Petra Arck

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways
    Petra Clara Arck
    Department of Internal Medicine, Charite School of Medicine, Humboldt University, Berlin, Germany
    Am J Pathol 162:803-14. 2003
  2. pmc Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach
    Nadja Tariverdian
    Center of Internal Medicine and Dermatology, Division of PsychoNeurolmmunology, Charite, University Medicine Berlin, Berlin, Germany
    Semin Immunopathol 29:193-210. 2007
  3. ncbi From the decidual cell internet: trophoblast-recognizing T cells
    P Arck
    Charite, Campus Virchow Klinikum, Humbolt University, 13353 Berlin, Germany
    Biol Reprod 60:227-33. 1999
  4. ncbi From the brain-skin connection: the neuroendocrine-immune misalliance of stress and itch
    Petra Arck
    Center for Internal Medicine and Dermatology, Charite, University Medicine Berlin, and Department of Dermatology, University Hospital Schleswig Holstein, Lubeck, Germany
    Neuroimmunomodulation 13:347-56. 2006
  5. ncbi Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition
    Petra C Arck
    Biomedizinisches Forschungszentrum, Campus Virchow Klinikum, Charite University Medicine, Augustenburger Platz 1, 13353 Berlin, Germany
    J Mol Med (Berl) 83:386-96. 2005
  6. doi The alchemy of immune privilege explored from a neuroimmunological perspective
    Petra Clara Arck
    The Brain Body Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Pharmacol 8:480-9. 2008
  7. ncbi Topical minoxidil counteracts stress-induced hair growth inhibition in mice
    Petra Clara Arck
    Department of Internal Medicine, Charite, Humboldt University, Berlin, Germany
    Exp Dermatol 12:580-90. 2003
  8. ncbi Early risk factors for miscarriage: a prospective cohort study in pregnant women
    Petra C Arck
    Centre of Internal Medicine and Dermatology, Division of Psycho Neuro Immunology, Charite, University Medicine Berlin, Germany
    Reprod Biomed Online 17:101-13. 2008
  9. pmc Neuroimmunology of stress: skin takes center stage
    Petra C Arck
    Biomedical Research Center, Charite, University Medicine Berlin, Berlin, Germany
    J Invest Dermatol 126:1697-704. 2006
  10. ncbi Is there a 'gut-brain-skin axis'?
    Petra Arck
    Center of Internal Medicine and Dermatology, Charite University Medicine Berlin, Berlin, Germany
    Exp Dermatol 19:401-5. 2010

