Klaus Schughart

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. ncbi Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection
    Leonie Dengler
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Virol J 9:212. 2012
  2. ncbi Bioinformatics tools and database resources for systems genetics analysis in mice--a short review and an evaluation of future needs
    Caroline Durrant
    University of Oxford
    Brief Bioinform 13:135-42. 2012
  3. ncbi Sustained viral load and late death in Rag2-/- mice after influenza A virus infection
    Haiya Wu
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Virol J 7:172. 2010
  4. ncbi Dynamic gene network reconstruction from gene expression data in mice after influenza A (H1N1) infection
    Konstantina Dimitrakopoulou
    School of Medicine, University of Patras, Patras 26500, Greece
    J Clin Bioinforma 1:27. 2011
  5. ncbi XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments
    Morris A Swertz
    Genomics Coordination Center, Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Genome Biol 11:R27. 2010
  6. ncbi Data-driven assessment of eQTL mapping methods
    Jacob J Michaelson
    Cellular Networks and Systems Biology, Biotechnology Center TU Dresden, Dresden, Germany
    BMC Genomics 11:502. 2010
  7. ncbi SYSGENET: a meeting report from a new European network for systems genetics
    Klaus Schughart
    Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Mamm Genome 21:331-6. 2010
  8. ncbi Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factors
    Paulina Blazejewska
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    Virology 412:36-45. 2011
  9. ncbi Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures
    Rudi Alberts
    Department of Infection Genetics, University of Veterinary Medicine Hannover, Inhoffenstr, Braunschweig, Germany
    Respir Res 12:61. 2011
  10. ncbi Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease
    Rudi Alberts
    Department of Infection Genetics, University of Veterinary Medicine Hannover, Braunschweig, Germany
    BMC Genomics 12:610. 2011

Collaborators

Detail Information

Publications17

  1. ncbi Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection
    Leonie Dengler
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Virol J 9:212. 2012
    ..In particular, DBA/2J mice are highly susceptible to several influenza A subtypes, including human isolates and exhibit severe symptoms after infection with clinical isolates...
  2. ncbi Bioinformatics tools and database resources for systems genetics analysis in mice--a short review and an evaluation of future needs
    Caroline Durrant
    University of Oxford
    Brief Bioinform 13:135-42. 2012
    ..Furthermore, the working group recommended that all data models and software source code should be made visible in public repositories to allow a coordinated effort on the use of common data structures and file formats...
  3. ncbi Sustained viral load and late death in Rag2-/- mice after influenza A virus infection
    Haiya Wu
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Virol J 7:172. 2010
    ..Furthermore, they did not recruit virus-specific lymphocytes into the lung in the later stages after infection and exhibited sustained pulmonary lesions...
  4. ncbi Dynamic gene network reconstruction from gene expression data in mice after influenza A (H1N1) infection
    Konstantina Dimitrakopoulou
    School of Medicine, University of Patras, Patras 26500, Greece
    J Clin Bioinforma 1:27. 2011
    ..abstract:..
  5. ncbi XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments
    Morris A Swertz
    Genomics Coordination Center, Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Genome Biol 11:R27. 2010
    ..Current functionality includes tools ranging from eQTL analysis in mouse to genome-wide association studies in humans...
  6. ncbi Data-driven assessment of eQTL mapping methods
    Jacob J Michaelson
    Cellular Networks and Systems Biology, Biotechnology Center TU Dresden, Dresden, Germany
    BMC Genomics 11:502. 2010
    ..Often these methods are inappropriate for complex traits such as gene expression, particularly in the case of epistasis...
  7. ncbi SYSGENET: a meeting report from a new European network for systems genetics
    Klaus Schughart
    Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Mamm Genome 21:331-6. 2010
    ..In addition, the future of GRP resources and phenotyping in Europe was discussed...
  8. ncbi Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factors
    Paulina Blazejewska
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    Virology 412:36-45. 2011
    ..Infection of C57BL/6J mice with a re-assorted PR8 virus revealed that the HA gene is the main determinant of virulence of the PR8F variant...
  9. ncbi Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures
    Rudi Alberts
    Department of Infection Genetics, University of Veterinary Medicine Hannover, Inhoffenstr, Braunschweig, Germany
    Respir Res 12:61. 2011
    ....
  10. ncbi Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease
    Rudi Alberts
    Department of Infection Genetics, University of Veterinary Medicine Hannover, Braunschweig, Germany
    BMC Genomics 12:610. 2011
    ....
  11. ncbi Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection
    Mahmoud M Bahgat
    Department of Infection Genetics and University of Veterinary Medicine Hannover, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Virol J 8:27. 2011
    ..Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice...
  12. ncbi Host genetic background strongly influences the response to influenza a virus infections
    Barkha Srivastava
    Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    PLoS ONE 4:e4857. 2009
    ..The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses...
  13. ncbi 6th annual meeting of the Complex Trait Consortium
    Klaus Schughart
    Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr. 7, D-38124, Braunschweig, Germany
    Mamm Genome 18:683-5. 2007
  14. ncbi QTLminer: identifying genes regulating quantitative traits
    Rudi Alberts
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    BMC Bioinformatics 11:516. 2010
    ..To find the most promising candidate genes that regulate the trait, the biologist typically collects information from multiple resources about the genes in the QTL interval. This process is very laborious and time consuming...
  15. ncbi Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection
    Rudi Alberts
    Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Microbes Infect 12:309-18. 2010
    ..Thus, susceptible DBA/2J mice showed a hyper-inflammatory response. This response is similar to infections with highly pathogenic influenza virus and may serve as a paradigm for a hyper-inflammatory host response to influenza A virus...
  16. ncbi Maintaining your immune system--one method for enhanced longevity
    Evi Wollscheid-Lengeling
    German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Sci Aging Knowledge Environ 2004:pe2. 2004
    ..Whether certain immune parameters vary with increased age is influenced by the genotype and lifestyle of the individual...
  17. ncbi Use of adenovirus vectors for functional gene analysis in the chicken chorioallantoic membrane
    Klaus Schughart
    GBF, German Research Center for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Biotechniques 34:178-83. 2003
    ..This improved method saves a considerable amount of time in the identification of genes that can influence blood vessel formation because the expensive and time-consuming production and purification of recombinant protein can be omitted...