Stefan Wirth

Summary

Affiliation: HELIOS Klinikum Wuppertal
Country: Germany

Publications

  1. ncbi request reprint Recombinant alfa-interferon plus ribavirin therapy in children and adolescents with chronic hepatitis C
    Stefan Wirth
    Children s Hospital Wuppertal, Affiliated Clinic to Witten Herdecke University, Wuppertal, Germany
    Hepatology 36:1280-4. 2002
  2. doi request reprint Guidance for clinical trials for children and adolescents with chronic hepatitis C
    Stefan Wirth
    Clinic for Children and Adolescence, HELIOS Klinikum Wuppertal, Witten Herdecke University, Germany
    J Pediatr Gastroenterol Nutr 52:233-7. 2011
  3. doi request reprint Hepatitis B virus genotype change in children is closely related to HBeAg/anti-HBe seroconversion
    Stefan Wirth
    Department of Pediatrics, Helios Medical Centre, Witten Herdecke University, Wuppertal, Germany
    J Pediatr Gastroenterol Nutr 57:363-6. 2013
  4. doi request reprint High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin
    Stefan Wirth
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Heusnerstrasse 40, Wuppertal, Germany
    J Hepatol 52:501-7. 2010
  5. ncbi request reprint Relationship between viral load and genotypes of hepatitis B virus in children with chronic hepatitis B
    Prasad T Oommen
    Children s Hospital, HELIOS Klinikum Wuppertal, University of Witten Herdecke, Wuppertal, Germany
    J Pediatr Gastroenterol Nutr 43:342-7. 2006
  6. ncbi request reprint Peginterferon alfa-2b plus ribavirin treatment in children and adolescents with chronic hepatitis C
    Stefan Wirth
    HELIOS Children s Hospital Wuppertal, Witten Herdecke University, Germany
    Hepatology 41:1013-8. 2005
  7. pmc Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1
    Andreas C W Jenke
    Children s and Adolescents Hospital, Witten Herdecke University, HELIOS Klinikum Wuppertal, 42283 Wuppertal, Germany
    Antimicrob Agents Chemother 52:2355-9. 2008
  8. doi request reprint Human β-defensin 2 expression in ELBW infants with severe necrotizing enterocolitis
    Andreas C W Jenke
    Department of Neonatology, HELIOS Children s Hospital, Witten Herdecke University, Wuppertal, Germany
    Pediatr Res 72:513-20. 2012
  9. ncbi request reprint Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-alpha
    Stephan Gehring
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Heusnerstr 40, D 42283 Wuppertal, Germany
    World J Gastroenterol 12:5787-92. 2006
  10. ncbi request reprint Re-treatment of children with chronic hepatitis C who did not respond to interferon-alpha treatment
    Patrick Gerner
    Witten Herdecke University, Witten, Germany
    J Pediatr Gastroenterol Nutr 51:187-90. 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Recombinant alfa-interferon plus ribavirin therapy in children and adolescents with chronic hepatitis C
    Stefan Wirth
    Children s Hospital Wuppertal, Affiliated Clinic to Witten Herdecke University, Wuppertal, Germany
    Hepatology 36:1280-4. 2002
    ..This also is true for both vertically infected patients and for individuals with normal transaminase levels before therapy...
  2. doi request reprint Guidance for clinical trials for children and adolescents with chronic hepatitis C
    Stefan Wirth
    Clinic for Children and Adolescence, HELIOS Klinikum Wuppertal, Witten Herdecke University, Germany
    J Pediatr Gastroenterol Nutr 52:233-7. 2011
    ..Safety measures should include the standard recommended laboratory investigations, growth parameters, quality-of-life or psychological measures, and a requirement for long-term follow-up for up to 5 years...
  3. doi request reprint Hepatitis B virus genotype change in children is closely related to HBeAg/anti-HBe seroconversion
    Stefan Wirth
    Department of Pediatrics, Helios Medical Centre, Witten Herdecke University, Wuppertal, Germany
    J Pediatr Gastroenterol Nutr 57:363-6. 2013
    ..The aim of this study was to assess the frequency and distribution of HBV genotype shifts in treated and untreated European children during the different phases of chronic hepatitis B...
  4. doi request reprint High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin
    Stefan Wirth
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Heusnerstrasse 40, Wuppertal, Germany
    J Hepatol 52:501-7. 2010
    ..The aim of this study was to evaluate the efficacy and safety of PEG-IFN alfa-2b plus RBV in children...
