Wolfgang Herrmann

Summary

Country: Germany

Publications

  1. doi request reprint Homocysteine: a biomarker in neurodegenerative diseases
    Wolfgang Herrmann
    Department of Clinical Chemistry, Medical School, Saarland University, Homburg, Germany
    Clin Chem Lab Med 49:435-41. 2011
  2. doi request reprint Enhanced bone metabolism in vegetarians--the role of vitamin B12 deficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 47:1381-7. 2009
  3. doi request reprint Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    Bone 44:467-75. 2009
  4. doi request reprint Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm 115:1651-9. 2008
  5. ncbi request reprint Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine and Neurology, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:1129-36. 2007
  6. ncbi request reprint Comparison of the influence of volume-oriented training and high-intensity interval training on serum homocysteine and its cofactors in young, healthy swimmers
    Markus Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 41:1525-31. 2003
  7. pmc Excess dietary methionine does not affect fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Med Sci Monit 18:BR469-74. 2012
  8. doi request reprint Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 48:821-7. 2010
  9. ncbi request reprint Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk
    Wolfgang Herrmann
    Department of Clinical Chemistry, School of Medicine, Saarland University, Homburg, Germany
    Clin Chem Lab Med 41:1478-88. 2003
  10. doi request reprint Experimental folate and vitamin B12 deficiency does not alter bone quality in rats
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    J Bone Miner Res 24:589-96. 2009

Detail Information

Publications75

  1. doi request reprint Homocysteine: a biomarker in neurodegenerative diseases
    Wolfgang Herrmann
    Department of Clinical Chemistry, Medical School, Saarland University, Homburg, Germany
    Clin Chem Lab Med 49:435-41. 2011
    ..Therefore, it seems prudent to identify B vitamin deficient subjects and to ensure sufficient vitamin intake. Therefore, recent evidence supports the role of Hcy as a potential biomarker in age-related neurodegenerative diseases...
  2. doi request reprint Enhanced bone metabolism in vegetarians--the role of vitamin B12 deficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 47:1381-7. 2009
    ..Vitamin B12 deficiency and bone fractures are common in vegetarians. However, a direct relationship between vitamin B12 status and bone metabolism in vegetarians has not been tested sufficiently...
  3. doi request reprint Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    Bone 44:467-75. 2009
    ..This study investigated if an experimental HHCY in rats induces an accumulation of homocysteine (HCY) in bone tissue that is accompanied by bone loss and reduced bone strength...
  4. doi request reprint Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm 115:1651-9. 2008
    ..Finally, CSF Abeta42 levels declined significantly in both groups within 12 months supporting the notion that CSF Abeta42 may be valid not only for diagnostic but also for prognostic purposes in AD...
  5. ncbi request reprint Folate and methylation status in relation to phosphorylated tau protein(181P) and beta-amyloid(1-42) in cerebrospinal fluid
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine and Neurology, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:1129-36. 2007
    ..Increased plasma total homocysteine (tHcy) is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained...
  6. ncbi request reprint Comparison of the influence of volume-oriented training and high-intensity interval training on serum homocysteine and its cofactors in young, healthy swimmers
    Markus Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 41:1525-31. 2003
    ..Previous studies have suggested that endurance training influences Hcy. However, little is known about the effect of training intensity on Hcy...
  7. pmc Excess dietary methionine does not affect fracture healing in mice
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Med Sci Monit 18:BR469-74. 2012
    ..As the essential amino acid, methionine, is a precursor of homocysteine, we aimed to investigate whether excess methionine intake affects bone repair...
  8. doi request reprint Hyperhomocysteinemia is not associated with reduced bone quality in humans with hip osteoarthritis
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 48:821-7. 2010
    ..This study investigated the relationship between morphological as well as biomechanical bone properties and HCY serum concentrations in humans suffering from hip osteoarthritis (OA)...
  9. ncbi request reprint Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk
    Wolfgang Herrmann
    Department of Clinical Chemistry, School of Medicine, Saarland University, Homburg, Germany
    Clin Chem Lab Med 41:1478-88. 2003
    ..In this study we investigated the diagnostic value of storage (holoTC) of vitamin B12 and functional markers (methylmalonic acid (MMA)) of vitamin B12 metabolism in populations who are at risk of vitamin B12 deficiency...
  10. doi request reprint Experimental folate and vitamin B12 deficiency does not alter bone quality in rats
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg, Germany
    J Bone Miner Res 24:589-96. 2009
    ..The unchanged HCY metabolism in bone is the most probable explanation for the missing effect of the vitamin-free diet on bone...
