Regine Hengge

Summary

Country: Germany

Publications

  1. ncbi request reprint Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli
    Harald Weber
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 62:1014-34. 2006
  2. ncbi request reprint The -35 sequence location and the Fis-sigma factor interface determine sigmas selectivity of the proP (P2) promoter in Escherichia coli
    Athanasios Typas
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 63:780-96. 2007
  3. ncbi request reprint Recent insights into the general stress response regulatory network in Escherichia coli
    Regine Hengge-Aronis
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Germany
    J Mol Microbiol Biotechnol 4:341-6. 2002
  4. ncbi request reprint The molecular basis of selective promoter activation by the sigmaS subunit of RNA polymerase
    Athanasios Typas
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 63:1296-306. 2007
  5. ncbi request reprint Cellular levels and activity of the flagellar sigma factor FliA of Escherichia coli are controlled by FlgM-modulated proteolysis
    Claudia Barembruch
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 65:76-89. 2007
  6. pmc Bacterial regulatory networks--from self-organizing molecules to cell shape and patterns in bacterial communities
    Regine Hengge
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Berlin, Germany
    EMBO Rep 14:667-9. 2013
  7. ncbi request reprint Interplay of global regulators and cell physiology in the general stress response of Escherichia coli
    R Hengge-Aronis
    Institute of Plant Physiology and Microbiology, Department of Biology, Free University of Berlin, Königin Luise Str 12 16a, 14195, Berlin, Germany
    Curr Opin Microbiol 2:148-52. 1999
  8. doi request reprint Cyclic-di-GMP reaches out into the bacterial RNA world
    Regine Hengge
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Sci Signal 3:pe44. 2010
  9. doi request reprint Principles of c-di-GMP signalling in bacteria
    Regine Hengge
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Nat Rev Microbiol 7:263-73. 2009
  10. doi request reprint The two-component network and the general stress sigma factor RpoS (sigma S) in Escherichia coli
    Regine Hengge
    Institut für Biologie Mikrobiologie, FB Biologie, Chemie und Pharmazie, Freie, Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Adv Exp Med Biol 631:40-53. 2008

