Humboldt University

..Here, we provide evidence of a novel function of CCN1 as a modulator of immune cell migration...

..At present, contrast-enhanced ultrasonography is of particular interest for clinical studies in monitoring the new anti-inflammatory drugs used to treat rheumatological diseases...

..To evaluate the effects of pretreatment (silanization) and thermocycling on bond strengths of 2 core materials to 3 different types of fiber posts...

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..The aim of this study was to develop an internet platform to document the quality of individual sections of treatment for patients with germ cell tumours in Berlin and to improve the therapy in conformity with the S2 guidelines...

..Thus, local thymic expression of IL-10 not only improves outcome but also reduces local tissue apoptosis and caspase-3 activity, and appears to attenuate the systemic proinflammatory cytokine response...

..304, p<0.05). HMW-APN correlates positively with MPO in patients with type 2 diabetes. Therefore, HMW-APN may exert possible pro-inflammatory effects in type 2 diabetes...

..This novel technique provides a useful tool for clinical examinations...

..Pressure ulcers are common in acute and long-term care. However, critically ill patients usually have multiple risk factors for pressure ulcers...

..Our description of the individual steps involved and the corresponding timeline may be useful to organizations of a similar type and size seeking professional external certification...

..This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma...

..The age-specific relevance of these categories of sensitization throughout childhood is unknown...

..These disturbances are not seen in underweight according to BMI. Bioelectrical impedance vector analysis appears to be an attractive tool to identify disease-related malnutrition and to monitor nutritional intervention...

..This is systematic research on ex vivo beef livers to find which capacity parameters produce high energy in the tissue and achieve large lesion volumes...

..As the transepithelial voltage generated by such a current alters the driving force for all ions, this may be the major mechanism to regulate Mg(2+) and Ca(2+) absorption in the kidney...

..All three approaches highlighted potentials for an extended integration of the patient's perspective in the assessment and evaluation of their quality of life...

..Despite impressive results, there is room for improvement for those patients who are either resistant or intolerant to imatinib...

..Furthermore, there is no evidence that MTX increases the effects or prevents the side effects of TNF-blockers if given in combination. In this paper the available data of MTX in AS will be discussed...

..The opportunities of modern multidetector computed tomography (MDCT) with image postprocessing can be expected to enhance the diagnostic performance if accurate criteria are elaborated...

..Such a mechanism could integrate endogenous and exogenous functional demands under the joint criterion of whether they challenge an individual's homeostasis...

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..Therefore, xenon/remifentanil anesthesia protects against circulatory side effects of losartan pretreatment and thus may afford safer therapeutic use of losartan during acute hemorrhage...

..Due to this complexity the independence of the self-employed physician becomes increasingly obscure. At the same time, though, the image of the doctor as "an appropriate attendant" has not lost any of its radiance...

..A new GFR-equation will be developed and validated using Iohexol clearance as gold standard to estimate GFR accurately and precisely. Data of 2,000 subjects will be used to estimate prevalence of CKD...

..For phenotyping specific language impairment (SLI) in kindergarten children in clinical practice and research issues, we need a valid diagnostic method for dichotomous classification (language impaired, normal developing)...

..To determine the effects of MRI-assayed vascular leakiness on the delivery of macromolecular therapeutics to tumors...

..Simple measures can reduce, perhaps substantially, the impact of such bias. The decision to proceed to clinical trial should be based on a thorough and systematic review of the animal data...

..Thus, exposure to amyloid-beta leads to altered astrocyte properties and this change might be beneficial to maintain synaptic function...

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..The objective of this study is, therefore, to analyse direct and indirect costs in patients with hypercholesterolemia and to determine predictors of costs...

..preceding lesion of the VTA seems to prohibit further detection of DA in the NAc. We conclude that STN-HFS significantly affects neurotransmission in the limbic system, which might contribute to explain the non-motor effects of STN-HFS...

..Our aim is to reduce the mortality rate by introducing a treatment procedure supported by a second opinion center...

..Only few studies on gender-related differences in skin physiology have been performed--and they provided conflicting results...

..Thus, the 5-year outcome data of a prospective randomized trial comparing patients who initially underwent bladder tumor resection (TUR) under standard white light or with ALA induced fluorescence were evaluated...

..Possible cut-off levels depending on the tPSA should be established...

..In summary, a functional Zn finger of USP15 is needed to maintain a conformation essential for disassembling poly-Ub chains, a prerequisite for rescuing the E3 ligase Rbx1...

..Pathologists must be aware of the morphologic changes induced by UAE in leiomyoma to avoid misinterpretation of induced tissue alterations as signs of malignant tumor growth...

..A number of studies have been performed with the one aim, to shed some light onto the pathophysiology of CIN. These have led to manifold interpretations and sometimes contradicting conclusions...

..Classification of the different findings based on the typical signal-intensity changes seen on MR images enables standardized reporting, and scoring the lesions may be helpful in clinical trials...

..These findings demonstrate an increased expression of NGF in AD and effects on tryptase and histamine. Mast cells may be major mediators of neurotrophin effects in AD...

..The traditional neurotransmitter catecholamine and the neuropeptide tyrosine in sympathetic airway nerves have been proposed to be involved in the pathogenesis of airway diseases...

..We investigated the effects of methylprednisolone on hepatocyte proliferation after partial hepatectomy with temporary inflow occlusion...

..To report the data from a multidisciplinary bad breath consultation in Germany...

..In the present study, we investigated the time-dependent effects of cadaveric renal transplantation on arterial elasticity in end-stage renal disease patients...

..Obese girls are also four times more likely to become a victim of peer aggression compared to obese boys or non-obese girls. Obese boys on the other hand are more likely to become media dependent...

..Our results indicate that malignant gliomas may down-regulate ING1 to allow more efficient tumor growth and progression. Also, ING1 down-regulation may sensitize GBM cells with deficient p53 to treatment with cisplatin...

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..Weight gain is a frequently observed adverse event in the treatment with atypical antipsychotics that significantly affects the patients' physical health and treatment compliance...

..With respect to smoking and alcohol consumption during pregnancy there seems to be an urgent need for political action...

..Our aim was to assess the impact of laparoscopy on surgical site infections...

..A 32-year-old white man presented with features of inflammatory back pain, including awakening at night and morning stiffness. He had acute back pain 4 years earlier as a result of a herniated lumbar disc...

..To combine both ideas we trained medical students to give BLS courses and sent them to teach school children. This was a requirement for their emergency medicine course. Our model was compared to conventional teaching...

..Moreover, we present the first evidence for the ability of FJ-B to selectively label a discrete population of dying PCs, implying a higher selectivity of FJ-B than previously supposed...

..Using tasks designed to evoke episodic memory, one should be able to see memory reactivation of behaviorally relevant sequences of activity in the awake animal while recording from hippocampus and other cortical structures...

..Time course of response and antidepressant efficacy of mirtazapine, but not paroxetine, seem to be influenced in a clinically relevant manner by this allelic variation within the COMT gene...