M Heisenberg

Summary

Country: Germany

Publications

  1. ncbi request reprint An engram found? Evaluating the evidence from fruit flies
    Bertram Gerber
    Universitat Wurzburg, Lehrstuhl für Genetik und Neurobiologie, Biozentrum Am Hubland, D 970 74 Würzburg, Germany
    Curr Opin Neurobiol 14:737-44. 2004
  2. ncbi request reprint Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster
    Punita Sharma
    Department of Genetics, University of Cambridge, Cambridge, UK
    J Neurogenet 19:57-85. 2005
  3. doi request reprint 'Humans and other animals'-on the scope of brain science
    M Heisenberg
    Rudolf Virchow Center, University of Wurzburg, Wurzburg, Germany
    J Neurogenet 26:267-70. 2012
  4. pmc The Virtual Insect Brain protocol: creating and comparing standardized neuroanatomy
    Arnim Jenett
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
    BMC Bioinformatics 7:544. 2006
  5. pmc A high-level 3D visualization API for Java and ImageJ
    Benjamin Schmid
    Department of Neurobiology and Genetics, Biocenter, University of Wurzburg, Am Hubland, Wurzburg, Germany
    BMC Bioinformatics 11:274. 2010
  6. ncbi request reprint Mushroom body memoir: from maps to models
    Martin Heisenberg
    Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Nat Rev Neurosci 4:266-75. 2003
  7. ncbi request reprint Common design of mushroom bodies in bees and flies?
    Martin Heisenberg
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
    J Comp Neurol 450:1-3. 2002
  8. ncbi request reprint Flexibility in a single behavioral variable of Drosophila
    M Heisenberg
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, D 97074 Wurzburg, Germany
    Learn Mem 8:1-10. 2001
  9. ncbi request reprint Genetic approaches to neuroethology
    M Heisenberg
    Biozentrum, Lehrstuhl fur Genetik, Wurzburg, Germany
    Bioessays 19:1065-73. 1997
  10. ncbi request reprint Conditioning with compound stimuli in Drosophila melanogaster in the flight simulator
    B Brembs
    Lehrstuhl Genetik und Neurobiologie, Biozentrum, Wurzburg, Germany
    J Exp Biol 204:2849-59. 2001

