Wolfgang Holtmeier

Summary

Country: Germany

Publications

  1. ncbi Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohn's disease: good safety profile but lack of efficacy
    Wolfgang Holtmeier
    Department of Gastroenterology, Diabetes and Internal Medicine, Hospital Porz am Rhein, Cologne, Germany
    Inflamm Bowel Dis 17:573-82. 2011
  2. ncbi Distribution and development of the postnatal murine Vδ1 T-cell receptor repertoire
    Wolfgang Holtmeier
    Medizinische Klinik I, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Immunology 131:192-201. 2010
  3. ncbi Prenatal development of the porcine TCR delta repertoire: dominant expression of an invariant T cell receptor Vdelta3-Jdelta3 chain
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Eur J Immunol 34:1941-9. 2004
  4. ncbi Compartmentalization gamma/delta T cells and their putative role in mucosal immunity
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Crit Rev Immunol 23:473-88. 2003
  5. ncbi gammadelta T cells link innate and adaptive immune responses
    Wolfgang Holtmeier
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Chem Immunol Allergy 86:151-83. 2005
  6. ncbi Distinct TCR delta repertoires are present in the cutaneous lesions and inflamed duodenum of patients with dermatitis herpetiformis
    Wolfgang Holtmeier
    Department of Medicine II, Division of Gastroenterology, University of Frankfurt, Frankfurt am Main, Germany. W.Holtmeier.em.uni-frankfurt.de
    Exp Dermatol 11:527-31. 2002
  7. ncbi Development and compartmentalization of the porcine TCR delta repertoire at mucosal and extraintestinal sites: the pig as a model for analyzing the effects of age and microbial factors
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Immunol 169:1993-2002. 2002
  8. ncbi Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome)
    Ralf J Ludwig
    Department of Dermatology, University of Frankfurt, Frankfurt am Main, Germany
    J Am Acad Dermatol 48:S60-1. 2003
  9. ncbi Microtubule-targeted drugs inhibit VEGF receptor-2 expression by both transcriptional and post-transcriptional mechanisms
    Markus Meissner
    Department of Dermatology, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 128:2084-91. 2008
  10. ncbi T cell receptor delta repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Am J Physiol Gastrointest Liver Physiol 282:G1024-34. 2002

Collaborators

Detail Information

Publications11

  1. ncbi Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohn's disease: good safety profile but lack of efficacy
    Wolfgang Holtmeier
    Department of Gastroenterology, Diabetes and Internal Medicine, Hospital Porz am Rhein, Cologne, Germany
    Inflamm Bowel Dis 17:573-82. 2011
    ..The aim of this study was to evaluate the efficacy and safety of long-term therapy with a new Boswellia serrata extract (Boswelan, PS0201Bo) in maintaining remission in patients with Crohn's disease (CD)...
  2. ncbi Distribution and development of the postnatal murine Vδ1 T-cell receptor repertoire
    Wolfgang Holtmeier
    Medizinische Klinik I, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Immunology 131:192-201. 2010
    ..Thus, γ/δ T cells expressing conserved Vδ1 chains are likely to have important functions. We suggest a model in which this subset continuously recirculates throughout the organism and rapidly responds to stress-induced self antigens...
  3. ncbi Prenatal development of the porcine TCR delta repertoire: dominant expression of an invariant T cell receptor Vdelta3-Jdelta3 chain
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Eur J Immunol 34:1941-9. 2004
    ..We speculate that these gamma/delta T cells might have been selectively expanded by (self)-ligands and may have an important function throughout fetal development...
  4. ncbi Compartmentalization gamma/delta T cells and their putative role in mucosal immunity
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Crit Rev Immunol 23:473-88. 2003
    ..This review focuses on the distribution and repertoire of mucosal gamma/delta T cells and discusses what is currently known about the functions of these cells. Furthermore, their potential role in inflammatory bowel disease is examined...
  5. ncbi gammadelta T cells link innate and adaptive immune responses
    Wolfgang Holtmeier
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Chem Immunol Allergy 86:151-83. 2005
    ..Our increasing understanding of the ligand recognition and activation mechanisms of gamma/delta T cells also opens new perspectives for the development of gamma/delta T cell-based immunotherapies...
  6. ncbi Distinct TCR delta repertoires are present in the cutaneous lesions and inflamed duodenum of patients with dermatitis herpetiformis
    Wolfgang Holtmeier
    Department of Medicine II, Division of Gastroenterology, University of Frankfurt, Frankfurt am Main, Germany. W.Holtmeier.em.uni-frankfurt.de
    Exp Dermatol 11:527-31. 2002
    ..Thus, cutaneous gammadelta T cells are not specifically expanded within the involved skin and are unlikely to be derived from the inflamed duodenum...
  7. ncbi Development and compartmentalization of the porcine TCR delta repertoire at mucosal and extraintestinal sites: the pig as a model for analyzing the effects of age and microbial factors
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Immunol 169:1993-2002. 2002
    ..Furthermore, these data support the hypothesis that in each mucosal site, different Ags are responsible for selecting and maintaining the gammadelta TCR over time...
  8. ncbi Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome)
    Ralf J Ludwig
    Department of Dermatology, University of Frankfurt, Frankfurt am Main, Germany
    J Am Acad Dermatol 48:S60-1. 2003
    ..Antiviral therapy led to a complete remission of eosinophilic cellulitis, indicating that causative treatment of underlying diseases can be effective in controlling eosinophilic cellulitis...
  9. ncbi Microtubule-targeted drugs inhibit VEGF receptor-2 expression by both transcriptional and post-transcriptional mechanisms
    Markus Meissner
    Department of Dermatology, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Invest Dermatol 128:2084-91. 2008
    ..Hence, both inhibition of the rate of gene transcription and increased mRNA turnover represent critical molecular mechanisms by which MT disruption inhibits VEGFR2 expression...
  10. ncbi T cell receptor delta repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping
    Wolfgang Holtmeier
    Medizinische Klinik II, Division of Gastroenterology, Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Am J Physiol Gastrointest Liver Physiol 282:G1024-34. 2002
    ..In conclusion, those changes indicate that gamma/delta T cells might play an important role in a subset of patients with IBD...
  11. ncbi Celiac disease
    Wolfgang Holtmeier
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Orphanet J Rare Dis 1:3. 2006
    ..Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years...