J G Hengstler

Summary

Country: Germany

Publications

  1. ncbi request reprint Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 151:29-41. 2004
  2. ncbi request reprint Induction and control of oxidative stress
    Jan G Hengstler
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse 67, 44139 Dortmund, Germany
    Arch Toxicol 81:823-4. 2007
  3. pmc Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation: influence on tumour development in an ERBB2-dependent mouse tumour model
    M Hermes
    Leibniz Research Centre for Working Environment and Human Factors, University of Dortmund, Ardeystrasse 67, Dortmund D 44139, Germany
    Br J Cancer 98:1525-32. 2008
  4. pmc Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients
    Wulf Siggelkow
    Department of Obstetrics and Gynecology, Diakonischen Dienste Hannover GmbH, Diakoniekrankenhaus Henriettenstiftung und Diakoniekrankenhaus Friederikenstift, Hanover, Germany
    BMC Cancer 12:562. 2012
  5. pmc Survival models with preclustered gene groups as covariates
    Kai Kammers
    Department of Statistics, TU Dortmund University, Dortmund, Germany
    BMC Bioinformatics 12:478. 2011
  6. pmc Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Mol Cancer 9:2. 2010
  7. pmc Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
    Cristina Cadenas
    Department of Bioanalytics, Leibniz Institut für Analytische Wissenschaften ISAS e, V, Bunsen Kirchhoff Strasse 11, Dortmund, Germany
    Breast Cancer Res 12:R44. 2010
  8. pmc Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes
    Birte Hellwig
    Department of Statistics, TU Dortmund University, 44221 Dortmund, Germany
    BMC Bioinformatics 11:276. 2010
  9. pmc Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A
    J G Hengstler
    Leibniz Research Centre for Working Environment and Human Factors IfADo, University of Dortmund, Dortmund, Germany
    Crit Rev Toxicol 41:263-91. 2011
  10. doi request reprint Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytes
    Patricio Godoy
    Leibniz Research Center for Working Environment and Human Factors IfADo, Ardeystrasse 67, D 44139 Dortmund, Germany
    Biol Chem 391:73-83. 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 151:29-41. 2004
    ..This should be changed, as the philosophy of separation of a strictly sequential "hazard assessment" and "risk assessment" appears out-of-date...
  2. ncbi request reprint Induction and control of oxidative stress
    Jan G Hengstler
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse 67, 44139 Dortmund, Germany
    Arch Toxicol 81:823-4. 2007
  3. pmc Trastuzumab therapy vs tetracycline controlled ERBB2 downregulation: influence on tumour development in an ERBB2-dependent mouse tumour model
    M Hermes
    Leibniz Research Centre for Working Environment and Human Factors, University of Dortmund, Ardeystrasse 67, Dortmund D 44139, Germany
    Br J Cancer 98:1525-32. 2008
    ..The suboptimal effect of trastuzumab compared to the maximally possible effect induced by ATc demonstrates a high potential for improved ERBB2 blocking therapies...
  4. pmc Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients
    Wulf Siggelkow
    Department of Obstetrics and Gynecology, Diakonischen Dienste Hannover GmbH, Diakoniekrankenhaus Henriettenstiftung und Diakoniekrankenhaus Friederikenstift, Hanover, Germany
    BMC Cancer 12:562. 2012
    ..Inhibitors targeting the cell cycle-regulated aurora kinase A (AURKA) are currently being developed. Here, we examine the prognostic impact of AURKA in node-negative breast cancer patients without adjuvant systemic therapy (n = 766)...
  5. pmc Survival models with preclustered gene groups as covariates
    Kai Kammers
    Department of Statistics, TU Dortmund University, Dortmund, Germany
    BMC Bioinformatics 12:478. 2011
    ..We apply preclustering to genes within GO groups according to the correlation of their gene expression measurements...
  6. pmc Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Mol Cancer 9:2. 2010
    ..In the present work we investigated whether carnosine also affects tumor growth in vivo and may therefore be considered for human cancer therapy...
