R Hock

Summary

Country: Germany

Publications

  1. pmc Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins
    Marta Prymakowska-Bosak
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:6809-19. 2002
  2. pmc Cross-linking of DNA through HMGA1 suggests a DNA scaffold
    Benjamin Vogel
    Department of Cell and Developmental Biology and Department of Biotechnology and Biophysics, University of Wuerzburg, Biocenter, Am Hubland, D 97074 Wuerzburg, Germany
    Nucleic Acids Res 39:7124-33. 2011
  3. pmc HMGA1 down-regulation is crucial for chromatin composition and a gene expression profile permitting myogenic differentiation
    Jan Brocher
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Block S1A, Level 6, 117543 Singapore
    BMC Cell Biol 11:64. 2010
  4. pmc HMG chromosomal proteins in development and disease
    Robert Hock
    Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Trends Cell Biol 17:72-9. 2007
  5. ncbi request reprint Expression of HMGA2 variants during oogenesis and early embryogenesis of Xenopus laevis
    Robert Hock
    Department of Cell and Developmental Biology, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Eur J Cell Biol 85:519-28. 2006
  6. pmc Dynamic relocation of chromosomal protein HMG-17 in the nucleus is dependent on transcriptional activity
    R Hock
    Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    EMBO J 17:6992-7001. 1998
  7. ncbi request reprint Identification of a novel mRNA-associated protein in oocytes of Pleurodeles waltl and Xenopus laevis
    B Lieb
    Biocenter, University of Wurzburg, Am Hubland, Wurzburg, D 97074, Germany
    Exp Cell Res 245:272-81. 1998
  8. ncbi request reprint Structure and function of the nucleolus
    U Scheer
    Department of Cell and Developmental Biology, Biocenter University of Würzburg, Am Hubland, D 97074, Wurzburg, Germany
    Curr Opin Cell Biol 11:385-90. 1999
  9. ncbi request reprint Localization of glucocorticoid hormone receptors in mitochondria of human cells
    K Scheller
    Department of Cell and Developmental Biology, Biocenter, University of Wurzburg, Germany
    Eur J Cell Biol 79:299-307. 2000
  10. pmc Architecture of the nuclear periphery of rat pachytene spermatocytes: distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sites
    M Alsheimer
    Department of Cell and Developmental Biology, Theodor Boveri Institute Biocenter, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Mol Biol Cell 10:1235-45. 1999

