Karl F Hilgers

Summary

Country: Germany

Publications

  1. ncbi request reprint ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal disease
    Karl F Hilgers
    Department of Medicine IV, University of Erlangen Nurnberg, Nurnberg, Germany
    J Am Soc Nephrol 13:1100-8. 2002
  2. doi request reprint Intrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Clin Sci (Lond) 123:437-44. 2012
  3. doi request reprint Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Kidney Dis 53:281-9. 2009
  4. doi request reprint Deletion of the alpha8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension
    Andrea Hartner
    Department of Pediatric and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 22:92-9. 2009
  5. ncbi request reprint Impaired myocardial performance in a normotensive rat model of intrauterine growth restriction
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Pediatr Res 75:697-706. 2014
  6. doi request reprint Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Krankenhausstrasse 12, Erlangen, Germany
    Pharmacogenet Genomics 21:347-9. 2011
  7. doi request reprint Early glomerular alterations in genetically determined low nephron number
    Kerstin Benz
    Department of Pediatrics, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 300:F521-30. 2011
  8. pmc Darbepoetin alpha reduces oxidative stress and chronic inflammation in atherosclerotic lesions of apo E deficient mice in experimental renal failure
    Nicole Arend
    Department of Internal Medicine Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 9:e88601. 2014
  9. pmc Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 6:e20369. 2011
  10. pmc High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy
    Karin Tyralla
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 6:e15287. 2011