Collaborators

Detail Information

Publications52

  1. ncbi request reprint An engram found? Evaluating the evidence from fruit flies
    Bertram Gerber
    Universitat Wurzburg, Lehrstuhl für Genetik und Neurobiologie, Biozentrum Am Hubland, D 970 74 Würzburg, Germany
    Curr Opin Neurobiol 14:737-44. 2004
    ..With regard to olfactory learning in flies, we argue that the notion of the olfactory memory trace being localized to the Kenyon cells of the mushroom bodies is a reasonable working hypothesis...
  2. ncbi request reprint Isogenic autosomes to be applied in optimal screening for novel mutants with viable phenotypes in Drosophila melanogaster
    Punita Sharma
    Department of Genetics, University of Cambridge, Cambridge, UK
    J Neurogenet 19:57-85. 2005
    ..The lines generated are now being used as target chromosomes in mutagenesis screens, and the characterization reported here will facilitate their use in screens of these lines for behavioral and other viable phenotypes...
  3. doi request reprint 'Humans and other animals'-on the scope of brain science
    M Heisenberg
    Rudolf Virchow Center, University of Wurzburg, Wurzburg, Germany
    J Neurogenet 26:267-70. 2012
    ..It is just a little piece of writing. It is meant to honor Obaid for his contributions to Drosophila neurogenetics in 40 years and to science in India. I hope he takes it instead of a bowl of flowers-adding to the praise...
  4. pmc The Virtual Insect Brain protocol: creating and comparing standardized neuroanatomy
    Arnim Jenett
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
    BMC Bioinformatics 7:544. 2006
    ..To take advantage of these patterns one needs to know their typical anatomy...
  5. pmc A high-level 3D visualization API for Java and ImageJ
    Benjamin Schmid
    Department of Neurobiology and Genetics, Biocenter, University of Wurzburg, Am Hubland, Wurzburg, Germany
    BMC Bioinformatics 11:274. 2010
    ..The reconstruction, segmentation and registration are best approached from the 3D representation of the data set...
  6. ncbi request reprint Mushroom body memoir: from maps to models
    Martin Heisenberg
    Biozentrum der Universität Würzburg, Am Hubland, D 97074 Wurzburg, Germany
    Nat Rev Neurosci 4:266-75. 2003
  7. ncbi request reprint Common design of mushroom bodies in bees and flies?
    Martin Heisenberg
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
    J Comp Neurol 450:1-3. 2002
  8. ncbi request reprint Flexibility in a single behavioral variable of Drosophila
    M Heisenberg
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, D 97074 Wurzburg, Germany
    Learn Mem 8:1-10. 2001
    ..We start with a brief summary of visual flight control at the torque meter...
  9. ncbi request reprint Genetic approaches to neuroethology
    M Heisenberg
    Biozentrum, Lehrstuhl fur Genetik, Wurzburg, Germany
    Bioessays 19:1065-73. 1997
    ..The 'graininess' of a functional model of the brain, therefore, is defined by the independent regulatory units of the genes rather than by the genes themselves...
  10. ncbi request reprint Conditioning with compound stimuli in Drosophila melanogaster in the flight simulator
    B Brembs
    Lehrstuhl Genetik und Neurobiologie, Biozentrum, Wurzburg, Germany
    J Exp Biol 204:2849-59. 2001
    ....
  11. ncbi request reprint Vision affects mushroom bodies and central complex in Drosophila melanogaster
    M Barth
    Theodor Boveri Institut für Biowissenschaften Lehrstuhl für Genetik, Wurzburg, Germany
    Learn Mem 4:219-29. 1997
    ..This stimulating effect of crowding is not observed in any of the cAMP mutants, including rutabaga1...
  12. ncbi request reprint Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila
    Martin Schwaerzel
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D 97074 Wurzburg, Germany
    J Neurosci 23:10495-502. 2003
    ..Our results suggest that in associative conditioning, different memories are formed of the same odor under different circumstances, and that they are linked to the respective motivational systems by their specific modulatory pathways...
  13. pmc Drosophila mushroom bodies are dispensable for visual, tactile, and motor learning
    R Wolf
    Lehrstuhl fur Genetik, Biozentrum, Wurzburg, Germany
    Learn Mem 5:166-78. 1998
    ..With respect to short-term memory the mushroom bodies of Drosophila are specially required for chemosensory learning tasks, but not for associative learning and memory in general...
  14. ncbi request reprint The central complex of Drosophila melanogaster is involved in flight control: studies on mutants and mosaics of the gene ellipsoid body open
    M Ilius
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Wurzburg, Germany
    J Neurogenet 9:189-206. 1994
    ..The results support the hypothesis that the central complex is involved in the control of flight behavior...
  15. pmc Mushroom bodies suppress locomotor activity in Drosophila melanogaster
    J R Martin
    Lehrstuhl fur Genetik, Biozentrum, Wurzburg, Germany
    Learn Mem 5:179-91. 1998
    ..How this finding relates to the well-documented role of the mushroom bodies in olfactory learning and memory remains to be understood...
  16. ncbi request reprint Localization of a short-term memory in Drosophila
    T Zars
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Biozentrum Am Hubland, D97074, Wurzburg, Germany
    Science 288:672-5. 2000
    ..This demonstrates that synaptic plasticity in a small brain region can be sufficient for memory formation...