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli
    Harald Weber
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 62:1014-34. 2006
    ....
  2. ncbi request reprint The -35 sequence location and the Fis-sigma factor interface determine sigmas selectivity of the proP (P2) promoter in Escherichia coli
    Athanasios Typas
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 63:780-96. 2007
    ....
  3. ncbi request reprint Recent insights into the general stress response regulatory network in Escherichia coli
    Regine Hengge-Aronis
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Germany
    J Mol Microbiol Biotechnol 4:341-6. 2002
    ....
  4. ncbi request reprint The molecular basis of selective promoter activation by the sigmaS subunit of RNA polymerase
    Athanasios Typas
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 63:1296-306. 2007
    ..Finally, these topics are discussed in the context of sigma factor evolution and the benefits a cell gains from retaining competing and closely related sigma factors with overlapping sets of target genes...
  5. ncbi request reprint Cellular levels and activity of the flagellar sigma factor FliA of Escherichia coli are controlled by FlgM-modulated proteolysis
    Claudia Barembruch
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 65:76-89. 2007
    ..Experiments with a lon mutant indicate that Lon protease and FliA degradation maintain appropriate FliA : FlgM stoichiometry upon induction of the flagellar system and thereby contribute to timely shut-off of this system...
  6. pmc Bacterial regulatory networks--from self-organizing molecules to cell shape and patterns in bacterial communities
    Regine Hengge
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Berlin, Germany
    EMBO Rep 14:667-9. 2013
    ..It brought together 164 molecular microbiologists, bacterial systems biologists and synthetic biologists to discuss the architecture, function and dynamics of regulatory networks in bacteria. ..
  7. ncbi request reprint Interplay of global regulators and cell physiology in the general stress response of Escherichia coli
    R Hengge-Aronis
    Institute of Plant Physiology and Microbiology, Department of Biology, Free University of Berlin, Königin Luise Str 12 16a, 14195, Berlin, Germany
    Curr Opin Microbiol 2:148-52. 1999
    ....
  8. doi request reprint Cyclic-di-GMP reaches out into the bacterial RNA world
    Regine Hengge
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Sci Signal 3:pe44. 2010
    ....
  9. doi request reprint Principles of c-di-GMP signalling in bacteria
    Regine Hengge
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Nat Rev Microbiol 7:263-73. 2009
    ..This Review focuses on emerging principles of c-di-GMP signalling using selected systems in different bacteria as examples...
  10. doi request reprint The two-component network and the general stress sigma factor RpoS (sigma S) in Escherichia coli
    Regine Hengge
    Institut für Biologie Mikrobiologie, FB Biologie, Chemie und Pharmazie, Freie, Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Adv Exp Med Biol 631:40-53. 2008
    ..These systems are involved in the control of motility, biofilm formation and/or virulence, suggesting that further studying a potential role of RpoS in these physiological functions may be rewarding...
  11. doi request reprint Proteolysis of sigmaS (RpoS) and the general stress response in Escherichia coli
    Regine Hengge
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Res Microbiol 160:667-76. 2009
    ..As sigma(S) has become a paradigm for regulated proteolysis in bacteria, this review summarizes our current knowledge about the molecular mechanisms and multiple signal integration in sigma(S) degradation...
  12. ncbi request reprint Proteolysis in prokaryotes: protein quality control and regulatory principles
    Regine Hengge
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 49:1451-62. 2003
  13. ncbi request reprint Stationary phase gene regulation: what makes an Escherichia coli promoter sigmaS-selective?
    Regine Hengge-Aronis
    Institute of Biology, Microbiology, Freie Universitat Berlin, Königin Luise Strasse12 16, Berlin, Germany
    Curr Opin Microbiol 5:591-5. 2002
    ..These results throw novel light on the details of transcription initiation, as well as on the co-evolution of sigma factors and their cognate promoter sequences...
  14. pmc Signal transduction and regulatory mechanisms involved in control of the sigma(S) (RpoS) subunit of RNA polymerase
    Regine Hengge-Aronis
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Microbiol Mol Biol Rev 66:373-95, table of contents. 2002
    ....
  15. doi request reprint Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli
    Nicole Sommerfeldt
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Microbiology 155:1318-31. 2009
    ..Finally, we discuss why other GGDEF/EAL domain-encoding genes, despite being expressed, do not influence motility and/or curli formation...
  16. pmc Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli
    Christina Pesavento
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Genes Dev 22:2434-46. 2008
    ..In summary, these data reveal the logic and sequence of molecular events underlying the motile-to-adhesive "lifestyle" switch in E. coli...
  17. pmc Targeting of csgD by the small regulatory RNA RprA links stationary phase, biofilm formation and cell envelope stress in Escherichia coli
    Franziska Mika
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 84:51-65. 2012
    ..Thus, antagonistic regulation of csgD and RprA at the mRNA level integrates cell envelope stress signals with global gene expression during stationary phase and biofilm formation...
  18. pmc A two-component phosphotransfer network involving ArcB, ArcA, and RssB coordinates synthesis and proteolysis of sigmaS (RpoS) in E. coli
    Franziska Mika
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Germany
    Genes Dev 19:2770-81. 2005
    ..Moreover, this induction is enhanced by a positive feedback that involves sigma(S)-dependent induction of ArcA, which further reduces sigma(S) proteolysis, probably by competing with RssB for residual phosphorylation by ArcB...
  19. pmc The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue-light response of Escherichia coli
    Natalia Tschowri
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Genes Dev 23:522-34. 2009
    ..In conclusion, this pathway may modulate biofilm formation via the two-component network when E. coli has to survive in an extrahost aquatic environment...
  20. pmc Stationary phase reorganisation of the Escherichia coli transcription machinery by Crl protein, a fine-tuner of sigmas activity and levels
    Athanasios Typas
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Berlin, Germany
    EMBO J 26:1569-78. 2007
    ..In conclusion, Crl has a key role in reorganising the Escherichia coli transcriptional machinery and global gene expression during entry into stationary phase...
