R Heun

Summary

Country: Germany

Publications

  1. ncbi request reprint The validity of psychometric instruments for detection of dementia in the elderly general population
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Int J Geriatr Psychiatry 13:368-80. 1998
  2. ncbi request reprint Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 262:171-4. 1999
  3. ncbi request reprint A family study of Alzheimer disease and early- and late-onset depression in elderly patients
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Arch Gen Psychiatry 58:190-6. 2001
  4. ncbi request reprint Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
    F Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Neurology 55:684-8. 2000
  5. ncbi request reprint Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population
    S G Schwab
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:469-72. 1999
  6. ncbi request reprint Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 57:930-2. 2001
  7. ncbi request reprint Gene variations in GSTM3 are a risk factor for Alzheimer's disease
    G S Hong
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurobiol Aging 30:691-6. 2009
  8. doi request reprint Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions
    H Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neural Transm 116:467-72. 2009
  9. ncbi request reprint Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients
    S Sauder
    Department of Psychiatry, University of Bonn, Germany
    J Neural Transm 112:1381-9. 2005
  10. ncbi request reprint Seasonal distribution of births in patients with Alzheimer's disease and elderly depressive patients
    U Ptok
    Department of Psychiatry, University of Bonn, Sigmund Freud St 25 53105, Bonn, Germany
    Eur Psychiatry 16:157-61. 2001