  17. ncbi request reprint Experience-dependent developmental plasticity in the optic lobe of Drosophila melanogaster
    M Barth
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, 97074 Wurzburg, Germany
    J Neurosci 17:1493-504. 1997
    ..Dark-rearing for 1 d or more at any stage during that period decreases its volume to the level of flies raised in constant darkness. A lamina that is once reduced in size seems not to recover...
  18. ncbi request reprint Context generalization in Drosophila visual learning requires the mushroom bodies
    L Liu
    Lehrstuhl fur Genetik, Biozentrum, Wurzburg, Germany
    Nature 400:753-6. 1999
    ..In visual learning in Drosophila, it appears that a facilitating effect of context cues for memory retrieval is the default state, whereas making recall context-independent requires additional processing...
  19. ncbi request reprint A higher control center of locomotor behavior in the Drosophila brain
    R Strauss
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Wurzburg, Germany
    J Neurosci 13:1852-61. 1993
    ....
  20. ncbi request reprint A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system
    J Melzig
    Lehrstuhl fur Genetik, Universitat Wurzburg, Germany
    Curr Biol 8:1223-6. 1998
    ..We show that mutations in mbt primarily interfere with the generation or survival of the intrinsic cells (Kenyon cells) of the mushroom body, a paired neuropil structure in the adult brain involved in learning and memory...
  21. ncbi request reprint Associative odor learning in Drosophila abolished by chemical ablation of mushroom bodies
    J S de Belle
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Universitat Wurzburg, Germany
    Science 263:692-5. 1994
    ..This deficit cannot be attributed to reductions in olfactory sensitivity, shock reactivity, or locomotor behavior. The results demonstrate that MBs mediate associative odor learning in flies...
  22. ncbi request reprint Mutations in the proximal region of the optomotor-blind locus of Drosophila melanogaster reveal a gradient of neuroanatomical and behavioral phenotypes
    A Brunner
    Institut fur Genetik und Mikrobiologie, Wurzburg, Germany
    J Neurogenet 8:43-55. 1992
    ..On this basis the 3'-regulatory region is divided into three domains each having specific effects on optic lobe development...
  23. ncbi request reprint Multiple memory traces for olfactory reward learning in Drosophila
    Andreas S Thum
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Neurosci 27:11132-8. 2007
    ..This difference in the organization of memory traces is consistent with the internal representation of reward and punishment...
  24. ncbi request reprint Extinction antagonizes olfactory memory at the subcellular level
    Martin Schwaerzel
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, Wurzburg, Germany
    Neuron 35:951-60. 2002
    ..Thus, unreinforced presentation of learned odorants antagonizes intracellularly the signaling cascade underlying memory formation...
  25. ncbi request reprint Temporal pattern of locomotor activity in Drosophila melanogaster
    J R Martin
    Lehrstuhl fur Genetik, Biozentrum, Am Hubland, Wurzburg, Germany
    J Comp Physiol A 184:73-84. 1999
    ..We propose that time-course, bout structure and fractal dimension of the temporal pattern of locomotor activity describe different aspects of the fly's central pattern generator for locomotion and its motivational control...
  26. ncbi request reprint Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster
    S Albert
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Universitat Wurzburg, Germany
    Gene 198:181-9. 1997
    ..In-situ hybridization and Northern blot analysis indicate a widespread function of this gene during embryogenesis and in the CNS...
  27. doi request reprint P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons
    Matthias Fischer
    Institute for Clinical Neurobiology, University of Wurzburg, 97080 Wurzburg, Germany
    Mol Cell Neurosci 42:134-41. 2009
    ..Thus, the functional defects observed in the nervous system of CLS patients and animal models with Rsk2 deficiency might be caused by dysregulated neurite growth rather than primary neurodegeneration...
  28. doi request reprint Drosophila RSK negatively regulates bouton number at the neuromuscular junction
    Matthias Fischer
    Institute for Clinical Neurobiology, University of Wurzburg, Würzburg 97078, Germany
    Dev Neurobiol 69:212-20. 2009
    ..These experiments provided evidence that RSK mediates its negative effect on bouton formation at the Drosophila NMJ by inhibition of ERK signaling...
  29. ncbi request reprint The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task
    Gabriele Putz
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D 97074 Wuerzburg, Germany
    J Neurosci 24:9745-51. 2004
    ..Overexpression of S6KII in wild type has a dominant-negative effect on the operant task that is rescued by the null mutant, whereas in the pavlovian task overexpression may even enhance learning performance...
  30. ncbi request reprint Experimental psychology: event timing turns punishment to reward
    Hiromu Tanimoto
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Nature 430:983. 2004
    ..These opposing behaviours depend on the relative timing of the shock and odour presentations during training, and indicate that a shock can act as either an aversive reinforcer or an appetitive one...
  31. ncbi request reprint Visual learning in individually assayed Drosophila larvae