Collaborators

Detail Information

Publications35

  1. pmc Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways
    Petra Clara Arck
    Department of Internal Medicine, Charite School of Medicine, Humboldt University, Berlin, Germany
    Am J Pathol 162:803-14. 2003
    ..This offers the first convincing rationale how stress-induced hair loss in men may be pharmacologically managed effectively...
  2. pmc Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach
    Nadja Tariverdian
    Center of Internal Medicine and Dermatology, Division of PsychoNeurolmmunology, Charite, University Medicine Berlin, Berlin, Germany
    Semin Immunopathol 29:193-210. 2007
    ..Finally, we introduce the concept of endometrial dissemination as result of a neuroendocrine-immune disequilibrium in response to high levels of perceived stress caused by cardinal clinical symptoms of endometriosis...
  3. ncbi From the decidual cell internet: trophoblast-recognizing T cells
    P Arck
    Charite, Campus Virchow Klinikum, Humbolt University, 13353 Berlin, Germany
    Biol Reprod 60:227-33. 1999
    ....
  4. ncbi From the brain-skin connection: the neuroendocrine-immune misalliance of stress and itch
    Petra Arck
    Center for Internal Medicine and Dermatology, Charite, University Medicine Berlin, and Department of Dermatology, University Hospital Schleswig Holstein, Lubeck, Germany
    Neuroimmunomodulation 13:347-56. 2006
    ....
  5. ncbi Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition
    Petra C Arck
    Biomedizinisches Forschungszentrum, Campus Virchow Klinikum, Charite University Medicine, Augustenburger Platz 1, 13353 Berlin, Germany
    J Mol Med (Berl) 83:386-96. 2005
    ..These results indicate that the cross-talk between SP and mast cell activation via NK-1R appears to be the most important pathway in the regulation of hair follicle cycling upon stress response...
  6. doi The alchemy of immune privilege explored from a neuroimmunological perspective
    Petra Clara Arck
    The Brain Body Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Opin Pharmacol 8:480-9. 2008
    ....
  7. ncbi Topical minoxidil counteracts stress-induced hair growth inhibition in mice
    Petra Clara Arck
    Department of Internal Medicine, Charite, Humboldt University, Berlin, Germany
    Exp Dermatol 12:580-90. 2003
    ..This encourages one to explore clinically whether topical minoxidil is a safe and effective pharmacologic tool for the management of stress-associated telogen effluvium in humans...
  8. ncbi Early risk factors for miscarriage: a prospective cohort study in pregnant women
    Petra C Arck
    Centre of Internal Medicine and Dermatology, Division of Psycho Neuro Immunology, Charite, University Medicine Berlin, Germany
    Reprod Biomed Online 17:101-13. 2008
    ....
  9. pmc Neuroimmunology of stress: skin takes center stage
    Petra C Arck
    Biomedical Research Center, Charite, University Medicine Berlin, Berlin, Germany
    J Invest Dermatol 126:1697-704. 2006
    ....
  10. ncbi Is there a 'gut-brain-skin axis'?
    Petra Arck
    Center of Internal Medicine and Dermatology, Charite University Medicine Berlin, Berlin, Germany
    Exp Dermatol 19:401-5. 2010
    ....
  11. ncbi Indications for a 'brain-hair follicle axis (BHA)': inhibition of keratinocyte proliferation and up-regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P
    P C Arck
    Department of Internal Medicine, Charite, Humboldt University, Berlin, Germany
    FASEB J 15:2536-8. 2001
    ..We conclude that stress can indeed inhibit hair growth in vivo, probably via a substance P-dependent activation of macrophages and/or mast cells in the context of a brain-hair follicle axis...
  12. ncbi Pregnancy as a model of controlled invasion might be attributed to the ratio of CD3/CD8 to CD56
    P C Arck
    Department of Medicine Psychosomatics, Charite, Humboldt University Berlin, Germany
    Am J Reprod Immunol 44:1-8. 2000
    ....
  13. ncbi Stress and pregnancy loss: role of immune mediators, hormones and neurotransmitters
    P C Arck
    Humboldt University, Berlin, Germany
    Am J Reprod Immunol 46:117-23. 2001
    ..Since a well-balanced interaction of nervous, endocrine and immune system is crucial for the maintenance of successful pregnancy, putative mechanisms and recent observations on stress-triggered pregnancy failure have been reviewed...
  14. ncbi Stress and immune mediators in miscarriage
    P C Arck
    Charite, Campus Virchow Klinik, Biomedical Research Center, Humboldt University, Raum 2 0549, Augustenburger Platz 1, 13353 Berlin, Germany
    Hum Reprod 16:1505-11. 2001
    ..In order to test the validity of the conclusions drawn from murine experiments and the role of stress in human pregnancy loss, the following study was performed...
  15. pmc p75 Neurotrophin Receptor-Mediated Signaling Promotes Human Hair Follicle Regression (Catagen)
    Eva M J Peters
    Biomedical Research Center, Room No 2 0549, Charité Campus Virchow Hospital, Augustenburger Platz 1, D 13353 Berlin, Germany
    Am J Pathol 168:221-34. 2006
    ....
  16. doi Neuroendocrine perspectives in alopecia areata: does stress play a role?
    Ralf Paus
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 129:1324-6. 2009
    ..This has triggered debates about whether AA should be considered a psychosomatic disorder (Misery and Rousset, 2001; Willemsen et al., 2009)...
  17. ncbi Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress
    Petra Arck
    Charite, University Medicine Berlin, Berlin, Germany
    Am J Reprod Immunol 58:268-79. 2007
    ..These effects are corrected by progesterone supplementation. These findings indicate the significance of a progesterone-dependent immuno-modulation in maternal tolerance of the fetus, which is discussed in this review...
  18. ncbi The Perceived Stress Questionnaire (PSQ) reconsidered: validation and reference values from different clinical and healthy adult samples
    Herbert Fliege
    Department of Psychosomatic Medicine, Charite University Hospital Berlin, Luisenstrasse 13 a, D 10117 Berlin, Germany
    Psychosom Med 67:78-88. 2005
    ..The aim was to translate, revise, and standardize the Perceived Stress Questionnaire (PSQ) by Levenstein et al. (1993) in German. The instrument assesses subjectively experienced stress independent of a specific and objective occasion...
  19. pmc Inflammatory breast diseases during lactation: health effects on the newborn-a literature review
    Achim Wockel
    Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
    Mediators Inflamm 2008:298760. 2008