Collaborators

Detail Information

Publications50

  1. ncbi request reprint The validity of psychometric instruments for detection of dementia in the elderly general population
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Int J Geriatr Psychiatry 13:368-80. 1998
    ..To compare the validity of different instruments for screening and diagnosis of dementia and to provide threshold scores for these purposes, ie screening focusing on a high sensitivity and diagnosis focusing on a high specificity...
  2. ncbi request reprint Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 262:171-4. 1999
    ..The odds ratio for subjects with the apolipoprotein E epsilon 4 and the cathepsin D*T allele was 5.9. Our data suggest that the cathepsin D genotype is strongly associated with the risk for Alzheimer's disease...
  3. ncbi request reprint A family study of Alzheimer disease and early- and late-onset depression in elderly patients
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Arch Gen Psychiatry 58:190-6. 2001
    ..The substantial symptomatic overlap between depression and dementia in old age may be explained by common genetic vulnerability factors...
  4. ncbi request reprint Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
    F Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Neurology 55:684-8. 2000
    ..The reduction of N-acetylaspartate (NAA) detected by proton MR spectroscopy (1H-MRS) represents a robust but unspecific marker for neuronal loss or dysfunction...
  5. ncbi request reprint Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population
    S G Schwab
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:469-72. 1999
    ..When we analyzed the polymorphism in APOE epsilon4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers. Copyrightz1999S.KargerAG,Basel..
  6. ncbi request reprint Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 57:930-2. 2001
    ..The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients...
  7. ncbi request reprint Gene variations in GSTM3 are a risk factor for Alzheimer's disease
    G S Hong
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurobiol Aging 30:691-6. 2009
    ..95). The population attributable risk of this haplotype in APOE4-allele non-carriers was 32.2%. Our results suggest that there is a group of AD patients in which variations in metabolism of oxidative stress play an important role...
  8. doi request reprint Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions
    H Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neural Transm 116:467-72. 2009
    ..009). Our results suggest that CETP gene polymorphisms might influence WML load and the risk of VD, the latter in non-carriers of the APOE4 allele...
  9. ncbi request reprint Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients
    S Sauder
    Department of Psychiatry, University of Bonn, Germany
    J Neural Transm 112:1381-9. 2005
    ..PPARgamma polymorphism did not influence the risk of AD. These results might point to an influence of PPARgamma Pro12Ala polymorphism on the elimination of 24S-hydroxycholesterol...
  10. ncbi request reprint Seasonal distribution of births in patients with Alzheimer's disease and elderly depressive patients
    U Ptok
    Department of Psychiatry, University of Bonn, Sigmund Freud St 25 53105, Bonn, Germany
    Eur Psychiatry 16:157-61. 2001
    ..We concluded that in our sample a seasonal distribution of births was not found to increase the risk for AD or geriatric depression...
  11. ncbi request reprint Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke
    H Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Neurology 63:2255-60. 2004
    ..Polymorphisms in GSTO1 might influence the function of the protein and thus the risk of AD, VaD, and stroke...
  12. ncbi request reprint No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neurol Sci 167:34-6. 1999
    ..Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E epsilon4 allele...
  13. ncbi request reprint Early-onset and late-onset depression are independent of the genetic polymorphism of apolipoprotein E
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:258-61. 1999
    ..Our data do not disconfirm the hypothesis of depression sharing some common pathophysiologic features with AD, however, it seems very unlikely that the APOE genotype will elucidate the assumed common mechanisms...
  14. ncbi request reprint Allelic association between the D10S1423 marker and Alzheimer's disease in a German population
    M Majores
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 289:224-6. 2000
    ..033). In conclusion, our results support that the D10S1423 marker is associated with an increased AD risk and provides further evidence for an AD susceptibility locus on chromosome 10...
  15. ncbi request reprint Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Neural Transm 113:231-8. 2006
    ..Both NPY polymorphisms did not influence the risk of AD. Our data support the observation, that NPY polymorphisms might influence cholesterol metabolism, but might not act as major risk factor in AD...
  16. ncbi request reprint Response-related fMRI analysis during encoding and retrieval revealed differences in cerebral activation by retrieval success
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, Venusberg, D 53105, Bonn, Germany
    Psychiatry Res 99:137-50. 2000
    ..Increased activation during false alarms might reflect a source-monitoring deficit or an increased subjective familiarity with distractors that have been most intensively processed in extrastriate visual cortex...
  17. ncbi request reprint Inter-rater reliability of family history information on psychiatric disorders in relatives
    U Ptok
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 251:279-83. 2001
    ..41-1.00) and any psychiatric disorder (kappa=0.79, 95% CI=0.66-0.91). We concluded that the family history interview is a useful family study instrument that can be applied reliably by different raters for frequent psychiatric disorders...
  18. ncbi request reprint ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 377:37-9. 2005
    ..Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD...
  19. ncbi request reprint Functional MRI of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Hum Brain Mapp 8:157-69. 1999
    ..The comparison of event-related activation occurring within one trial block instead of among several trial blocks may significantly improve the performance of memory studies...
  20. ncbi request reprint Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmind Freud Str 25, 53105 Bonn, Germany
    Am J Psychiatry 158:1319-21. 2001
    ..In this study, the authors tested whether sensory gating is disturbed in patients with Alzheimer's disease...
  21. ncbi request reprint Influence of lysosomal acid lipase polymorphisms on chromosome 10 on the risk of Alzheimer's disease and cholesterol metabolism
    K T von Trotha
    Department of Psychiatry, Sigmund Freud Street 25, University of Bonn, 53105 Bonn, Germany
    Neurosci Lett 402:262-6. 2006
    ..Even though the biological function and gene location of LIPA on chromosome 10 suggest that LIPA might be a candidate for an AD risk gene, our results revealed that polymorphisms in LIPA did not influence the risk of AD in our study...
  22. ncbi request reprint Amygdala-hippocampal atrophy and memory performance in dementia of Alzheimer type
    R Heun
    Department of Psychiatry, University of Mainz, Germany
    Dement Geriatr Cogn Disord 8:329-36. 1997
    ..Consequently, DAT seems to affect the amygdala-hippocampal complex and their related function (i.e. memory) more than other cerebral structures, but cerebral degeneration in DAT is not restricted to these structures...
  23. ncbi request reprint The concreteness effect: evidence for dual coding and context availability
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Brain Lang 74:103-12. 2000
    ....
  24. ncbi request reprint Advanced parental age: a risk factor for Alzheimer's disease or depression in the elderly?
    U Ptok
    Department of Psychiatry, University of Bonn, Germany
    Int Psychogeriatr 12:445-51. 2000
    ..In the present investigation, a sample of gerontopsychiatric patients was examined for a possible parental age effect...
  25. ncbi request reprint Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease
    S Brune
    Department of Psychiatry, University of Bonn, Germany
    J Neural Transm 110:1041-50. 2003
    ..Cerebrospinal fluid amyloid-beta levels were influenced by PPAR-alpha L162V genotype. These results suggest, that PPAR-alpha polymorphism may be a risk factor for AD...
