Klaus Schughart

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. pmc Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses
    Claudia Pommerenke
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    PLoS ONE 7:e41169. 2012
  2. pmc Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice
    Bastian Hatesuer
    Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 9:e1003774. 2013
  3. pmc Bioinformatics tools and database resources for systems genetics analysis in mice--a short review and an evaluation of future needs
    Caroline Durrant
    University of Oxford
    Brief Bioinform 13:135-42. 2012
  4. pmc Dynamic gene network reconstruction from gene expression data in mice after influenza A (H1N1) infection
    Konstantina Dimitrakopoulou
    School of Medicine, University of Patras, Patras 26500, Greece
    J Clin Bioinforma 1:27. 2011
  5. pmc XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments
    Morris A Swertz
    Genomics Coordination Center, Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Genome Biol 11:R27. 2010
  6. pmc Data-driven assessment of eQTL mapping methods
    Jacob J Michaelson
    Cellular Networks and Systems Biology, Biotechnology Center TU Dresden, Dresden, Germany
    BMC Genomics 11:502. 2010
  7. pmc SYSGENET: a meeting report from a new European network for systems genetics
    Klaus Schughart
    Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Mamm Genome 21:331-6. 2010
  8. pmc Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner
    Tatiana Nedelko
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, 38124, Braunschweig, Germany
    BMC Genomics 13:411. 2012
  9. pmc Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease
    Rudi Alberts
    Department of Infection Genetics, University of Veterinary Medicine Hannover, Braunschweig, Germany
    BMC Genomics 12:610. 2011
  10. pmc Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures
    Rudi Alberts
    Department of Infection Genetics, University of Veterinary Medicine Hannover, Inhoffenstr, Braunschweig, Germany
    Respir Res 12:61. 2011

