Sabine Hoffjan

Summary

Country: Germany

Publications

  1. doi request reprint The genetics of multiple sclerosis: an update 2010
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University, Universitatsstrasse 150, 44801 Bochum, Germany
    Mol Cell Probes 24:237-43. 2010
  2. ncbi request reprint The genetics of atopic dermatitis: recent findings and future options
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University, Universitatsstrasse 150, 44801 Bochum, Germany
    J Mol Med (Berl) 83:682-92. 2005
  3. doi request reprint No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort
    Jasmin Beygo
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    Mol Cell Probes 23:16-9. 2009
  4. doi request reprint Variation in the BDNF and NGFB genes in German atopic dermatitis patients
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    Mol Cell Probes 23:35-8. 2009
  5. doi request reprint Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients
    Linda K Rey
    Department of Human Genetics, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Mol Cell Probes 25:255-9. 2011
  6. pmc Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany
    Qumar Parwez
    Department of Human Genetics, Ruhr University, Bochum, Germany
    J Negat Results Biomed 7:9. 2008
  7. pmc Association of toll-interacting protein gene polymorphisms with atopic dermatitis
    Tobias T Schimming
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    BMC Dermatol 7:3. 2007
  8. ncbi request reprint Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis
    Filippina Macaluso
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    Exp Dermatol 16:692-8. 2007
  9. ncbi request reprint Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery
    Moritz Lebe
    Department of Medical Psychology and Medical Sociology, Faculty of Medicine, Ruhr University of Bochum, Universitatsstrasse 150, Bochum, Germany
    Pain 154:377-84. 2013
  10. pmc Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University Bochum, Germany
    BMC Med Genet 6:34. 2005

