Holger Loessner

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. ncbi request reprint Differential effect of auxotrophies on the release of macromolecules by Salmonella enterica vaccine strains
    Holger Loessner
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    FEMS Microbiol Lett 265:81-8. 2006
  2. ncbi request reprint Remote control of tumour-targeted Salmonella enterica serovar Typhimurium by the use of L-arabinose as inducer of bacterial gene expression in vivo
    Holger Loessner
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Cell Microbiol 9:1529-37. 2007
  3. doi request reprint Drug-inducible remote control of gene expression by probiotic Escherichia coli Nissle 1917 in intestine, tumor and gall bladder of mice
    Holger Loessner
    Molecular Immunology, Helmholtz Centre for Infection Research, HZI, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Microbes Infect 11:1097-105. 2009
  4. ncbi request reprint Improving live attenuated bacterial carriers for vaccination and therapy
    Holger Loessner
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Int J Med Microbiol 298:21-6. 2008
  5. doi request reprint Biofilm formation by Salmonella enterica serovar Typhimurium colonizing solid tumours
    Katja Crull
    Molecular Immunology, HZI Helmholtz Centre for Infection Research, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Cell Microbiol 13:1223-33. 2011
  6. doi request reprint Biofilm formation by Pseudomonas aeruginosa in solid murine tumors - a novel model system
    Uliana Komor
    Molecular Immunology, Helmholtz Center for Infection Research, Inhoffenstrasse 7, Braunschweig 38124, Germany
    Microbes Infect 14:951-8. 2012
  7. pmc Identification of tumor-specific Salmonella Typhimurium promoters and their regulatory logic
    Sara Leschner
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124 Braunschweig, Germany
    Nucleic Acids Res 40:2984-94. 2012
  8. doi request reprint Containment of tumor-colonizing bacteria by host neutrophils
    Kathrin Westphal
    Molecular Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany
    Cancer Res 68:2952-60. 2008
  9. pmc Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha
    Sara Leschner
    Molecular Immunology, HZI Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 4:e6692. 2009

Detail Information

Publications9

  1. ncbi request reprint Differential effect of auxotrophies on the release of macromolecules by Salmonella enterica vaccine strains
    Holger Loessner
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    FEMS Microbiol Lett 265:81-8. 2006
    ..Thus, the release of macromolecules from the bacterial carrier occurs as a consequence of appropriate lethal attenuation. This might substitute for sophisticated secretion systems...
  2. ncbi request reprint Remote control of tumour-targeted Salmonella enterica serovar Typhimurium by the use of L-arabinose as inducer of bacterial gene expression in vivo
    Holger Loessner
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Cell Microbiol 9:1529-37. 2007
    ..The possibility to deliberately induce genes in bacterial carriers within the host should render them extremely powerful tools for tumour therapy...
  3. doi request reprint Drug-inducible remote control of gene expression by probiotic Escherichia coli Nissle 1917 in intestine, tumor and gall bladder of mice
    Holger Loessner
    Molecular Immunology, Helmholtz Centre for Infection Research, HZI, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Microbes Infect 11:1097-105. 2009
    ..Importantly, we also observed colonization of gall bladders of mice when EcN was administered systemically at high doses. Bacteria in this anatomical compartment remained accessible to remote control of bacterial gene expression...
  4. ncbi request reprint Improving live attenuated bacterial carriers for vaccination and therapy
    Holger Loessner
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Int J Med Microbiol 298:21-6. 2008
    ..No background activity could be observed with P(BAD) such that an inducible suicide gene could be introduced. This is adding an important safety feature to such live attenuated carrier bacteria...
  5. doi request reprint Biofilm formation by Salmonella enterica serovar Typhimurium colonizing solid tumours
    Katja Crull
    Molecular Immunology, HZI Helmholtz Centre for Infection Research, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Cell Microbiol 13:1223-33. 2011
    ..Thus, tumour colonizing S. typhimurium might form biofilms as protection against phagocytosis. Since other bacteria are behaving similarly, solid murine tumours might represent a unique model to study biofilm formation in vivo...
  6. doi request reprint Biofilm formation by Pseudomonas aeruginosa in solid murine tumors - a novel model system
    Uliana Komor
    Molecular Immunology, Helmholtz Center for Infection Research, Inhoffenstrasse 7, Braunschweig 38124, Germany
    Microbes Infect 14:951-8. 2012
    ....
  7. pmc Identification of tumor-specific Salmonella Typhimurium promoters and their regulatory logic
    Sara Leschner
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124 Braunschweig, Germany
    Nucleic Acids Res 40:2984-94. 2012
    ..Now, such tumor-specific promoters can be used to safely express therapeutic proteins by tumor-colonizing S. Typhimurium directly in the neoplasia...
  8. doi request reprint Containment of tumor-colonizing bacteria by host neutrophils
    Kathrin Westphal
    Molecular Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany
    Cancer Res 68:2952-60. 2008
    ..Thus, bacteria-mediated tumor therapy can be amplified by depletion of host neutrophils...
  9. pmc Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha
    Sara Leschner
    Molecular Immunology, HZI Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 4:e6692. 2009
    ..How they efficiently find and invade the tumors is still unclear. However, this is an important issue to be clarified when bacteria should be tailored for application in cancer therapy...