M R Hoehe

Summary

Country: Germany

Publications

  1. ncbi Comparative sequencing of the human CB1 cannabinoid receptor gene coding exon: no structural mutations in individuals exhibiting extreme responses to cannabis
    M R Hoehe
    Genome Research, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Psychiatr Genet 10:173-7. 2000
  2. ncbi Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence
    M R Hoehe
    Genome Research, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    Hum Mol Genet 9:2895-908. 2000
  3. ncbi Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and Susceptibility to idiopathic generalized epilepsy
    T Sander
    Department of Neurology, University Hospital Charite, Berlin, Germany
    Epilepsy Res 41:75-81. 2000
  4. ncbi Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?
    S Podlowski
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 78:87-93. 2000
  5. ncbi Genetic mapping of adrenergic receptor genes in humans
    M R Hoehe
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 73:299-306. 1995
  6. ncbi The human beta-myosin heavy chain gene: sequence diversity and functional characteristics of the protein
    B Wendel
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biochem 79:566-75. 2000
  7. ncbi Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15
    M R Hoehe
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892
    New Biol 3:880-5. 1991
  8. ncbi Genetic variation of the human mu-opioid receptor and susceptibility to idiopathic absence epilepsy
    T Sander
    Department of Neurology, University Hospital Charite, Humboldt University of Berlin, Germany
    Epilepsy Res 39:57-61. 2000
  9. ncbi The human small conductance calcium-regulated potassium channel gene (hSKCa3) contains two CAG repeats in exon 1, is on chromosome 1q21.3, and shows a possible association with schizophrenia
    O Wittekindt
    Institut für Humangenetik and Anthropologie, Universitat Freiburg, Germany
    Neurogenetics 1:259-65. 1998
  10. ncbi Beta-2 adrenergic receptor gene variations and blood pressure under stress in normal twins
    G H Li
    , , Humboldt University of Berlin, Germany
    Psychophysiology 38:485-9. 2001

Collaborators

Detail Information

Publications11

  1. ncbi Comparative sequencing of the human CB1 cannabinoid receptor gene coding exon: no structural mutations in individuals exhibiting extreme responses to cannabis
    M R Hoehe
    Genome Research, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Psychiatr Genet 10:173-7. 2000
    ..Comparison of CB1 cannabinoid receptor amino acid sequences between species substantiated evidence that the protein sequence is relatively well conserved...
  2. ncbi Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence
    M R Hoehe
    Genome Research, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    Hum Mol Genet 9:2895-908. 2000
    ..This study provides an example of approaches that have been successfully applied to the establishment of complex genotype-phenotype relationships in the presence of abundant DNA sequence variation...
  3. ncbi Variation of the genes encoding the human glutamate EAAT2, serotonin and dopamine transporters and Susceptibility to idiopathic generalized epilepsy
    T Sander
    Department of Neurology, University Hospital Charite, Berlin, Germany
    Epilepsy Res 41:75-81. 2000
    ..81, d.f. = 1, P = 0.005) compared with the controls. The present findings strengthen previous evidence that genetic variation of the DAT gene modulates neuronal network excitability and contributes to the epileptogenesis of IAE...
  4. ncbi Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?
    S Podlowski
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 78:87-93. 2000
    ..The present results may provide a clue on the molecular mechanisms involved in IDCM, and add moreover interesting information on nature, distribution, and evolutionary aspects of sequence variation in human adrenergic receptor genes...
  5. ncbi Genetic mapping of adrenergic receptor genes in humans
    M R Hoehe
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 73:299-306. 1995
    ..The positioning of these genes on high-density framework maps allows them to be tested as candidates in a spectrum of diseases that might involve AR dysfunction...
  6. ncbi The human beta-myosin heavy chain gene: sequence diversity and functional characteristics of the protein
    B Wendel
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biochem 79:566-75. 2000
    ..Analysis of the kinetic behaviour of beta-MHC in the intact contractile structure of normal individuals and HCM patients revealed apparent rate constants of tension development ranging between 1.58 s(-1) and 1.48 s(-1)...
  7. ncbi Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15
    M R Hoehe
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892
    New Biol 3:880-5. 1991
    ..In situ hybridization using a biotinylated cosmid probe localizes the gene to 6q14-q15, thereby confirming the linkage analysis and defining a precise alignment of the genetic and cytogenetic maps...
  8. ncbi Genetic variation of the human mu-opioid receptor and susceptibility to idiopathic absence epilepsy
    T Sander
    Department of Neurology, University Hospital Charite, Humboldt University of Berlin, Germany
    Epilepsy Res 39:57-61. 2000
    ..078; chi2 = 5.467, df = 1, P = 0.019; OR = 2.03; 95%-CI: 1.12-3.68]. This allelic association suggests that the functional Asp40 variant of OPRM modulates neuronal excitability underlying the epileptogenesis of IAE...
  9. ncbi The human small conductance calcium-regulated potassium channel gene (hSKCa3) contains two CAG repeats in exon 1, is on chromosome 1q21.3, and shows a possible association with schizophrenia
    O Wittekindt
    Institut für Humangenetik and Anthropologie, Universitat Freiburg, Germany
    Neurogenetics 1:259-65. 1998
    ..Both CAG repeats have been typed in 86 bipolar I disorder patients, and no significant difference in allele distribution was observed between our bipolar disorder patients and controls...
  10. ncbi Beta-2 adrenergic receptor gene variations and blood pressure under stress in normal twins
    G H Li
    , , Humboldt University of Berlin, Germany
    Psychophysiology 38:485-9. 2001
    ..These findings support a role for the beta-2 AR gene in BP regulation. They also indicate that the beta-2 AR gene influences the level of not only resting but also stress-related BP...
  11. ncbi Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site
    J Kraus
    Department of Pharmacology, University of Magdeburg, 44 Leipziger Strasse, 39120 Magdeburg, Germany
    J Biol Chem 276:43901-8. 2001
    ..These findings provide a molecular basis for understanding bidirectional interactions between the opioid system and the immune system...