Helmut Hildebrandt

Summary

Country: Germany

Publications

  1. ncbi request reprint Group therapy for memory impaired patients: a partial remediation is possible
    Helmut Hildebrandt
    Central Hospital of Bremen Ost, Department of Neurology, Züricher Str 40, 28325, Bremen, Germany
    J Neurol 253:512-9. 2006
  2. pmc Cognitive profiles of patients with mild cognitive impairment or dementia in Alzheimer's or Parkinson's disease
    Helmut Hildebrandt
    Department of Neurology, Klinikum Bremen Ost, Bremen, University of Oldenburg, Oldenburg Institute of Psychology, University of Oldenburg, Oldenburg
    Dement Geriatr Cogn Dis Extra 3:102-12. 2013
  3. doi request reprint Neural correlates of stimulus response and stimulus outcome shifting in healthy participants and MS patients
    Helmut Hildebrandt
    Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany
    Brain Cogn 81:57-66. 2013
  4. doi request reprint False recognition correlates with amyloid-beta (1-42) but not with total tau in cerebrospinal fluid of patients with dementia and mild cognitive impairment
    Helmut Hildebrandt
    Municipal Hospital of Bremen Ost, Department of Neurology, Bremen, Germany
    J Alzheimers Dis 16:157-65. 2009
  5. ncbi request reprint Brain perfusion and VEP reactivity in occipital and parietal areas are associated to recovery from hypoxic vegetative state
    Helmut Hildebrandt
    Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany University of Oldenburg, Institute of Psychology, Germany
    J Neurol Sci 260:150-8. 2007
  6. ncbi request reprint Cognitive training in MS: effects and relation to brain atrophy
    Helmut Hildebrandt
    Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany
    Restor Neurol Neurosci 25:33-43. 2007
  7. doi request reprint False recognition helps to distinguish patients with Alzheimer's disease and amnestic MCI from patients with other kinds of dementia
    Helmut Hildebrandt
    Department of Neurology, Municipal Hospital of Bremen Ost, Bremen, Germany
    Dement Geriatr Cogn Disord 28:159-67. 2009
  8. ncbi request reprint Memory performance in multiple sclerosis patients correlates with central brain atrophy
    H Hildebrandt
    Department of Neurology, Klinikum Bremen Ost, Züricher Str 40, 28325 Bremen, Germany
    Mult Scler 12:428-36. 2006
  9. ncbi request reprint Conditional responding is impaired in chronic alcoholics
    Helmut Hildebrandt
    Department of Neurology, Municipal Hospital of Bremen, Bremen, Germany
    J Clin Exp Neuropsychol 28:631-45. 2006
  10. ncbi request reprint Visual search for item- and array-centered locations in patients with left middle cerebral artery stroke
    Helmut Hildebrandt
    Hospital of Bremen Ost, Neurology, Bremen, The Netherlands
    Neurocase 11:416-26. 2005

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Group therapy for memory impaired patients: a partial remediation is possible
    Helmut Hildebrandt
    Central Hospital of Bremen Ost, Department of Neurology, Züricher Str 40, 28325, Bremen, Germany
    J Neurol 253:512-9. 2006
    ..To analyse the prospect of memory training for patients with organic brain damage...
  2. pmc Cognitive profiles of patients with mild cognitive impairment or dementia in Alzheimer's or Parkinson's disease
    Helmut Hildebrandt
    Department of Neurology, Klinikum Bremen Ost, Bremen, University of Oldenburg, Oldenburg Institute of Psychology, University of Oldenburg, Oldenburg
    Dement Geriatr Cogn Dis Extra 3:102-12. 2013
    ..Alzheimer's disease (AD) and Parkinson's disease (PD) are associated with severe cognitive decline, but it is still unclear to what extent they become functionally more similar over time...
  3. doi request reprint Neural correlates of stimulus response and stimulus outcome shifting in healthy participants and MS patients
    Helmut Hildebrandt
    Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany
    Brain Cogn 81:57-66. 2013
    ..However, these studies rarely compared both kinds of adaptation directly and existing fMRI studies with healthy subjects are not informative about the role of the two fiber systems...
  4. doi request reprint False recognition correlates with amyloid-beta (1-42) but not with total tau in cerebrospinal fluid of patients with dementia and mild cognitive impairment
    Helmut Hildebrandt
    Municipal Hospital of Bremen Ost, Department of Neurology, Bremen, Germany
    J Alzheimers Dis 16:157-65. 2009
    ..This process might be more specific for AD than the increase of tau, and therefore it is stronger correlated with recognition errors...