  7. pmc Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
    Cristina Cadenas
    Department of Bioanalytics, Leibniz Institut für Analytische Wissenschaften ISAS e, V, Bunsen Kirchhoff Strasse 11, Dortmund, Germany
    Breast Cancer Res 12:R44. 2010
    ....
  8. pmc Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes
    Birte Hellwig
    Department of Statistics, TU Dortmund University, 44221 Dortmund, Germany
    BMC Bioinformatics 11:276. 2010
    ..The kurtosis, e.g., measures divergence from a normal distribution. An alternative is the outlier-sum statistic that identifies genes with extremely high or low expression values in a subset of the samples...
  9. pmc Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A
    J G Hengstler
    Leibniz Research Centre for Working Environment and Human Factors IfADo, University of Dortmund, Dortmund, Germany
    Crit Rev Toxicol 41:263-91. 2011
    ....
  10. doi request reprint Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytes
    Patricio Godoy
    Leibniz Research Center for Working Environment and Human Factors IfADo, Ardeystrasse 67, D 44139 Dortmund, Germany
    Biol Chem 391:73-83. 2010
    ..In conclusion, EMT markers in hepatocytes can be classified as dexamethasone-dependent versus -independent...
  11. ncbi request reprint Predictive biomarkers and signatures in urinary bladder cancer
    Peter H Roos
    Dortmund University, IfADo Leibniz Research Centre for Working Environment and Human Factors, Ardeystrasse 67, 44139 Dortmund, Germany
    Curr Opin Mol Ther 10:243-50. 2008
    ..In this review, developments in tumor-marker identification with a focus on bladder cancer are described...
  12. doi request reprint Developments in industrial and occupational toxicology: REACH, toxicogenomics, mycotoxins, lead, asbestos, boron, bitumen, deletions polymorphisms and SNP interactions: meeting report of the 16th EUROTOX training and discussion session
    Gisela H Degen
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany
    Arch Toxicol 82:483-7. 2008
  13. doi request reprint Tracking of human cells in mice
    Wiebke Schormann
    Leibniz Research Centre for Working Environment and Human Factors at the University of Dortmund IfADo, Ardeystrasse 67, 44139, Dortmund, Germany
    Histochem Cell Biol 130:329-38. 2008
    ..Additional procedures, such as ISH with alu-probes, are essential, when characterizing individual cells...
  14. ncbi request reprint Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers
    Marc Brulport
    Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Hepatology 46:861-70. 2007
    ..Qualitatively similar results were obtained with all 4 human precursor cell types through different routes of administration with and without the induction of liver damage...
  15. ncbi request reprint Perfluorinated compounds (PFC) hit the headlines : meeting report on a satellite symposium of the annual meeting of the German Society of Toxicology
    Peter H Roos
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 82:57-9. 2008
  16. doi request reprint Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure
    Klaus Golka
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse, Dortmund, Germany
    Pharmacogenet Genomics 19:903-6. 2009
    ..Therefore, the degree to which rs9642880[T] and GSTM1 0/0 confer susceptibility to urinary bladder cancer seems to depend on the extent of exposure to urinary bladder carcinogens...
  17. doi request reprint Primary rat hepatocytes as in vitro system for gene expression studies: comparison of sandwich, Matrigel and 2D cultures
    M Schug
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse 67, 44139 Dortmund, Germany
    Arch Toxicol 82:923-31. 2008
    ..In conclusion, the presented data strongly suggest that sandwich cultures are most adequate for detection of MPy-induced gene expression alterations and the effect of MPy was detected at in vivo relevant concentrations...
  18. doi request reprint Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by 31P NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholines
    Alexander Bauer
    Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Chem Phys Lipids 159:21-9. 2009
    ..It is concluded that LPC represents a useful biomarker of CCl(4)-mediated damaging of hepatocytes. It is also speculated that de novo biosynthesis of PC is influenced by CCl(4)...