  26. ncbi request reprint Interindividual variation of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Eur Psychiatry 15:470-9. 2000
    ..The investigation of these interindividual variations will be an exciting scientific challenge in the near future...
  27. ncbi request reprint Distinction of early- and late-onset depression in the elderly by their lifetime symptomatology
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Int J Geriatr Psychiatry 15:1138-42. 2000
    ..To validate the phenomenological distinction, the affective symptoms of elderly subjects with EOD and LOD were compared...
  28. ncbi request reprint Detection of subthreshold depression and subthreshold anxiety in the elderly
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Int J Geriatr Psychiatry 14:643-50. 1999
    ..To assess the ability of screening instruments to detect subthreshold depression or subthreshold anxiety and to make suggestions for the improvement of instrument performance...
  29. ncbi request reprint Activation of human language processing brain regions after the presentation of random letter strings demonstrated with event-related functional magnetic resonance imaging
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 270:13-6. 1999
    ..Real words contrasted with random letter strings activated the left angular gyrus, bilateral precuneus and the left posterior cingulate gyrus, which may reflect the access of higher semantic associations...
  30. ncbi request reprint Differential validity of informant-based diagnoses of dementia and depression in index subjects and in their first-degree relatives
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Soc Psychiatry Psychiatr Epidemiol 33:510-3. 1998
    ..Observations in selected samples, i.e. subjects treated, hospitalised and/or autopsied, cannot be generalised to first-degree relatives in family studies...
  31. ncbi request reprint Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 368:303-8. 2004
    ..Our results support the observation, that cholesterol metabolism is altered in dementing disorders, indicated by different plasma concentrations of brain specific and peripherally produced oxysterols...
  32. ncbi request reprint Multicenter assessment of reliability of cranial MRI
    M Ewers
    Department of Psychiatry, Dementia and Neuroimaging Section, Alzheimer Memorial Center D2, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Neurobiol Aging 27:1051-9. 2006
    ..42) showed that the total sample size needed is N=180. In conclusion, despite minimal inclusion criteria, the reliability of MRI across centers was relatively good...
  33. ncbi request reprint Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25 53105 Bonn, Germany
    Neurosci Lett 309:185-8. 2001
    ..These results provide first evidence for disturbed sensory memory in relatives of patients with schizophrenia...
  34. ncbi request reprint The factor structure in the cognitive battery of the structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia, and dementias of other aetiology
    M Kockler
    Department of Psychiatry, University of Bonn, Germany
    Int Psychogeriatr 13:311-23. 2001
    ..Syndrome scores should reflect these dimensions. Consequently, we propose to consider the empirically found factor structure in a new version of the SIDAM...
  35. doi request reprint A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 72:1735-40. 2009
    ..Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS...
  36. ncbi request reprint Psychometric analysis of the selective reminding procedure in a sample from the general elderly population
    M Burkart
    Department of Psychiatry, University of Mainz, Germany
    Dement Geriatr Cogn Disord 11:74-80. 2000
    ..Thus, the SRP may neither be recommended for assessment of different subfunctions of memory nor for dementia screening...
  37. ncbi request reprint Screening for depression in the elderly: a study on misclassification by screening instruments and improvement of scale performance
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 23:431-46. 1999
    ..However, both questionnaires yielded a considerable proportion of false positive results. Elevation of the cut-off score may reduce the misclassification rate of the GHQ-12 but not that of the CES-D...
  38. ncbi request reprint Interinformant reliability of family history information on psychiatric disorders in relatives
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 248:104-9. 1998
    ..It seems more important for the diagnosis of depression than for a diagnosis of dementia to get information from multiple informants...
  39. ncbi request reprint The impact of gender and age at onset on the familial aggregation of schizophrenia
    W Maier
    Department of Psychiatry, University of Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 242:279-85. 1993
    ..Affective disorders occurred in families independently of the probands' gender. Aetiological heterogeneity or ascertainment bias may account for the modifying effect of proband's gender in schizophrenia...
  40. ncbi request reprint The role of 24S-hydroxycholesterol in Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    J Nutr Health Aging 7:37-41. 2003
    ..This review will give a brief overview on the relevance of 24S-hydroxycholesterol as a possible risk factor and diagnostic state marker for AD...
  41. ncbi request reprint Identification of items which predict later development of depression in primary health care
    K Barkow
    Department of Psychiatry, University of Bonn
    Eur Arch Psychiatry Clin Neurosci 251:II21-6. 2001
    ..The present results might be helpful for future development of prediction scales...
  42. ncbi request reprint Validity of the five-item WHO Well-Being Index (WHO-5) in an elderly population
    M Bonsignore
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 251:II27-31. 2001
    ..The second version is a stronger scale and was more specific for the detection of depression. The WHO-5 is an useful instrument for identifying elderly subjects with depression...
  43. ncbi request reprint Fertility and number of children in patients with Alzheimer's disease
    U Ptok
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Arch Womens Ment Health 5:83-6. 2002
    ..The number of children did not seem to affect the risk of Alzheimer's disease, neither in female nor in male subjects. Natural exposure to oestrogen seems to reduce the risk of Alzheimer's disease in women...
  44. ncbi request reprint CYP2D6 polymorphism and tardive dyskinesia in schizophrenic patients
    P L Lohmann
    Department of Psychiatry, University of Bonn, Germany
    Pharmacopsychiatry 36:73-8. 2003
    ..In conclusion, our results provide no evidence for the contribution of CYP2D6 genotype to the development of TD in schizophrenic patients receiving long-term antipsychotic medication...
  45. doi request reprint Type-2 diabetes mellitus in schizophrenia: increased prevalence and major risk factor of excess mortality in a naturalistic 7-year follow-up
    D Schoepf
    Department of Psychiatry and Psychotherapy, University of Bonn, 53125 Bonn, Germany
    Eur Psychiatry 27:33-42. 2012
    ....
  46. ncbi request reprint Selection bias during recruitment of elderly subjects from the general population for psychiatric interviews
    R Heun
    Department of Psychiatry, University of Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 247:87-92. 1997
    ..The latter finding demonstrates the need to determine and assess the selection bias in psychiatric epidemiologic studies in elderly subjects...
  47. ncbi request reprint Encoding and retrieval related cerebral activation in continuous verbal recognition
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Brain Res Cogn Brain Res 12:199-206. 2001
    ..The results are discussed in relation to current concepts of spatial differentiation of memory function and findings from event-related potentials studies of continuous recognition...
  48. ncbi request reprint Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 7:899-902. 2002
    ..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain...
  49. ncbi request reprint Possible influence of selection bias on gender differences in the risk of Alzheimer's disease
    M Bonsignore
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Arch Womens Ment Health 5:73-7. 2002
    ..Study methods must be taken into account when interpreting information on gender differences in the risk of AD...
  50. ncbi request reprint CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects
    K Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neurology 59:627-9. 2002
    ..Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI...