Genomes and Genes
- The genome sequence of the extreme thermophile Thermus thermophilusAnke Henne
Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, University of Gottingen, Germany
Nat Biotechnol 22:547-53. 2004..thermophilus HB27. Candidates include various proteases and key enzymes of other fundamental biological processes such as DNA replication, DNA repair and RNA maturation...
- The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potentialBirgit Veith
Göttingen Genomics Laboratory and Competence Centre for Genome Research on Bacteria, Institute of Microbiology and Genetics, University of Gottingen, Gottingen, Germany
J Mol Microbiol Biotechnol 7:204-11. 2004..Many new genes of potential interest for biotechnological applications were found in B. licheniformis; candidates include proteases, pectate lyases, lipases and various polysaccharide degrading enzymes...
- The genome sequence of Clostridium tetani, the causative agent of tetanus diseaseHolger Bruggemann
Göttingen Genomics Laboratory and Department of General Microbiology, Institute of Microbiology and Genetics, Georg August University, Grisebachstrasse 8, D 37077 Gottingen, Germany
Proc Natl Acad Sci U S A 100:1316-21. 2003..tetani: The organism can rely on an extensive sodium ion bioenergetics. Additional candidate genes involved in the establishment and maintenance of a pathogenic lifestyle of C. tetani are presented...
- Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxideAxel W Strittmatter
Göttingen Genomics Laboratory, Georg August University, Gottingen, Germany
Environ Microbiol 11:1038-55. 2009..This enzyme is involved in energy conservation in methanoarchaea and it is speculated that it exhibits a similar function in the process of dissimilatory sulfate reduction in Db. autotrophicum HRM2...
- The complete genome sequence of Propionibacterium acnes, a commensal of human skinHolger Bruggemann
Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
Science 305:671-3. 2004..Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases...
- The genome sequence of Methanosphaera stadtmanae reveals why this human intestinal archaeon is restricted to methanol and H2 for methane formation and ATP synthesisWolfgang F Fricke
Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University, Grisebachstr 8, D 37077 Gottingen, Germany
J Bacteriol 188:642-58. 2006....
- The genome of Methanosarcina mazei: evidence for lateral gene transfer between bacteria and archaeaUwe Deppenmeier
Department of General Microbiology, Institute of Microbiology and Genetics, Georg August University, Goettingen, Germany
J Mol Microbiol Biotechnol 4:453-61. 2002..These findings might indicate that lateral gene transfer has played an important evolutionary role in forging the physiology of this metabolically versatile methanogen...
- Construction and screening of metagenomic libraries derived from enrichment cultures: generation of a gene bank for genes conferring alcohol oxidoreductase activity on Escherichia coliAnja Knietsch
Abteilung Allgemeine Mikrobiologie, Göttingen Genomics Laboratory, Institut für Mikrobiologie und Genetik der Georg August Universität, Grisebachstrasse 8, 37077 Gottingen, Germany
Appl Environ Microbiol 69:1408-16. 2003....
- Complete nucleotide sequence of the 113-kilobase linear catabolic plasmid pAL1 of Arthrobacter nitroguajacolicus Rü61a and transcriptional analysis of genes involved in quinaldine degradationKatja Parschat
Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
J Bacteriol 189:3855-67. 2007..Even if the putative proteins encoded by ORFs 101 to 103 share motifs with the Tap and terminal proteins involved in telomere patching of Streptomyces linear replicons, their overall sequences and domain structures differ significantly...
- The high-affinity maltose/trehalose ABC transporter in the extremely thermophilic bacterium Thermus thermophilus HB27 also recognizes sucrose and palatinoseZélia Silva
Centro de Neurociencias e Biologia Celular, Departamento de Zoologia, Universidade de Coimbra, Coimbra, Portugal
J Bacteriol 187:1210-8. 2005..This work demonstrates that malEFG1 and malK1 constitute the high-affinity ABC transport system of T. thermophilus HB27 for trehalose, maltose, sucrose, and palatinose...
- Binding to pyruvylated compounds as an ancestral mechanism to anchor the outer envelope in primitive bacteriaFelipe Cava
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain
Mol Microbiol 52:677-90. 2004....
