Ioannis Anagnostopoulos

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. doi request reprint [Epstein-Barr virus-associated lymphoproliferations and lymphomas]
    I Anagnostopoulos
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Deutschland
    Pathologe 34:262-71. 2013
  2. ncbi request reprint Epstein-barr virus infection of monocytoid B-cell proliferates: an early feature of primary viral infection?
    Ioannis Anagnostopoulos
    Consultation and Reference Center for Hematopathology at the Institute of Pathology, Charite, Campus Benjamin Franklin, Medical University, Berlin, Germany
    Am J Surg Pathol 29:595-601. 2005
  3. doi request reprint Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after Upfront chemotherapy: the role of single-agent rituximab
    Ralf U Trappe
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 84:1708-12. 2007
  4. ncbi request reprint Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells
    Franziska Jundt
    Department of Hematology and Oncology, Charite, Campus Virchow Klinikum, University Medicine Berlin, Berlin, Germany
    Blood 103:3511-5. 2004
  5. doi request reprint T-box-expressed-in-T-cells (T-bet) expression by the tumor cells of hairy-cell leukemia correlates with interferon-gamma production
    Korinna Johrens
    Consultation and Reference Center for Hematopathology, Institute of Pathology, Charite University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany
    Leuk Lymphoma 50:1687-92. 2009
  6. doi request reprint Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma
    Armin Rehm
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Int J Cancer 125:2367-74. 2009
  7. doi request reprint Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial
    Ralf Trappe
    Department of Haematology and Oncology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Lancet Oncol 13:196-206. 2012
  8. doi request reprint Interferon-gamma and T-bet expression in a patient with toxoplasmic lymphadenopathy
    Korinna Johrens
    Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm, Berlin, Germany
    Hum Immunol 71:366-71. 2010
  9. doi request reprint A novel CD11c monoclonal antibody effective in formalin-fixed tissue for the diagnosis of hairy cell leukemia
    Korinna Johrens
    Institute of Pathology and Reference Center for Hematopathology, Charite, Medical University Berlin, Berlin, Germany
    Pathobiology 75:252-6. 2008
  10. doi request reprint Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha
    Björn Lamprecht
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Blood 112:3339-47. 2008

Detail Information

Publications50

  1. doi request reprint [Epstein-Barr virus-associated lymphoproliferations and lymphomas]
    I Anagnostopoulos
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Deutschland
    Pathologe 34:262-71. 2013
    ....
  2. ncbi request reprint Epstein-barr virus infection of monocytoid B-cell proliferates: an early feature of primary viral infection?
    Ioannis Anagnostopoulos
    Consultation and Reference Center for Hematopathology at the Institute of Pathology, Charite, Campus Benjamin Franklin, Medical University, Berlin, Germany
    Am J Surg Pathol 29:595-601. 2005
    ....
  3. doi request reprint Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after Upfront chemotherapy: the role of single-agent rituximab
    Ralf U Trappe
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 84:1708-12. 2007
    ..Single-agent rituximab salvage therapy is an effective treatment option in this setting of intensively pretreated patients, with virtually no therapy-associated toxicity...
  4. ncbi request reprint Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells
    Franziska Jundt
    Department of Hematology and Oncology, Charite, Campus Virchow Klinikum, University Medicine Berlin, Berlin, Germany
    Blood 103:3511-5. 2004
    ..Functional data indicate that ligand-induced Notch signaling is a growth factor for MM cells and suggest that these interactions contribute to myelomagenesis in vivo...
  5. doi request reprint T-box-expressed-in-T-cells (T-bet) expression by the tumor cells of hairy-cell leukemia correlates with interferon-gamma production
    Korinna Johrens
    Consultation and Reference Center for Hematopathology, Institute of Pathology, Charite University Medicine Berlin, Campus Benjamin Franklin, 12203 Berlin, Germany
    Leuk Lymphoma 50:1687-92. 2009
    ....
  6. doi request reprint Identification of a chemokine receptor profile characteristic for mediastinal large B-cell lymphoma
    Armin Rehm
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Int J Cancer 125:2367-74. 2009
    ..Furthermore, we suggest that low-abundance expression of CCR7 and CXCR5 may hinder lymphoma cells from nodal dissemination...
