Research Topics
| Holger RüssmannSummaryAffiliation: HELIOS Klinikum Wuppertal Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Inverted pathogenicity: the use of pathogen-specific molecular mechanisms for prevention or therapy of diseaseHolger Rüssmann
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
Int J Med Microbiol 293:565-9. 2004..Surprisingly, cytosolic delivery of YopE/LLO by Yersinia also results in LLO-specific CD4 T-cell priming...
Alternative endogenous protein processing via an autophagy-dependent pathway compensates for Yersinia-mediated inhibition of endosomal major histocompatibility complex class II antigen presentationHolger Rüssmann
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
Infect Immun 78:5138-50. 2010..We provide critical new insights into the interaction between the mammalian immune system and a human pathogen...
Rapid clearance of a recombinant Salmonella vaccine carrier prevents enhanced antigen-specific CD8 T-cell responses after oral boost immunizationsVictòria E Sevil Domènech
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, 80336 Munich, Germany
Microbes Infect 7:860-6. 2005....
Superior protective immunity against murine listeriosis by combined vaccination with CpG DNA and recombinant Salmonella enterica serovar typhimuriumChristina Berchtold
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
Infect Immun 77:5501-8. 2009....
Pre-existing anti-Salmonella vector immunity prevents the development of protective antigen-specific CD8 T-cell frequencies against murine listeriosisVictòria E Sevil Domènech
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Pettenkoferstrasse 9a, 80336 Munich, Bavaria, Germany
Microbes Infect 9:1447-53. 2007..Compared to the significantly higher numbers of p60-specific T lymphocytes elicited after single oral immunization, the low amount of Listeria-specific CD8 T cells did not confer protection against listeriosis...
"One size fits it all": translocation of foreign antigens by Yersinia type III secretion system (TTSS) leads to concomitant CD4 and CD8 T-cell primingHolger Rüssmann
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
Int J Med Microbiol 294:313-7. 2004..This "one-size-fits-it-all"-feature of Yersinia-translocated heterologous antigens might be advantageous to mount T-cellular immune responses against complex microbes and tumors...
Heterologous prime-boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell inductionVictòria E Sevil Domènech
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Pettenkoferstrasse 9a, 80336 Munich, Bavaria, Germany
Vaccine 26:1879-86. 2008....
Salmonella type III-mediated heterologous antigen delivery: a versatile oral vaccination strategy to induce cellular immunity against infectious agents and tumorsKlaus Panthel
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
Int J Med Microbiol 298:99-103. 2008..This vaccination strategy can also be employed to efficiently protect mice from an aggressive fibrosarcoma transfected with p60 in a prophylactic setting...
Yersinia outer protein E, YopE. A versatile type III effector molecule for cytosolic targeting of heterologous antigens by attenuated SalmonellaHolger Rüssmann
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, 80336 Munchen, Germany
Adv Exp Med Biol 529:407-13. 2003..In orally immunized mice, this novel vaccination strategy results in the induction of pronounced peptide-specific cytotoxic CD8 T cell responses...
Yersinia outer protein P inhibits CD8 T cell priming in the mouse infection modelKonrad Trulzsch
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Munchen, Germany
J Immunol 174:4244-51. 2005..Using this approach we could further show that the listeriolysin O-specific CD8 T cells generated in vivo by the yopP mutant are functional and are able to protect mice against a lethal challenge with wild type Listeria...
Attenuated Yersinia pseudotuberculosis carrier vaccine for simultaneous antigen-specific CD4 and CD8 T-cell inductionHolger Rüssmann
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
Infect Immun 71:3463-72. 2003..For the first time, it is shown that cytosolic antigen display mediated by an extracellular bacterial carrier vaccine results in simultaneous CD4 and CD8 T-cell priming, conferring protection against an intracellular pathogen...
Evaluation of the novel Helicobacter pylori ClariRes real-time PCR assay for detection and clarithromycin susceptibility testing of H. pylori in stool specimens from symptomatic childrenChristian Lottspeich
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians University, Pettenkoferstr 9a, 80336 Munich, Germany
J Clin Microbiol 45:1718-22. 2007..7%) for the accurate diagnosis of H. pylori infection in children...