- Structural and functional characterization of gene clusters directing nonribosomal synthesis of bioactive cyclic lipopeptides in Bacillus amyloliquefaciens strain FZB42Alexandra Koumoutsi
Institut fur Biologie, Humboldt Universitat Berlin, Institut für Biochemie der Freien Universität, Berlin, Germany
J Bacteriol 186:1084-96. 2004....
- Complete nucleotide sequence of the circular megaplasmid pHCG3 of Oligotropha carboxidovorans: function in the chemolithoautotrophic utilization of CO, H(2) and CO(2)Sven Fuhrmann
Department of Microbiology and Bayreuth Center of Molecular Biosciences, University of Bayreuth, D 95440 Bayreuth, Germany
Gene 322:67-75. 2003..carboxidovorans. An oriV encodes the replication proteins RepABC. Sequence comparisons of pHCG3-encoded genes suggest that major genetic exchange between O. carboxidovorans and the proteobacteria has occurred...
- Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H(2)-based ithoautotrophy and anaerobiosisEdward Schwartz
Institut fur Biologie, Mikrobiologie, Humboldt Universitat zu Berlin, Chausseestr 117, 10115 Berlin, Germany
J Mol Biol 332:369-83. 2003..Among the mobile elements is a novel member of the IS5 family, in which the transposase gene is interrupted by a group II intron...
- Pilin-like proteins in the extremely thermophilic bacterium Thermus thermophilus HB27: implication in competence for natural transformation and links to type IV pilus biogenesisAlexandra Friedrich
Bereich Genetik und Mikrobiologie, Department Biologie I, Ludwig Maximilians Universitat Munchen, Maria Ward Strasse 1a, D 80638 Munich, Germany
Appl Environ Microbiol 69:3695-700. 2003..thermophilus pilus structures are type IV pili. Furthermore, the loss of the transformation and piliation phenotype in the pilA4 mutant suggests that type IV pili are implicated in natural transformation of T. thermophilus HB27...
- The bacterium Thermus thermophilus, like hyperthermophilic archaea, uses a two-step pathway for the synthesis of mannosylglycerateNuno Empadinhas
Departamento de Bioquimica, Universidade de Coimbra, 3004 517 Coimbra, Portugal
Appl Environ Microbiol 69:3272-9. 2003..The biosynthesis of MG in the thermophilic bacterium T. thermophilus HB27, proceeding through a phosphorylated intermediate, is similar to the system found in hyperthermophilic archaea...
- Visualizing tmRNA entry into a stalled ribosomeMikel Valle
Howard Hughes Medical Institute, Wadsworth Center, Health Research, Inc, Empire State Plaza, Albany, NY 12201 0509, USA
Science 300:127-30. 2003..The structure reveals how tmRNA could move through the ribosome despite its complicated topology and also suggests roles for proteins S1 and SmpB in the function of tmRNA...
- Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesisAnn Kristin Kollas
Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392, Giessen, Germany
FEBS Lett 532:432-6. 2002..The maximal specific activity was 0.6 micromol x min(-1) x mg(-1) at pH 7.5 and 55 degrees C. The kcat value was 0.4 s(-1) and the K(m) value for HMBPP 0.42 mM...
- Preliminary characterization and crystal structure of a thermostable cytochrome P450 from Thermus thermophilusJason K Yano
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
J Biol Chem 278:608-16. 2003..Additional factors involved in the thermal stability increase are a decrease in the overall size, especially shortening of loops and connecting regions, and a decrease in the number of labile residues such as Asn, Gln, and Cys...
- Molecular analyses of the natural transformation machinery and identification of pilus structures in the extremely thermophilic bacterium Thermus thermophilus strain HB27Alexandra Friedrich
Institut fur Genetik und Mikrobiologie, Ludwig Maximilians Universitat, Maria Ward Strasse 1a, D 80638 Munich, Germany
Appl Environ Microbiol 68:745-55. 2002..These results suggest that pili and natural transformation in T. thermophilus HB27 are functionally linked...