Jochen Huehn

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. doi request reprint Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    Jochen Huehn
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nat Rev Immunol 9:83-9. 2009
  2. doi request reprint Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    Aras Toker
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3180-8. 2013
  3. doi request reprint IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
    Marc Schuster
    Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
    Immunity 37:998-1008. 2012
  4. doi request reprint To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
    Aras Toker
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Sci Signal 4:pe4. 2011
  5. pmc Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    Julia K Polansky
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
    J Mol Med (Berl) 88:1029-40. 2010

Collaborators

  • Shohei Hori
  • Karsten Kretschmer
  • Siegfried Weiss
  • Aras Toker
  • Stefan Floess
  • Julia K Polansky
  • Marc Schuster
  • Alf Hamann
  • Lisa Schreiber
  • Dirk Engelbert
  • Sonja Schallenberg
  • Jorn Walter
  • Robert Geffers
  • Sandra Düber
  • Sven Olek
  • Udo Baron
  • Pascal Giehr
  • Garima Garg
  • Takahisa Miyao
  • Tim Sparwasser
  • Rainer Glauben
  • Michaela Annemann
  • Klaus Schulze-Osthoff
  • Anja A Kuhl
  • Britta Siegmund
  • Linda K Clayton
  • Ingo Schmitz
  • Carlos Plaza-Sirvent
  • Klaus Pfeffer
  • Ria Baumgrass
  • Leif Ludwig
  • Melanie Krüger
  • Sascha Cording
  • Christoph Thelemann

Detail Information

Publications5

  1. doi request reprint Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
    Jochen Huehn
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Nat Rev Immunol 9:83-9. 2009
    ....
  2. doi request reprint Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    Aras Toker
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3180-8. 2013
    ..Together, our results demonstrate that initiating TSDR demethylation during early stages of thymic Treg development commences stabilization of Foxp3 expression and guarantees full functionality and long-term lineage stability of Tregs...
  3. doi request reprint IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor
    Marc Schuster
    Systems oriented Immunology and Inflammation Research, Helmholtz Center for Infection Research, Braunschweig, Germany
    Immunity 37:998-1008. 2012
    ..Our results demonstrate that IκB(NS) critically regulates Treg cell development in the thymus and during gut inflammation, indicating that strategies targeting IκB(NS) could modulate the Treg cell compartment...
  4. doi request reprint To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms
    Aras Toker
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Sci Signal 4:pe4. 2011
    ....
  5. pmc Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    Julia K Polansky
    Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr 7, 38124, Braunschweig, Germany
    J Mol Med (Berl) 88:1029-40. 2010
    ..We therefore propose that Ets-1 is part of a larger protein complex, which binds to the TSDR only in its demethylated state, thereby restricting stable Foxp3 expression to the Treg lineage...