Collaborators

Detail Information

Publications34

  1. ncbi request reprint ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal disease
    Karl F Hilgers
    Department of Medicine IV, University of Erlangen Nurnberg, Nurnberg, Germany
    J Am Soc Nephrol 13:1100-8. 2002
  2. doi request reprint Intrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Clin Sci (Lond) 123:437-44. 2012
    ..We conclude that IUGR aggravates atherosclerotic vascular remodelling induced by a second injury later in life...
  3. doi request reprint Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus
    Martin Ritt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Kidney Dis 53:281-9. 2009
    ..Basal nitric oxide (NO) activity has a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments, its alteration has been associated with morphological changes characteristic of diabetic nephropathy...
  4. doi request reprint Deletion of the alpha8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension
    Andrea Hartner
    Department of Pediatric and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 22:92-9. 2009
    ..Integrins can contribute to tissue fibrosis in several organs. We tested the hypothesis that alpha8 integrin-mediated cell-matrix interactions add to cardiac fibrotic alterations during hypertension...
  5. ncbi request reprint Impaired myocardial performance in a normotensive rat model of intrauterine growth restriction
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    Pediatr Res 75:697-706. 2014
    ..Previous studies revealed altered myocardial matrix composition after IUGR. We hypothesized that IUGR is accompanied by compromised myocardial performance independently from arterial hypertension...
  6. doi request reprint Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Krankenhausstrasse 12, Erlangen, Germany
    Pharmacogenet Genomics 21:347-9. 2011
    ..05). These findings indicate that C-allele carriers have lower systolic BP than T-allele carriers. Thus, our data suggest that (P)RR influences BP regulation in Caucasian men, potentially through altered aldosterone release...
  7. doi request reprint Early glomerular alterations in genetically determined low nephron number
    Kerstin Benz
    Department of Pediatrics, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 300:F521-30. 2011
    ....
  8. pmc Darbepoetin alpha reduces oxidative stress and chronic inflammation in atherosclerotic lesions of apo E deficient mice in experimental renal failure
    Nicole Arend
    Department of Internal Medicine Nephrology, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 9:e88601. 2014
    ..Therefore, this study evaluates the effects of Darbepoetin on markers of oxidative stress and chronic inflammation in atherosclerotic lesions in apo E knockout mice with renal dysfunction...
  9. pmc Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction
    Carlos Menendez-Castro
    Department of Pediatrics and Adolescent Medicine, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 6:e20369. 2011
    ..Hence, altered matrix composition of the vascular wall and the myocardium may predispose IUGR animals to cardiovascular disease later in life...
  10. pmc High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy
    Karin Tyralla
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    PLoS ONE 6:e15287. 2011
    ..It is unclear, however, to what extent ACE-inhibitors can also reverse existing cardiovascular alterations. Therefore, we investigated the effect of high dose enalapril treatment on these alterations...
  11. ncbi request reprint Treatment strategies in patients with chronic renal disease: ACE inhibitors, angiotensin receptor antagonists, or both?
    Karl F Hilgers
    Department of Medicine IV, University of Erlangen Nurnberg, Germany
    Pediatr Nephrol 19:956-61. 2004
    ..A trial of ARB plus ACEI is justified in selected patients if blood pressure and/or proteinuria cannot adequately be lowered by ACEI or ARB alone...
  12. ncbi request reprint Role of fibrillin-1 in hypertensive and diabetic glomerular disease
    Andrea Hartner
    Hospital for Children and Adolescents, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 290:F1329-36. 2006
    ..We conclude that fibrillin-1 may contribute to glomerular damage in hypertensive and diabetic kidney disease...
  13. ncbi request reprint Sensory neurons with afferents from hind limbs: enhanced sensitivity in secondary hypertension
    Peter Linz
    Department of Internal Medicine 4 Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Hypertension 47:527-31. 2006
    ..We speculate that this observation may indicate an increased activity of these neurons, their axons, and neurotransmitters in the control of resistance vessels in hypertension...
  14. ncbi request reprint Malignant hypertension and the angiotensinogen gene
    Claudia Handtrack
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    J Hypertens 25:2199-201. 2007
  15. doi request reprint The German Chronic Kidney Disease (GCKD) study: design and methods
    Kai Uwe Eckardt
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Nephrol Dial Transplant 27:1454-60. 2012
    ....
  16. ncbi request reprint Left-ventricular structure and function are influenced by angiotensinogen gene polymorphism (-20 A/C) in young male patients
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Erlangen, Germany
    Am J Hypertens 20:974-80. 2007
    ..Therefore, we questioned whether left-ventricular (LV) structure and function are influenced by the -20 A/C variant of the angiotensinogen (AGT) gene in young normotensive or mildly hypertensive patients...
  17. ncbi request reprint Characterization of the renal phenotype in a mouse model of Marfan syndrome
    Andrea Hartner
    Department of Pediatrics, University of Erlangen Nurnberg, Loschgestrasse 15, 91054 Erlangen, Germany
    Virchows Arch 445:382-8. 2004
    ..Alterations in renal histology were only subtle with a reduced glomerular volume and mesangial area likely due to a reduced mesangial cell volume...
  18. ncbi request reprint Mechanosensitive cardiac C-fiber response to changes in left ventricular filling, coronary perfusion pressure, hemorrhage, and volume expansion in rats
    Tilmann Ditting
