David Horst

Summary

Country: Germany

Publications

  1. doi request reprint [Plasticity of WNT signaling activity in colorectal cancer]
    D Horst
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Thalkirchner Str 36, 80337 München
    Pathologe 33:194-7. 2012
  2. doi request reprint Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer
    David Horst
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Germany
    Cancer Invest 27:844-50. 2009
  3. pmc SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Cancer 11:518. 2011
  4. doi request reprint The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
  5. doi request reprint Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer
    Helge Siemens
    Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Clin Cancer Res 19:710-20. 2013
  6. pmc LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer
    Lydia Kriegl
    Department of Pathology, Ludwig Maximilians Universität LMU, Thalkirchnerstr, 36, 80337, Munich, Germany
    J Transl Med 8:123. 2010
  7. doi request reprint Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer
    Abdelhamid Beji
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Munich, Germany
    Clin Cancer Res 18:956-68. 2012

Collaborators

Detail Information

Publications7

  1. doi request reprint [Plasticity of WNT signaling activity in colorectal cancer]
    D Horst
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Thalkirchner Str 36, 80337 München
    Pathologe 33:194-7. 2012
    ..Furthermore, WNT/β-Catenin activity in colon cancer cells can be modulated by MAPK signaling thus revealing a means of how other signaling pathways contribute to WNT signaling plasticity in colon cancer...
  2. doi request reprint Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer
    David Horst
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Germany
    Cancer Invest 27:844-50. 2009
    ..We show that CD133 is the best sole marker to predict low patient survival, while the combined analysis of all three markers may be superior in identification of low-, intermediate-, and high-risk cases of colorectal cancer...
  3. pmc SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer
    Jens Neumann
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Munich, Germany
    BMC Cancer 11:518. 2011
    ....
  4. doi request reprint The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
    ..Thus, we conclude that CD133 expression is a marker with high prognostic impact for colon cancer, while it seems to have no obvious functional role as a driving force of this malignancy...
  5. doi request reprint Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer
    Helge Siemens
    Experimental and Molecular Pathology, Institute of Pathology, Institute of Pathology, and Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Clin Cancer Res 19:710-20. 2013
    ..Here, we determined whether epigenetic inactivation of miR-34a and miR-34b/c genes may serve as a prognostic marker for distant metastases in colon cancer...
  6. pmc LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer
    Lydia Kriegl
    Department of Pathology, Ludwig Maximilians Universität LMU, Thalkirchnerstr, 36, 80337, Munich, Germany
    J Transl Med 8:123. 2010
    ..In this study we investigated the expression of β-Catenin, LEF1 and TCF4 in colorectal carcinomas and their prognostic significance...
  7. doi request reprint Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer
    Abdelhamid Beji
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Munich, Germany
    Clin Cancer Res 18:956-68. 2012
    ..We have previously shown that in melanoma HER3 is frequently overexpressed and is associated with poor prognosis. However, the importance of HER3 in colon cancer and its putative prognostic significance is still unknown...