Holger Rüssmann

Summary

Affiliation: HELIOS Klinikum Wuppertal
Country: Germany

Publications

  1. ncbi request reprint Inverted pathogenicity: the use of pathogen-specific molecular mechanisms for prevention or therapy of disease
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
    Int J Med Microbiol 293:565-9. 2004
  2. pmc CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma
    Stefan Jellbauer
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Munich, Germany
    PLoS ONE 7:e34214. 2012
  3. pmc Alternative endogenous protein processing via an autophagy-dependent pathway compensates for Yersinia-mediated inhibition of endosomal major histocompatibility complex class II antigen presentation
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    Infect Immun 78:5138-50. 2010
  4. pmc Concomitant cytosolic delivery of two immunodominant listerial antigens by Salmonella enterica serovar typhimurium confers superior protection against murine listeriosis
    Emeka I Igwe
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Germany
    Infect Immun 70:7114-9. 2002
  5. doi request reprint Invasion and destruction of a murine fibrosarcoma by Salmonella-induced effector CD8 T cells as a therapeutic intervention against cancer
    Elisabeth Roider
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Munich, Germany
    Cancer Immunol Immunother 60:371-80. 2011
  6. ncbi request reprint Rapid clearance of a recombinant Salmonella vaccine carrier prevents enhanced antigen-specific CD8 T-cell responses after oral boost immunizations
    Victòria E Sevil Domènech
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, 80336 Munich, Germany
    Microbes Infect 7:860-6. 2005
  7. pmc Superior protective immunity against murine listeriosis by combined vaccination with CpG DNA and recombinant Salmonella enterica serovar typhimurium
    Christina Berchtold
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Infect Immun 77:5501-8. 2009
  8. ncbi request reprint Pre-existing anti-Salmonella vector immunity prevents the development of protective antigen-specific CD8 T-cell frequencies against murine listeriosis
    Victòria E Sevil Domènech
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Pettenkoferstrasse 9a, 80336 Munich, Bavaria, Germany
    Microbes Infect 9:1447-53. 2007
  9. ncbi request reprint "One size fits it all": translocation of foreign antigens by Yersinia type III secretion system (TTSS) leads to concomitant CD4 and CD8 T-cell priming
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
    Int J Med Microbiol 294:313-7. 2004
  10. pmc Salmonella pathogenicity island 2-mediated overexpression of chimeric SspH2 proteins for simultaneous induction of antigen-specific CD4 and CD8 T cells
    Klaus Panthel
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 9a, 80336 Munchen, Germany
    Infect Immun 73:334-41. 2005

Collaborators

  • Jurgen Heesemann
  • Hans Wolf-Watz
  • Carole Bourquin
  • Wolf Dietrich Hardt
  • Christian Hotz
  • Klaus Ruckdeschel
  • Bärbel Stecher
  • Klaus Panthel
  • Victòria E Sevil Domènech
  • Stefan Jellbauer
  • Katrin M Meinel
  • Konrad Trulzsch
  • Elisabeth Roider
  • Christina Berchtold
  • Emeka I Igwe
  • Simon Heidegger
  • Gernot Geginat
  • Stefan Endres
  • Miriam Partilla
  • Brigitte Köhn
  • Dirk H Busch
  • Sebastian E Winter
  • Christian Lottspeich
  • Sibylle Koletzko
  • Thorsten Sporleder
  • Vincens Weingart
  • Bernadette Bohn
  • Nina Suhartha
  • Nadja Sandholzer
  • David Anz
  • Nicolas Stephan
  • Sophie Kathrin Kirchner
  • Justin H Hetrodt
  • Andrea Schwarzer
  • Kathrin Linkemann
  • Heike Retzbach
  • Reinhardt Hoffmann
  • Josef Weingart
  • Wilhelm Höchter
  • Michael Sackmann