  19. doi request reprint Micro-Raman detection of nuclear membrane lipid fluctuations in senescent epithelial breast cancer cells
    Melissa M Mariani
    ISAS Institute for Analytical Sciences, Bunsen Kirchhoff Strasse 11, 44139 Dortmund, Germany
    Anal Chem 82:4259-63. 2010
    ....
  20. doi request reprint Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P450 1A1
    Sabine Plottner
    Leibniz Research Centre for Working Environment and Human Factors, Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 83:131-8. 2009
    ..In conclusion, we have identified two functionally distinct subpopulations of urinary bladder epithelial cells. It will be interesting to study whether the CYP1A inducible subtype is more susceptible to bladder carcinogens...
  21. ncbi request reprint Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix-mediated manipulation of signaling activities
    Patricio Godoy
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
    Methods Mol Biol 640:139-55. 2010
    ..In this chapter we focus on mechanisms that influence apoptosis sensitivity in cultured mouse hepatocytes...
  22. pmc Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers
    Ines Aurich
    1st Department of Medicine, Heinrich Damerow Strasse 1, Martin Luther University of Halle Wittenberg, D 06120 Halle Saale, Germany
    Gut 56:405-15. 2007
    ..Hence, novel cell sources are required to deliver hepatocytes of adequate quality for clinical use. Mesenchymal stem cells (MSCs) from human bone marrow may have the potential to differentiate into hepatocytes in vitro and in vivo...
  23. ncbi request reprint Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells
    Maren Ruhnke
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    Gastroenterology 128:1774-86. 2005
    ..We evaluated the differentiation potential of human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells...
  24. ncbi request reprint Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy
    Maren Ruhnke
    Department of General and Thoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplantation 79:1097-103. 2005
    ..We have generated hepatocyte-like (NeoHep) cells from terminally differentiated peripheral blood monocytes and, in this study, have evaluated these cells as a possible tool for autologous cell therapy...
  25. ncbi request reprint SPOC1, a novel PHD-finger protein: association with residual disease and survival in ovarian cancer
    Gerrit Mohrmann
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Cancer 116:547-54. 2005
    ..In conclusion, SPOC1 is a novel PHD-finger protein showing strong expression in spermatogonia and ovarian cancer cells. SPOC1 overexpression was associated with unresectable carcinomas and shorter survival in ovarian cancer...
  26. ncbi request reprint No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI
    Ilka B Schiffer
    Institute of Toxicology, University of Mainz, Mainz, Germany
    Bioelectromagnetics 24:241-50. 2003
    ..Care was taken to control secondary parameters of influence, such as vibration by the MR scanner or temperature to avoid false positive results...
  27. ncbi request reprint Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected
    Jan G Hengstler
    Institute of Toxicology, Obere Zahlbacher Str 67, 55131 Mainz, Germany
    Carcinogenesis 24:63-73. 2003
    ..Co-exposure may cause genotoxic effects, even if the concentrations of individual heavy metals do not exceed TRK-values...
  28. ncbi request reprint Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars
    Thomas Schupp
    Elastogran, Department for Ecology and Product Safety, P O Box 1140, D 49440 Lemförde, Germany
    Toxicology 206:461-70. 2005
    ..With respect to STELIAs and extrapolated concentrations at 65 degrees C (14.7, 1.47 and 1.68 mg/m(3), for xylene, formaldehyde and acetaldehyde, respectively), however, a reduction of the concentration of formaldehyde may be necessary...
  29. ncbi request reprint Molecular modes of action of artesunate in tumor cell lines
    Thomas Efferth
    Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
    Mol Pharmacol 64:382-94. 2003
    ..ART acts via p53-dependent and- independent pathways in isogenic p53+/+ p21WAF1/CIP1+/+, p53-/- p21WAF1/CIP1+/+, and p53+/+ p21WAF1/CIP1-/- colon carcinoma cells...
  30. ncbi request reprint Mathematical modelling of liver regeneration after intoxication with CCl(4)
    Stefan Höhme
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Chem Biol Interact 168:74-93. 2007
    ....
