Gerhard Heusipp

Summary

Country: Germany

Publications

  1. pmc Differential modulation by Ca2+ of type III secretion of diffusely adhering enteropathogenic Escherichia coli
    Tina Ide
    Institut für Infektiologie Zentrum für Molekularbiologie der Entzündung ZMBE, Westfalische Wilhelms Universitat Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Infect Immun 71:1725-32. 2003
  2. ncbi request reprint Regulation of htrA expression in Yersinia enterocolitica
    Gerhard Heusipp
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Universitatsklinikum Munster, Von Esmarch Strasse 56, 48149 Munster, Germany
    FEMS Microbiol Lett 231:227-35. 2004
  3. pmc Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: evidence of defective M-cell formation in vivo
    Sabine Westphal
    Department of Medicine B, University of Muenster, Albert Schweitzer Strasse 33, D 48149 Muenster, Germany
    Am J Pathol 172:671-80. 2008
  4. ncbi request reprint DNA adenine methylation and bacterial pathogenesis
    Gerhard Heusipp
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Universitatsklinikum Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Int J Med Microbiol 297:1-7. 2007
  5. ncbi request reprint YopM of Yersinia enterocolitica specifically interacts with alpha1-antitrypsin without affecting the anti-protease activity
    Gerhard Heusipp
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Universitatsklinikum Munster, Von Esmarch Str 56, 48149 Munster, Germany
    Microbiology 152:1327-35. 2006
  6. ncbi request reprint Identification of rpoE and nadB as host responsive elements of Yersinia enterocolitica
    Gerhard Heusipp
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    FEMS Microbiol Lett 226:291-8. 2003
  7. pmc Identification of unconventional intestinal pathogenic Escherichia coli isolates expressing intermediate virulence factor profiles by using a novel single-step multiplex PCR
    Daniel Muller
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Von Esmarch Str 56, D 48149 Munster, Germany
    Appl Environ Microbiol 73:3380-90. 2007
  8. pmc Altered Ca(2+) regulation of Yop secretion in Yersinia enterocolitica after DNA adenine methyltransferase overproduction is mediated by Clp-dependent degradation of LcrG
    Stefan Fälker
    ZMBE, Institut für Infektiologie, Von Esmarch Str 56, 48149 Munster, Germany
    J Bacteriol 188:7072-81. 2006
  9. pmc Transcriptional activation of the tad type IVb pilus operon by PypB in Yersinia enterocolitica
    Jennifer Schilling
    Westfalische Wilhelms Universitat Munster, Zentrum fur Molekularbiologie der Entzundung, Institut für Infektiologie, Munster, Germany
    J Bacteriol 192:3809-21. 2010
  10. pmc Overproduction of DNA adenine methyltransferase alters motility, invasion, and the lipopolysaccharide O-antigen composition of Yersinia enterocolitica
    Stefan Fälker
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    Infect Immun 75:4990-7. 2007

Collaborators

  • Virginia L Miller
  • M Alexander Schmidt
  • Helge Karch
  • Martina Bielaszewska
  • Christof von Eiff
  • C Maaser
  • Kwang Kim
  • Stefan Fälker
  • Jennifer Schilling
  • Daniel Muller
  • Karin Wagner
  • Christian Rüter
  • Lilo Greune
  • Bojan Shutinoski
  • Christoph Buss
  • Inga Blädel
  • Silke Michgehl
  • Sabine Knappstein
  • Tina Ide
  • Karin Rönnebäumer
  • Sabine Westphal
  • Silke Kügler
  • Anna Beck
  • M Alexander Schmidt
  • Julia Scharnert
  • Verena Humberg
  • Stephanie Seekircher
  • Gunnar Sander
  • Hermann Herbst
  • Torsten Kucharzik
  • Andreas Lugering
  • Thomas Spahn
  • Wolfram Domschke
  • Julia von Wedel
  • Ifor R Williams
  • Helmut Tschäpe
  • Kathrin Böcker
  • Angelika Fruth
  • Sabine Brast
  • Alexander W Friedrich
  • Peter Hagedorn

