Genomes and Genes
- Ubiquitin-binding domains and their role in the DNA damage responseKay Hofmann
Bioinformatics Group, Miltenyi Biotec GmbH, Friedrich Ebert Strasse 68, 51429 Bergisch Gladbach, Germany
DNA Repair (Amst) 8:544-56. 2009..For several repair pathways, current knowledge of the events downstream of the ubiquitin mark is sketchy. A closer look at orphan UBD proteins might lead to the identification of missing pieces in the DNA response puzzle...
- Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformaticsHartmut Scheel
Bioinformatics Group, Memorec Biotec GmbH, Koln, Germany
Hum Mol Genet 12:2845-52. 2003..Moreover, both findings have implications for the general pathogenesis of spinocerebellar ataxias by providing a direct connection of these diseases with ubiquitin metabolism and histone acetylation...
- Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexesHartmut Scheel
Bioinformatics Group, Memorec Biotec GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
BMC Bioinformatics 6:71. 2005..Initially, the PCI domain was defined as the region of detectable sequence similarity between the components mentioned above...
- A common protein interaction domain links two recently identified epilepsy genesHartmut Scheel
Bioinformatics Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
Hum Mol Genet 11:1757-62. 2002..The EAR domain is likely to play an important role in the pathogenesis of epilepsy, either by binding to an unknown anti-epileptic ligand, or more likely by interfering with axon guidance or synaptogenesis...
- Sequence similarity in structurally dissimilar proteinsStefan Tomiuk
Bioinformatics Group, MEMOREC Stoffel GmbH, , , Germany
Curr Biol 13:R124-5. 2003
- A novel interaction motif, SARAH, connects three classes of tumor suppressorHartmut Scheel
Bioinformatics Group, Memorec Biotec GmbH, , , Germany
Curr Biol 13:R899-900. 2003