  11. doi request reprint Methylation status and neurodegenerative markers in Parkinson disease
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Department of Neurology, University Hospital of Saarland, Homburg, Germany
    Clin Chem 55:1852-60. 2009
    ..Methylation status might link Hcy metabolism to neurodegenerative proteins in patients with PD...
  12. ncbi request reprint Plasma B vitamins and their relation to the severity of chronic heart failure
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Am J Clin Nutr 85:117-23. 2007
    ..Total homocysteine (tHcy) has been linked to the severity of chronic heart failure (CHF). Elevated tHcy concentrations are mainly caused by folate and vitamin B-12 deficiencies...
  13. ncbi request reprint Stimulation of osteoclast activity by low B-vitamin concentrations
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Bone 41:584-91. 2007
    ..Moreover, HCY activates osteoclasts (OC). Elevated HCY concentrations are mainly caused by folate, vitamin B12 (B12) and B6 (B6) deficiencies. We hypothesized that folate, B12 and B6 deficiencies stimulate OC activity...
  14. doi request reprint One year B and D vitamins supplementation improves metabolic bone markers
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg Saar, Germany
    Clin Chem Lab Med 51:639-47. 2013
    ..Supplementation with these vitamins is a promising preventative strategy. The objective of this study was to evaluate the effects of vitamins D3 and B supplementation on bone turnover and metabolism in elderly people...
  15. ncbi request reprint The role of genetic factors in the development of hyperhomocysteinemia
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1427-34. 2003
    ..Although the TC and COMT mutations influence cellular vitamin B12 metabolism, this effect did not result in overt homocysteine elevation...
  16. ncbi request reprint The effect of endurance exercise-induced lactacidosis on biochemical markers of bone turnover
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1381-9. 2007
    ..In vitro, decreases in pH stimulate osteoclasts and inhibit osteoblasts. We hypothesized that exercise-induced lactacidosis stimulates osteoclasts and reduces osteoblast activity in vivo...
  17. ncbi request reprint Altered vitamin B12 status in recreational endurance athletes
    Markus Herrmann
    University Hospital of Saarland, Dept of Clinical Chemistry and Laboratory Medicine, Homburg Saar, Germany
    Int J Sport Nutr Exerc Metab 15:433-41. 2005
    ..51), MMA and holoTC (r = -0.36). In athletes, MMA did not correlate with vitamin B(12)and holoTC. Our data suggests an altered vitamin B(12)metabolism in recreational athletes that needs further investigation...
  18. ncbi request reprint The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings
    Wolfgang Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Curr Drug Metab 6:47-53. 2005
    ..Elevated MMA and normal holoTC in patients with renal insufficiency may not exclude vitamin B12 deficiency. HoloTC seems not to be a promising marker in predicting B12 status in renal patients...
  19. doi request reprint Stimulation of osteoblast activity by homocysteine
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    J Cell Mol Med 12:1205-10. 2008
    ..However, the magnitude of this effect seems to be less pronounced than recent observations on primary human osteoclasts, suggesting a dysbalance between OBs and osteoclasts in favour of osteoclasts...
  20. ncbi request reprint Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians
    Wolfgang Herrmann
    Central Laboratory, Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
    Am J Clin Nutr 78:131-6. 2003
    ..Vegetarians have a lower intake of vitamin B-12 than do omnivores. Early and reliable diagnosis of vitamin B-12 deficiency is very important...
  21. ncbi request reprint Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes
    Wolfgang Herrmann
    Department of Clinical Chemistry, Central Laboratory, Saarland University Hospital, Homburg, Germany
    Clin Chem 51:891-7. 2005
    ....
  22. doi request reprint Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg, Germany
    J Neurochem 117:1047-54. 2011
    ..The effect of the diet on P-tau and pNF-H seemed not to be explained by a lower activity or protein level of PP2A. Folate might prove protective against multiple steps in the process of neurodegeneration...
  23. ncbi request reprint Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:326-33. 2007
    ..Increased HCY has been related to neurological and psychiatric disorders. We studied the role of the B-vitamins in HCY metabolism in the brain...
  24. ncbi request reprint The vegetarian lifestyle and DNA methylation
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 43:1164-9. 2005
    ..In conclusion, an inhibitory effect of SAH on whole-genome methylation was found, but from our data no interaction between vegetarian lifestyle and DNA methylation could be determined...
