J G Hengstler
- Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspectiveHermann M Bolt
Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
Toxicol Lett 151:29-41. 2004..This should be changed, as the philosophy of separation of a strictly sequential "hazard assessment" and "risk assessment" appears out-of-date...
- Induction and control of oxidative stressJan G Hengstler
Leibniz Research Centre for Working Environment and Human Factors (IfADo, Ardeystrasse 67, 44139 Dortmund, Germany
Arch Toxicol 81:823-4. 2007
- Survival models with preclustered gene groups as covariatesKai Kammers
Department of Statistics, TU Dortmund University, Dortmund, Germany
BMC Bioinformatics 12:478. 2011..We apply preclustering to genes within GO groups according to the correlation of their gene expression measurements...
- Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse modelChristof Renner
Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
Mol Cancer 9:2. 2010..In the present work we investigated whether carnosine also affects tumor growth in vivo and may therefore be considered for human cancer therapy...
- Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancerCristina Cadenas
Department of Bioanalytics, Leibniz Institut für Analytische Wissenschaften ISAS e, V, Bunsen Kirchhoff Strasse 11, Dortmund, Germany
Breast Cancer Res 12:R44. 2010....
- Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genesBirte Hellwig
Department of Statistics, TU Dortmund University, 44221 Dortmund, Germany
BMC Bioinformatics 11:276. 2010..The kurtosis, e.g., measures divergence from a normal distribution. An alternative is the outlier-sum statistic that identifies genes with extremely high or low expression values in a subset of the samples...
- Critical evaluation of key evidence on the human health hazards of exposure to bisphenol AJ G Hengstler
Leibniz Research Centre for Working Environment and Human Factors IfADo, University of Dortmund, Dortmund, Germany
Crit Rev Toxicol 41:263-91. 2011....
- Primary rat hepatocytes as in vitro system for gene expression studies: comparison of sandwich, Matrigel and 2D culturesM Schug
Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse 67, 44139 Dortmund, Germany
Arch Toxicol 82:923-31. 2008..In conclusion, the presented data strongly suggest that sandwich cultures are most adequate for detection of MPy-induced gene expression alterations and the effect of MPy was detected at in vivo relevant concentrations...
- Tracking of human cells in miceWiebke Schormann
Leibniz Research Centre for Working Environment and Human Factors at the University of Dortmund IfADo, Ardeystrasse 67, 44139, Dortmund, Germany
Histochem Cell Biol 130:329-38. 2008..Additional procedures, such as ISH with alu-probes, are essential, when characterizing individual cells...
- Perfluorinated compounds (PFC) hit the headlines : meeting report on a satellite symposium of the annual meeting of the German Society of ToxicologyPeter H Roos
, Ardeystr. 67, 44139 Dortmund, Germany
Arch Toxicol 82:57-9. 2008
- Dexamethasone-dependent versus -independent markers of epithelial to mesenchymal transition in primary hepatocytesPatricio Godoy
Leibniz Research Center for Working Environment and Human Factors IfADo, Ardeystrasse 67, D 44139 Dortmund, Germany
Biol Chem 391:73-83. 2010..In conclusion, EMT markers in hepatocytes can be classified as dexamethasone-dependent versus -independent...
- Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposureKlaus Golka
Leibniz Research Centre for Working Environment and Human Factors IfADo, Ardeystrasse, Dortmund, Germany
Pharmacogenet Genomics 19:903-6. 2009..Therefore, the degree to which rs9642880[T] and GSTM1 0/0 confer susceptibility to urinary bladder cancer seems to depend on the extent of exposure to urinary bladder carcinogens...
- Fate of extrahepatic human stem and precursor cells after transplantation into mouse liversMarc Brulport
Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
Hepatology 46:861-70. 2007..CONCLUSION: We observed evidence not for transdifferentiation but instead for a complex situation including partial differentiation and possibly horizontal gene transfer...
- Predictive biomarkers and signatures in urinary bladder cancerPeter H Roos
Dortmund University, IfADo Leibniz Research Centre for Working Environment and Human Factors, Ardeystrasse 67, 44139 Dortmund, Germany
Curr Opin Mol Ther 10:243-50. 2008..In this review, developments in tumor-marker identification with a focus on bladder cancer are described...
