Karen Herlyn

Summary

Country: Germany

Publications

  1. doi request reprint Doubled prevalence rates of ANCA-associated vasculitides and giant cell arteritis between 1994 and 2006 in northern Germany
    Karen Herlyn
    Department of Rheumatology, University Medical Center, Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck D 23538, Germany
    Rheumatology (Oxford) 53:882-9. 2014
  2. pmc Patient-reported outcome assessment in vasculitis may provide important data and a unique perspective
    Karen Herlyn
    University Hospital Schleswig Holstein, Lubeck, Germany
    Arthritis Care Res (Hoboken) 62:1639-45. 2010
  3. doi request reprint [The significance of health-related quality of life in systemic vasculitides]
    K Herlyn
    Poliklinik fur Rheumatologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, und Medizinische Krankenhausabteilung Klinikum Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Deutschland
    Z Rheumatol 69:220-6. 2010
  4. ncbi request reprint Autoantibodies against the bactericidal/permeability-increasing protein from inflammatory bowel disease patients can impair the antibiotic activity of bactericidal/permeability-increasing protein
    Susanne Schinke
    Department of Rheumatology, University of Luebeck, Bad Bramstedt, Germany
    Inflamm Bowel Dis 10:763-70. 2004
  5. doi request reprint Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
    Ann Rheum Dis 71:327-33. 2012
  6. doi request reprint Toll-like receptor TLR2 and TLR9 ligation triggers neutrophil activation in granulomatosis with polyangiitis
    Julia U Holle
    Department of Rheumatology and Immunology, University Hospital Schleswig Holstein, Campus Luebeck and Klinikum Bad Bramstedt, Oskar Alexander Straße 26, 24576 Bad Bramstedt, Germany
    Rheumatology (Oxford) 52:1183-9. 2013
  7. ncbi request reprint Stable incidence of primary systemic vasculitides over five years: results from the German vasculitis register
    Eva Reinhold-Keller
    University of Schleswig Holstein, Campus Luebeck, Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany
    Arthritis Rheum 53:93-9. 2005
  8. ncbi request reprint BPI-ANCA of pediatric cystic fibrosis patients can impair BPI-mediated killing of E. coli DH5alpha in vitro
    Hendrik Schultz
    Department of Rheumatology, University of Lubeck, Lubeck, Germany
    Pediatr Pulmonol 37:158-64. 2004
  9. ncbi request reprint High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low-dose methotrexate
    Eva Reinhold-Keller
    Medical University of Lubeck, Lubeck, Germany
    Arthritis Rheum 47:326-32. 2002
  10. ncbi request reprint Effect of Wegener's granulomatosis on work disability, need for medical care, and quality of life in patients younger than 40 years at diagnosis
    Eva Reinhold-Keller
    Medical University of Lübeck and Rheumaklinik Bad Bramstedt GmbH, Lubeck, Germany
    Arthritis Rheum 47:320-5. 2002