  5. ncbi request reprint Brain perfusion and VEP reactivity in occipital and parietal areas are associated to recovery from hypoxic vegetative state
    Helmut Hildebrandt
    Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany University of Oldenburg, Institute of Psychology, Germany
    J Neurol Sci 260:150-8. 2007
    ..Although this may just reflect haemodynamics during hypoxia leading to differences in severity of VS, it also may be regarded as a functional precondition for orientation towards stimuli and therefore for conscious actions in general...
  6. ncbi request reprint Cognitive training in MS: effects and relation to brain atrophy
    Helmut Hildebrandt
    Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany
    Restor Neurol Neurosci 25:33-43. 2007
    ..We explored the benefits of a home-based cognitive training program for memory and working memory functions in relapsing-remitting MS patients controlling for whole brain and central brain atrophy as covariates...
  7. doi request reprint False recognition helps to distinguish patients with Alzheimer's disease and amnestic MCI from patients with other kinds of dementia
    Helmut Hildebrandt
    Department of Neurology, Municipal Hospital of Bremen Ost, Bremen, Germany
    Dement Geriatr Cogn Disord 28:159-67. 2009
    ..The quality of the differential diagnosis may therefore be enhanced significantly by taking into account both delayed recall and false recognitions provoked by a picture recognition task...
  8. ncbi request reprint Memory performance in multiple sclerosis patients correlates with central brain atrophy
    H Hildebrandt
    Department of Neurology, Klinikum Bremen Ost, Züricher Str 40, 28325 Bremen, Germany
    Mult Scler 12:428-36. 2006
    ..To assess whole brain and central brain atrophy as well as their differential relation to memory, cognitive performance, fatigue, depression and quality of life in patients with relapsing-remitting multiple sclerosis (RRMS)...
  9. ncbi request reprint Conditional responding is impaired in chronic alcoholics
    Helmut Hildebrandt
    Department of Neurology, Municipal Hospital of Bremen, Bremen, Germany
    J Clin Exp Neuropsychol 28:631-45. 2006
    ..We conclude that long-term alcohol abuse leads to an impairment in conditional responding, provided the response depends on former reactions or the inhibition of pre-potent response patterns...
  10. ncbi request reprint Visual search for item- and array-centered locations in patients with left middle cerebral artery stroke
    Helmut Hildebrandt
    Hospital of Bremen Ost, Neurology, Bremen, The Netherlands
    Neurocase 11:416-26. 2005
    ..This suggests that spatial attention works with different reference frames, with spatial orientation being more basic than analyzing spatial aspects of objects...
  11. ncbi request reprint Differential impact of parvocellular and magnocellular pathways on visual impairment in apperceptive agnosia?
    Helmut Hildebrandt
    Municipal Hospital of Bremen, Germany
    Neurocase 10:207-14. 2004
    ..This may be interpreted as a disorder of the magnocellular system, with intact parvocellular system and therefore preserved ability to detect both local features and colors...
  12. ncbi request reprint Response shifting and inhibition, but not working memory, are impaired after long-term heavy alcohol consumption
    Helmut Hildebrandt
    Department of Neurology, Municipal Hospital of Bremen, Bremen, Germany
    Neuropsychology 18:203-11. 2004
    ..The neurotoxic side effects of alcohol therefore lead to a specific deficit in alternating between response rules but not in working memory, independently of whether the working memory task involves interference resolution or not...
  13. ncbi request reprint [Neglect dyslexia owing to traumatic fronto-temporal right hemisphere bleeding]
    H Hildebrandt
    Universitat Oldenburg, Klinische und Gesundheitspsychologie
    Fortschr Neurol Psychiatr 71:8-16. 2003
    ....
  14. ncbi request reprint Visuospatial hemi-inattention following cerebellar/brain stem bleeding
    H Hildebrandt
    Department of Neurology, Central Hospital Bremen Ost, Züricher Str 40, Germany
    Neurocase 8:323-9. 2002
    ....
  15. doi request reprint Efficacy of an executive function intervention programme in MS: a placebo-controlled and pseudo-randomized trial
    Frauke Fink
    Klinikum Bremen Ost, Department of Neurology, Züricher Str 40, 28325 Bremen, Germany
    Mult Scler 16:1148-51. 2010
    ..Consequently, cognitive intervention may be beneficial and baseline brain atrophy has some predictive value in determining treatment outcome for executive functioning...
