyelinase
    Anke G Roth
    Institut fur Chemie, Humboldt Universitat zu Berlin, 12489 Berlin, Germany
    Bioorg Med Chem 18:939-44. 2010
    ..The resulting compound is more active than its parent compound and offers new means for further structural modification...
  22. doi request reprint Potent inhibition of acid sphingomyelinase by phosphoinositide analogues
    Anke Gundula Roth
    Institut fur Chemie, Humboldt Universitat zu Berlin, Brook Taylor Strasse 2, 12489 Berlin, Germany
    Chembiochem 10:2367-74. 2009
    ..Last but not least, the new inhibitor partially protected cells from dexamethasone-induced cell death...