Joerg H Holstein

Summary

Country: Germany

Publications

  1. doi request reprint Exercise enhances angiogenesis during bone defect healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Orthop Res 29:1086-92. 2011
  2. doi request reprint High bone concentrations of homocysteine are associated with altered bone morphology in humans
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Br J Nutr 106:378-82. 2011
  3. doi request reprint Endostatin inhibits Callus remodeling during fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse, 66421, Homburg Saar, Germany
    J Orthop Res 31:1579-84. 2013
  4. pmc What are predictors for patients' quality of life after pelvic ring fractures?
    Joerg H Holstein
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421, Homburg, Germany
    Clin Orthop Relat Res 471:2841-5. 2013
  5. pmc Excess dietary methionine does not affect fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Med Sci Monit 18:BR469-74. 2012
  6. pmc What are predictors of mortality in patients with pelvic fractures?
    Joerg H Holstein
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg, Germany
    Clin Orthop Relat Res 470:2090-7. 2012
  7. doi request reprint Increased exercise after stable closed fracture fixation does not affect fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Biomech 45:1299-304. 2012
  8. doi request reprint Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 48:821-7. 2010
  9. doi request reprint Erythropoietin stimulates bone formation, cell proliferation, and angiogenesis in a femoral segmental defect model in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg Saar, Germany
    Bone 49:1037-45. 2011
  10. doi request reprint Deficiencies of folate and vitamin B12 do not affect fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Bone 47:151-5. 2010