Detail Information

Publications21

  1. ncbi request reprint Inverted pathogenicity: the use of pathogen-specific molecular mechanisms for prevention or therapy of disease
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
    Int J Med Microbiol 293:565-9. 2004
    ..Surprisingly, cytosolic delivery of YopE/LLO by Yersinia also results in LLO-specific CD4 T-cell priming...
  2. pmc CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma
    Stefan Jellbauer
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Munich, Germany
    PLoS ONE 7:e34214. 2012
    ..Moreover, in the lung metastasis model, immunization with recombinant Salmonella resulted in a reduction of the metastatic melanoma burden by approximately 60%...
  3. pmc Alternative endogenous protein processing via an autophagy-dependent pathway compensates for Yersinia-mediated inhibition of endosomal major histocompatibility complex class II antigen presentation
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    Infect Immun 78:5138-50. 2010
    ..We provide critical new insights into the interaction between the mammalian immune system and a human pathogen...
  4. pmc Concomitant cytosolic delivery of two immunodominant listerial antigens by Salmonella enterica serovar typhimurium confers superior protection against murine listeriosis
    Emeka I Igwe
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Germany
    Infect Immun 70:7114-9. 2002
    ..In conclusion, these findings emphasize the versatility of Salmonella type III-mediated heterologous antigen delivery for the induction of cytotoxic T-lymphocyte-mediated immunity...
  5. doi request reprint Invasion and destruction of a murine fibrosarcoma by Salmonella-induced effector CD8 T cells as a therapeutic intervention against cancer
    Elisabeth Roider
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Munich, Germany
    Cancer Immunol Immunother 60:371-80. 2011
    ..In summary, our study demonstrates that therapeutic vaccination with Salmonella leads to efficient induction of tumor-invading effector CD8 T cells that may result in significant tumor regression...
  6. ncbi request reprint Rapid clearance of a recombinant Salmonella vaccine carrier prevents enhanced antigen-specific CD8 T-cell responses after oral boost immunizations
    Victòria E Sevil Domènech
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, 80336 Munich, Germany
    Microbes Infect 7:860-6. 2005
    ....
  7. pmc Superior protective immunity against murine listeriosis by combined vaccination with CpG DNA and recombinant Salmonella enterica serovar typhimurium
    Christina Berchtold
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Infect Immun 77:5501-8. 2009
    ....
  8. ncbi request reprint Pre-existing anti-Salmonella vector immunity prevents the development of protective antigen-specific CD8 T-cell frequencies against murine listeriosis
    Victòria E Sevil Domènech
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Pettenkoferstrasse 9a, 80336 Munich, Bavaria, Germany
    Microbes Infect 9:1447-53. 2007
    ..Compared to the significantly higher numbers of p60-specific T lymphocytes elicited after single oral immunization, the low amount of Listeria-specific CD8 T cells did not confer protection against listeriosis...
  9. ncbi request reprint "One size fits it all": translocation of foreign antigens by Yersinia type III secretion system (TTSS) leads to concomitant CD4 and CD8 T-cell priming
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
    Int J Med Microbiol 294:313-7. 2004
    ..This "one-size-fits-it-all"-feature of Yersinia-translocated heterologous antigens might be advantageous to mount T-cellular immune responses against complex microbes and tumors...
  10. pmc Salmonella pathogenicity island 2-mediated overexpression of chimeric SspH2 proteins for simultaneous induction of antigen-specific CD4 and CD8 T cells
    Klaus Panthel
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 9a, 80336 Munchen, Germany
    Infect Immun 73:334-41. 2005
    ....
  11. ncbi request reprint Prophylactic anti-tumor immunity against a murine fibrosarcoma triggered by the Salmonella type III secretion system
    Klaus Panthel
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Pettenkoferstrasse 9a, 80336 Munich, Bavaria, Germany
    Microbes Infect 8:2539-46. 2006
    ....
  12. ncbi request reprint Yersinia outer protein P inhibits CD8 T cell priming in the mouse infection model
    Konrad Trulzsch
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Munchen, Germany
    J Immunol 174:4244-51. 2005
    ..Using this approach we could further show that the listeriolysin O-specific CD8 T cells generated in vivo by the yopP mutant are functional and are able to protect mice against a lethal challenge with wild type Listeria...
  13. ncbi request reprint Salmonella type III-mediated heterologous antigen delivery: a versatile oral vaccination strategy to induce cellular immunity against infectious agents and tumors
    Klaus Panthel
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
    Int J Med Microbiol 298:99-103. 2008
    ..This vaccination strategy can also be employed to efficiently protect mice from an aggressive fibrosarcoma transfected with p60 in a prophylactic setting...
  14. doi request reprint Heterologous prime-boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction
    Victòria E Sevil Domènech
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Pettenkoferstrasse 9a, 80336 Munich, Bavaria, Germany
    Vaccine 26:1879-86. 2008
    ....
  15. pmc Attenuated Yersinia pseudotuberculosis carrier vaccine for simultaneous antigen-specific CD4 and CD8 T-cell induction
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    Infect Immun 71:3463-72. 2003
    ..For the first time, it is shown that cytosolic antigen display mediated by an extracellular bacterial carrier vaccine results in simultaneous CD4 and CD8 T-cell priming, conferring protection against an intracellular pathogen...
  16. ncbi request reprint Yersinia outer protein E, YopE. A versatile type III effector molecule for cytosolic targeting of heterologous antigens by attenuated Salmonella
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, 80336 Munchen, Germany
    Adv Exp Med Biol 529:407-13. 2003
    ..In orally immunized mice, this novel vaccination strategy results in the induction of pronounced peptide-specific cytotoxic CD8 T cell responses...
  17. doi request reprint TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice
    Simon Heidegger
    Center for Integrated Protein Science Munich, Klinische Pharmakologie, Medizinische Klinik und Poliklinik IV, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    J Immunol 190:5313-20. 2013
    ..Our data identify a mechanism that excludes noncognate CD8(+) T cells from selected immune compartments during TLR-induced systemic inflammation...
  18. pmc Contribution of the major secreted yops of Yersinia enterocolitica O:8 to pathogenicity in the mouse infection model
    Konrad Trulzsch
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University, Munich, Germany
    Infect Immun 72:5227-34. 2004
    ..The DeltayopE mutant was eliminated from the small intestine 3 weeks after infection, whereas the DeltayopH, DeltayopP, DeltayopM, and DeltayopQ mutants continued to colonize the small intestine at this time...
  19. pmc Sensitivity of a novel stool antigen test for detection of Helicobacter pylori in adult outpatients before and after eradication therapy
    Vincens Weingart
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    J Clin Microbiol 42:1319-21. 2004
    ..The two tests showed identical levels of sensitivity when used to identify H. pylori-infected patients before and after eradication therapy...
  20. ncbi request reprint Molecular and functional analysis of the type III secretion signal of the Salmonella enterica InvJ protein
    Holger Rüssmann
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, 80336 Munchen, Germany
    Mol Microbiol 46:769-79. 2002
    ..Introduction of silent mutations in the secretion signal coding sequence that result in drastically different predicted mRNA folds had no effect on InvJ secretion or expression...
  21. pmc Evaluation of the novel Helicobacter pylori ClariRes real-time PCR assay for detection and clarithromycin susceptibility testing of H. pylori in stool specimens from symptomatic children
    Christian Lottspeich
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians University, Pettenkoferstr 9a, 80336 Munich, Germany
    J Clin Microbiol 45:1718-22. 2007
    ..7%) for the accurate diagnosis of H. pylori infection in children...