Karl F HilgersSummaryCountry: Germany Publications
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Publications
ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal diseaseKarl F Hilgers
Department of Medicine IV, , , Germany
J Am Soc Nephrol 13:1100-8. 2002- Treatment strategies in patients with chronic renal disease: ACE inhibitors, angiotensin receptor antagonists, or both?Karl F Hilgers
Department of Medicine IV, University of Erlangen Nurnberg, Germany
Pediatr Nephrol 19:956-61. 2004..A trial of ARB plus ACEI is justified in selected patients if blood pressure and/or proteinuria cannot adequately be lowered by ACEI or ARB alone... - Renin-angiotensin system and cardiovascular riskRoland E Schmieder
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
Lancet 369:1208-19. 2007..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk... - High sodium intake modulates left ventricular mass in patients with G expression of +1675 G/A angiotensin II receptor type 2 geneChristian Ott
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Nuremberg, Germany
J Hypertens 25:1627-32. 2007..Hypertension and LVH are often aggravated by salt intake. Our objective was to assess the relationship between AT2R gene variation and salt intake and their impact on left ventricular mass (LVM)... - Renal sympathetic nerves modulate erythropoietin plasma levels after transient hemorrhage in ratsTilmann Ditting
Department of Nephrology, Friedrich Alexander Univ Erlangen Nürnberg, Erlangen, Germany
Am J Physiol Renal Physiol 293:F1099-106. 2007..Renal sympathoinhibition during hypotensive hemorrhage might help to preserve sufficient oxygenation of renal tissue by modulation of hemodynamic mechanisms that act to adapt renal oxygen availability to demand... - Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b+/-) after unilateral nephrectomySabine Endele
Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, University Hospital Erlangen, Schwabachanlage 10, 91054 Erlangen, Germany
Transgenic Res 16:723-9. 2007..Moreover, this is the first report of a phenotype in heterozygous Lmx1b (Lmx1b ( +/-)) knockout animals... 
Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndromeMarko Bertog
Institut fur Zellulare und Molekulare Physiologie, Waldstr 6, 91054 Erlangen, Germany
J Physiol 586:459-75. 2008..This may be pathophysiologically relevant in patients with Liddle's syndrome, in particular on a high salt diet, when suppression of P Aldo is likely to be insufficient to reduce Na+ absorption to an appropriate level...
(Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt ratsDominik N Muller
Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, and HELIOS Klinikum Berlin Buch, and Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
Hypertension 51:676-81. 2008..Our results indicate that blockade of the (P)RR with HRP does not improve target organ damage in renovascular hypertensive rats...- A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney diseaseRaoul Zeltner
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
Nephron Clin Pract 108:c169-75. 2008..We investigated whether the -414 T/C polymorphism in the promoter region of the alpha 8 integrin chain gene (ITGA8) is associated with the progression of renal disease in ADPKD... - Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4aJens H Westhoff
Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
Hypertension 52:123-9. 2008..Thus, hypertension induces cellular senescence via p16(INK4a), possibly through p38, thereby contributing to hypertensive target organ damage. This detrimental effect can be overcome by different therapeutic drug strategies... - Effect of the angiotensinogen genotype on experimental hypertension in miceClaudia Handtrack
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
J Mol Med (Berl) 85:343-50. 2007..We conclude that the Agt genotype exerts a marked effect on blood pressure in a low-renin form of hypertension but no effect in the face of stimulated renin, at least in mice... - Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetesAndrea Hartner
Children and Youth Hospital, University of Erlangen Nuremberg, Erlangen, Germany
Am J Physiol Renal Physiol 292:F820-7. 2007..However, the long-term course of this animal model resembles severe hypertensive nephrosclerosis, rather than progressive diabetic nephropathy... - Renoprotection with antihypertensive agentsKarl F Hilgers
Lancet 359:1693; author reply 1693-4. 2002 - Putative role of epithelial sodium channels (ENaC) in the afferent limb of cardio renal reflexes in ratsTilmann Ditting
Department of Nephrology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Basic Res Cardiol 98:388-400. 2003..Other ion channels might be involved. Furthermore the observed findings in vivo could also be due to unspecific disturbance of afferent signal conduction... - Mechanosensitive cardiac C-fiber response to changes in left ventricular filling, coronary perfusion pressure, hemorrhage, and volume expansion in ratsTilmann Ditting
Department of Nephrology, Johann Wolfgang University, Frankfurt, Germany
Am J Physiol Heart Circ Physiol 288:H541-52. 2005..Thus neither LVEDP nor CPP fully accounts directly for afferent C-fiber and reflex sympathetic responses. The intrinsic afferent stimuli and receptive fields accounting for reflex sympathoinhibition still remain cryptic... - Characterization of the renal phenotype in a mouse model of Marfan syndromeAndrea Hartner
Department of Pediatrics, University of Erlangen Nurnberg, Loschgestrasse 15, 91054 Erlangen, Germany
Virchows Arch 445:382-8. 2004..Alterations in renal histology were only subtle with a reduced glomerular volume and mesangial area likely due to a reduced mesangial cell volume... - Effects of diabetes and hypertension on macrophage infiltration and matrix expansion in the rat kidneyAndrea Hartner
Children and Youth Hospital, University of Erlangen Nuremberg, Loschgestrasse 15, D 91054 Erlangen, Germany
BMC Nephrol 6:6. 2005..Inflammatory mechanisms contribute to renal damage in both diseases. We investigated whether hypertension and diabetes mellitus act synergistically to induce macrophage infiltration and matrix expansion in the kidney... - Detection of angiotensin II in supernatants of stimulated mononuclear leukocytes by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass analysisVera Jankowski
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin Medizinische Klinik IV, Germany
Hypertension 46:591-7. 2005.... - Sensory neurons with afferents from hind limbs: enhanced sensitivity in secondary hypertensionPeter Linz
Department of Internal Medicine 4/Nephrology and Hypertension, , Erlangen, Germany
Hypertension 47:527-31. 2006..We speculate that this observation may indicate an increased activity of these neurons, their axons, and neurotransmitters in the control of resistance vessels in hypertension... - Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive ratsAndrea Hartner
University Hospital for Children and Adolescents, University of Erlangen Nuremberg, Erlangen, Germany
Nephrol Dial Transplant 21:1778-85. 2006..We tested the hypothesis that local angiotensin II formation occurs at sites of renal vascular and interstitial injury in this model... - Transient receptor potential vanilloid type 1 receptors in hypertensive renal damage: a promising therapeutic target?Tilmann Ditting
Hypertension 52:213-4. 2008