  21. ncbi request reprint A role for Lon protease in the control of the acid resistance genes of Escherichia coli
    Johanna Heuveling
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 69:534-47. 2008
    ..e. at low pH or during entry into stationary phase). GadE degradation was found to rapidly terminate the acid resistance response upon shift back to neutral pH and to avoid overexpression of acid resistance genes in stationary phase...
  22. pmc The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control
    Sandra Lindenberg
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Berlin, Germany
    EMBO J 32:2001-14. 2013
    ..As a consequence, YdaM then generates c-di-GMP and-by direct and specific interaction-activates MlrA to stimulate csgD transcription. Trigger enzymes may represent a general principle in local c-di-GMP signalling...
  23. pmc Molecular function and potential evolution of the biofilm-modulating blue light-signalling pathway of Escherichia coli
    Natalia Tschowri
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 85:893-906. 2012
    ..Altogether, we propose that BluF evolved from a blue light-regulated PDE into a specific antagonist of a duplicate of MlrA that became BluR, which controls not only curli but various biofilm functions via the Ymg/Rcs pathway...
  24. ncbi request reprint Dynamic control of Dps protein levels by ClpXP and ClpAP proteases in Escherichia coli
    Kunigunde Stephani
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 49:1605-14. 2003
    ..In summary, both ClpXP and ClpAP exert significant control of Dps levels by affecting log phase stability and stationary phase synthesis of Dps respectively...
  25. ncbi request reprint The sigmaS subunit of RNA polymerase as a signal integrator and network master regulator in the general stress response in Escherichia coli
    Eberhard Klauck
    Freie Universitat Berlin, Germany
    Sci Prog 90:103-27. 2007
    ....
  26. pmc The global repressor FliZ antagonizes gene expression by σS-containing RNA polymerase due to overlapping DNA binding specificity
    Christina Pesavento
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Königin Luise Strasse 12 16, 14195 Berlin, Germany
    Nucleic Acids Res 40:4783-93. 2012
    ....
  27. ncbi request reprint Differential ability of sigma(s) and sigma70 of Escherichia coli to utilize promoters containing half or full UP-element sites
    Athanasios Typas
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 55:250-60. 2005
    ..Finally, experiments using single amino acid substitutions of sigma(s) indicate that the foundation for this preference lies in an inability of sigma(s) to interact with the a subunit C-terminal domain...
  28. pmc Sequential recognition of two distinct sites in sigma(S) by the proteolytic targeting factor RssB and ClpX
    Andrea Stüdemann
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, D 14195 Berlin, Germany
    EMBO J 22:4111-20. 2003
    ..Our data indicate that RssB plays a second role in the initiation of sigma(S) proteolysis that goes beyond targeting of sigma(S) to ClpX, and suggest a model for the sequence of events in the initiation of sigma(S) proteolysis...
  29. doi request reprint Cellulose as an architectural element in spatially structured Escherichia coli biofilms
    Diego O Serra
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Berlin, Germany
    J Bacteriol 195:5540-54. 2013
    ..These studies now set the stage for clarifying how regulatory networks and in particular c-di-GMP signaling operate in the three-dimensional space of highly structured and "tissue-like" bacterial biofilms. ..
  30. ncbi request reprint Role of the spacer between the -35 and -10 regions in sigmas promoter selectivity in Escherichia coli
    Athanasios Typas
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16, 14195 Berlin, Germany
    Mol Microbiol 59:1037-51. 2006
    ..Based on mutational analysis of sigma(s), we suggest a role of regions 2.5 and 4 of sigma(s) in sensing sub-optimally located -35 elements...
  31. ncbi request reprint Multiple stress signal integration in the regulation of the complex sigma S-dependent csiD-ygaF-gabDTP operon in Escherichia coli
    Martin Metzner
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    Mol Microbiol 51:799-811. 2004
    ....
  32. pmc Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity
    Harald Weber
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Königin Luise Str 12 16a, 14195 Berlin, Germany
    J Bacteriol 187:1591-603. 2005
    ..Thus, not only the expression of genes within a regulatory network but also the architecture of the network itself can be subject to regulation...
  33. pmc Microanatomy at cellular resolution and spatial order of physiological differentiation in a bacterial biofilm
    Diego O Serra
    Institut fur Biologie, Mikrobiologie, Freie Universitat Berlin, Berlin, Germany
    MBio 4:e00103-13. 2013
    ....
  34. doi request reprint Rare codons play a positive role in the expression of the stationary phase sigma factor RpoS (σ(S)) in Escherichia coli
    Tim Kolmsee
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Berlin, Germany
    RNA Biol 8:913-21. 2011
    ....
  35. doi request reprint 'Life-style' control networks in Escherichia coli: signaling by the second messenger c-di-GMP
    Tatyana L Povolotsky
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Berlin, Germany
    J Biotechnol 160:10-6. 2012
    ....
  36. doi request reprint Bacterial nucleotide-based second messengers
    Christina Pesavento
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Germany
    Curr Opin Microbiol 12:170-6. 2009
    ..Moreover, recent advances in c-di-GMP-mediated signaling will be presented and the integration of c-di-GMP signaling with other nucleotide-based signaling systems will be discussed...
  37. pmc Small Regulatory RNAs in the Control of Motility and Biofilm Formation in E. coli and Salmonella
    Franziska Mika
    Institut für Biologie Mikrobiologie, Freie Universitat Berlin, Berlin 14195, Germany
    Int J Mol Sci 14:4560-79. 2013
    ....
  38. ncbi request reprint Poly(A)-polymerase I links transcription with mRNA degradation via sigmaS proteolysis
    Jorge M Santos
    Instituto de Tecnologia Química e Biológica ITQB, Universidade Nova de Lisboa, Apt 127, 2781 901 Oeiras, Portugal
    Mol Microbiol 60:177-88. 2006
    ..PAPI could work as a linker between transcription and mRNA degradation with the ultimate goal of adapting and surviving to growth-limiting conditions...
  39. ncbi request reprint Region 2.1 of the Escherichia coli heat-shock sigma factor RpoH (sigma32) is necessary but not sufficient for degradation by the FtsH protease
    Markus Obrist
    Institute of Microbiology, ETH Zurich, Switzerland
    Microbiology 153:2560-71. 2007
    ..The in vivo stability of the mutated RpoH proteins correlated with their stability in a purified in vitro degradation system, suggesting that region 2.1 might be directly involved in the interaction with the FtsH protease...