  25. ncbi request reprint Experimental hyperhomocysteinemia reduces bone quality in rats
    Markus Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:1455-61. 2007
    ..Recently, hyperhomocysteinemia (HHCY) has been suggested as a new risk factor for osteoporosis. This study investigated if HHCY is a causal osteoporotic factor in vivo...
  26. ncbi request reprint The impact of vegetarianism on some haematological parameters
    Rima Obeid
    Department of Clinical Chemistry, University Hospital of Saarland, Homburg, Germany
    Eur J Haematol 69:275-9. 2002
    ..The current work was undertaken to investigate some haematological parameters in relation to vitamin B12 and iron status in vegetarians...
  27. doi request reprint Factors affecting the distribution of folate forms in the serum of elderly German adults
    Susanne H Kirsch
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg, Saarland, Germany
    Eur J Nutr 52:497-504. 2013
    ..We investigated the roles of age, vitamin B(12) markers, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism as determinants of folate forms in serum...
  28. doi request reprint Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Am J Clin Nutr 90:1440-5. 2009
    ..Several clinical trials have reported B vitamins to be associated with osteoporosis...
  29. ncbi request reprint Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, Homburg, Germany
    Clin Chem Lab Med 42:1109-16. 2004
    ..Therefore, the demand for vitamin B6 is increased in these patients. Furthermore, renal dysfunction and low vitamin B6 levels contribute to the increase of cystathionine in pre-eclampsia and HELLP patients...
  30. ncbi request reprint Decreased p66Shc promoter methylation in patients with end-stage renal disease
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland University Hospital, Homburg, Germany
    Clin Chem Lab Med 45:1764-70. 2007
    ..First, patients with ESRD have a disturbed homocysteine metabolism, and second an increased risk of morbidity and mortality from cardiovascular disease is a constant finding in these patients...
  31. pmc Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial
    Holger Kessler
    Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg Saar, Germany
    J Neural Transm 115:1181-7. 2008
    ..Despite a number of findings supporting the hypothesis of environmental Cu modulating AD, our results demonstrate that oral Cu intake has neither a detrimental nor a promoting effect on the progression of AD...
  32. ncbi request reprint Vitamin B12 status in the elderly as judged by available biochemical markers
    Rima Obeid
    Department of Clinical Chemistry Central Laboratory, Saarland University Hospital, Homburg, Germany
    Clin Chem 50:238-41. 2004
  33. doi request reprint Assay of whole blood (6S)-5-CH3-H4folate using ultra performance liquid chromatography tandem mass spectrometry
    Susanne H Kirsch
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg, Saarland, Germany
    Anal Bioanal Chem 404:895-902. 2012
    ..We observed a dose-dependent oxidation of (6S)-H(4)folate, which resulted in the formation of artificial folic acid in serum and WB. To minimize this effect, we recommend a fast sample preparation...
  34. ncbi request reprint Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplay
    Wolfgang Herrmann
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:547-53. 2003
    ..The influence of MTHFR 677 mutation on homocysteine (HCY) levels in relation to vitamin B12 and folate status was investigated in the current study...
  35. ncbi request reprint Long-distance mountain biking does not disturb the measurement of total, free or complexed prostate-specific antigen in healthy men
    Markus Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 42:347-9. 2004
    ..Long-distance mountain biking is an excellent model to study the combined effect of mechanical prostate manipulation by bicycle riding and strenuous endurance exercise on total, free and complexed PSA (tPSA, fPSA, cPSA)...
  36. ncbi request reprint The measurement of complexed prostate-specific antigen has a better performance than total prostate-specific antigen
    Wolfgang Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 42:1051-7. 2004
    ..Thus, cPSA might be seen as the superior first-line parameter in screening for prostate cancer. Using lower cut-off values for tPSA or cPSA than the commonly accepted values seems reasonable for screening purposes...
  37. ncbi request reprint Priorities in the discovery of the implications of water channels in epilepsy and Duchenne muscular dystrophy
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Cell Mol Biol (Noisy-le-grand) 52:16-20. 2006
    ..This review discusses the relationship between brain and blood levels of key vitamins and metabolites related to one carbon metabolism...
  38. ncbi request reprint The impact of hyperhomocysteinemia as a cardiovascular risk factor in the prediction of coronary heart disease
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1513-7. 2003
    ..6 micromol/l. This data strongly suggests that plasma homocysteine helps identify individuals at risk, especially among those with elevated C-reactive protein levels...
  39. doi request reprint Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University, Medical Centre, Homburg, Germany
    Mol Nutr Food Res 56:1582-9. 2012
    ..The study tests the metabolites of the methylation cycle in individuals with Down syndrome (DS) and applies a mathematical model in order to change this cycle by nutritional factors...
  40. ncbi request reprint The cobalamin-binding proteins transcobalamin and haptocorrin in maternal and cord blood sera at birth
    Rima Obeid
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 52:263-9. 2006
    ..Transcobalamin (TC) carries approximately 25% of total plasma vitamin B12 and is 6% to 20% saturated with cobalamin. Haptocorrin (HC) binds approximately 80% of total cobalamin and is largely saturated with cobalamin...
  41. ncbi request reprint Concentrations of homocysteine, related metabolites and asymmetric dimethylarginine in preeclamptic women with poor nutritional status
    Wolfgang Herrmann
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 43:1139-46. 2005
    ..Asymmetric dimethylarginine (ADMA) is an inhibitor of NO-synthase that may adversely affect the endothelium...
  42. ncbi request reprint Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women
    Markus Herrmann
    Abteilung für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Chem Lab Med 43:1118-23. 2005
    ..Therefore, it is tempting to speculate that Hcy adversely affects bone metabolism. This study aimed to analyze the relation between Hcy and biochemical markers of bone metabolism and bone mineral density (BMD)...
  43. doi request reprint Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes
    Rima Obeid
    Department of Clinical Chemistry, Saarland University Medical Centre, Homburg, Germany
    Biochimie 95:1056-61. 2013
    ..Metformin treatment was associated with low serum vitamin B12 and improved intracellular vitamin B12 metabolism despite low serum vitamin B12...
  44. ncbi request reprint Homocysteine increases during endurance exercise
    Markus Herrmann
    Department of Clinical Chemistry Central Laboratory, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 41:1518-24. 2003
    ..Furthermore, about 25% of recreational endurance athletes exhibited hyperhomocysteinemia in association with low vitamin B12 and folate levels...
  45. ncbi request reprint Response of homocysteine, cystathionine, and methylmalonic acid to vitamin treatment in dialysis patients
    Rima Obeid
    Department of Clinical Chemistry, Central Laboratory, Saarland University Hospital, 66421 Homburg, Germany
    Clin Chem 51:196-201. 2005
    ..Vitamin treatment lowers total homocysteine (tHcy) concentrations in plasma and may therefore reduce the associated risk. Current treatment strategies have not achieved normalization of tHcy in the majority of dialysis patients...
  46. doi request reprint Markers of enhanced cholesterol absorption are a strong predictor for cardiovascular diseases in patients without diabetes mellitus
    Oliver Weingärtner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg, Saar, Germany
    Chem Phys Lipids 164:451-6. 2011
    ..The aim of the present study was to evaluate markers of cholesterol metabolism and determine their relationship with CVD in patients without diabetes mellitus who were not receiving statin treatment...
  47. ncbi request reprint Cellular uptake of vitamin B12 in patients with chronic renal failure
    Rima Obeid
    Department of Clinical Chemistry, Central Laboratory, Saarland University Hospital, Homburg, Germany
    Nephron Clin Pract 99:c42-8. 2005
    ..Elevated concentration of plasma homocysteine (tHcy) is common in renal patients, however, the reason behind the resistance to vitamin B(12) and folate therapy are poorly understood...
  48. ncbi request reprint Hyperhomocysteinemia and myocardial expression of brain natriuretic peptide in rats
    Markus Herrmann
    Department of Clinical Chemistry, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem 53:773-80. 2007
    ..We hypothesized that HHcy stimulates myocardial brain natriuretic peptide (BNP) expression and induces adverse left ventricular remodeling...
  49. ncbi request reprint Hyperhomocysteinemia--the biochemical link between a weak heart and brittle bones?
    Markus Herrmann
    Institut für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Lab 52:137-47. 2006
    ..Existing data suggest that HHCY could be a useful paradigm with most interesting therapeutic implications, because HCY lowering therapy could favourably influence the course in CHF and osteoporotic patients...
  50. doi request reprint Utility and limitations of biochemical markers of vitamin B12 deficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg Saar, Germany
    Eur J Clin Invest 43:231-7. 2013
    ..We worked out a diagnostic algorithm that provides a two-step detection of vitamin B12 deficiency using holotranscobalamin as a first line marker and methylmalonic acid (MMA) as a second line marker...
