Jochen Huehn

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. pmc Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    Julia K Polansky
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
    J Mol Med (Berl) 88:1029-40. 2010
  2. pmc The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling
    Lisa Schreiber
    Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 9:e88318. 2014
  3. doi request reprint Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    Jochen Huehn
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nat Rev Immunol 9:83-9. 2009
  4. doi request reprint Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    Aras Toker
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3180-8. 2013
  5. ncbi request reprint Induced and thymus-derived Foxp3(+) regulatory T cells share a common niche
    Yi Ju Huang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 44:460-8. 2014
  6. doi request reprint IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
    Marc Schuster
    Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
    Immunity 37:998-1008. 2012
  7. doi request reprint To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
    Aras Toker
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Sci Signal 4:pe4. 2011
  8. pmc First insight into the kinome of human regulatory T cells
    Sebastian König
    Department of Molecular Structural Biology, Helmholtz Zentrum für Infektionsforschung, Braunschweig, Germany
    PLoS ONE 7:e40896. 2012

Collaborators

  • Ingo Schmitz
  • Immo Prinz
  • Burkhart Schraven
  • Jorn Walter
  • Shohei Hori
  • Karsten Kretschmer
  • Siegfried Weiss
  • Stefan Floess
  • Lisa Schreiber
  • Aras Toker
  • Julia K Polansky
  • Yi Ju Huang
  • Lothar Jänsch
  • Sebastian König
  • Marc Schuster
  • Alf Hamann
  • Verena Haist
  • Sebastian Suerbaum
  • Wolfgang Baumgartner
  • Carla Farah
  • Beate Pietzsch
  • Lisa Föhse
  • Robert Geffers
  • Garima Garg
  • Dirk Engelbert
  • Takahisa Miyao
  • Sonja Schallenberg
  • Sven Olek
  • Pascal Giehr
  • Sandra Düber
  • Udo Baron
  • Tobias Reinl
  • Klaus Schulze-Osthoff
  • Linda K Clayton
  • Andreas Jeron
  • Tim Sparwasser
  • Rainer Glauben
  • Michaela Annemann
  • Anja A Kuhl
  • Britta Siegmund
  • Klaus Pfeffer
  • Michael Probst-Kepper
  • Carlos Plaza-Sirvent
  • Leif Ludwig
  • Melanie Krüger
  • Christoph Thelemann
  • Sascha Cording
  • Ria Baumgrass

Detail Information

Publications8

  1. pmc Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    Julia K Polansky
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
    J Mol Med (Berl) 88:1029-40. 2010
    ..We therefore propose that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage...
  2. pmc The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling
    Lisa Schreiber
    Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 9:e88318. 2014
    ..In conclusion, we show that NF-κB signaling is not substantially involved in TSDR-mediated stabilization of Foxp3 expression in Tregs. ..
  3. doi request reprint Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    Jochen Huehn
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nat Rev Immunol 9:83-9. 2009
    ....
  4. doi request reprint Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    Aras Toker
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3180-8. 2013
    ..Together, our results demonstrate that initiating TSDR demethylation during early stages of thymic Treg development commences stabilization of Foxp3 expression and guarantees full functionality and long-term lineage stability of Tregs...
  5. ncbi request reprint Induced and thymus-derived Foxp3(+) regulatory T cells share a common niche
    Yi Ju Huang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 44:460-8. 2014
    ..However, when transferred together Nrp1(+) tTreg cells outcompeted Nrp1(-) iTreg cells and dominated the Treg-cell compartment. Taken together, our data suggest that tTreg cells and iTreg cells share a common peripheral niche. ..
  6. doi request reprint IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
    Marc Schuster
    Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
    Immunity 37:998-1008. 2012
    ..Our results demonstrate that IκB(NS) critically regulates Treg cell development in the thymus and during gut inflammation, indicating that strategies targeting IκB(NS) could modulate the Treg cell compartment...
  7. doi request reprint To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
    Aras Toker
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Sci Signal 4:pe4. 2011
    ....
  8. pmc First insight into the kinome of human regulatory T cells
    Sebastian König
    Department of Molecular Structural Biology, Helmholtz Zentrum für Infektionsforschung, Braunschweig, Germany
    PLoS ONE 7:e40896. 2012
    ....