  31. doi request reprint Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors
    Felix Glahn
    Institute of Environmental Toxicology, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
    Arch Toxicol 82:513-24. 2008
    ..This study gives an overview of the most responsive genes...
  32. ncbi request reprint Use of a standardised and validated long-term human hepatocyte culture system for repetitive analyses of drugs: repeated administrations of acetaminophen reduces albumin and urea secretion
    Anett Ullrich
    PRIMACYT Cell Culture Technology GmbH, FRG, Schwerin, Germany
    ALTEX 24:35-40. 2007
    ..This culture technique may help to overcome the sparse availability of human hepatocytes for testing drugmediated responses in man...
  33. ncbi request reprint Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity
    Helena Carmo
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Pharmacogenet Genomics 16:789-99. 2006
    ..Therefore, we tested whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibility to 3,4-methylenedioxymethamphetamine...
  34. ncbi request reprint Could treatment with neohepatocytes benefit patients with decompensated chronic liver disease?
    James A Hutchinson
    Am J Hematol 82:947-8. 2007
  35. ncbi request reprint Distribution of detoxifying genes polymorphism in Maharastrian population of central India
    Sivanesan Saravana Devi
    Environmental Biotechnology Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur, Maharashtra 440 020, India
    Chemosphere 70:1835-9. 2008
    ..The genotype frequencies GSTM1 and GSTT1 of the population when compared with other ethnic groups of Asia and Caucasians show distinct nature of Maharastrian population from other Asian and Caucasian population...
  36. ncbi request reprint Heavy metal status and oxidative stress in diesel engine tuning workers of central Indian population
    Sivanesan Saravana Devi
    Environmental Biotechnology Division, National Environmental Engineering Research Institute, Nagpur, India
    J Occup Environ Med 49:1228-34. 2007
    ..To assess the oxidative stress induced due to heavy metal exposure. Exposed populations are selected from an engine tuning station and control from the same area with no occupational exposure...
  37. ncbi request reprint Generation of human hepatocytes by stem cell technology: definition of the hepatocyte
    Jan G Hengstler
    University of Leipzig, Center for Toxicology, Institute of Legal Medicine and Rudolf Boehm Institute of Pharmacology and Toxicology, Haertelstr 16 18, 04107 Leipzig, Germany
    Expert Opin Drug Metab Toxicol 1:61-74. 2005
    ..Although the stem cell-derived-hepatocyte does not yet exist there is a good chance that this aim may be achieved in the future...
  38. ncbi request reprint Tumor cell specific toxicity of Inula helenium extracts
    David C Dorn
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Phytother Res 20:970-80. 2006
    ....
  39. ncbi request reprint Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue
    Walter Meinl
    Department of Toxicology, German Institute of Human Nutrition DIfE Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Int J Cancer 118:1090-7. 2006
    ..Finally, we discuss the possibility that reactive sulphuric acid conjugates produced in other tissues are transferred to kidney and ureter...
  40. ncbi request reprint Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobiles
    Thomas Schupp
    Elastogran, Department for Ecology and Product Safety, Lemförde, Germany
    Toxicol Lett 160:93-104. 2006
    ..A systematic toxicological evaluation of the risk associated with benzene exposure in cars seems to be necessary...
  41. doi request reprint The humoral immune system has a key prognostic impact in node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:5405-13. 2008
    ..83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast...
  42. doi request reprint Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?
    Mathias Gehrmann
    Siemens Medical Solutions Diagnostics GmbH, Leverkusen, Germany
    Pharmacogenomics 9:969-74. 2008
    ..In the future, studies with SNP chips and studies on the transcriptome, proteome and metabolome level should be performed in order to identify signatures differentiating between paclitaxel-sensitive and -resistant patients...
  43. ncbi request reprint A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage
    Marcel Osterod
    Institute of Pharmacy, University of Mainz, D 55099 Mainz, Germany
    Oncogene 21:8232-9. 2002
    ..The data indicate a role for Csb in the removal of 8-oxoG from the overall genome that is independent of both Ogg1-mediated base excision repair and regular transcription...