Collaborators

Detail Information

Publications18

  1. pmc Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins
    Marta Prymakowska-Bosak
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:6809-19. 2002
    ..Taken together with the results of previous studies, our results suggest a dual role for mitotic phosphorylation of HMGN1: abolishment of chromatin binding and inhibition of nuclear import...
  2. pmc Cross-linking of DNA through HMGA1 suggests a DNA scaffold
    Benjamin Vogel
    Department of Cell and Developmental Biology and Department of Biotechnology and Biophysics, University of Wuerzburg, Biocenter, Am Hubland, D 97074 Wuerzburg, Germany
    Nucleic Acids Res 39:7124-33. 2011
    ..This capacity has profound implications for the spatial organization of DNA in the cell nucleus and suggests cross-linking activities for additional nuclear proteins...
  3. pmc HMGA1 down-regulation is crucial for chromatin composition and a gene expression profile permitting myogenic differentiation
    Jan Brocher
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Block S1A, Level 6, 117543 Singapore
    BMC Cell Biol 11:64. 2010
    ..Here we used mouse C2C12 myoblasts and C2C12 cells stably over-expressing HMGA1a-eGFP to study the impact of deregulated HMGA1 expression levels on cellular differentiation...
  4. pmc HMG chromosomal proteins in development and disease
    Robert Hock
    Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Trends Cell Biol 17:72-9. 2007
    ..Here, we focus on the biological function of HMG proteins and highlight their possible roles in cellular differentiation and in the etiology of various diseases...
  5. ncbi request reprint Expression of HMGA2 variants during oogenesis and early embryogenesis of Xenopus laevis
    Robert Hock
    Department of Cell and Developmental Biology, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Eur J Cell Biol 85:519-28. 2006
    ....
  6. pmc Dynamic relocation of chromosomal protein HMG-17 in the nucleus is dependent on transcriptional activity
    R Hock
    Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    EMBO J 17:6992-7001. 1998
    ..Thus, the intranuclear distribution of chromosomal proteins which act as architectural elements of chromatin structure may be dynamic and functionally related to the transcriptional activity of the cell...
  7. ncbi request reprint Identification of a novel mRNA-associated protein in oocytes of Pleurodeles waltl and Xenopus laevis
    B Lieb
    Biocenter, University of Wurzburg, Am Hubland, Wurzburg, D 97074, Germany
    Exp Cell Res 245:272-81. 1998
    ..The expression pattern and intracellular distribution of RAP55 suggest that it is part of those mRNP particles which are translationally repressed during oogenesis and become activated upon progesterone-induced oocyte maturation...
  8. ncbi request reprint Structure and function of the nucleolus
    U Scheer
    Department of Cell and Developmental Biology, Biocenter University of Würzburg, Am Hubland, D 97074, Wurzburg, Germany
    Curr Opin Cell Biol 11:385-90. 1999
    ..Evidence is accumulating that nucleoli functionally interact with coiled bodies and are also involved in the maturation of non-ribosomal RNA species...
  9. ncbi request reprint Localization of glucocorticoid hormone receptors in mitochondria of human cells
    K Scheller
    Department of Cell and Developmental Biology, Biocenter, University of Wurzburg, Germany
    Eur J Cell Biol 79:299-307. 2000
    ..Our results support the concept of a receptor-mediated direct action of steroid hormones on mitochondrial gene transcription...
  10. pmc Architecture of the nuclear periphery of rat pachytene spermatocytes: distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sites
    M Alsheimer
    Department of Cell and Developmental Biology, Theodor Boveri Institute Biocenter, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Mol Biol Cell 10:1235-45. 1999
    ..According to these results, we propose that the C2-containing domains represent local reinforcements of the NE that are involved in the proper attachment of SCs...
  11. pmc Cell cycle-dependent binding of HMGN proteins to chromatin
    Srujana Cherukuri
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 19:1816-24. 2008
    ..Our studies demonstrate that the mode of binding of HMGNs to chromatin is cell cycle dependent...
  12. ncbi request reprint Modulation of HMG-N2 binding to chromatin by butyrate-induced acetylation in human colon adenocarcinoma cells
    Hardi Lührs
    Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Int J Cancer 97:567-73. 2002
    ..Modulation of nonhistone chromatin proteins, like the ubiquitous HMG-N2 proteins, may be partly responsible for the wide range of butyrate-associated effects...
  13. ncbi request reprint Dynamic interaction of HMGA1a proteins with chromatin
    Monika Harrer
    Department of Cell and Developmental Biology, University of Wurzburg, Wurzburg 97080, Germany
    J Cell Sci 117:3459-71. 2004
    ..The regulated dynamic properties of HMGA1a fusion proteins indicate that HMGA1 proteins are mechanistically involved in local and global changes in chromatin structure...
  14. ncbi request reprint Developmental role of HMGN proteins in Xenopus laevis
    Ulrich Körner
    Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
    Mech Dev 120:1177-92. 2003
    ..Our results demonstrate that proper embryonic development of Xenopus laevis requires precisely regulated levels of HMGN proteins and suggest that these nucleosomal binding proteins modulate the expression of specific genes...
  15. ncbi request reprint HMGN dynamics and chromatin function
    Frédéric Catez
    Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Cell Biol 81:113-22. 2003
    ..Studies with HMGN proteins underscore the important role of protein dynamics in chromatin function...
  16. ncbi request reprint Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells
    Tzutzuy Ramirez
    Department of Cell and Developmental Biology, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    Chromosoma 117:147-57. 2008
    ..As the chromatin compaction is crucial for the regulation of gene expression as well as for genome stability, we propose that chromatin opening by NaAsO(2) may play a significant role to impart its genotoxic effects...
  17. pmc Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins
    Andreas W Thomae
    Department of Gene Vectors, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Marchioninistrasse 25, 81377 Munchen, Germany
    Proc Natl Acad Sci U S A 105:1692-7. 2008
    ..Our experiments indicate that chromatin proteins can target ORC to DNA, suggesting they might specify origins of DNA replication in metazoan cells...
  18. ncbi request reprint Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I
    Morten O Christensen
    Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich Heine University, Medical School, Moorenstrasse 5, D 40225 Duesseldorf
    J Biol Chem 279:21873-82. 2004
    ..Thus, nucleolar/nucleoplasmic partitioning of topoisomerase I is regulated by interactions with RNA polymerase I and DNA but not by sumoylation...