Collaborators

Detail Information

Publications23

  1. pmc Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses
    Claudia Pommerenke
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    PLoS ONE 7:e41169. 2012
    ..In conclusion, our comprehensive gene expression study describes for the first time the entire host response and its kinetics to an acute influenza A infection at the transcriptome level...
  2. pmc Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice
    Bastian Hatesuer
    Department of Infection Genetics, Helmholtz Centre for Infection Research, University of Veterinary Medicine Hannover, Braunschweig, Germany, and University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 9:e1003774. 2013
    ..In conclusion, these results identify TMPRSS2 as a host cell factor essential for viral spread and pathogenesis of mono-basic H1N1 and H3N2 influenza A viruses. ..
  3. pmc Bioinformatics tools and database resources for systems genetics analysis in mice--a short review and an evaluation of future needs
    Caroline Durrant
    University of Oxford
    Brief Bioinform 13:135-42. 2012
    ..Furthermore, the working group recommended that all data models and software source code should be made visible in public repositories to allow a coordinated effort on the use of common data structures and file formats...
  4. pmc Dynamic gene network reconstruction from gene expression data in mice after influenza A (H1N1) infection
    Konstantina Dimitrakopoulou
    School of Medicine, University of Patras, Patras 26500, Greece
    J Clin Bioinforma 1:27. 2011
    ..abstract:..
  5. pmc XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments
    Morris A Swertz
    Genomics Coordination Center, Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Genome Biol 11:R27. 2010
    ..Current functionality includes tools ranging from eQTL analysis in mouse to genome-wide association studies in humans...
  6. pmc Data-driven assessment of eQTL mapping methods
    Jacob J Michaelson
    Cellular Networks and Systems Biology, Biotechnology Center TU Dresden, Dresden, Germany
    BMC Genomics 11:502. 2010
    ..Often these methods are inappropriate for complex traits such as gene expression, particularly in the case of epistasis...
  7. pmc SYSGENET: a meeting report from a new European network for systems genetics
    Klaus Schughart
    Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Mamm Genome 21:331-6. 2010
    ..In addition, the future of GRP resources and phenotyping in Europe was discussed...
  8. pmc Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner
    Tatiana Nedelko
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, 38124, Braunschweig, Germany
    BMC Genomics 13:411. 2012
    ..In particular, C57BL/6J, the most widely used mouse strain in biomedical research, is comparatively resistant. In contrast, DBA/2J is highly susceptible...
  9. pmc Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease
    Rudi Alberts
    Department of Infection Genetics, University of Veterinary Medicine Hannover, Braunschweig, Germany
    BMC Genomics 12:610. 2011
    ....
  10. pmc Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures
    Rudi Alberts
    Department of Infection Genetics, University of Veterinary Medicine Hannover, Inhoffenstr, Braunschweig, Germany
    Respir Res 12:61. 2011
    ....
  11. pmc Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection
    Mahmoud M Bahgat
    Department of Infection Genetics and University of Veterinary Medicine Hannover, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Virol J 8:27. 2011
    ..Therefore, we studied the activity and expression of serine proteases in lungs from mice infected with influenza and evaluated the effect of serine protease inhibitors on virus replication both in cell culture and in infected mice...
  12. doi request reprint Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factors
    Paulina Blazejewska
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    Virology 412:36-45. 2011
    ..Infection of C57BL/6J mice with a re-assorted PR8 virus revealed that the HA gene is the main determinant of virulence of the PR8F variant...
  13. doi request reprint Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection
    Rudi Alberts
    Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Microbes Infect 12:309-18. 2010
    ..Thus, susceptible DBA/2J mice showed a hyper-inflammatory response. This response is similar to infections with highly pathogenic influenza virus and may serve as a paradigm for a hyper-inflammatory host response to influenza A virus...
  14. pmc PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells
    Feng He
    Department of Infection Genetics, Helmholtz Centre for Infection Research HZI, University of Veterinary Medicine Hannover, Braunschweig, Germany
    Mol Syst Biol 8:624. 2012
    ..Our study demonstrates the potential for identifying novel key genes for complex dynamic biological processes using a network strategy based on HTR data, and reveals a critical role for PLAU in Treg suppressor function...
  15. pmc Sustained viral load and late death in Rag2-/- mice after influenza A virus infection
    Haiya Wu
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Virol J 7:172. 2010
    ..Furthermore, they did not recruit virus-specific lymphocytes into the lung in the later stages after infection and exhibited sustained pulmonary lesions...
  16. pmc Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection
    Leonie Dengler
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Virol J 9:212. 2012
    ..In particular, DBA/2J mice are highly susceptible to several influenza A subtypes, including human isolates and exhibit severe symptoms after infection with clinical isolates...
  17. pmc Influence of internalin A murinisation on host resistance to orally acquired listeriosis in mice
    Silke Bergmann
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig D 38124, Germany
    BMC Microbiol 13:90. 2013
    ..In the present study, we have used bioluminescent murinised and non-murinised Listeria strains to examine the spatiotemporal dissemination of Listeria in four diverse mouse genetic backgrounds after oral inoculation...
  18. pmc 6th annual meeting of the Complex Trait Consortium
    Klaus Schughart
    Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr 7, D 38124, Braunschweig, Germany
    Mamm Genome 18:683-5. 2007
  19. doi request reprint Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy
    Marion Bankstahl
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany
    Behav Brain Res 230:182-91. 2012
    ....
  20. pmc Host genetic background strongly influences the response to influenza a virus infections
    Barkha Srivastava
    Department of Experimental Mouse Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    PLoS ONE 4:e4857. 2009
    ..The overall response in highly susceptible DBA/2J mice resembled the pathology described for infections with the highly virulent influenza H1N1-1918 and newly emerged H5N1 viruses...
  21. pmc QTLminer: identifying genes regulating quantitative traits
    Rudi Alberts
    Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany
    BMC Bioinformatics 11:516. 2010
    ..To find the most promising candidate genes that regulate the trait, the biologist typically collects information from multiple resources about the genes in the QTL interval. This process is very laborious and time consuming...
  22. ncbi request reprint Maintaining your immune system--one method for enhanced longevity
    Evi Wollscheid-Lengeling
    German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Sci Aging Knowledge Environ 2004:pe2. 2004
    ..Whether certain immune parameters vary with increased age is influenced by the genotype and lifestyle of the individual...
  23. ncbi request reprint Use of adenovirus vectors for functional gene analysis in the chicken chorioallantoic membrane
    Klaus Schughart
    GBF, German Research Center for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Biotechniques 34:178-83. 2003
    ..This improved method saves a considerable amount of time in the identification of genes that can influence blood vessel formation because the expensive and time-consuming production and purification of recombinant protein can be omitted...