Nelson O Gekara

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. ncbi The multiple mechanisms of Ca2+ signalling by listeriolysin O, the cholesterol-dependent cytolysin of Listeria monocytogenes
    Nelson O Gekara
    Department of Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Cell Microbiol 9:2008-21. 2007
  2. ncbi Mast cells initiate early anti-Listeria host defences
    Nelson O Gekara
    Helmholtz Centre for Infection Research, Department of Molecular Immunology, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Cell Microbiol 10:225-36. 2008
  3. ncbi Listeria monocytogenes desensitizes immune cells to subsequent Ca2+ signaling via listeriolysin O-induced depletion of intracellular Ca2+ stores
    Nelson O Gekara
    Department of Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Infect Immun 76:857-62. 2008
  4. ncbi Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition
    Nelson O Gekara
    Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Infect Dis 199:124-33. 2009
  5. ncbi Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria
    Nicole Dietrich
    Department of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    Proc Natl Acad Sci U S A 107:8748-53. 2010
  6. ncbi Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments
    Nicole Dietrich
    Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 5:e10250. 2010
  7. ncbi Listeria monocytogenes induces T cell receptor unresponsiveness through pore-forming toxin listeriolysin O
    Nelson O Gekara
    Molecular Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany
    J Infect Dis 202:1698-707. 2010
  8. ncbi The cholesterol-dependent cytolysin listeriolysin O aggregates rafts via oligomerization
    Nelson O Gekara
    Molecular Immunology, German Research Centre for Biotechnology GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Cell Microbiol 7:1345-56. 2005
  9. ncbi Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O
    Andrej Bavdek
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia
    Biochemistry 46:4425-37. 2007

Collaborators

Detail Information

Publications9

  1. ncbi The multiple mechanisms of Ca2+ signalling by listeriolysin O, the cholesterol-dependent cytolysin of Listeria monocytogenes
    Nelson O Gekara
    Department of Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Cell Microbiol 9:2008-21. 2007
    ..In addition to Ca(2+) signalling, the discovery that LLO causes damage to an intracellular organelle provides a new perspective in our understanding of how CDCs affect target cells during infection by the respective bacterial pathogens...
  2. ncbi Mast cells initiate early anti-Listeria host defences
    Nelson O Gekara
    Helmholtz Centre for Infection Research, Department of Molecular Immunology, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Cell Microbiol 10:225-36. 2008
    ..m. We also show that upon recruitment, neutrophils also become activated and additionally secrete TNF-alpha thus amplifying the anti-L. m. inflammatory response...
  3. ncbi Listeria monocytogenes desensitizes immune cells to subsequent Ca2+ signaling via listeriolysin O-induced depletion of intracellular Ca2+ stores
    Nelson O Gekara
    Department of Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Infect Immun 76:857-62. 2008
    ..The ability of LLO to desensitize immune cells provides a significant hint about the possible role played by CDCs in the evasion of the immune system by bacterial pathogens...
  4. ncbi Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition
    Nelson O Gekara
    Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Infect Dis 199:124-33. 2009
    ..However, in some gram-positive bacterial infections, TLR2 is dispensable. One of the outstanding questions regarding host-bacteria interactions is why TLR2 is essential in some infections but dispensable in others...
  5. ncbi Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria
    Nicole Dietrich
    Department of Molecular Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    Proc Natl Acad Sci U S A 107:8748-53. 2010
    ....
  6. ncbi Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments
    Nicole Dietrich
    Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 5:e10250. 2010
    ..Until now, TLR2 activation by bacterial ligands has long been associated with pro-inflammatory cytokines but not type I interferon responses...
  7. ncbi Listeria monocytogenes induces T cell receptor unresponsiveness through pore-forming toxin listeriolysin O
    Nelson O Gekara
    Molecular Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany
    J Infect Dis 202:1698-707. 2010
    ..Listeriolysin O (LLO), a prototype CDC, is the main virulence factor of Listeria monocytogenes...
  8. ncbi The cholesterol-dependent cytolysin listeriolysin O aggregates rafts via oligomerization
    Nelson O Gekara
    Molecular Immunology, German Research Centre for Biotechnology GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Cell Microbiol 7:1345-56. 2005
    ..Thus, LLO most likely induces signalling through the coaggregation of rafts' associated receptors, kinases and adaptors...
  9. ncbi Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O
    Andrej Bavdek
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia
    Biochemistry 46:4425-37. 2007
    ..The results clearly show that LLO activity at physiological pH cannot be neglected and that its action at sites distal to cell entry may have important physiological consequences for Listeria pathogenesis...