A Herpin


Country: Germany


  1. Herpin A, Rohr S, Riedel D, Kluever N, Raz E, Schartl M. Specification of primordial germ cells in medaka (Oryzias latipes). BMC Dev Biol. 2007;7:3 pubmed
    ..Taken together, these results are consistent with the idea that in medaka the inheritance of maternally provided asymmetrically-localized cytoplasmic determinants directs cells to assume the germ line fate similar to zebrafish PGCs. ..
  2. Herpin A, Schindler D, Kraiss A, Hornung U, Winkler C, Schartl M. Inhibition of primordial germ cell proliferation by the medaka male determining gene Dmrt I bY. BMC Dev Biol. 2007;7:99 pubmed
    ..In medaka, dmrt I bY mediates a mitotic arrest of PGCs in males prior to testes differentiation at the sex determination stage. This occurs possibly via a cross-talk of Sertoli cells and PGCs. ..
  3. Herpin A, Lelong C, Becker T, Rosa F, Favrel P, Cunningham C. Structural and functional evidences for a type 1 TGF-beta sensu stricto receptor in the lophotrochozoan Crassostrea gigas suggest conserved molecular mechanisms controlling mesodermal patterning across bilateria. Mech Dev. 2005;122:695-705 pubmed
    ..s. pathway in lophotrochozoans. ..
  4. Herpin A, Lelong C, Becker T, Rosa F, Favrel P, Cunningham C. Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway. FEBS J. 2005;272:3424-40 pubmed
  5. Herpin A, Nakamura S, Wagner T, Tanaka M, Schartl M. A highly conserved cis-regulatory motif directs differential gonadal synexpression of Dmrt1 transcripts during gonad development. Nucleic Acids Res. 2009;37:1510-20 pubmed publisher
    ..The sequence motif was found to be conserved in most of the dmrt1 homologous genes from flies to humans suggesting a widespread conservation of this specific mechanism. ..
  6. Herpin A, Braasch I, Kraeussling M, Schmidt C, Thoma E, Nakamura S, et al. Transcriptional rewiring of the sex determining dmrt1 gene duplicate by transposable elements. PLoS Genet. 2010;6:e1000844 pubmed publisher
    ..In the particular case of dmrt1bY, this contributed to create new hierarchies of sex-determining genes...