    Department of Nephrology, Johann Wolfgang University, Frankfurt, Germany
    Am J Physiol Heart Circ Physiol 288:H541-52. 2005
    ..Thus neither LVEDP nor CPP fully accounts directly for afferent C-fiber and reflex sympathetic responses. The intrinsic afferent stimuli and receptive fields accounting for reflex sympathoinhibition still remain cryptic...
  19. pmc Effects of diabetes and hypertension on macrophage infiltration and matrix expansion in the rat kidney
    Andrea Hartner
    Children and Youth Hospital, University of Erlangen Nuremberg, Loschgestrasse 15, D 91054 Erlangen, Germany
    BMC Nephrol 6:6. 2005
    ..Inflammatory mechanisms contribute to renal damage in both diseases. We investigated whether hypertension and diabetes mellitus act synergistically to induce macrophage infiltration and matrix expansion in the kidney...
  20. ncbi request reprint Renoprotection with antihypertensive agents
    Karl F Hilgers
    Lancet 359:1693; author reply 1693-4. 2002
  21. ncbi request reprint Detection of angiotensin II in supernatants of stimulated mononuclear leukocytes by matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass analysis
    Vera Jankowski
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin Medizinische Klinik IV, Germany
    Hypertension 46:591-7. 2005
    ....
  22. ncbi request reprint Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats
    Andrea Hartner
    University Hospital for Children and Adolescents, University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 21:1778-85. 2006
    ..We tested the hypothesis that local angiotensin II formation occurs at sites of renal vascular and interstitial injury in this model...
  23. ncbi request reprint Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes
    Andrea Hartner
    Children and Youth Hospital, University of Erlangen Nuremberg, Erlangen, Germany
    Am J Physiol Renal Physiol 292:F820-7. 2007
    ..However, the long-term course of this animal model resembles severe hypertensive nephrosclerosis, rather than progressive diabetic nephropathy...
  24. ncbi request reprint Effect of the angiotensinogen genotype on experimental hypertension in mice
    Claudia Handtrack
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    J Mol Med (Berl) 85:343-50. 2007
    ..We conclude that the Agt genotype exerts a marked effect on blood pressure in a low-renin form of hypertension but no effect in the face of stimulated renin, at least in mice...
  25. ncbi request reprint Renin-angiotensin system and cardiovascular risk
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Lancet 369:1208-19. 2007
    ..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
  26. ncbi request reprint Putative role of epithelial sodium channels (ENaC) in the afferent limb of cardio renal reflexes in rats
    Tilmann Ditting
    Department of Nephrology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Basic Res Cardiol 98:388-400. 2003
    ..Other ion channels might be involved. Furthermore the observed findings in vivo could also be due to unspecific disturbance of afferent signal conduction...
  27. ncbi request reprint High sodium intake modulates left ventricular mass in patients with G expression of +1675 G/A angiotensin II receptor type 2 gene
    Christian Ott
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Nuremberg, Germany
    J Hypertens 25:1627-32. 2007
    ..Hypertension and LVH are often aggravated by salt intake. Our objective was to assess the relationship between AT2R gene variation and salt intake and their impact on left ventricular mass (LVM)...
  28. ncbi request reprint Transient receptor potential vanilloid type 1 receptors in hypertensive renal damage: a promising therapeutic target?
    Tilmann Ditting
    Hypertension 52:213-4. 2008
  29. ncbi request reprint Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a
    Jens H Westhoff
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    Hypertension 52:123-9. 2008
    ..Thus, hypertension induces cellular senescence via p16(INK4a), possibly through p38, thereby contributing to hypertensive target organ damage. This detrimental effect can be overcome by different therapeutic drug strategies...
  30. doi request reprint A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease
    Raoul Zeltner
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Nephron Clin Pract 108:c169-75. 2008
    ..We investigated whether the -414 T/C polymorphism in the promoter region of the alpha 8 integrin chain gene (ITGA8) is associated with the progression of renal disease in ADPKD...
  31. doi request reprint (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats
    Dominik N Muller
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Franz Volhard Clinic, and HELIOS Klinikum Berlin Buch, and Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 51:676-81. 2008
    ..Our results indicate that blockade of the (P)RR with HRP does not improve target organ damage in renovascular hypertensive rats...
  32. ncbi request reprint Renal sympathetic nerves modulate erythropoietin plasma levels after transient hemorrhage in rats
    Tilmann Ditting
    Department of Nephrology, Friedrich Alexander Univ Erlangen Nürnberg, Erlangen, Germany
    Am J Physiol Renal Physiol 293:F1099-106. 2007
    ..Renal sympathoinhibition during hypotensive hemorrhage might help to preserve sufficient oxygenation of renal tissue by modulation of hemodynamic mechanisms that act to adapt renal oxygen availability to demand...
  33. ncbi request reprint Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b+/-) after unilateral nephrectomy
    Sabine Endele
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, University Hospital Erlangen, Schwabachanlage 10, 91054 Erlangen, Germany
    Transgenic Res 16:723-9. 2007
    ..Moreover, this is the first report of a phenotype in heterozygous Lmx1b (Lmx1b ( +/-)) knockout animals...
  34. pmc Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome
    Marko Bertog
    Institut fur Zellulare und Molekulare Physiologie, Waldstr 6, 91054 Erlangen, Germany
    J Physiol 586:459-75. 2008
    ..This may be pathophysiologically relevant in patients with Liddle's syndrome, in particular on a high salt diet, when suppression of P Aldo is likely to be insufficient to reduce Na+ absorption to an appropriate level...