D Trenk

Summary

Affiliation: Herz-Zentrum Bad Krozingen
Country: Germany

Publications

  1. doi request reprint A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: results of the TRIGGER-PCI (Testing Platelet Reactivity
    Dietmar Trenk
    Universitaets Herzzentrum Freiburg Bad Krozingen, Klinik fuer Kardiologie und Angiologie, Bad Krozingen, Germany
    J Am Coll Cardiol 59:2159-64. 2012
  2. doi request reprint Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    J Am Coll Cardiol 51:1925-34. 2008
  3. ncbi request reprint Proton pump inhibitors for prevention of bleeding episodes in cardiac patients with dual antiplatelet therapy - between Scylla and Charybdis?
    D Trenk
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    Int J Clin Pharmacol Ther 47:1-10. 2009
  4. doi request reprint Impact of cytochrome P450 3A4-metabolized statins on the antiplatelet effect of a 600-mg loading dose clopidogrel and on clinical outcome in patients undergoing elective coronary stent placement
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Suedring 15, 79189 Bad Krozingen, Germany
    Thromb Haemost 99:174-81. 2008
  5. doi request reprint Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Germany
    Circ Cardiovasc Genet 4:429-36. 2011
  6. ncbi request reprint Antiplatelet response to the 150-mg maintenance dose of clopidogrel in patients with insufficient platelet inhibition after clopidogrel loading for elective coronary stent placement
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    EuroIntervention 4:214-21. 2008
  7. doi request reprint Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement
    Willibald Hochholzer
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    J Am Coll Cardiol 55:2427-34. 2010
  8. ncbi request reprint Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention
    Willibald Hochholzer
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    Circulation 111:2560-4. 2005
  9. ncbi request reprint Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement
    Willibald Hochholzer
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    J Am Coll Cardiol 48:1742-50. 2006
  10. doi request reprint Personalizing antiplatelet therapy with clopidogrel
    D Trenk
    Universitäts Herzzentrum Freiburg Bad Krozingen, Klinik für Kardiologie und Angiologie II, Bad Krozingen, Germany
    Clin Pharmacol Ther 92:476-85. 2012

Collaborators

Detail Information

Publications24

  1. doi request reprint A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: results of the TRIGGER-PCI (Testing Platelet Reactivity
    Dietmar Trenk
    Universitaets Herzzentrum Freiburg Bad Krozingen, Klinik fuer Kardiologie und Angiologie, Bad Krozingen, Germany
    J Am Coll Cardiol 59:2159-64. 2012
    ..This study sought to investigate the efficacy, safety, and antiplatelet effect of prasugrel as compared with clopidogrel in patients with high on-treatment platelet reactivity (HTPR) after elective percutaneous coronary intervention (PCI)...
  2. doi request reprint Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    J Am Coll Cardiol 51:1925-34. 2008
    ....
  3. ncbi request reprint Proton pump inhibitors for prevention of bleeding episodes in cardiac patients with dual antiplatelet therapy - between Scylla and Charybdis?
    D Trenk
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    Int J Clin Pharmacol Ther 47:1-10. 2009
    ..Therefore, sufficiently powered prospective clinical studies in cardiac patients on dual antiplatelet therapy investigating the potential drug interaction between PPIs and the antiplatelet effect of clopidogrel are awaited eagerly...
  4. doi request reprint Impact of cytochrome P450 3A4-metabolized statins on the antiplatelet effect of a 600-mg loading dose clopidogrel and on clinical outcome in patients undergoing elective coronary stent placement
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Suedring 15, 79189 Bad Krozingen, Germany
    Thromb Haemost 99:174-81. 2008
    ..645). Thus, peri-interventional atorvastatin and simvastatin had no effect on the antiplatelet activity of a loading dose of clopidogrel 600 mg and did not affect clinical outcome after PCI...
  5. doi request reprint Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Germany
    Circ Cardiovasc Genet 4:429-36. 2011
    ..We sought to investigate whether the PON1 Q192R gene polymorphism affects platelet reactivity in patients undergoing elective coronary stent placement...
  6. ncbi request reprint Antiplatelet response to the 150-mg maintenance dose of clopidogrel in patients with insufficient platelet inhibition after clopidogrel loading for elective coronary stent placement
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    EuroIntervention 4:214-21. 2008
    ..Our prospective study sought to investigate whether inadequate platelet responses to clopidogrel can be corrected by increasing the daily maintenance dose from 75 mg to 150 mg...
  7. doi request reprint Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement
    Willibald Hochholzer
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    J Am Coll Cardiol 55:2427-34. 2010
    ..The aim of this study was to evaluate the relative impact of demographic and clinical variables versus the cytochrome P450 2C19 (CYP2C19) polymorphism on antiplatelet effects of clopidogrel...
  8. ncbi request reprint Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention
    Willibald Hochholzer
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    Circulation 111:2560-4. 2005
    ..To shorten the time for clopidogrel to become effective, a 600-mg loading dose has been used. We sought to validate this regimen in a large cohort and investigated the time dependence of the antiplatelet effect of 600 mg of clopidogrel...
  9. ncbi request reprint Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement
    Willibald Hochholzer
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    J Am Coll Cardiol 48:1742-50. 2006
    ..Our prospective study tested the hypothesis that the 30-day clinical outcome of elective percutaneous catheter intervention (PCI) differs between strata defined by quartiles of platelet aggregation after loading with 600 mg clopidogrel...
  10. doi request reprint Personalizing antiplatelet therapy with clopidogrel
    D Trenk
    Universitäts Herzzentrum Freiburg Bad Krozingen, Klinik für Kardiologie und Angiologie II, Bad Krozingen, Germany
    Clin Pharmacol Ther 92:476-85. 2012
    ..We discuss strategies based on platelet function testing or genotyping for improvement of antiplatelet effects of clopidogrel and thereby clinical outcome...
  11. doi request reprint Effects of aspirin and desmopressin on platelet reactivity in patients undergoing cardiac surgery with extracorporeal circulation
    Cornelius Keyl
    Department of Anaesthesiology, Heart Centre Bad Krozingen, Bad Krozingen, Germany
    Thromb Haemost 105:113-21. 2011
    ..63 for between-subjects contrast). Our data suggest that desmopressin does not affect platelet reactivity in patients on ASA undergoing CABG and is, therefore, not useful in this clinical setting...
  12. ncbi request reprint Whole blood aggregometry for evaluation of the antiplatelet effects of clopidogrel
    Willibald Hochholzer
    Herz Zentrum Bad Krozingen, D 79189 Bad Krozingen, Germany
    Thromb Res 119:285-91. 2007
    ..Established methods for monitoring antiplatelet drug activity such as optical aggregometry and determination of surface protein expression are not suitable for routine bedside testing...
  13. ncbi request reprint Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter
    Willibald Hochholzer
    Herz Zentrum Bad Krozingen, Suedring 15, 79189, Bad Krozingen, Germany
    Europace 9:490-5. 2007
    ..Due to the delayed occurrence of cryolesions it is currently unknown, if cryoenergy and RF energy are associated with similar platelet activation and myocardial necrosis in the days after the procedure...
  14. doi request reprint High on-treatment platelet reactivity and P2Y12 antagonists in clinical trials
    D Trenk
    Dietmar Trenk, PhD, Universitaets Herzzentrum Freiburg Bad Krozingen, Klinik für Kardiologie und Angiologie II, Bad Krozingen, Suedring 15, D 79189 Bad Krozingen, Germany, E mail
    Thromb Haemost 109:834-45. 2013
    ..This review will focus on the current status of alternate strategies for more sufficient suppression of high platelet reactivity...
  15. ncbi request reprint Short-term hemodynamic, anti-ischemic, and antianginal effects of pirsidomine, a new sydnonimine
    E Stengele
    Department of Clinical Pharmacology, Heart Center, Bad Krozingen, Germany
    Am J Cardiol 77:937-41. 1996
    ..Thus, pirsidomine is an effective anti-ischemic and antianginal agent. A significant preload reduction was obtained with plasma metabolite concentrations lower than those necessary to achieve a satisfactory antianginal effect...
  16. doi request reprint New definition of myocardial infarction: impact on long-term mortality
    Willibald Hochholzer
    Herz Zentrum, Bad Krozingen, Germany
    Am J Med 121:399-405. 2008
    ....
  17. ncbi request reprint The impact of platelet count on mortality in unstable angina/non-ST-segment elevation myocardial infarction
    Christian Mueller
    Herz Zentrum, Bad Krozingen, Germany
    Am Heart J 151:1214.e1-7. 2006
    ..Therefore, we sought to determine the impact of platelet count on long-term outcome in unstable angina/non-ST-segment elevation myocardial infarction (UA/NSTEMI) receiving contemporary treatment...
  18. doi request reprint Predicted and measured plasma propofol concentration and bispectral index during deep sedation in patients with impaired left ventricular function
    Cornelius Keyl
    Department of Anesthesiology, Heart Centre, Bad Krozingen, Germany
    J Cardiothorac Vasc Anesth 23:182-7. 2009
    ....
  19. ncbi request reprint Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial
    Stephen D Wiviott
    Brigham and Women s Hospital, Cardiovascular Division, 75 Francis St, Boston, MA 02115, USA
    Circulation 116:2923-32. 2007
    ..The relative antiplatelet effects of prasugrel versus high-dose clopidogrel in percutaneous coronary intervention patients are unknown...
  20. doi request reprint Identification of 5-HT3 receptors on human platelets: increased surface immunoreactivity after activation with adenosine diphosphate (ADP) and thrombin receptor-activating peptide (TRAP)
    Christian Stratz
    Thromb Haemost 99:784-6. 2008
  21. doi request reprint Aspirin resistance an underestimated risk in patients with drug-eluting stents?
    Dietmar Trenk
    J Am Coll Cardiol 52:740-2. 2008
  22. ncbi request reprint Drug-eluting coronary stents: as safe as bare-metal stents, but optimized antiplatelet therapy may further improve clinical outcome
    Dietmar Trenk
    Eur J Clin Pharmacol 64:227-32. 2008
  23. ncbi request reprint The use of B-type natriuretic peptides in the detection of myocardial ischemia in settings with rapid access to coronary angiography
    David Conen
    Int J Cardiol 119:416-8. 2007
    ..In conclusion, BNP and NT-proBNP are not helpful in the evaluation of male patients with suspected myocardial ischemia in a tertiary care cardiology center with rapid access to coronary angiography...
  24. doi request reprint Percutaneous coronary intervention versus coronary artery bypass grafting as primary revascularization in patients with acute coronary syndrome
    Willibald Hochholzer
    Herz Zentrum, Bad Krozingen, Germany Department of Internal Medicine, University Hospital, Basel, Switzerland
    Am J Cardiol 102:173-9. 2008
    ....