  7. doi request reprint Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial
    Ralf Trappe
    Department of Haematology and Oncology, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Lancet Oncol 13:196-206. 2012
    ....
  8. doi request reprint Interferon-gamma and T-bet expression in a patient with toxoplasmic lymphadenopathy
    Korinna Johrens
    Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm, Berlin, Germany
    Hum Immunol 71:366-71. 2010
    ..We conclude that the pathogenesis and course of toxoplasmic lymphadenopathy is based on a T(h)1-cell defect, which becomes compensated by the B cells mounting a T(h)1-like immune response...
  9. doi request reprint A novel CD11c monoclonal antibody effective in formalin-fixed tissue for the diagnosis of hairy cell leukemia
    Korinna Johrens
    Institute of Pathology and Reference Center for Hematopathology, Charite, Medical University Berlin, Berlin, Germany
    Pathobiology 75:252-6. 2008
    ..In this study, we assessed the utility of a newly developed antibody against a formalin-resistant CD11c epitope (5D11) for the diagnosis and monitoring of HCL in formalin-fixed tissue...
  10. doi request reprint Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha
    Björn Lamprecht
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Blood 112:3339-47. 2008
    ..Together, these data support the concept that aberrant expression of B lineage-inappropriate genes plays an important role for the biology of HL tumor cells...
  11. ncbi request reprint Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
    Franziska Jundt
    Charite, Robert Rossle Klinik, Humboldt University of Berlin, Germany
    Blood 99:3398-403. 2002
    ..Thus, our data suggest that activated Notch1 signaling plays an important role in the pathobiology of Hodgkin and anaplastic large cell lymphoma and that it might be a potential new target for treatment...
  12. pmc Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification
    Christoph Loddenkemper
    Institute of Pathology, Charite University Medicine Berlin, Berlin, Germany
    Virchows Arch 450:493-502. 2007
    ..This study provides relevant data on the distribution of hepatic lymphomas and demonstrates the applicability of the WHO classification proposing a diagnostic algorithm for liver biopsies...
  13. ncbi request reprint T-bet transcription factor detection facilitates the diagnosis of minimal hairy cell leukemia infiltrates in bone marrow trephines
    Korinna Johrens
    Consultation and Reference Center for Hematopathology at the Institute of Pathology, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Germany
    Am J Surg Pathol 31:1181-5. 2007
    ..Therefore, the immunohistochemical detection of T-bet in infiltrated bone marrow trephines represents an important adjunct for the diagnosis of HCL...
  14. ncbi request reprint Influence of antigen on the development of MALT lymphoma
    Dido Lenze
    Institute of Pathology, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Germany
    Blood 107:1141-8. 2006
    ....
  15. ncbi request reprint Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab
    Ralf Trappe
    1Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 83:912-8. 2007
    ..This retrospective analysis was undertaken to determine the efficacy and safety of salvage therapy in recipients of solid organ transplants with progression of PTLD after rituximab first-line therapy...
  16. doi request reprint Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
    Björn Lamprecht
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Nat Med 16:571-9, 1p following 579. 2010
    ..We conclude that LTR derepression is involved in the pathogenesis of human lymphomas, a finding that might have diagnostic, prognostic and therapeutic implications...
  17. ncbi request reprint Expression of immunoglobulin transcription factors in primary intraocular lymphoma and primary central nervous system lymphoma
    Sarah E Coupland
    Department of Pathology, Charite University Medicine, Campus Benjamin Franklin, Berlin, Germany
    Invest Ophthalmol Vis Sci 46:3957-64. 2005
    ..PIOL is a rare non-Hodgkin lymphoma, considered a subtype of PCNSL. Both are usually diffuse, large B-cell lymphoma (DLBCL), rarely manifest outside the CNS, and carry a poor prognosis...
  18. ncbi request reprint Salvage chemotherapy for refractory or relapsed post-transplant lymphoproliferative disorder in patients after solid organ transplantation with a combination of carboplatin and etoposide
    Stephan H Oertel
    Humboldt Universitat Berlin, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Berlin, Germany
    Br J Haematol 123:830-5. 2003
    ....
  19. ncbi request reprint Radiologic and pathologic features of a posttransplantation primary central nervous system lymphoma demonstrating Epstein-Barr virus-positive Hodgkin lymphoma
    Marion Subklewe
    Med Klinik m S Haematologie Onkologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Clin Lymphoma Myeloma 7:535-7. 2007
    ..The 65-year-old patient was treated by reduction of immunosuppression and cerebral radiation therapy and remains in remission 18 months after the initial diagnosis...
  20. pmc Common clonal origin of an acute B-lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity
    Richard Ratei
    Department of Hematology, Oncology, and Tumor Immunology, Helios Klinikum Berlin Buch, Berlin, Germany
    Haematologica 95:1461-6. 2010
    ..Here we report on a patient who presented with an acute B-lymphoblastic leukemia and developed a Langerhans' cell sarcoma 9 years later. We provide evidence that the second neoplasm is the result of transdifferentiation...
  21. ncbi request reprint T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution
    Korinna Johrens
    Institute for Pathology, Charite, Campus Benjamin Franklin, Medical University Berlin, Germany
    Haematologica 90:1070-7. 2005
    ..To clarify this issue we studied the antigen profile and topographical distribution of these cell types...
  22. doi request reprint Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease
    Korinna Johrens
    Institute for Pathology, Charite, Campus Benjamin Franklin, Medical University Berlin, Berlin, Germany
    Virchows Arch 457:451-6. 2010
    ..Also, most of the CD8+ lamina propria T cells in CD were T-bet+. We conclude that in contrast to CD, which exhibits immunophenotypical features of a Th1-response, LC shows features of a mixed Th1/Th2 immune response...
  23. doi request reprint Non-neoplastic TdT-positive cells in bone marrow trephines with acute myeloid leukaemia before and after treatment express myeloid molecules
    Korinna Johrens
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Pathobiology 78:35-40. 2011
    ..During our routine bone marrow trephine analysis of patients with acute myeloid leukaemia (AML) before and after treatment, we observed the presence of TdT-positive cells lacking CD34, CD10 and B cell antigens...
  24. doi request reprint Peripheral blood sCD3⁻ CD4⁺ T cells: a useful diagnostic tool in angioimmunoblastic T cell lymphoma
    Anju Singh
    Department of Hematology, Oncology and Tumor Immunology, Charite University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany Labor Berlin Charité Vivantes GmbH, Berlin, Germany
    Hematol Oncol 32:16-21. 2014
    ..Flow cytometry is particularly useful in the differential diagnosis of AITL, even if the aberrant T cell population has a very low frequency. Further biological characterization of this subfraction of lymphoma cells is warranted...
  25. ncbi request reprint Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease
    Franziska Jundt
    Charite, Robert Rossle Klinik, Humboldt University of Berlin, Germany
    Blood 99:3060-2. 2002
    ..Our study identifies PU.1 deficiency as a recurrent defect in HRS cells that might contribute to their impairment of immunoglobulin transcription...
  26. doi request reprint Three different expression patterns of T-bet in angioimmunoblastic T-cell lymphoma
    Korinna Johrens
    Institute of Pathology, Charite University Medicine Berlin, Campus Mitte, Berlin, Germany
    Leuk Lymphoma 53:152-5. 2012
    ....
  27. pmc Reevaluation of the 22-1-1 antibody and its putative antigen, EBAG9/RCAS1, as a tumor marker
    Tatiana A Reimer
    Department of Hematology, Oncology and Tumorimmunology, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    BMC Cancer 5:47. 2005
    ..This raised the question if EBAG9 is tumor-specific and mediates apoptosis itself or through O-linked glycans generated, among them the cognate 22-1-1 antigen Tn...
  28. ncbi request reprint Evidence of haematopoiesis within the developing human diencephalon. Correlations with vertebrate phylogeny
    Volkhard Seitz
    Max Planck Institute for Molecular Genetics, Universitatsmedizin Berlin, Berlin, Germany
    Pathobiology 73:55-62. 2006
    ..As haematopoiesis has been described in the diencephalon and pituitary gland of water-inhabiting vertebrates we wanted to find out whether such a phenomenon also occurs in human embryos...
  29. doi request reprint IL-6 and IL-10 in post-transplant lymphoproliferative disorders development and maintenance: a longitudinal study of cytokine plasma levels and T-cell subsets in 38 patients undergoing treatment
    Carl Hinrichs
    Department of Nephrology and Intensive Care, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transpl Int 24:892-903. 2011
    ..Although the specificity of these cells is unclear, their increase might correlate with the impaired tumor-specific cytotoxic-T-lymphocyte (CTL)-response in PTLD...
  30. ncbi request reprint Identification of early antigen BZLF1/ZEBRA protein of Epstein-Barr virus can predict the effectiveness of antiviral treatment in patients with post-transplant lymphoproliferative disease
    Stephan H Oertel
    Hämatologie und Onkologie, Universitätsklinikum Charite Campus Virchow, Humboldt Universitat Berlin, Berlin, Germany
    Br J Haematol 118:1120-3. 2002
    ..Response of PTLD to antiviral treatment correlated with the expression of lytic phase antigen BZLF1/ZEBRA protein, an early antigen of lytic EBV-activity, in the biopsied PTLD specimens...
  31. pmc Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma
    Stephan Mathas
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 106:5831-6. 2009
    ..Also, our data demonstrate that deregulation of breakpoint-proximal genes has a key role in ALCL...
  32. doi request reprint Hepatosplenic T-cell lymphomas and therapy with TNF-alpha-blocking biologics: a risk for psoriasis patients?
    Marc Beyer
    Department of Dermatology, Venerology and Allergology, Charite Universitatsmedizin Berlin, Berlin D 10117, Germany
    J Dtsch Dermatol Ges 7:191-4. 2009
    ....
  33. pmc High-dose methotrexate is beneficial in parenchymal brain masses of uncertain origin suspicious for primary CNS lymphoma
    Philipp Kiewe
    Department of Hematology, Oncology, and Transfusion Medicine, Charite Campus Benjamin Franklin, Hindenburgdamm 30 31, 12200 Berlin, Germany
    Neuro Oncol 9:96-102. 2007
    ..No symptoms of late neurotoxicity have occurred so far. The response and survival data in this small series of patients are encouraging and suggest a benefit for patients with suspected PCNSL after initial treatment with HDMTX...
  34. doi request reprint Anti-cancer immune response mechanisms in neoadjuvant and targeted therapy
    Carsten Denkert
    Institute of Pathology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    Semin Immunopathol 33:341-51. 2011
    ..This review gives an overview on clinical data on response to classical chemotherapy as well as molecular targeted therapy and its interaction with the immune system...
  35. ncbi request reprint A 62-year-old man with chronic pyothorax
    Christoph Loddenkemper
    Department of Pathology, Consultation and Reference Centre for Lymph Node Pathology and Haematopathology, Berlin, Germany
    Brain Pathol 15:371-3. 2005
    ..To best of our knowledge, this is the first case of a pyothorax-associated lymphoma initially diagnosed on brain biopsy...
  36. ncbi request reprint Use of oxytocin receptor expression in distinguishing between uterine smooth muscle tumors and endometrial stromal sarcoma
    Christoph Loddenkemper
    Institute of Pathology, Consultation and Reference Center for Lymph Node Pathology and Haematopathology, University Hospital Benjamin Franklin, Free University, Berlin, Germany
    Am J Surg Pathol 27:1458-62. 2003
    ..Our study indicates that the evaluation of OTR expression is useful in the distinction of uterine smooth muscle tumors from ESSs, and that the OTR is expressed in normal and neoplastic uterine smooth muscle cells...
  37. ncbi request reprint Marginal zone lymphomas with monocytoid morphology express T-bet and are associated with a low number of T cells in extranodal locations
    Philipp Lohneis
    Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Leuk Lymphoma 55:143-8. 2014
    ..In analogy to reactive monocytoid B lymphocytes, we also found a significantly lower relative amount of intratumoral T lymphocytes in extranodal MZL with monocytoid morphology...
  38. ncbi request reprint Individualized target therapy of malignant lymphomas: an outlook
    Ioannis Anagnostopoulos
    Institut fur Pathologie, Charite Campus Benjamin Franklin, Berlin, Germany
    Recent Results Cancer Res 176:177-88. 2007
    ....
  39. pmc Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity
    Michael Hinz
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    J Exp Med 196:605-17. 2002
    ..The gene profile underscores a central role of NF-kappaB in the pathogenesis of HD and potentially of other tumors with constitutive NF-kappaB activation...
  40. ncbi request reprint Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia
    Matthias T F Wolf
    Department of Paediatrics, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur J Pediatr 162:180-3. 2003
    ..An X-ray film revealed persistent pneumonia in the right lung. Lung biopsy showed a large, diffuse EBV-associated B-cell lymphoma. This constellation suggested re-occurrence of the primary PTLD...
  41. ncbi request reprint Differential Emu enhancer activity and expression of BOB.1/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas
    Christoph Loddenkemper
    Institute of Pathology, Consultation and Reference Centre for Lymph Node Pathology and Haematopathology, Benjamin Franklin University Hospital, Free University Berlin, Germany
    J Pathol 202:60-9. 2004
    ..This supports the concept that the down-regulation of Ig in cHL does not reflect a physiological situation, but a defect probably closely linked to the pathogenesis of cHL...
  42. ncbi request reprint Acquired immunodeficiency syndrome-related lymphoma: simultaneous treatment with combined cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy and highly active antiretroviral therapy is safe and improves survival--results of the German
    Rudolf Weiss
    Private Practice for Hematology, Oncology and Infectious Diseases, Bremen, Germany
    Cancer 106:1560-8. 2006
    ....
  43. pmc c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis
    Stephan Mathas
    Max Delbruck Center for Molecular Medicine, FG Dörken, D 13125 Berlin, Germany
    J Exp Med 199:1041-52. 2004
    ..Therefore, c-FLIP is a key regulator of death receptor resistance in HRS cells...
  44. ncbi request reprint Epstein-Barr virus infection in Western European pediatric non-Hodgkin lymphomas
    Matthias A Karajannis
    Blood 102:4244. 2003
  45. ncbi request reprint Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas
    Stephan Mathas
    Max Delbruck Center for Molecular Medicine, FG Dörken, D 13125 Berlin, Germany
    Blood 106:4287-93. 2005
    ..Together, these data suggest that elevated Bcl-3 expression has an important function in cHL and peripheral T-NHL, in particular ALCL...
  46. ncbi request reprint The Wisconsin breast cancer problem: Diagnosis and TTR/DFS time prognosis using probabilistic and generalised regression information classifiers
    Ioannis Anagnostopoulos
    Department of Information and Communication Systems Engineering, University of the Aegean, Karlovassi 83200, Samos, Greece
    Oncol Rep 15:975-81. 2006
    ..Both architectures were compared with other similar approaches. The robustness and real-time response of the proposed classifiers were further tested over the web as a potential integrated web-based decision support system...
  47. pmc Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B
    Stephan Mathas
    Max Delbrück Center for Molecular Medicine and Universitätsklinikum Charité, Robert Rossle Klinik, Humboldt University, Lindenberger Weg 80, D 13125 Berlin
    EMBO J 21:4104-13. 2002
    ..Together, these data suggest an important role of AP-1 in lymphoma pathogenesis...
  48. ncbi request reprint Single-cell analysis of CD30+ cells in lymphomatoid papulosis demonstrates a common clonal T-cell origin
    Matthias Steinhoff
    Department of Dermatology, Ludwig Maximillians University Munich, Germany
    Blood 100:578-84. 2002
    ..Our results demonstrate that LyP unequivocally represents a monoclonal T-cell disorder of CD30+ cells in all instances...
  49. ncbi request reprint Neural network-based diagnostic and prognostic estimations in breast cancer microscopic instances
    Ioannis Anagnostopoulos
    Department of Information and Communication Systems Engineering, University of the Aegean, Karlovassi, 83200, Samos, Greece
    Med Biol Eng Comput 44:773-84. 2006
    ..9 and 97.9%, depending on the tested fold and the partition of the predicted period. The prognostic recurrence predictions were then further evaluated using survival analysis and compared with other techniques found in literature...
  50. ncbi request reprint Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma
    Stephan Mathas
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Nat Immunol 7:207-15. 2006
    ..These data demonstrate the plasticity of mature human lymphoid cells and offer an explanation for the unique classical Hodgkin lymphoma phenotype...