Detail Information

Publications21

  1. pmc Differential modulation by Ca2+ of type III secretion of diffusely adhering enteropathogenic Escherichia coli
    Tina Ide
    Institut für Infektiologie Zentrum für Molekularbiologie der Entzündung ZMBE, Westfalische Wilhelms Universitat Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Infect Immun 71:1725-32. 2003
    ..These data suggest that under Ca(2+)-depleted conditions Tir might be secreted into the medium and integrated into host membranes by an Esp-independent mechanism, without the need for a functional type III translocation machinery...
  2. ncbi request reprint Regulation of htrA expression in Yersinia enterocolitica
    Gerhard Heusipp
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Universitatsklinikum Munster, Von Esmarch Strasse 56, 48149 Munster, Germany
    FEMS Microbiol Lett 231:227-35. 2004
    ..coli, led to the induction of htrA expression via the Cpx system in Y. enterocolitica. Interestingly, a Y. enterocolitica CpxR mutant strain was not impaired for virulence in a mouse model of infection...
  3. pmc Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: evidence of defective M-cell formation in vivo
    Sabine Westphal
    Department of Medicine B, University of Muenster, Albert Schweitzer Strasse 33, D 48149 Muenster, Germany
    Am J Pathol 172:671-80. 2008
    ..CCR6-deficient mice may therefore represent a suitable model for the study of M-cell function in vivo...
  4. ncbi request reprint DNA adenine methylation and bacterial pathogenesis
    Gerhard Heusipp
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Universitatsklinikum Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Int J Med Microbiol 297:1-7. 2007
    ..Here, we summarize the current knowledge about the influence of DNA methylation on virulence functions and discuss perspectives for future research...
  5. ncbi request reprint YopM of Yersinia enterocolitica specifically interacts with alpha1-antitrypsin without affecting the anti-protease activity
    Gerhard Heusipp
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Universitatsklinikum Munster, Von Esmarch Str 56, 48149 Munster, Germany
    Microbiology 152:1327-35. 2006
    ..The data suggest that AAT has additional functions in the host response against bacterial infections that are not related to its anti-protease activity...
  6. ncbi request reprint Identification of rpoE and nadB as host responsive elements of Yersinia enterocolitica
    Gerhard Heusipp
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    FEMS Microbiol Lett 226:291-8. 2003
    ..coli, sigmaE of Y. enterocolitica is not induced by heat shock or ethanol. Overproduction of the outer membrane protein Ail does not lead to the induction of rpoE expression. However, rpoE expression is induced by osmotic stress...
  7. pmc Identification of unconventional intestinal pathogenic Escherichia coli isolates expressing intermediate virulence factor profiles by using a novel single-step multiplex PCR
    Daniel Muller
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Von Esmarch Str 56, D 48149 Munster, Germany
    Appl Environ Microbiol 73:3380-90. 2007
    ..coli genome. Moreover, this implies that the important identification of specific pathotypes has to be based on a broad matrix of indicator genes. In addition, the presence of intermediate strains needs to be accounted for...
  8. pmc Altered Ca(2+) regulation of Yop secretion in Yersinia enterocolitica after DNA adenine methyltransferase overproduction is mediated by Clp-dependent degradation of LcrG
    Stefan Fälker
    ZMBE, Institut für Infektiologie, Von Esmarch Str 56, 48149 Munster, Germany
    J Bacteriol 188:7072-81. 2006
    ..This is the first example of posttranslational regulation of type III secretion by the Clp protease and adds a new flavor to the complex regulatory mechanisms underlying the controlled release of effector proteins from bacterial cells...
  9. pmc Transcriptional activation of the tad type IVb pilus operon by PypB in Yersinia enterocolitica
    Jennifer Schilling
    Westfalische Wilhelms Universitat Munster, Zentrum fur Molekularbiologie der Entzundung, Institut für Infektiologie, Munster, Germany
    J Bacteriol 192:3809-21. 2010
    ..Our data describe the transcriptional regulation of the tad type IVb pilus operon by PypB in Y. enterocolitica but fail to show most previously described phenotypes associated with this type of pilus in other bacteria...
  10. pmc Overproduction of DNA adenine methyltransferase alters motility, invasion, and the lipopolysaccharide O-antigen composition of Yersinia enterocolitica
    Stefan Fälker
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    Infect Immun 75:4990-7. 2007
    ..enterocolitica and indicate that Dam targets regulatory processes modulating the composition and function of the bacterial surface...
  11. doi request reprint Controlled activation of the Cpx system is essential for growth of Yersinia enterocolitica
    Karin Rönnebäumer
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Westfalische Wilhelms Universitat Munster, Munster, Germany
    FEMS Microbiol Lett 296:274-81. 2009
    ..In addition, we show that cpxR and cpxP mutant strains have no defect in Y. enterocolitica invasion of host cells...