  16. pmc Age-dependent effects of carotid endarterectomy or stenting on cognitive performance
    Katrin Wasser
    Department of Neurology, University of Gottingen, Robert Koch Straße 40, 37075, Gottingen, Germany
    J Neurol 259:2309-18. 2012
    ....
  17. doi request reprint The association between California Verbal Learning Test performance and fibre impairment in multiple sclerosis: evidence from diffusion tensor imaging
    Frauke Fink
    Klinikum Bremen Ost, Department of Neurology, Züricher Strasse 40, 28325 Bremen, Germany
    Mult Scler 16:332-41. 2010
    ..Finally, DTI-derived measurements appear to reflect disease progression in MS. The results are discussed in light of functional MRI studies investigating compensatory brain activity during cognitive processing in MS...
  18. doi request reprint Impaired stimulus-outcome but preserved stimulus-response shifting in young substance-dependent individuals
    Helmut Hildebrandt
    Department of Neurology, Municipal Hospital of Bremen, Bremen, Germany
    J Clin Exp Neuropsychol 30:946-55. 2008
    ....
  19. ncbi request reprint Discriminant analysis of the cognitive performance profile of MS patients differentiates their clinical course
    Jürgen A Kraus
    Klinikum Bremen Ost, Dept of Neurology, Züricher Str 40, 28325 Bremen, Germany
    J Neurol 252:808-13. 2005
    ..To compare the neuropsychological deficits of primary progressive multiple sclerosis with those of relapsing-remitting and secondary progressive multiple sclerosis...
  20. doi request reprint Comparison of diffusion tensor-based tractography and quantified brain atrophy for analyzing demyelination and axonal loss in MS
    Frauke Fink
    From the Klinikum Bremen Ost, Department of Neurology, Bremen, Germany
    J Neuroimaging 20:334-44. 2010
    ..In light of our results, animal studies focusing on demyelination and axonal loss are reinterpreted...
  21. doi request reprint Correlation between cognitive impairment and CSF biomarkers in amnesic MCI, non-amnesic MCI, and Alzheimer's disease
    Andreas Haldenwanger
    Municipal Hospital of Bremen Mitte, Department of Neurology, Stroke Unit, FRG, Bremen, Germany
    J Alzheimers Dis 22:971-80. 2010
    ..The decrease of Aβ1-42 reaches a plateau only in the full blown demented syndrome and further functional disease progression is then related to neurodegeneration without further reduction of Aβ1-42 in the CSF...
  22. doi request reprint Enhancing memory performance after organic brain disease relies on retrieval processes rather than encoding or consolidation
    Helmut Hildebrandt
    Institute of Psychology, University of Oldenburg, Oldenburg, Germany
    J Clin Exp Neuropsychol 33:257-70. 2011
    ..However, the two groups of the second experiment showed no significant differences for the treatment, although the absolute scores pointed in the same direction as in the first experiment...
  23. doi request reprint A randomized controlled trial comparing 2 interventions for visual field loss with standard occupational therapy during inpatient stroke rehabilitation
    Claudia Modden
    Rehabilitationszentrum Oldenburg, Oldenburg, Germany
    Neurorehabil Neural Repair 26:463-9. 2012
    ..Compensatory and restorative treatments have been developed to improve visual field defects after stroke. However, no controlled trials have compared these interventions with standard occupational therapy (OT)...
  24. doi request reprint New brain lesions after carotid revascularization are not associated with cognitive performance
    Katrin Wasser
    Department of Neurology, University of Gottingen, Gottingen, Germany
    J Vasc Surg 53:61-70. 2011
    ..However, diffusion-weighted imaging (DWI) has indicated that CAS is associated with a significantly higher burden of microemboli. This study evaluated the potential effect on intellectual functions of new DWI lesions after CEA or CAS...
  25. doi request reprint Decreased hippocampal volume, indirectly measured, is associated with depressive symptoms and consolidation deficits in multiple sclerosis
    Gevrey Kiy
    Department of Neurology, Klinikum Bremen Mitte, Bremen, Germany
    Mult Scler 17:1088-97. 2011
    ..Recently, it has been shown, using manual tracings, that the hippocampus is smaller in volume in MS patients compared with healthy controls, and that, at least for depression, hippocampal atrophy correlates with symptom severity...