Detail Information

Publications35

  1. doi request reprint Exercise enhances angiogenesis during bone defect healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Orthop Res 29:1086-92. 2011
    ..The newly woven bone was covered by a neo-periosteum containing those blood vessels, which were visible by IVM. We conclude that exercise accelerates bone defect healing and stimulates angiogenesis during bore repair...
  2. doi request reprint High bone concentrations of homocysteine are associated with altered bone morphology in humans
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Br J Nutr 106:378-82. 2011
    ..The results of the present study indicate an association between altered bone morphology and elevated bone concentrations of homocysteine and S-adenosylhomocysteine, but not between altered bone morphology and methylation capacity...
  3. doi request reprint Endostatin inhibits Callus remodeling during fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse, 66421, Homburg Saar, Germany
    J Orthop Res 31:1579-84. 2013
    ..The results of the present study indicate endostatin promotes soft callus formation but inhibits callus remodeling during fracture healing most probably by an inhibition of angiogenesis...
  4. pmc What are predictors for patients' quality of life after pelvic ring fractures?
    Joerg H Holstein
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421, Homburg, Germany
    Clin Orthop Relat Res 471:2841-5. 2013
    ..Data from literature on predictors for patients' quality of life after pelvic ring fractures are conflicting and based on small study populations...
  5. pmc Excess dietary methionine does not affect fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Med Sci Monit 18:BR469-74. 2012
    ..As the essential amino acid, methionine, is a precursor of homocysteine, we aimed to investigate whether excess methionine intake affects bone repair...
  6. pmc What are predictors of mortality in patients with pelvic fractures?
    Joerg H Holstein
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg, Germany
    Clin Orthop Relat Res 470:2090-7. 2012
    ..Our knowledge of factors influencing mortality of patients with pelvic ring injuries and the impact of associated injuries is currently based on limited information...
  7. doi request reprint Increased exercise after stable closed fracture fixation does not affect fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Biomech 45:1299-304. 2012
    ..The aim of the present study was to evaluate the systemic biological effect of increased exercise on bone repair after stable fracture fixation...
  8. doi request reprint Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 48:821-7. 2010
    ..This study investigated the relationship between morphological as well as biomechanical bone properties and HCY serum concentrations in humans suffering from hip osteoarthritis (OA)...
  9. doi request reprint Erythropoietin stimulates bone formation, cell proliferation, and angiogenesis in a femoral segmental defect model in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg Saar, Germany
    Bone 49:1037-45. 2011
    ..We conclude that EPO is capable of stimulating bone formation, cell proliferation and VEGF-mediated angiogenesis in a femoral segmental defect model...
  10. doi request reprint Deficiencies of folate and vitamin B12 do not affect fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Bone 47:151-5. 2010
    ..The main causes for hyperhomocysteinemia are deficiencies of folate and vitamin B12. However, there is no information on whether deficiencies of these B vitamins are affecting bone repair, too...
  11. doi request reprint Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Am J Clin Nutr 90:1440-5. 2009
    ..Several clinical trials have reported B vitamins to be associated with osteoporosis...
  12. doi request reprint Advances in the establishment of defined mouse models for the study of fracture healing and bone regeneration
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Trauma 23:S31-8. 2009
    ..The use of these mouse models may now allow studying the influence of fracture stabilization techniques on molecular mechanisms of bone healing...
  13. doi request reprint Delayed fracture healing in aged senescence-accelerated P6 mice
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Invest Surg 26:30-5. 2013
    ..However, it is still controversially discussed whether osteoporosis compromises fracture healing. Herein, we studied whether the course of healing of a femur fracture is affected by osteoporosis or age...
  14. doi request reprint Increased osteoblast and osteoclast activity in female senescence-accelerated, osteoporotic SAMP6 mice during fracture healing
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 175:271-7. 2012
    ..There is no information, however, whether the alteration of fracture healing in osteoporosis also depends on gender...
  15. doi request reprint Development of a stable closed femoral fracture model in mice
    Joerg H Holstein
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 153:71-5. 2009
    ..Herein, we studied whether longitudinal fracture compression by an intramedullary screw represents a standardized, stable osteosynthesis technique in mice, and whether it may accelerate fracture healing...
  16. ncbi request reprint Microdialysis of the rectus abdominis muscle for early detection of impending abdominal compartment syndrome
    Christoph Meier
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    Intensive Care Med 33:1434-43. 2007
    ....
  17. doi request reprint Melatonin impairs fracture healing by suppressing RANKL-mediated bone remodeling
    Tina Histing
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 173:83-90. 2012
    ..There is no information, however, whether melatonin affects fracture healing. We therefore studied in a mouse femur fracture model the influence of melatonin on callus formation and biomechanics during fracture healing...
  18. doi request reprint Sildenafil accelerates fracture healing in mice
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 29:867-73. 2011
    ..We show for the first time that sildenafil treatment accelerates fracture healing by enhancing bone formation, most probably by a CYR61-associated pathway...
  19. doi request reprint An internal locking plate to study intramembranous bone healing in a mouse femur fracture model
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 28:397-402. 2010
    ..The fractures that healed by intramembranous ossification showed an increased stiffness compared to fractures that healed by endochondral ossification. This model may be used to study molecular mechanisms of intramembranous bone healing...
  20. doi request reprint The LockingMouseNail--a new implant for standardized stable osteosynthesis in mice
    Patric Garcia
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 169:220-6. 2011
    ..Mouse models are of increasing interest to study cellular and molecular mechanisms during fracture healing. However, unlike in large animals and in humans, stable fixation of fractures has been difficult due to the small size of the mouse...
  21. ncbi request reprint Erythropoietin (EPO): EPO-receptor signaling improves early endochondral ossification and mechanical strength in fracture healing
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Life Sci 80:893-900. 2007
    ..We conclude that EPO-EPOR signaling is involved in the process of early endochondral ossification, enhancing the transition of soft callus to hard callus...
  22. doi request reprint A new model to analyze metaphyseal bone healing in mice
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 178:715-21. 2012
    ..Using a special locking plate system, we herein introduce a new model, which allows the analysis of metaphyseal bone healing in mice...
  23. doi request reprint Ex vivo analysis of rotational stiffness of different osteosynthesis techniques in mouse femur fracture
    Tina Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 27:1152-6. 2009
    ..By the use of the presented data a more specific choice of stabilization technique will be possible according to the various questions concerning molecular aspects in fracture healing...
  24. pmc Trauma registry record linkage: methodological approach to benefit from complementary data using the example of the German Pelvic Injury Register and the TraumaRegister DGU(®)
    Markus Burkhardt
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstrasse 100, 66421, Homburg Saar, Germany
    BMC Med Res Methodol 13:30. 2013
    ..The aim of the approach is to create an intersection set that benefit from complementary data of each registry, respectively. Furthermore, the concordance of data entry of some clinical variables entered in both registries was evaluated...
  25. pmc Initial experience using a pelvic emergency simulator to train reduction in blood loss
    Tim Pohlemann
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, Homburg, Germany
    Clin Orthop Relat Res 470:2098-103. 2012
    ..We have developed a novel pelvic emergency simulator to train surgeons in controlling blood loss...
  26. ncbi request reprint A new model for the study of the abdominal compartment syndrome in rats
    Christoph Meier
    Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Surg Res 139:209-16. 2007
    ..The purpose of the present study was to develop of a rodent model of abdominal compartment syndrome (ACS), which allows detailed analysis of intra-abdominal hypertension (IAH)- and decompression-associated reperfusion injury...
  27. doi request reprint In vivo gait analysis in a mouse femur fracture model
    T Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Biomech 43:3240-3. 2010
    ..Thus, our study demonstrates distinct alterations of the gait of mice at 2 weeks after femur fracture and stabilization. Our results support the need of gait analysis in fracture healing studies to assess the animals' well-being...
  28. doi request reprint Low dose erythropoietin stimulates bone healing in mice
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 29:165-72. 2011
    ..The herein shown acceleration of healing by EPO may represent a promising novel treatment strategy for fractures with delayed healing and non-union formation...
  29. pmc Rapamycin affects early fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, Homburg Saar, Germany
    Br J Pharmacol 154:1055-62. 2008
    ....
  30. doi request reprint Soft tissue fibroblasts from well healing and chronic human wounds show different rates of myofibroblasts in vitro
    Florian Schwarz
    Department of Trauma, Hand and Reconstructive Surgery, Saarland University, Kirrberger Strasse, Bldng 57, 66421, Homburg, Germany
    Mol Biol Rep 40:1721-33. 2013
    ..Thus, current therapeutic approaches and individual healing prediction might benefit from this assay...
  31. doi request reprint Early detection of subclinical organ dysfunction by microdialysis of the rectus abdominis muscle in a porcine model of critical intra-abdominal hypertension
    Emanuel Benninger
    Division of Trauma Surgery, Department of Surgery, University Hospital Zurich, Switzerland
    Shock 38:420-8. 2012
    ..Thus, the RAM represents an important and easily accessible site for the early detection of subclinical organ dysfunction during critical IAH...
  32. ncbi request reprint Development of a locking femur nail for mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Biomech 40:215-9. 2007
    ..With the advantage that closed fractures can be fixed with rotation stability, the herein introduced model may represent an ideal tool to study bone healing in transgenic and knockout mice...
  33. doi request reprint A new technique for internal fixation of femoral fractures in mice: impact of stability on fracture healing
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstr 1, D 66421 Homburg, Saar, Germany
    J Biomech 41:1689-96. 2008
    ..We further show that a more stable osteosynthesis significantly improves the process of fracture healing also in mice...
  34. pmc Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Br J Pharmacol 159:1672-80. 2010
    ..Therefore, we studied the expression and function of the key RAS component, angiotensin-converting enzyme (ACE), during fracture healing...
  35. doi request reprint Different stabilisation techniques for typical acetabular fractures in the elderly--a biomechanical assessment
    U Culemann
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Injury 41:405-10. 2010
    ....