  12. doi request reprint Transcriptional regulation of the Yts1 type II secretion system of Yersinia enterocolitica and identification of secretion substrates
    Bojan Shutinoski
    Westfalische Wilhelms Universitat Munster, Zentrum für Molekularbiologie der Entzündung ZMBE, Institut für Infektiologie, Von Esmarch Str 56, 48149 Munster, Germany
    Mol Microbiol 75:676-91. 2010
    ..As ChiY and EngY both bind to chitin, and YE3650 shows motifs conserved in oligosaccharide-binding enzymes, all secreted proteins might be important for polysaccharide interaction/degradation during infection or in the environment...
  13. ncbi request reprint DNA methylation in Yersinia enterocolitica: role of the DNA adenine methyltransferase in mismatch repair and regulation of virulence factors
    Stefan Fälker
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Universitatsklinikum Munster, Von Esmarch Str 56, 48149 Munster, Germany
    Microbiology 151:2291-9. 2005
    ..Furthermore, Dam mediates virulence of Y. enterocolitica. Dam overproduction results in increased tissue culture invasion of Y. enterocolitica, while the expression of specifically in vivo-expressed genes is not altered...
  14. pmc A regulatory network controls expression of the in vivo-expressed HreP protease of Yersinia enterocolitica
    Karin Wagner
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Westfalische Wilhelms Universitat Munster, Germany
    J Bacteriol 191:1666-76. 2009
    ..Our data reveal a new regulatory network that might have implications for the controlled expression of further virulence-associated functions in Yersinia...
  15. doi request reprint A newly identified bacterial cell-penetrating peptide that reduces the transcription of pro-inflammatory cytokines
    Christian Rüter
    Westfalische Wilhelms Universitat Munster, Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Von Esmarch Strasse 56, D 48149 Munster, Germany
    J Cell Sci 123:2190-8. 2010
    ..Furthermore, it can lead to important advances in understanding and evaluating the intracellular and molecular function of YopM without the need for infection with Yersinia...
  16. doi request reprint The H-NS protein silences the pyp regulatory network of Yersinia enterocolitica and is involved in controlling biofilm formation
    Inga Blädel
    Westfalische Wilhelms Universitat Munster, Zentrum für Molekularbiologie der Entzündung ZMBE, Institut für Infektiologie, Munster, Germany
    FEMS Microbiol Lett 340:41-8. 2013
    ..While the H-NS antagonist RovA activates pypC, it has no effect on pypA and pypB. Furthermore, H-NS affects biofilm formation in Y. enterocolitica...
  17. pmc Rapid identification and differentiation of clinical isolates of enteropathogenic Escherichia coli (EPEC), atypical EPEC, and Shiga toxin-producing Escherichia coli by a one-step multiplex PCR method
    Daniel Muller
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Von Esmarch Str 56, D 48149 Munster, Germany
    J Clin Microbiol 44:2626-9. 2006
    ..We developed and evaluated a robust multiplex PCR to identify these pathogroups based on sequences complementary to escV, bfpB, stx1, and stx2...
  18. doi request reprint Identification and characterization of Ibe, a novel type III effector protein of A/E pathogens targeting human IQGAP1
    Christoph Buss
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Cell Microbiol 11:661-77. 2009
    ..Homologues of the novel effector Ibe are widely distributed among EPEC, ATEC and EHEC strains but are not necessarily genetically linked to the LEE as they have occasionally also been found to be encoded within lambdoid prophages...
  19. pmc Alpha 1-antitrypsin binds to and interferes with functionality of EspB from atypical and typical enteropathogenic Escherichia coli strains
    Sabine Knappstein
    Institut für Infektiologie, Zentrum fur Molekularbiologie der Entzundung, Universitatsklinikum Munster, 48149 Muenster, Germany
    Infect Immun 72:4344-50. 2004
    ..In this study, we identify AAT as a new binding partner for EspB and EspD, suggesting a previously unappreciated role for AAT in host cell defense against EPEC infections and potentially also against other bacterial pathogens...
  20. ncbi request reprint Pertussis toxin transiently affects barrier integrity, organelle organization and transmigration of monocytes in a human brain microvascular endothelial cell barrier model
    Silke Kügler
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Westfälische Wilhelms Universität Universitätsklinikum Münster, 48149 Munster, Germany
    Cell Microbiol 9:619-32. 2007
    ..We suggest that these findings reflect early steps in the development of neurological disorders associated with pertussis disease...
  21. ncbi request reprint Esp-independent functional integration of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC) into host cell membranes
    Silke Michgehl
    Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung ZMBE, Universitat Munster, Von Esmarch Strasse 56, 48149 Munster, Germany
    Cell Microbiol 8:625-33. 2006
    ..Together, our results demonstrate that under conditions of limited Ca(2+) an alternative mechanism for Tir integration can trigger the induction of A/E lesions...