Affiliation: Helmholtz Centre for Infection Research
- Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?Jochen Huehn
Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
Nat Rev Immunol 9:83-9. 2009....
- Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymusAras Toker
Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
J Immunol 190:3180-8. 2013..Together, our results demonstrate that initiating TSDR demethylation during early stages of thymic Treg development commences stabilization of Foxp3 expression and guarantees full functionality and long-term lineage stability of Tregs...
- IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factorMarc Schuster
Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
Immunity 37:998-1008. 2012..Our results demonstrate that IκB(NS) critically regulates Treg cell development in the thymus and during gut inflammation, indicating that strategies targeting IκB(NS) could modulate the Treg cell compartment...
- To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanismsAras Toker
Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
Sci Signal 4:pe4. 2011....
- Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cellsJulia K Polansky
Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
J Mol Med (Berl) 88:1029-40. 2010..We therefore propose that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage...