Jochen Huehn

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. doi request reprint Epigenetic and transcriptional control of Foxp3+ regulatory T cells
    Jochen Huehn
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124 Braunschweig, Germany Electronic address
    Semin Immunol 27:10-8. 2015
  2. doi request reprint Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    Jochen Huehn
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nat Rev Immunol 9:83-9. 2009
  3. doi request reprint Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    Aras Toker
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3180-8. 2013
  4. doi request reprint Induced and thymus-derived Foxp3⁺ regulatory T cells share a common niche
    Yi Ju Huang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 44:460-8. 2014
  5. doi request reprint Foxp3+ regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen
    Pedro Milanez-Almeida
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 45:153-66. 2015
  6. pmc The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling
    Lisa Schreiber
    Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 9:e88318. 2014
  7. pmc Development of a unique epigenetic signature during in vivo Th17 differentiation
    Bi Huei Yang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nucleic Acids Res 43:1537-48. 2015
  8. doi request reprint To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
    Aras Toker
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Sci Signal 4:pe4. 2011
  9. doi request reprint IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
    Marc Schuster
    Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
    Immunity 37:998-1008. 2012
  10. pmc Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    Julia K Polansky
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
    J Mol Med (Berl) 88:1029-40. 2010

Collaborators

  • Michael Meyer-Hermann
  • Ingo Schmitz
  • Eva Medina
  • Andreas Beineke
  • Igor V Deyneko
  • Marc Beyer
  • Immo Prinz
  • Jorn Walter
  • Burkhart Schraven
  • Karsten Kretschmer
  • Siegfried Weiss
  • Shohei Hori
  • Stefan Floess
  • Aras Toker
  • Lisa Schreiber
  • Sahamoddin Khailaie
  • Tim Sparwasser
  • Julia K Polansky
  • Christina Tebartz
  • Bi Huei Yang
  • Pedro Milanez-Almeida
  • Yi Ju Huang
  • Lothar Jänsch
  • Marc Schuster
  • Sebastian König
  • Alf Hamann
  • Joern Pezoldt
  • Sarah Anita Horst
  • Lothar Groebe
  • Matthias Lochner
  • Georg Peters
  • Stefanie Hagemann
  • Wolfgang Baumgartner
  • Beate Pietzsch
  • Lisa Föhse
  • Sebastian Suerbaum
  • Philippe A Robert
  • Carla Farah
  • Verena Haist
  • Sven Olek
  • Sonja Schallenberg
  • Dirk Engelbert
  • Takahisa Miyao
  • Robert Geffers
  • Udo Baron
  • Garima Garg
  • Pascal Giehr
  • Sandra Düber
  • Klaus Schulze-Osthoff
  • Anja A Kuhl
  • Michaela Annemann
  • Britta Siegmund
  • Michael Probst-Kepper
  • Andreas Jeron
  • Carlos Plaza-Sirvent
  • Linda K Clayton
  • Klaus Pfeffer
  • Rainer Glauben
  • Tobias Reinl
  • Sascha Cording
  • Ria Baumgrass
  • Christoph Thelemann
  • Leif Ludwig
  • Melanie Krüger

Detail Information

Publications13

  1. doi request reprint Epigenetic and transcriptional control of Foxp3+ regulatory T cells
    Jochen Huehn
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124 Braunschweig, Germany Electronic address
    Semin Immunol 27:10-8. 2015
    ....
  2. doi request reprint Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    Jochen Huehn
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nat Rev Immunol 9:83-9. 2009
    ....
  3. doi request reprint Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    Aras Toker
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3180-8. 2013
    ..Together, our results demonstrate that initiating TSDR demethylation during early stages of thymic Treg development commences stabilization of Foxp3 expression and guarantees full functionality and long-term lineage stability of Tregs...
  4. doi request reprint Induced and thymus-derived Foxp3⁺ regulatory T cells share a common niche
    Yi Ju Huang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 44:460-8. 2014
    ..However, when transferred together Nrp1⁺ tTreg cells outcompeted Nrp1⁻ iTreg cells and dominated the Treg-cell compartment. Taken together, our data suggest that tTreg cells and iTreg cells share a common peripheral niche...
  5. doi request reprint Foxp3+ regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen
    Pedro Milanez-Almeida
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 45:153-66. 2015
    ..Hence, we provide the first estimation of the peripheral Treg-cell conversion rate and propose additional facets of Treg-cell-mediated immune regulation that may previously have escaped attention. ..
  6. pmc The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-κB signaling
    Lisa Schreiber
    Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 9:e88318. 2014
    ..In conclusion, we show that NF-κB signaling is not substantially involved in TSDR-mediated stabilization of Foxp3 expression in Tregs. ..
  7. pmc Development of a unique epigenetic signature during in vivo Th17 differentiation
    Bi Huei Yang
    Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nucleic Acids Res 43:1537-48. 2015
    ....
  8. doi request reprint To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
    Aras Toker
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Sci Signal 4:pe4. 2011
    ....
  9. doi request reprint IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
    Marc Schuster
    Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
    Immunity 37:998-1008. 2012
    ..Our results demonstrate that IκB(NS) critically regulates Treg cell development in the thymus and during gut inflammation, indicating that strategies targeting IκB(NS) could modulate the Treg cell compartment...
  10. pmc Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    Julia K Polansky
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
    J Mol Med (Berl) 88:1029-40. 2010
    ..We therefore propose that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage...
  11. doi request reprint A signal integration model of thymic selection and natural regulatory T cell commitment
    Sahamoddin Khailaie
    Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    J Immunol 193:5983-96. 2014
    ..This study provides a mechanistic model showing that time integration of TCR-mediated signals, as opposed to single-cell interaction events, is needed to gain a full view on the properties emerging from thymic selection. ..
  12. doi request reprint A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection
    Christina Tebartz
    Infection Immunology Research Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    J Immunol 194:1100-11. 2015
    ..In summary, our results indicate that expansion of MDSC and, to a minor degree, of regulatory T cells in S. aureus-infected mice may create an immunosuppressive environment that sustains chronic infection. ..
  13. pmc First insight into the kinome of human regulatory T cells
    Sebastian König
    Department of Molecular Structural Biology, Helmholtz Zentrum für Infektionsforschung, Braunschweig, Germany
    PLoS ONE 7:e40896. 2012
    ....