  51. ncbi request reprint Evaluation of alkaline phosphatase activity assay for the Reflotron system after substitution of the comparison method
    Ulrich Hübner
    Department of Clinical Chemistry Central Laboratory, Saarland University Hospital, Homburg, Germany
    Clin Lab 51:49-53. 2005
    ..The ALP Reflotron assay is an adequate method for decentralized testing. It shows a good precision and agreement with the comparison method, although the systematic differences for placental and bone ALP isoenzymes have to be considered...
  52. doi request reprint Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine and Gynecology, University Hospital of Saarland, Homburg, Germany
    Am J Clin Nutr 92:1416-22. 2010
    ..The importance of unmetabolized folic acid in maternal and fetal blood is not known...
  53. doi request reprint Low serum vitamin B12 is associated with recurrent pregnancy loss in Syrian women
    Ulrich Hübner
    Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 46:1265-9. 2008
    ..Hyperhomocysteinemia and B-vitamin deficiency are associated with recurrent abortion. Recent studies have not investigated functional markers of vitamin B12 deficiency, such as methylmalonic acid...
  54. ncbi request reprint Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acid
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1746-50. 2007
    ..Serum concentration of holoTC is a new marker in laboratory diagnosis of cobalamin deficiency. We tested the utility of holoTC in assessing vitamin B(12) status...
  55. ncbi request reprint Hyperhomocysteinemia and vitamin B-12 deficiency are more striking in Syrians than in Germans--causes and implications
    Wolfgang Herrmann
    Department of Clinical Chemistry, Saarland Medical School, Building 40, Kirrberger Str, D 66421 Homburg, Germany
    Atherosclerosis 166:143-50. 2003
    ..Vitamin B-12 deficiency induces folate trapping. Besides lifestyle, other presently unknown factors may contribute to hyperhomocysteinemia and vitamin B-12 deficiency in Syrians...
  56. ncbi request reprint Biomarkers of folate and vitamin B(12) status in cerebrospinal fluid
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1614-20. 2007
    ..This review discusses the relationship between brain and blood levels of key vitamins and metabolites related to one carbon metabolism...
  57. ncbi request reprint Hyperhomocysteinemia and response of methionine cycle intermediates to vitamin treatment in renal patients
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, School of Medicine, Saarland University, Germany
    Clin Chem Lab Med 43:1039-47. 2005
    ..Future studies may consider extending the duration of vitamin treatment, as well as agents that may enhance the hydrolysis of SAH and cystathionine...
  58. ncbi request reprint Homocysteine, brain natriuretic peptide and chronic heart failure: a critical review
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 45:1633-44. 2007
    ..Future studies need to explore the pathomechanisms of HHCY in CHF. Moreover, larger intervention trials are needed to clarify whether modification of plasma HCY by B-vitamin supplementation improves the clinical outcome in CHF patients...
  59. ncbi request reprint Homocysteine--a newly recognised risk factor for osteoporosis
    Markus Herrmann
    Institut für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Chem Lab Med 43:1111-7. 2005
    ..However, more studies are needed to clarify the mechanistic role of Hcy, folate, vitamin B6 and vitamin B12 in bone metabolism...
  60. ncbi request reprint Relationship of plasma homocysteine with the severity of chronic heart failure
    Markus Herrmann
    Abteilung für Klinische Chemie und Laboratoriumsmedizin Zentrallabor, Klinik fur Innere Medizin III, Institut fur Medizinische Biometrie, Epidemiologie und Medizinische Informatik, Universitätsklinikum des Saarland, Homburg Saar, Germany
    Clin Chem 51:1512-5. 2005
  61. ncbi request reprint Stimulatory effect of homocysteine on interleukin-8 expression in human endothelial cells
    Jurgen Geisel
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1045-8. 2003
    ..The formation of homocysteine-induced oxidation products might serve as one of the underlying mechanisms of this effect...
  62. ncbi request reprint Biochemical indexes of the B vitamins in cord serum are predicted by maternal B vitamin status
    Rima Obeid
    Department of Clinical Chemistry, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Am J Clin Nutr 82:133-9. 2005
    ..Vitamin B-12 is the major determinant of tHcy in newborns. Maternal status of folate, vitamin B-12, and vitamin B-6 during pregnancy may affect the biochemical markers of these micronutrients in newborns...
  63. ncbi request reprint Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects
    Rima Obeid
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 43:1052-7. 2005
    ..Concentrations of tHcy and MMA are useful indicators of B-vitamin status in the pediatric laboratory. Using these functional markers may facilitate detecting sub-optimal B-vitamin status in children...