  5. ncbi request reprint Relationship between viral load and genotypes of hepatitis B virus in children with chronic hepatitis B
    Prasad T Oommen
    Children s Hospital, HELIOS Klinikum Wuppertal, University of Witten Herdecke, Wuppertal, Germany
    J Pediatr Gastroenterol Nutr 43:342-7. 2006
    ..We evaluated the prevalence and clinical significance of hepatitis B virus (HBV) genotypes in children with chronic hepatitis B...
  6. ncbi request reprint Peginterferon alfa-2b plus ribavirin treatment in children and adolescents with chronic hepatitis C
    Stefan Wirth
    HELIOS Children s Hospital Wuppertal, Witten Herdecke University, Germany
    Hepatology 41:1013-8. 2005
    ..Weekly dosing of peginterferon alfa-2b is a considerable advance for this age group. The treatment is not approved for children. Further controlled trials are needed...
  7. pmc Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1
    Andreas C W Jenke
    Children s and Adolescents Hospital, Witten Herdecke University, HELIOS Klinikum Wuppertal, 42283 Wuppertal, Germany
    Antimicrob Agents Chemother 52:2355-9. 2008
    ..Due to its unique properties compared to commonly used vectors, it provides an interesting option for the treatment of chronically HBV-infected individuals...
  8. doi request reprint Human β-defensin 2 expression in ELBW infants with severe necrotizing enterocolitis
    Andreas C W Jenke
    Department of Neonatology, HELIOS Children s Hospital, Witten Herdecke University, Wuppertal, Germany
    Pediatr Res 72:513-20. 2012
    ..The aim of this study was to analyze whether the mucosal innate immune response of extremely-low-birth-weight (ELBW) infants might play a role in the development of necrotizing enterocolitis (NEC)...
  9. ncbi request reprint Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-alpha
    Stephan Gehring
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Heusnerstr 40, D 42283 Wuppertal, Germany
    World J Gastroenterol 12:5787-92. 2006
    ..To evaluate the prevalence of autoantibodies in chronic hepatitis C virus (HCV)-infected children focusing on thyroid autoimmunity...
  10. ncbi request reprint Re-treatment of children with chronic hepatitis C who did not respond to interferon-alpha treatment
    Patrick Gerner
    Witten Herdecke University, Witten, Germany
    J Pediatr Gastroenterol Nutr 51:187-90. 2010
    ..Because the response to re-treatment in children is not well defined we evaluated the efficacy and safety of interferon (IFN)-alpha plus ribavirin in patients who have failed to respond to previous treatment...
  11. doi request reprint Vertical transmission of hepatitis B virus (HBV) from mothers negative for HBV surface antigen and positive for antibody to HBV core antigen
    Alexander Walz
    Childrens Hospital Helios Klinikum Wuppertal, Witten Herdecke University, Witten, Germany
    J Infect Dis 200:1227-31. 2009
    ..Therefore, we evaluated the risk of infection for babies of mothers with this serostatus...
  12. ncbi request reprint Prevalence of hepatitis B virus precore stop codon mutations in chronically infected children
    Philip Wintermeyer
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Germany
    World J Gastroenterol 12:2235-8. 2006
    ..To find out whether there is a significant difference in the prevalence of the precore stop codon mutation between HBeAg positive and anti-HBe positive children...
  13. ncbi request reprint Prevalence of hepatitis C virus infection in children admitted to an urban hospital
    Patrick Gerner
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Heusnerstr 40, D 42283 Wuppertal, Germany
    J Infect 52:305-8. 2006
    ..Hepatitis C infection is a global health problem affecting about 3% of the world's population. However, very little data exists on the prevalence of hepatitis C virus infection in childhood...
  14. pmc Vitamin E treatment for children with chronic hepatitis B: a randomized placebo controlled trial
    Patrick Gerner
    Children s Hospital, Duisburg Essen University, Klinik 2, Essen 45122, Germany
    World J Gastroenterol 14:7208-13. 2008
    ..To evaluate the safety and efficacy of Vitamin E in children with chronic hepatitis B...
  15. ncbi request reprint Complete hepatitis B virus genome analysis in chronically infected children before and during lamivudine treatment
    Isabel Conzelmann
    Children s Hospital Helios Klinikum Wuppertal, Witten Herdecke University, Heusnerstrasse 40, Wuppertal, Germany
    J Med Virol 77:194-202. 2005
    ..An increased mutation rate and the occurrence of specific mutations could not be proven for the early phase of lamivudine treatment...