  26. doi request reprint Prism adaptation improves ego-centered but not allocentric neglect in early rehabilitation patients
    Anja Gossmann
    Klinikum Bremen Ost, Bremen, Germany
    Neurorehabil Neural Repair 27:534-41. 2013
    ..Moreover, it is not known whether PA affects all aspects of neglect recovery or ego-centered spatial orientation only...
  27. doi request reprint Self-reported sleep problems, but not fatigue, lead to decline in sustained attention in MS patients
    Pia Lehmann
    Department of Neurology, Klinikum Bremen Ost, Bremen, Germany
    Mult Scler 19:490-7. 2013
    ..Recently, it has been argued that fatigue may result from poor sleep. Both explanations predict a worsening of fatigue and a cognitive decline during sustained attention tasks (higher fatigability)...
  28. ncbi request reprint Brain atrophy and cognitive impairment in multiple sclerosis: a review
    Michael Lanz
    Dept of Neurology, Klinikum Bremen Ost, Züricher Str 40, 28325, Bremen, Germany
    J Neurol 254:II43-8. 2007
    ..Brain atrophy has therefore been proposed to be a tool for monitoring disease progress. Here, we review the possible origins of brain atrophy and its correlation with cognitive impairment in MS...
  29. ncbi request reprint Frontal lobe dysfunctions in Korsakoff's syndrome and chronic alcoholism: continuity or discontinuity?
    B Brokate
    Department of Psychiatry and Psychotherapy, Municipal Hospital of Bremen, Germany
    Neuropsychology 17:420-8. 2003
    ..Second, the decline in the ability to alternate between different responses argues for a restricted neurotoxic effect of alcohol on some frontal lobe areas...
  30. ncbi request reprint Are some memory deficits unique to lesions of the mammillary bodies?
    H Hildebrandt
    Department of Psychology, Health Research Unit, University of Oldenburg, Germany
    J Clin Exp Neuropsychol 23:490-501. 2001
    ..We conclude that the mammillary bodies do play a prominent role in human memory, although the role differs slightly from that of the hippocampus...
  31. ncbi request reprint [Verbal memory disorders provoked by a variety of stokes]
    H Hildebrandt
    Universitat Oldenburg
    Fortschr Neurol Psychiatr 69:32-41. 2001
    ..Starting from this observation we try to define a neuropsychological pattern of memory impairment which enables differential clinical diagnoses using the CVLT as a memory test...
  32. ncbi request reprint Visual search and visual target detection in patients with infarctions of the left or right posterior or the right middle brain artery
    H Hildebrandt
    Health Research Unit, Program in Neuropsychology, Ossietzky University Oldenburg, Germany
    J Clin Exp Neuropsychol 21:94-107. 1999
    ..Infarctions of left and R-PBA therefore resulted in different visual search patterns. The behavior of the patients with R-MBA is consistent with Kinsbourne's (1992) interactive inhibition theory of neglect...
  33. ncbi request reprint Profiles of patients with left prefrontal and left temporal lobe lesions after cerebrovascular infarcations on California Verbal Learning Test-like indices
    H Hildebrandt
    Health Research Unit, Ossietzky University Oldenburg, Germany
    J Clin Exp Neuropsychol 20:673-83. 1998
    ..The results are discussed within the framework of recent cognitive neuropsychological findings and with a distinction between fronto-subcortical and cortical memory disorders...
  34. ncbi request reprint A longitudinal study on fatigue, depression, and their relation to neurocognition in multiple sclerosis
    Helmut Hildebrandt
    a Department of Neurology, Klinikum Bremen Ost, Bremen, Germany
    J Clin Exp Neuropsychol 36:410-7. 2014
    ..Our results fit the proposal that fatigue is a reversible syndrome similar to sickness behavior, and that depressive mood is at least partially related to neurodegeneration. ..
  35. ncbi request reprint Working memory related gamma oscillations in schizophrenia patients
    Canan Basar-Eroglu
    Institute of Psychology and Cognition Research and Center for Cognitive Sciences, University of Bremen, Grazer Str 4, 28359 Bremen, Germany
    Int J Psychophysiol 64:39-45. 2007
    ....
  36. doi request reprint Dissociation of egocentric and allocentric coding of space in visual search after right middle cerebral artery stroke
    Cathleen Grimsen
    Department of Human Neurobiology, University of Bremen, Argonnenstr 3, D 28211 Bremen, Germany
    Neuropsychologia 46:902-14. 2008
    ..Allocentric impairment on the other hand was linked to lesions in more ventral regions near the parahippocampal gyrus (PHG)...