Luka Cicin-Sain

Summary

Affiliation: Helmholtz Centre for Infection Research
Country: Germany

Publications

  1. pmc Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency
    Franziska Dağ
    Department for Vaccinology Immune Aging and Chronic Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 10:e1003962. 2014
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  3. pmc Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging
    Luka Cicin-Sain
    Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1002849. 2012
  4. doi request reprint The context of gene expression defines the immunodominance hierarchy of cytomegalovirus antigens
    Iryna Dekhtiarenko
    Department of Vaccinology, Helmholtz Center for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3399-409. 2013
  5. pmc Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts
    Linda Ebermann
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1003062. 2012
  6. doi request reprint Activated NKT cells imprint NK-cell differentiation, functionality and education
    Peggy Riese
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 45:1794-807. 2015
  7. doi request reprint Mouse CMV infection delays antibody class switch upon an unrelated virus challenge
    Thomas F Marandu
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany Dar es salaam University College of Education, Tanzania
    Exp Gerontol 54:101-8. 2014
  8. doi request reprint Use of recombinant approaches to construct human cytomegalovirus mutants
    Iryna Dekhtiarenko
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Methods Mol Biol 1119:59-79. 2014

Collaborators

  • Zsolt Ruzsics
  • Dagmar Wirth
  • Stefan Lienenklaus
  • Lars Dölken
  • Janko Nikolich-Zugich
  • Barbara Adler
  • Iryna Dekhtiarenko
  • Peggy Riese
  • Martin Messerle
  • Thomas F Marandu
  • Franziska Dağ
  • Carlos A Guzman
  • Rafael Solana
  • Linda Ebermann
  • Stephanie Trittel
  • Benedict J Chambers
  • Tobias May
  • Andrea Kröger
  • Katja Finsterbusch
  • Siegfried Weiß
  • Johannes Schwerk
  • Julia Holzki
  • Mario Köster
  • Anja Drabig
  • Ianina Conte
  • Ulfert Rand
  • Adrien Weingärtner
  • Hansjorg Hauser
  • Colin Davenport
  • Robert Geffers
  • Michael A Jarvis
  • Ulrich Koszinowski
  • Andrea B Maier
  • Janet E McElhaney
  • Maciej Zielinski
  • Sara Ferrando-Martínez
  • Jerrald L Rector
  • Allison E Aiello
  • Ann Hill
  • Anis Larbi
  • Mark R Wills
  • Raquel Tarazona
  • Evelyna Derhovanessian
  • Mikko Hurme
  • Alejandra Pera
  • Rosaely Casalegno-Garduño
  • Rene van Lier
  • Paolo Sansoni
  • Natalie Riddell
  • Sara Cantisán
  • Florian Kern
  • George C Wang
  • Elissaveta Naumova
  • Nico Van Rooijen
  • Daniela Frasca
  • Miguel Lopez-Botet
  • Victor Appay
  • Sheila Govind
  • Jos A Bosch
  • Arne N Akbar
  • Paul Moss
  • Carmen Campos
  • Delphine Sauce
  • Beatrix Grubeck-Loebenstein
  • Beatriz Sanchez-Correa
  • Mark Beswick
  • Graham Pawelec
  • Tamas Fulop

Detail Information

Publications8

  1. pmc Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency
    Franziska Dağ
    Department for Vaccinology Immune Aging and Chronic Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 10:e1003962. 2014
    ....
  2. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  3. pmc Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging
    Luka Cicin-Sain
    Department of Vaccinology and Applied Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1002849. 2012
    ..Therefore, latent MCMV infection resulted in pronounced changes of the T-cell compartment consistent with impaired naïve T-cell function...
  4. doi request reprint The context of gene expression defines the immunodominance hierarchy of cytomegalovirus antigens
    Iryna Dekhtiarenko
    Department of Vaccinology, Helmholtz Center for Infection Research, Braunschweig 38124, Germany
    J Immunol 190:3399-409. 2013
    ....
  5. pmc Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts
    Linda Ebermann
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS Pathog 8:e1003062. 2012
    ....
  6. doi request reprint Activated NKT cells imprint NK-cell differentiation, functionality and education
    Peggy Riese
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 45:1794-807. 2015
    ..Thus, our findings reveal new fundamental aspects of the NKT-NK cell axis that provide important hints for the manipulation of NK cells in clinical settings. ..
  7. doi request reprint Mouse CMV infection delays antibody class switch upon an unrelated virus challenge
    Thomas F Marandu
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany Dar es salaam University College of Education, Tanzania
    Exp Gerontol 54:101-8. 2014
    ..Therefore, our results argue that latent CMV infection impairs B-cell, but not T-cell responses to a challenge with VSV and delays antibody class-switch by a mechanism which may be independent of T-cell help. ..
  8. doi request reprint Use of recombinant approaches to construct human cytomegalovirus mutants
    Iryna Dekhtiarenko
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Methods Mol Biol 1119:59-79. 2014
    ..Here we describe the methods used for the generation of a CMV BAC, targeted mutagenesis of BAC clones, and transfection of human cells with CMV BAC DNA in order to reconstitute the viral infection process. ..