  64. doi request reprint High bone concentrations of homocysteine are associated with altered bone morphology in humans
    Joerg H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Br J Nutr 106:378-82. 2011
    ..The results of the present study indicate an association between altered bone morphology and elevated bone concentrations of homocysteine and S-adenosylhomocysteine, but not between altered bone morphology and methylation capacity...
  65. ncbi request reprint The risk of venous thromboembolism associated with the factor V Leiden mutation and low B-vitamin status
    Rima Obeid
    Department of Clinical Chemistry, Saarland Medical School, Homburg, Germany
    Clin Chem Lab Med 41:1357-62. 2003
    ..The increased risk of VTE, accompanied by factor V Leiden, may be related to confounding environmental factors...
  66. ncbi request reprint Different kinetics of bone markers in normal and delayed fracture healing of long bones
    Markus Herrmann
    Department of Clinical Chemistry, University Hospital of the Saarland, D 66421 Homburg Saar, Germany
    Clin Chem 48:2263-6. 2002
  67. ncbi request reprint The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, University Hospital of Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 45:1590-606. 2007
    ..Treatment with folic acid, B(12) and B(6) lowers tHcy. For secondary and primary prevention from several neuropsychiatric disorders, it seems prudent to actively identify deficient subjects and ensure sufficient vitamin intake...
  68. doi request reprint Homocysteine and lipids: S-adenosyl methionine as a key intermediate
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Central Laboratory, University Hospital, Saarland University, D 66424 Homburg Saar, Germany
    FEBS Lett 583:1215-25. 2009
    ..The effect of Hcy on HDL-cholesterol is probably related to inhibiting enzymes or molecules participating in HDL-particle assembly...
  69. ncbi request reprint Continuous age-dependent reference ranges for thyroid hormones in neonates, infants, children and adolescents established using the ADVIA Centaur Analyzer
    Ulrich Hübner
    Department of Clinical Chemistry Central Laboratory, University Hospital of the Saarland, Homburg Saar, Germany
    Clin Chem Lab Med 40:1040-7. 2002
    ..Continuous age-dependent reference ranges comply better with the biological reality and are more reliable than discontinuous reference ranges...
  70. ncbi request reprint Clinical validation of a new blood collection tube for the accuracy of total homocysteine measurement by different methods
    Emmanuel Bisse
    Department of Clinical Chemistry, University Medical Center Freiburg, Hugstetterstrasse 55, D 79106 Freiburg, Germany
    Clin Biochem 40:739-43. 2007
    ..To evaluate the clinical use of Homocysteine-Primavette, a new blood collection medium for total homocysteine (tHcy) assay...
  71. ncbi request reprint Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease
    Frank Gerald Pajonk
    Department for Psychiatry, Saarland University, Building 90, 66421 Homburg Saar, Germany
    J Alzheimers Dis 8:23-7. 2005
    ..5% of the patients revealed a significant negative correlation between plasma Cu and ADAS-cog. This finding supports the hypothesis of a mild Cu deficiency in most AD patients...
  72. ncbi request reprint In vitro inhibition of fibrinolysis by apolipoprotein(a) and lipoprotein(a) is size- and concentration-dependent
    Jean Pierre Knapp
    Department of Clinical Chemistry, Central Laboratory, Saarland Medical School, Homburg Saar, Germany
    Clin Chem Lab Med 42:1013-9. 2004
    ..From the antifibrinolytic Lp(a)/apo(a) effect in vitro it may be hypothesized that Lp(a)/apo(a) also has an inhibitory influence on in vivo fibrinolysis...
  73. ncbi request reprint Cobalamin status (holo-transcobalamin, methylmalonic acid) and folate as determinants of homocysteine concentration
    Rima Obeid
    Department of Clinical Chemistry, University Hospital of Saarland, 66421 Homburg, Germany
    Clin Chem 48:2064-5. 2002
  74. doi request reprint Cobalamin deficiency
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine, University of Saarland, 66421, Homburg, Germany
    Subcell Biochem 56:301-22. 2012
    ..Because Cbl deficiency is a risk factor for neurodegenerative diseases an early diagnosis of a low B12 status is required which should be followed by an effective treatment in order to prevent irreversible damages...
  75. ncbi request reprint Hyperhomocysteinemia: a new risk factor for degenerative diseases
    Wolfgang Herrmann
    Department of Clinical Chemistry, Saarland Medical School, Homburg Saar, Germany
    Clin Lab 48:471-81. 2002
    ....