Research Topics
| R HockSummaryCountry: Germany Publications
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Detail Information
Publications
Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteinsMarta Prymakowska-Bosak
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Cell Biol 22:6809-19. 2002..Taken together with the results of previous studies, our results suggest a dual role for mitotic phosphorylation of HMGN1: abolishment of chromatin binding and inhibition of nuclear import...- HMGA1 down-regulation is crucial for chromatin composition and a gene expression profile permitting myogenic differentiationJan Brocher
Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Block S1A, Level 6, 117543 Singapore
BMC Cell Biol 11:64. 2010..Here we used mouse C2C12 myoblasts and C2C12 cells stably over-expressing HMGA1a-eGFP to study the impact of deregulated HMGA1 expression levels on cellular differentiation... - HMG chromosomal proteins in development and diseaseRobert Hock
Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
Trends Cell Biol 17:72-9. 2007..Here, we focus on the biological function of HMG proteins and highlight their possible roles in cellular differentiation and in the etiology of various diseases... 
Expression of HMGA2 variants during oogenesis and early embryogenesis of Xenopus laevisRobert Hock
Department of Cell and Developmental Biology, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
Eur J Cell Biol 85:519-28. 2006....- Dynamic relocation of chromosomal protein HMG-17 in the nucleus is dependent on transcriptional activityR Hock
Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
EMBO J 17:6992-7001. 1998..Thus, the intranuclear distribution of chromosomal proteins which act as architectural elements of chromatin structure may be dynamic and functionally related to the transcriptional activity of the cell... - Identification of a novel mRNA-associated protein in oocytes of Pleurodeles waltl and Xenopus laevisB Lieb
Biocenter, University of Wurzburg, Am Hubland, Wurzburg, D 97074, Germany
Exp Cell Res 245:272-81. 1998..The expression pattern and intracellular distribution of RAP55 suggest that it is part of those mRNP particles which are translationally repressed during oogenesis and become activated upon progesterone-induced oocyte maturation... - Structure and function of the nucleolusU Scheer
Department of Cell and Developmental Biology, Biocenter University of Würzburg, Am Hubland, D 97074, Wurzburg, Germany
Curr Opin Cell Biol 11:385-90. 1999..Evidence is accumulating that nucleoli functionally interact with coiled bodies and are also involved in the maturation of non-ribosomal RNA species... - Architecture of the nuclear periphery of rat pachytene spermatocytes: distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sitesM Alsheimer
Department of Cell and Developmental Biology, Theodor Boveri Institute Biocenter, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
Mol Biol Cell 10:1235-45. 1999..According to these results, we propose that the C2-containing domains represent local reinforcements of the NE that are involved in the proper attachment of SCs... - Localization of glucocorticoid hormone receptors in mitochondria of human cellsK Scheller
Department of Cell and Developmental Biology, Biocenter, University of Wurzburg, Germany
Eur J Cell Biol 79:299-307. 2000..Our results support the concept of a receptor-mediated direct action of steroid hormones on mitochondrial gene transcription... - Cell cycle-dependent binding of HMGN proteins to chromatinSrujana Cherukuri
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biol Cell 19:1816-24. 2008..Our studies demonstrate that the mode of binding of HMGNs to chromatin is cell cycle dependent... - Dynamic interaction of HMGA1a proteins with chromatinMonika Harrer
Department of Cell and Developmental Biology, University of Wurzburg, Wurzburg 97080, Germany
J Cell Sci 117:3459-71. 2004..The regulated dynamic properties of HMGA1a fusion proteins indicate that HMGA1 proteins are mechanistically involved in local and global changes in chromatin structure... - HMGN dynamics and chromatin functionFrédéric Catez
Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Biochem Cell Biol 81:113-22. 2003..Studies with HMGN proteins underscore the important role of protein dynamics in chromatin function... - Modulation of HMG-N2 binding to chromatin by butyrate-induced acetylation in human colon adenocarcinoma cellsHardi Lührs
Department of Medicine, University of Wurzburg, Wurzburg, Germany
Int J Cancer 97:567-73. 2002..Modulation of nonhistone chromatin proteins, like the ubiquitous HMG-N2 proteins, may be partly responsible for the wide range of butyrate-associated effects... - Developmental role of HMGN proteins in Xenopus laevisUlrich Körner
Department of Cell and Developmental Biology, Biocenter, University of Wuerzburg, Am Hubland, D 97074 Wuerzburg, Germany
Mech Dev 120:1177-92. 2003..Our results demonstrate that proper embryonic development of Xenopus laevis requires precisely regulated levels of HMGN proteins and suggest that these nucleosomal binding proteins modulate the expression of specific genes... - Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase IMorten O Christensen
Institute of Clinical Chemistry and Laboratory Diagnostics, Heinrich Heine University, Medical School, Moorenstrasse 5, D 40225 Duesseldorf
J Biol Chem 279:21873-82. 2004..Thus, nucleolar/nucleoplasmic partitioning of topoisomerase I is regulated by interactions with RNA polymerase I and DNA but not by sumoylation... - Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cellsTzutzuy Ramirez
Department of Cell and Developmental Biology, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
Chromosoma 117:147-57. 2008..As the chromatin compaction is crucial for the regulation of gene expression as well as for genome stability, we propose that chromatin opening by NaAsO(2) may play a significant role to impart its genotoxic effects... - Interaction between HMGA1a and the origin recognition complex creates site-specific replication originsAndreas W Thomae
Department of Gene Vectors, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Marchioninistrasse 25, 81377 Munchen, Germany
Proc Natl Acad Sci U S A 105:1692-7. 2008..Our experiments indicate that chromatin proteins can target ORC to DNA, suggesting they might specify origins of DNA replication in metazoan cells...