Detail Information

Publications15

  1. doi request reprint Doubled prevalence rates of ANCA-associated vasculitides and giant cell arteritis between 1994 and 2006 in northern Germany
    Karen Herlyn
    Department of Rheumatology, University Medical Center, Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, Luebeck D 23538, Germany
    Rheumatology (Oxford) 53:882-9. 2014
    ..Aspects such as environmental factors and exposure to certain substances need further research. ..
  2. pmc Patient-reported outcome assessment in vasculitis may provide important data and a unique perspective
    Karen Herlyn
    University Hospital Schleswig Holstein, Lubeck, Germany
    Arthritis Care Res (Hoboken) 62:1639-45. 2010
    ..Outcome assessment in vasculitis primarily focuses on physician evaluations of disease activity and damage. Little is known about the patients' perspectives regarding the burden of disease...
  3. doi request reprint [The significance of health-related quality of life in systemic vasculitides]
    K Herlyn
    Poliklinik fur Rheumatologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, und Medizinische Krankenhausabteilung Klinikum Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Deutschland
    Z Rheumatol 69:220-6. 2010
    ..Moreover, data indicate that tiredness (fatigue) and reduced energy levels play a significant role. This article presents an overview of the existing literature...
  4. ncbi request reprint Autoantibodies against the bactericidal/permeability-increasing protein from inflammatory bowel disease patients can impair the antibiotic activity of bactericidal/permeability-increasing protein
    Susanne Schinke
    Department of Rheumatology, University of Luebeck, Bad Bramstedt, Germany
    Inflamm Bowel Dis 10:763-70. 2004
    ..Inhibition of the antibiotic function mediated by the N-terminal region of BPI by these autoantibodies may contribute to a proinflammatory environment in IBD patients...
  5. doi request reprint Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations
    Julia U Holle
    Department of Rheumatology and Clinical Immunology, Vasculitis Center, University Hospital Schleswig Holstein, Campus Lübeck and Klinikum Bad Bramstedt, Bad Bramstedt, Germany
    Ann Rheum Dis 71:327-33. 2012
    ..Second, to compare the efficacy of RTX in granulomatous and vasculitic manifestations in GPA...
  6. doi request reprint Toll-like receptor TLR2 and TLR9 ligation triggers neutrophil activation in granulomatosis with polyangiitis
    Julia U Holle
    Department of Rheumatology and Immunology, University Hospital Schleswig Holstein, Campus Luebeck and Klinikum Bad Bramstedt, Oskar Alexander Straße 26, 24576 Bad Bramstedt, Germany
    Rheumatology (Oxford) 52:1183-9. 2013
    ..The aim of the study was to characterize the expression of TLR2, TLR4 and TLR9 in PMNs of patients with granulomatosis with polyangiitis (GPA) and to elucidate the role of these receptors in GPA with respect to neutrophil activation...
  7. ncbi request reprint Stable incidence of primary systemic vasculitides over five years: results from the German vasculitis register
    Eva Reinhold-Keller
    University of Schleswig Holstein, Campus Luebeck, Rheumaklinik Bad Bramstedt, Bad Bramstedt, Germany
    Arthritis Rheum 53:93-9. 2005
    ..To register all newly diagnosed patients with primary systemic vasculitides (PSV) in a large region in northern Germany...
  8. ncbi request reprint BPI-ANCA of pediatric cystic fibrosis patients can impair BPI-mediated killing of E. coli DH5alpha in vitro
    Hendrik Schultz
    Department of Rheumatology, University of Lubeck, Lubeck, Germany
    Pediatr Pulmonol 37:158-64. 2004
    ..Thus, in pediatric CF patients, BPI-ANCA may contribute to diminished bacterial clearance by inhibiting the antibiotic function of BPI...
  9. ncbi request reprint High rate of renal relapse in 71 patients with Wegener's granulomatosis under maintenance of remission with low-dose methotrexate
    Eva Reinhold-Keller
    Medical University of Lubeck, Lubeck, Germany
    Arthritis Rheum 47:326-32. 2002
    ....
  10. ncbi request reprint Effect of Wegener's granulomatosis on work disability, need for medical care, and quality of life in patients younger than 40 years at diagnosis
    Eva Reinhold-Keller
    Medical University of Lübeck and Rheumaklinik Bad Bramstedt GmbH, Lubeck, Germany
    Arthritis Rheum 47:320-5. 2002
    ..To evaluate the effects of Wegener's granulomatosis (WG) on employment status, work disability, and need for medical care of 60 consecutive WG patients aged < or = 40 years at diagnosis...
  11. doi request reprint Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis
    Dorin Capraru
    University of Lubeck, Department of Rheumatology, Vasculitiscenter and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Clin Immunol 127:144-50. 2008
    ....
  12. ncbi request reprint ANCA against bactericidal/permeability-increasing protein, azurocidin, calprotectin and defensins in rheumatic and infectious diseases: prevalence and clinical associations
    H Schultz
    Department of Rheumatology, University of Lubeck, Lubeck, Germany
    Clin Exp Rheumatol 21:S117-20. 2003
    ..To determine the prevalence and clinical associations of ANCA against the antibiotic proteins and peptides: Bactericidal/permeability-increasing protein (BPI), Azurocidin (AZ), Calprotectin (CP) and beta-Defensin-1 and -2 (DF)...
  13. ncbi request reprint [B lymphocyte differentiation in granulomatous tissues of the lung and the nasal mucosa in Wegener's granulomatosis: origin of anti-neutrophil cytoplasmic antibody formation?]
    J A Kramer
    Poliklinik fur Rheumatologie, Universitatsklinikum Schleswig Holstein, Campus Lübeck und Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Z Rheumatol 66:421-9. 2007
    ..WG granulomata could be the place of autoantigen presentation and formation of high-affinity ANCA within neoformed ectopic or tertiary lymphoid-like tissue areas...
  14. ncbi request reprint [A new patient education program: vasculitis]
    K Herlyn
    Medizinische Krankenhausabteilung Rheumaklinik Bad Bramstedt, Poliklinik fur Rheumatologie, Universitätsklinikum Schleswig Holstein Campus Lübeck, Oskar Alexander Str 26, 24576 Bad Bramstedt, Germany
    Z Rheumatol 62:II17-20. 2003
    ..Patients completed the questionnaires at baseline, 4 weeks, 6 and 12 months after training. First results show statistically significant improvement of knowledge and health-related quality of life...
  15. ncbi request reprint Birmingham vasculitis activity score, disease extent index and complement factor C3c reflect disease activity best in hepatitis C virus-associated cryoglobulinemic vasculitis
    P Lamprecht
    Poliklinik fur Rheumatologie, Universitatsklinikum Lubeck, Medizinische Universitat zu Lubeck, Germany
    Clin Exp Rheumatol 18:319-25. 2000
    ....