- Developments in industrial and occupational toxicology: REACH, toxicogenomics, mycotoxins, lead, asbestos, boron, bitumen, deletions polymorphisms and SNP interactions: meeting report of the 16th EUROTOX training and discussion sessionGisela H Degen
Leibniz Research Centre for Working Environment and Human Factors (IfADo, , Ardeystrasse 67, 44139 Dortmund, Germany
Arch Toxicol 82:483-7. 2008
- Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by 31P NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholinesAlexander Bauer
Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
Chem Phys Lipids 159:21-9. 2009..It is concluded that LPC represents a useful biomarker of CCl(4)-mediated damaging of hepatocytes. It is also speculated that de novo biosynthesis of PC is influenced by CCl(4)...
- Micro-Raman detection of nuclear membrane lipid fluctuations in senescent epithelial breast cancer cellsMelissa M Mariani
ISAS Institute for Analytical Sciences, Bunsen Kirchhoff Strasse 11, 44139 Dortmund, Germany
Anal Chem 82:4259-63. 2010....
- Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P450 1A1Sabine Plottner
Leibniz Research Centre for Working Environment and Human Factors, Institut fur Arbeitsphysiologie an der Universitat Dortmund IfADo, Ardeystr 67, 44139 Dortmund, Germany
Arch Toxicol 83:131-8. 2009..In conclusion, we have identified two functionally distinct subpopulations of urinary bladder epithelial cells. It will be interesting to study whether the CYP1A inducible subtype is more susceptible to bladder carcinogens...
- Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix-mediated manipulation of signaling activitiesPatricio Godoy
Leibniz Research Centre for Working Environment and Human Factors IfADo, Dortmund, Germany
Methods Mol Biol 640:139-55. 2010..In this chapter we focus on mechanisms that influence apoptosis sensitivity in cultured mouse hepatocytes...
- Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse liversInes Aurich
1st Department of Medicine, Heinrich Damerow Strasse 1, Martin Luther University of Halle Wittenberg, D 06120 Halle Saale, Germany
Gut 56:405-15. 2007..Hence, novel cell sources are required to deliver hepatocytes of adequate quality for clinical use. Mesenchymal stem cells (MSCs) from human bone marrow may have the potential to differentiate into hepatocytes in vitro and in vivo...
- Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cellsMaren Ruhnke
Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany
Gastroenterology 128:1774-86. 2005....
- The humoral immune system has a key prognostic impact in node-negative breast cancerMarcus Schmidt
Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany
Cancer Res 68:5405-13. 2008..83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast...
- Maximum exposure levels for xylene, formaldehyde and acetaldehyde in carsThomas Schupp
Elastogran, Department for Ecology and Product Safety, P O Box 1140, D 49440 Lemförde, Germany
Toxicology 206:461-70. 2005..With respect to STELIAs and extrapolated concentrations at 65 degrees C (14.7, 1.47 and 1.68 mg/m(3), for xylene, formaldehyde and acetaldehyde, respectively), however, a reduction of the concentration of formaldehyde may be necessary...
- Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factorsFelix Glahn
Institute of Environmental Toxicology, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
Arch Toxicol 82:513-24. 2008..This study gives an overview of the most responsive genes...
- Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?Mathias Gehrmann
Siemens Medical Solutions Diagnostics GmbH, Leverkusen, Germany
Pharmacogenomics 9:969-74. 2008..In the future, studies with SNP chips and studies on the transcriptome, proteome and metabolome level should be performed in order to identify signatures differentiating between paclitaxel-sensitive and -resistant patients...
- Use of a standardised and validated long-term human hepatocyte culture system for repetitive analyses of drugs: repeated administrations of acetaminophen reduces albumin and urea secretionAnett Ullrich
PRIMACYT Cell Culture Technology GmbH, FRG, Schwerin, Germany
ALTEX 24:35-40. 2007..This culture technique may help to overcome the sparse availability of human hepatocytes for testing drugmediated responses in man...
- Heavy metal status and oxidative stress in diesel engine tuning workers of central Indian populationSivanesan Saravana Devi
Environmental Biotechnology Division, National Environmental Engineering Research Institute, Nagpur, India
J Occup Environ Med 49:1228-34. 2007..To assess the oxidative stress induced due to heavy metal exposure. Exposed populations are selected from an engine tuning station and control from the same area with no occupational exposure...
- Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expectedJan G Hengstler
Institute of Toxicology, Obere Zahlbacher Str 67, 55131 Mainz, Germany
Carcinogenesis 24:63-73. 2003..Co-exposure may cause genotoxic effects, even if the concentrations of individual heavy metals do not exceed TRK-values...
- No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRIIlka B Schiffer
Institute of Toxicology, University of Mainz, Mainz, Germany
Bioelectromagnetics 24:241-50. 2003..Care was taken to control secondary parameters of influence, such as vibration by the MR scanner or temperature to avoid false positive results...
- Molecular modes of action of artesunate in tumor cell linesThomas Efferth
Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
Mol Pharmacol 64:382-94. 2003..ART acts via p53-dependent and- independent pathways in isogenic p53+/+ p21WAF1/CIP1+/+, p53-/- p21WAF1/CIP1+/+, and p53+/+ p21WAF1/CIP1-/- colon carcinoma cells...
- SPOC1, a novel PHD-finger protein: association with residual disease and survival in ovarian cancerGerrit Mohrmann
Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
Int J Cancer 116:547-54. 2005..In conclusion, SPOC1 is a novel PHD-finger protein showing strong expression in spermatogonia and ovarian cancer cells. SPOC1 overexpression was associated with unresectable carcinomas and shorter survival in ovarian cancer...
- Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapyMaren Ruhnke
Department of General and Thoracic Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany
Transplantation 79:1097-103. 2005..These cells could thus be clinically applied in an autologous setting for the treatment of end-stage liver diseases or for improving liver function in patients who have undergone critical liver-mass resection...
- Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobilesThomas Schupp
Elastogran, Department for Ecology and Product Safety, Lemförde, Germany
Toxicol Lett 160:93-104. 2006..A systematic toxicological evaluation of the risk associated with benzene exposure in cars seems to be necessary...
- Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissueWalter Meinl
Department of Toxicology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany
Int J Cancer 118:1090-7. 2006..Finally, we discuss the possibility that reactive sulphuric acid conjugates produced in other tissues are transferred to kidney and ureter...
- Tumor cell specific toxicity of Inula helenium extractsDavid C Dorn
Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Phytother Res 20:970-80. 2006....
- Generation of human hepatocytes by stem cell technology: definition of the hepatocyteJan G Hengstler
University of Leipzig, Center for Toxicology, Institute of Legal Medicine and Rudolf Boehm Institute of Pharmacology and Toxicology, Haertelstr 16 18, 04107 Leipzig, Germany
Expert Opin Drug Metab Toxicol 1:61-74. 2005..Although the stem cell-derived-hepatocyte does not yet exist there is a good chance that this aim may be achieved in the future...
- Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicityHelena Carmo
REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
Pharmacogenet Genomics 16:789-99. 2006..Therefore, we tested whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibility to 3,4-methylenedioxymethamphetamine...
- Mathematical modelling of liver regeneration after intoxication with CCl(4)Stefan Höhme
Interdisciplinary Centre for Bioinformatics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
Chem Biol Interact 168:74-93. 2007....
- Could treatment with neohepatocytes benefit patients with decompensated chronic liver disease?James A Hutchinson
Am J Hematol 82:947-8. 2007
- Distribution of detoxifying genes polymorphism in Maharastrian population of central IndiaSivanesan Saravana Devi
Environmental Biotechnology Division, National Environmental Engineering Research Institute, Nehru Marg, Nagpur, Maharashtra 440 020, India
Chemosphere 70:1835-9. 2008..The genotype frequencies GSTM1 and GSTT1 of the population when compared with other ethnic groups of Asia and Caucasians show distinct nature of Maharastrian population from other Asian and Caucasian population...
- A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damageMarcel Osterod
Institute of Pharmacy, University of Mainz, D 55099 Mainz, Germany
Oncogene 21:8232-9. 2002..The data indicate a role for Csb in the removal of 8-oxoG from the overall genome that is independent of both Ogg1-mediated base excision repair and regular transcription...