    ..It also gives an overview on possible pathological effects, which these cytokine changes in the breast milk might have on the newborn...
  20. ncbi Towards a "free radical theory of graying": melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage
    Petra Clara Arck
    Cutaneous Neuroimmunology, Biomedical Research Center, Rm Nr 2 0549, University Medicine Charité, Virchow Campus, Humboldt University of Berlin, Augustenburger Platz 1, Berlin 13353, Germany
    FASEB J 20:1567-9. 2006
    ..The graying hair follicle, therefore, offers a unique model system to study oxidative stress and aging and to test antiaging therapeutics in their ability to slow down or even stop this process...
  21. ncbi ETA receptor blockade induces tubular cell proliferation and cyst growth in rats with polycystic kidney disease
    Berthold Hocher
    Department of Nephrology, University Hospital Charite, Humboldt University of Berlin, D 10098 Berlin, Germany
    J Am Soc Nephrol 14:367-76. 2003
    ..This is of major clinical impact because endothelin receptor antagonists are upcoming clinically used drugs...
  22. ncbi Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin
    Eva Milena J Peters
    Department of Internal Medicine, Charite University Medicine, Berlin, Germany
    Brain Behav Immun 19:252-62. 2005
    ..Thus, neuronal plasticity and increased neuro-immune interaction occur under stress and may alter inflammatory skin diseases and trophic functions in the skin where neurogenic inflammation plays a part...
  23. pmc Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor
    Eva Milena J Peters
    Center for Biomedical Research, Charite, University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Am J Pathol 165:259-71. 2004
    ....
  24. doi Developmental programming of allergic diseases
    Maike Pincus
    Department of Pediatrics, Pneumology and Immunology Division, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Chem Immunol Allergy 98:70-84. 2012
    ..Subsequently, therapeutic interventions designed to prevent negative consequences of prenatal environmental challenges on children's immune system would be within reach...
  25. ncbi Impact of a relaxation training on psychometric and immunologic parameters in tinnitus sufferers
    Cora Weber
    Clinic for Internal Medicine Psychosomatics, Charite Campus Virchow Clinic, Medical School of the Humboldt University, Augustenburger Platz 1, 13353, Berlin, Germany
    J Psychosom Res 52:29-33. 2002
    ..Based on this hypothesis, we investigated whether improving stress-managing capabilities would influence psychological and stress-related immunological parameters in chronic tinnitus sufferers...
  26. doi Causes for spontaneous abortion: what the bugs 'gut' to do with it?
    Astrid Friebe
    Charite, University Medicine, Berlin, Germany
    Int J Biochem Cell Biol 40:2348-52. 2008
    ..In turn, intestinal barrier function may be enhanced and mediators of immune tolerance may be restored, i.e. in the context of reproduction...
  27. doi Effects of complete vagotomy and blockage of cell adhesion molecules on interferon-α induced behavioral changes in mice
    Astrid Friebe
    Department of Medicine, The Brain Body Institute, McMaster University, Hamilton, Ontario, Canada
    Behav Brain Res 240:1-10. 2013
    ..However, underlying pathogenic mechanisms of cytokine-induced brain dysfunction largely remain unknown...
  28. ncbi Nuclear receptors of the peroxisome proliferator-activated receptor (PPAR) family in gestational diabetes: from animal models to clinical trials
    Petra Arck
    Center for Internal Medicine, Charite University Medicine Berlin, Berlin, Germany
    Biol Reprod 83:168-76. 2010
    ..Our objective herein is to review newly emerging generations of selective PPAR modulators and panagonists, which may have potent therapeutic implications in the context of GDM...
  29. ncbi (Neuro-)endocrinology of epithelial hair follicle stem cells
    Ralf Paus
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Mol Cell Endocrinol 288:38-51. 2008
    ..These considerations call for a concerted research effort to dissect the (neuro-)endocrinology of HFeSCs much more systematically than before...
  30. doi Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung
    Cherrie Lee Small
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    J Immunol 184:2048-56. 2010
    ..aureus phagocytosis by alveolar macrophages. Together, our study identifies the weakened NK cell response in the lung to be a novel critical mechanism for flu-mediated susceptibility to bacterial superinfection...
  31. pmc Stress-induced neurogenic inflammation in murine skin skews dendritic cells towards maturation and migration: key role of intercellular adhesion molecule-1/leukocyte function-associated antigen interactions
    Ricarda Alcira Joachim
    Center of Internal Medicine and Dermatology CC12, Charite, University of Medicine, Berlin, Germany
    Am J Pathol 173:1379-88. 2008
    ..However, present-day stressors have changed and such adaptations appear redundant and may overrun skin homeostasis by inducing immune dermatoses...
  32. ncbi Neuroimmunoendocrine circuitry of the 'brain-skin connection'
    Ralf Paus
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, D 23538 Lubeck, Germany
    Trends Immunol 27:32-9. 2006
    ..Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention...
  33. ncbi The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response
    Ricarda Joachim
    Charite, Department of Internal Medicine, Biomedizinisches Forschungszentrum, Humboldt University of Berlin, Campus Virchow, Raum 2 0549, Augustenburger Platz 1, 13353 Berlin, Germany
    Steroids 68:931-40. 2003
    ..Our data suggest that dydrogesterone abrogates stress-triggered abortion by inducing a Th2 biased local immune response...
  34. ncbi Mothers in stress: consequences for the offspring
    Maike Katharina Knackstedt
    Department of Pediatrics for Pneumology and Immunology, University Medicine Charité, Berlin, Germany
    Am J Reprod Immunol 54:63-9. 2005
    ....
  35. pmc Stress and reproductive failure: past notions, present insights and future directions
    Katrina Nakamura
    Interdisciplinary Studies Graduate Program, University of British Columbia, 6201 Cecil Green Park Road, Vancouver, BC, V6T 1Z1, Canada
    J Assist Reprod Genet 25:47-62. 2008
    ..The purpose of the present review is to critically assess the biological and epidemiological evidence that considers the plausibility of a stress link to human reproductive failure...