Steffi Hansen

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. pmc Nanoparticles for transcutaneous vaccination
    Steffi Hansen
    Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland HIPS, Helmholtz Center for Infection Research HZI, Saarbruecken, Germany
    Microb Biotechnol 5:156-67. 2012
  2. doi request reprint Improved input parameters for diffusion models of skin absorption
    Steffi Hansen
    Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland HIPS, Helmholtz Center for Infection Research HZI, Saarbruecken, Germany
    Adv Drug Deliv Rev 65:251-64. 2013
  3. doi request reprint The role of corneocytes in skin transport revised--a combined computational and experimental approach
    Steffi Hansen
    Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany
    Pharm Res 26:1379-97. 2009
  4. doi request reprint Non-invasive delivery of nanoparticles to hair follicles: a perspective for transcutaneous immunization
    Ankit Mittal
    Saarland University, Biopharmaceutics and Pharmaceutical Technology, Saarbruecken, Germany
    Vaccine 31:3442-51. 2013
  5. doi request reprint An extended database of keratin binding
    Steffi Hansen
    Saarland University, Biopharmaceutics and Pharmaceutical Technology, Saarbruecken, Germany
    J Pharm Sci 100:1712-26. 2011
  6. doi request reprint Measuring the stratum corneum reservoir: desorption kinetics from keratin
    Salem Seif
    Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany
    J Pharm Sci 101:3718-28. 2012
  7. ncbi request reprint In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients
    Steffi Hansen
    Saarland University, Department of Biopharmaceutics and Pharmaceutical Technology, Saarbruecken, Germany
    Eur J Pharm Biopharm 68:352-67. 2008
  8. doi request reprint Transfollicular delivery takes root: the future for vaccine design?
    Steffi Hansen
    Department Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland HIPS, Helmholtz Center for Infection Research, Saarbruecken, Germany
    Expert Rev Vaccines 13:5-7. 2014
  9. doi request reprint Advanced chemical imaging and comparison of human and porcine hair follicles for drug delivery by confocal Raman microscopy
    Lutz Franzen
    Saarland University, Department of Biopharmaceutics and Pharmaceutical Technology, Saarbruecken, Germany
    J Biomed Opt 18:061210. 2013

Collaborators

Detail Information

Publications9

  1. pmc Nanoparticles for transcutaneous vaccination
    Steffi Hansen
    Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland HIPS, Helmholtz Center for Infection Research HZI, Saarbruecken, Germany
    Microb Biotechnol 5:156-67. 2012
    ..The potential and pitfalls associated with these three classes of carriers will be discussed...
  2. doi request reprint Improved input parameters for diffusion models of skin absorption
    Steffi Hansen
    Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland HIPS, Helmholtz Center for Infection Research HZI, Saarbruecken, Germany
    Adv Drug Deliv Rev 65:251-64. 2013
    ..This will require input parameters for which no suitable estimates are yet available...
  3. doi request reprint The role of corneocytes in skin transport revised--a combined computational and experimental approach
    Steffi Hansen
    Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany
    Pharm Res 26:1379-97. 2009
    ..To investigate mechanisms of compound-corneocyte interactions in a combined experimental and theoretical approach...
  4. doi request reprint Non-invasive delivery of nanoparticles to hair follicles: a perspective for transcutaneous immunization
    Ankit Mittal
    Saarland University, Biopharmaceutics and Pharmaceutical Technology, Saarbruecken, Germany
    Vaccine 31:3442-51. 2013
    ..4. Consequently formulation of OVA into PLGA and Chit-PLGA NPs may offer to reduce the dose which needs to be applied for transfollicular immunization...
  5. doi request reprint An extended database of keratin binding
    Steffi Hansen
    Saarland University, Biopharmaceutics and Pharmaceutical Technology, Saarbruecken, Germany
    J Pharm Sci 100:1712-26. 2011
    ..This has consequences for the estimates of SC partition and diffusion coefficients for diffusion modeling of dermal absorption. ...
  6. doi request reprint Measuring the stratum corneum reservoir: desorption kinetics from keratin
    Salem Seif
    Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany
    J Pharm Sci 101:3718-28. 2012
    ..Also, they prove that reservoir formation is relevant for lipophilic solutes independent of drug class, thus allowing new options for topical pharmacotherapy...
  7. ncbi request reprint In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients
    Steffi Hansen
    Saarland University, Department of Biopharmaceutics and Pharmaceutical Technology, Saarbruecken, Germany
    Eur J Pharm Biopharm 68:352-67. 2008
    ..Based on these results time-dependent stratum corneum concentration-depth profiles were simulated and compared to experimental profiles in an accompanying study...
  8. doi request reprint Transfollicular delivery takes root: the future for vaccine design?
    Steffi Hansen
    Department Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland HIPS, Helmholtz Center for Infection Research, Saarbruecken, Germany
    Expert Rev Vaccines 13:5-7. 2014
    ..These problems may be overcome by developing more efficient adjuvant-coupled nanocarriers with high antigen payload. ..
  9. doi request reprint Advanced chemical imaging and comparison of human and porcine hair follicles for drug delivery by confocal Raman microscopy
    Lutz Franzen
    Saarland University, Department of Biopharmaceutics and Pharmaceutical Technology, Saarbruecken, Germany
    J Biomed Opt 18:061210. 2013
    ..Confocal Raman microscopy shows a high potential as a noninvasive and chemically selective technique for the analysis of trans-follicular drug delivery...