Collaborators

Detail Information

Publications23

  1. doi request reprint The genetics of multiple sclerosis: an update 2010
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University, Universitatsstrasse 150, 44801 Bochum, Germany
    Mol Cell Probes 24:237-43. 2010
    ....
  2. ncbi request reprint The genetics of atopic dermatitis: recent findings and future options
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University, Universitatsstrasse 150, 44801 Bochum, Germany
    J Mol Med (Berl) 83:682-92. 2005
    ..Candidate gene studies, on the other hand, have identified 19 genes that were shown to be associated with AD in at least one study. The results of genome-wide screens as well as candidate gene studies are evaluated here in detail...
  3. doi request reprint No evidence of an association between polymorphisms in the IRAK-M gene and atopic dermatitis in a German cohort
    Jasmin Beygo
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    Mol Cell Probes 23:16-9. 2009
    ..Analysis of single SNPs and haplotypes did not reveal a significant association between polymorphisms in the IRAK-M gene and AD in this cohort...
  4. doi request reprint Variation in the BDNF and NGFB genes in German atopic dermatitis patients
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    Mol Cell Probes 23:35-8. 2009
    ..In this cohort, no significant association with AD was detected, refuting the hypothesis that variation in these two neurotrophin genes contributes substantially to AD...
  5. doi request reprint Polymorphisms in genes encoding leptin, ghrelin and their receptors in German multiple sclerosis patients
    Linda K Rey
    Department of Human Genetics, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Mol Cell Probes 25:255-9. 2011
    ..However, a modest effect of GHSR variation cannot be ruled out and needs to be further evaluated in future studies...
  6. pmc Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany
    Qumar Parwez
    Department of Human Genetics, Ruhr University, Bochum, Germany
    J Negat Results Biomed 7:9. 2008
    ..We therefore genotyped selected single nucleotide polymorphisms within the ECP, EDN, EPO and MBP genes in a cohort of 361 German AD patients and 325 healthy controls...
  7. pmc Association of toll-interacting protein gene polymorphisms with atopic dermatitis
    Tobias T Schimming
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    BMC Dermatol 7:3. 2007
    ....
  8. ncbi request reprint Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis
    Filippina Macaluso
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    Exp Dermatol 16:692-8. 2007
    ..Investigations in other populations and functional studies are warranted to clarify contributions of NLR variation for this frequent skin disease...
  9. ncbi request reprint Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery
    Moritz Lebe
    Department of Medical Psychology and Medical Sociology, Faculty of Medicine, Ruhr University of Bochum, Universitatsstrasse 150, Bochum, Germany
    Pain 154:377-84. 2013
    ..Furthermore, this study demonstrates that pain after lumbar surgery modulates the association between 5HT gene polymorphisms and depression...
  10. pmc Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University Bochum, Germany
    BMC Med Genet 6:34. 2005
    ..We evaluated here the role of a coding variation, Ser249Pro, in the TLR6 gene in the pathogenesis of asthma, atopic dermatitis (AD) and chronic obstructive pulmonary disease (COPD)...
  11. pmc Three novel mutations in the ACTA2 gene in German patients with thoracic aortic aneurysms and dissections
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University Bochum, Bochum, Germany
    Eur J Hum Genet 19:520-4. 2011
    ..Detailed clinical investigations of additional families are warranted to further explore the full range of phenotypic signs associated with the three novel mutations described here...
  12. ncbi request reprint Electrophoresis of DNA in human genetic diagnostics - state-of-the-art, alternatives and future prospects
    René Gödde
    Department of Human Genetics, Ruhr University, Bochum, Germany
    Electrophoresis 27:939-46. 2006
    ..Although electrophoresis may be made redundant for many applications in DNA diagnostics within a few years, a number of electrophoretic vestiges will remain irreplaceable in the foreseeable future...
  13. ncbi request reprint Extreme phenotypic variability in a German family with X-linked myotubular myopathy associated with E404K mutation in MTM1
    Sabine Hoffjan
    Department of Human Genetics, Ruhr University Bochum, Germany
    Neuromuscul Disord 16:749-53. 2006
    ..Thus, this family represents a remarkable phenotypic variation of XLMTM ranging from a congenital to a mild adult form...
  14. ncbi request reprint Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis
    Susanne Stemmler
    J Invest Dermatol 127:722-4. 2007
  15. ncbi request reprint Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci
    Thorsten Kurz
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    J Allergy Clin Immunol 118:396-402. 2006
    ..Genome-wide linkage scans to identify asthma susceptibility loci have revealed many linked regions, including a broad region on chromosome 5p...
  16. ncbi request reprint Viral infections, cytokine dysregulation and the origins of childhood asthma and allergic diseases
    Samuel L Friedlander
    Department of Medicine, Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, WI, USA
    Pediatr Infect Dis J 24:S170-6, discussion S174-5. 2005
    ..The origins of asthma and allergic disease begin in early life for many individuals. It is vital to understand the factors and/or events leading to their development...
  17. pmc Gene-environment interaction effects on the development of immune responses in the 1st year of life
    Sabine Hoffjan
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 76:696-704. 2005
    ....
  18. ncbi request reprint Are common disease susceptibility alleles the same in outbred and founder populations?
    Dina L Newman
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Eur J Hum Genet 12:584-90. 2004
    ..05), with five loci remaining significant after adjusting for multiple comparisons. These data indicate that this founder population is informative and offers considerable advantages for genetic studies of common complex diseases...
  19. ncbi request reprint Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy
    Sabine Hoffjan
    Department of Human Genetics, University of Chicago, IL 60637, USA
    J Allergy Clin Immunol 113:511-8. 2004
    ..Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied associations with immune phenotypes in the first year that might be early clinical markers of asthma...
  20. ncbi request reprint Effects of dog ownership and genotype on immune development and atopy in infancy
    James E Gern
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 113:307-14. 2004
    ..Exposure to furred pets might confer protection against the development of allergic sensitization through a mechanism that is incompletely understood...
  21. pmc Association studies for asthma and atopic diseases: a comprehensive review of the literature
    Sabine Hoffjan
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Respir Res 4:14. 2003
    ..These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes...
  22. pmc Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus
    Catherine Bourgain
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    Am J Hum Genet 73:612-26. 2003
    ..10-6) between atopy and an amino acid polymorphism in the P-selectin gene, detected with the QLS test and also, but less significantly (P=.0014), with the transmission/disequilibrium test...
  23. ncbi request reprint Present status on the genetic studies of asthma
    Sabine Hoffjan
    Department of Human Genetics, The University of Chicago, Chicago, Illinois 60637, USA
    Curr Opin Immunol 14:709-17. 2002
    ..In addition, many candidate genes have been associated with asthma phenotypes, such as the genes in the IL-4/IL-13 pathway...