  16. ncbi request reprint Functional analysis of a rare HBV deletion mutant in chronically infected children
    Patrick Gerner
    Children s Hospital, Helios Klini Kum, Wuppertal, Heusnerstrasse 40, D 42283 Wuppertal, Germany
    Pediatr Res 53:891-7. 2003
    ..However, our functional and clinical follow-up studies in one child suggest that such a mutant may have the potential to aggravate liver inflammation, especially if corroborated with larger numbers of children...
  17. doi request reprint H3.5 is a novel hominid-specific histone H3 variant that is specifically expressed in the seminiferous tubules of human testes
    Raphael Schenk
    HELIOS Children s Hospital, HELIOS Klinikum Wuppertal, Research Laboratory, Witten Herdecke University, Germany
    Chromosoma 120:275-85. 2011
    ..5 is assembled into chromatin and targeted by PTM. H3.5 preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes and can replace an essential function of RNAi-depleted H3.3 in cell growth...
  18. ncbi request reprint Persistent hepatitis B virus replication after survival of fulminant hepatitis and clearance of HBsAG
    Stefan Wirth
    Children s Hospital Wuppertal Herdecke University, Wuppertal, Germany
    J Pediatr Gastroenterol Nutr 34:77-80. 2002
  19. doi request reprint Serologic analysis of the IgG antibody response in children with varicella zoster virus wild-type infection and vaccination
    Andreas C W Jenke
    HELIOS Children s Hospital Wuppertal, Witten Herdecke University, Germany
    Pediatr Infect Dis J 31:1148-52. 2012
    ..Because more people get vaccinated every year, the development of sensitive serological test systems for the detection of protective anti-VZV IgG will become important in the future...
  20. pmc Expression of human beta-defensins in children with chronic inflammatory bowel disease
    Matthias Zilbauer
    Department of Paediatrics, HELIOS Klinikum Wuppertal, Germany
    PLoS ONE 5:e15389. 2010
    ..Altered mucosal expression of hBDs has been suggested to be implicated in chronic inflammatory bowel disease pathogenesis. However, little is known about expression of these peptides in children...
  21. doi request reprint Facial palsy: etiology, outcome and management in children
    Andreas Christoph Jenke
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Heusnerstr 40, D 42283 Wuppertal, Germany
    Eur J Paediatr Neurol 15:209-13. 2011
    ..Currently there is much controversy whether to treat idiopathic facial palsy with corticosteroids with sparse data on the natural course of the disease in children...
  22. doi request reprint Fecal calprotectin concentrations in premature infants have a lower limit and show postnatal and gestational age dependence
    Luciano Zoppelli
    HELIOS Children s Hospital Wuppertal, Witten Herdecke University, Wuppertal, Germany
    Neonatology 102:68-74. 2012
    ..Whereas fecal calprotectin (fCP) has been reported to have insufficient sensitivity and specificity, no previous study has stratified for gestational and postnatal age...
  23. ncbi request reprint The nonviral episomal replicating vector pEPI-1 allows long-term inhibition of bcr-abl expression by shRNA
    Andreas C W Jenke
    Children s Hospital, HELIOS Klinikum Wuppertal, 42283 Wuppertal, Germany
    Hum Gene Ther 16:533-9. 2005
    ..These results demonstrate that the vector system pEPI-1 allows specific and efficient long term gene suppression by using a short hairpin RNA transcription unit...
  24. doi request reprint Intussusception: incidence and treatment-insights from the nationwide German surveillance
    Andreas Christoph Jenke
    Children s Hospital, HELIOS Klinikum Wuppertal, Witten Herdecke University, Herdecke, Germany
    J Pediatr Gastroenterol Nutr 52:446-51. 2011
    ..For different reasons, availability of reliable incidence data are useful and additionally may be fundamental to monitor potential effects of recently introduced rotavirus (RV) vaccines...
  25. doi request reprint Fecal S100A12: identifying intestinal distress in very-low-birth-weight infants
    Jan Däbritz
    Royal Children s Hospital Melbourne, Murdoch Children s Research Institute, Parkville, Australia
    J Pediatr Gastroenterol Nutr 57:204-10. 2013
    ....