J R Hirsch

Summary

Country: Germany

Publications

  1. ncbi request reprint Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Med Poliklinik, Experimentelle Nephrologie, Germany
    Kidney Int 51:473-6. 1997
  2. ncbi request reprint Cellular localization, membrane distribution, and possible function of guanylyl cyclases A and 1 in collecting ducts of rat
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Medizinische Poliklinik, Experimentelle Nephrologie, Domagkstr 3A, D 48149, Munster, Germany
    Cardiovasc Res 51:553-61. 2001
  3. ncbi request reprint cGMP serves as an extracellular regulator of a Ca(2+)-dependent K(+) channel in immortalized human proximal tubule cells
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Medizinische Poliklinik, Experimentelle Nephrologie, Munster, Germany
    Cell Physiol Biochem 11:77-82. 2001
  4. pmc A novel cGMP-regulated K+ channel in immortalized human kidney epitheliall cells (IHKE-1)
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Medizinische Poliklinik, Experimentelle Nephrologie, Domagkstrasse 3a, D 48149 Munster, Germany
    J Physiol 519:645-55. 1999
  5. ncbi request reprint cGMP-dependent and -independent inhibition of a K+ conductance by natriuretic peptides: molecular and functional studies in human proximal tubule cells
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Medizinische Poliklinik, Experimentelle Nephrologie, Germany
    J Am Soc Nephrol 10:472-80. 1999
  6. ncbi request reprint Na(+)-dependent and -independent amino acid transport systems in immortalized human kidney epithelial cells derived from the proximal tubule
    J R Hirsch
    Medizinische Poliklinik, Westfalische Wilhelms Universitat Munster, Germany
    Kidney Blood Press Res 21:50-8. 1998
  7. ncbi request reprint Properties and regulation of organic cation transport in freshly isolated human proximal tubules
    G Pietig
    Medizinische Klinik and Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, D 48149 Munster, Germany
    J Biol Chem 276:33741-6. 2001
  8. ncbi request reprint Natriuretic peptides and diadenosine polyphosphates modulate pH regulation of rat mesangial cells
    E A Schulte
    Westfalische Wilhelms Universitat, Medizinische Poliklinik, Experimentelle Nephrologie, Munster, Deutschland
    Cell Physiol Biochem 9:310-22. 1999
  9. ncbi request reprint The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP
    E Schlatter
    Universitatsklinikum Munster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Domagkstr 3A, D 48149 Munster, Germany
    J Membr Biol 189:237-44. 2002
  10. ncbi request reprint Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits
    C Derst
    Institute for Normal and Pathological Physiology, University of Marburg, Germany
    FEBS Lett 491:305-11. 2001

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Med Poliklinik, Experimentelle Nephrologie, Germany
    Kidney Int 51:473-6. 1997
    ..Thus, we conclude that in the rat CCD transport is not regulated via the NO-pathway and that SNP acts as an cGMP independent activator of K+ channels in the basolateral membrane of these cells...
  2. ncbi request reprint Cellular localization, membrane distribution, and possible function of guanylyl cyclases A and 1 in collecting ducts of rat
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Medizinische Poliklinik, Experimentelle Nephrologie, Domagkstr 3A, D 48149, Munster, Germany
    Cardiovasc Res 51:553-61. 2001
    ..We have shown that natriuretic peptides have no effect on ion conductances or water transport of principal cells (PC) even though a cGMP-regulated K+ channel is located in the basolateral membrane of these cells...
  3. ncbi request reprint cGMP serves as an extracellular regulator of a Ca(2+)-dependent K(+) channel in immortalized human proximal tubule cells
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Medizinische Poliklinik, Experimentelle Nephrologie, Munster, Germany
    Cell Physiol Biochem 11:77-82. 2001
    ..1 mM). cGMP inhibits a K(+) channel in human proximal tubule cells from the outside and may serve as an autocrine and paracrine regulatory factor in the kidney...
  4. pmc A novel cGMP-regulated K+ channel in immortalized human kidney epitheliall cells (IHKE-1)
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Medizinische Poliklinik, Experimentelle Nephrologie, Domagkstrasse 3a, D 48149 Munster, Germany
    J Physiol 519:645-55. 1999
    ..6. The results present the first electrophysiological characterization of a mammalian K+ channel that is directly regulated by cGMP...
  5. ncbi request reprint cGMP-dependent and -independent inhibition of a K+ conductance by natriuretic peptides: molecular and functional studies in human proximal tubule cells
    J R Hirsch
    Westfalische Wilhelms Universitat Munster, Medizinische Poliklinik, Experimentelle Nephrologie, Germany
    J Am Soc Nephrol 10:472-80. 1999
    ..These findings indicate that natriuretic peptides regulate electrogenic transport processes via cGMP-dependent and -independent pathways that influence the Vm of IHKE-1 cells...
  6. ncbi request reprint Na(+)-dependent and -independent amino acid transport systems in immortalized human kidney epithelial cells derived from the proximal tubule
    J R Hirsch
    Medizinische Poliklinik, Westfalische Wilhelms Universitat Munster, Germany
    Kidney Blood Press Res 21:50-8. 1998
    ..B system-related AA transporters might be responsible for the C(-)-independent SIAT, since we were able to detect its signal by Northern blot analysis...
  7. ncbi request reprint Properties and regulation of organic cation transport in freshly isolated human proximal tubules
    G Pietig
    Medizinische Klinik and Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, D 48149 Munster, Germany
    J Biol Chem 276:33741-6. 2001
    ....
  8. ncbi request reprint Natriuretic peptides and diadenosine polyphosphates modulate pH regulation of rat mesangial cells
    E A Schulte
    Westfalische Wilhelms Universitat, Medizinische Poliklinik, Experimentelle Nephrologie, Munster, Deutschland
    Cell Physiol Biochem 9:310-22. 1999
    ....
  9. ncbi request reprint The organic cation transporters rOCT1 and hOCT2 are inhibited by cGMP
    E Schlatter
    Universitatsklinikum Munster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Domagkstr 3A, D 48149 Munster, Germany
    J Membr Biol 189:237-44. 2002
    ..The data suggest that the inhibition mediated by cGMP observed in HEK293 cells occurs most likely via a mammalian cGMP-binding protein that interacts with OCT1-2 transporters...
  10. ncbi request reprint Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits
    C Derst
    Institute for Normal and Pathological Physiology, University of Marburg, Germany
    FEBS Lett 491:305-11. 2001
    ..When expressed in Xenopus oocytes, Kir5.1 is efficiently targeted to the cell surface and forms electrically silent channels together with Kir2.1, thus negatively controlling Kir2.1 channel activity in native cells...
  11. ncbi request reprint Cellular localization of the potassium channel Kir7.1 in guinea pig and human kidney
    C Derst
    Institut fur Normale und Pathologische Physiologie, Philipps Universitat, Marburg, Germany
    Kidney Int 59:2197-205. 2001
    ..The aim of this study was to obtain more information on the localization and possible functional role of the inwardly rectifying K(+) channel, Kir7.1...
  12. ncbi request reprint ANP and urodilatin: who is who in the kidney
    J R Hirsch
    Cardiopep Pharma GmbH, Karl Wiechert Allee 76, 30625 Hannover, Germany
    Eur J Med Res 11:447-54. 2006
    ..This review attempts to analyze the roles of both ANP and urodilatin and to discuss new potential candidates which may also play a role in electrolyte and water handling in the kidney...