    B Gerber
    Department of Genetics and Neurobiology, Biocentre Am Hubland, University of Wurzburg, D 970 74 Würzburg, Germany
    J Exp Biol 207:179-88. 2004
    ..It is now possible to investigate the behavioral and neuronal organization of appetitive visual learning in this simple and genetically easy-to-manipulate experimental system...
  32. ncbi request reprint Central complex substructures are required for the maintenance of locomotor activity in Drosophila melanogaster
    J R Martin
    Lehrstuhl fur Genetik, Biozentrum, Wurzburg, Germany
    J Comp Physiol A 185:277-88. 1999
    ..This finding suggests that the bridge and some of its neural connections to the other neuropil regions of the central complex are required for the maintenance but not the initiation of walking...
  33. ncbi request reprint The carrot, not the stick: appetitive rather than aversive gustatory stimuli support associative olfactory learning in individually assayed Drosophila larvae
    Thomas Hendel
    Department of Genetics and Neurobiology, University of Wurzburg, Biozentrum, Am Hubland, 97074, Wurzburg, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:265-79. 2005
    ..These results open the door to analyze how this dissociation is brought about on the cellular and molecular level; this should be facilitated by the cellular simplicity and genetic accessibility of the Drosophila larva...
  34. ncbi request reprint No-bridge of Drosophila melanogaster: portrait of a structural brain mutant of the central complex
    R Strauss
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl fur Genetik, Wurzburg, Federal Republic of Germany
    J Neurogenet 8:125-55. 1992
    ..The behavioral defects support the notion that the protocerebral bridge is part of a higher center for the regulation of behavior...
  35. ncbi request reprint Molecular and genetic analysis of the Drosophila mas-1 (mannosidase-1) gene which encodes a glycoprotein processing alpha 1,2-mannosidase
    S Kerscher
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl Genetik, Wurzburg, Germany
    Dev Biol 168:613-26. 1995
    ..These findings illustrate that the processing of N-linked glycans plays a functional role in Drosophila development. There is, however, ample evidence for genetic and biochemical redundancy in the mannose-trimming steps of this pathway...
  36. ncbi request reprint Differential potencies of effector genes in adult Drosophila
    Andreas S Thum
    Lehrstuhl Genetik und Neurobiologie, Universität Würzburg Am Hubland Biozentrum, D 97074 Wurzburg, Germany
    J Comp Neurol 498:194-203. 2006
    ..Altogether, the efficiency of effector genes depends on properties of the targeted neurons. Thus, we conclude that the selection of the appropriate effector gene is critical for evaluating the function of neural circuits...
  37. ncbi request reprint Flies lacking all synapsins are unexpectedly healthy but are impaired in complex behaviour
    Tanja A Godenschwege
    Theodor Boveri Institut für Biowissenschaften, Lehrstuhl für Genetik und Neurobiologie, Am Hubland D 97074 Wuerzburg, Germany
    Eur J Neurosci 20:611-22. 2004
    ..Larval behavioural defects are described in a separate paper. We conclude that Drosophila synapsins play a significant role in nervous system function, which is subtle at the cellular level but manifests itself in complex behaviour...
  38. pmc Distinct memories of odor intensity and quality in Drosophila
    Pavel Masek
    Biozentrum, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Proc Natl Acad Sci U S A 105:15985-90. 2008
    ....
  39. ncbi request reprint The Drosophila standard brain
    Karlheinz Rein
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, 97074 Wurzburg, Germany
    Curr Biol 12:227-31. 2002
    ..We now provide a representative standard for the brain of D. melanogaster wild-type with means and variances for several aspects of its shape. Its application to volumetry, mutants, and gene expression patterns is demonstrated...
  40. pmc Memories in drosophila heat-box learning
    Gabriele Putz
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D97074, Wuerzburg, Germany
    Learn Mem 9:349-59. 2002
    ..This exposure effect reveals a dispositional change that facilitates operant learning during the reminder training. The various memory effects are independent of the mushroom bodies...
  41. ncbi request reprint Distinct functions of neuronal synaptobrevin in developing and mature fly photoreceptors
    Jens Rister
    Lehrstuhl für Genetik und Neurobiologie der Universität Würzburg, Biozentrum Am Hubland, D 97074 Wurzburg, Germany
    J Neurobiol 66:1271-84. 2006
    ..These results need to be taken into account if TNT is used for neural circuit analysis...
  42. ncbi request reprint A quantitative three-dimensional model of the Drosophila optic lobes
    K Rein
    Lehrstuhl fur Genetik, Biozentrum Am Hubland, 97074 Wuerzburg, Germany
    Curr Biol 9:93-6. 1999
    ..For males, additional neuropil was found only at the posterior margin of the lobula. This finding supports the notion of male-specific neural processing in the lobula as described for muscid and calliphorid flies...
  43. doi request reprint Octopamine in male aggression of Drosophila
    Susanne C Hoyer
    Lehrstuhl für Genetik und Neurobiologie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Curr Biol 18:159-67. 2008
    ..Octopamine, a closely related biogenic amine, has been proposed to have a similar function in arthropods. However, the effect of octopamine on aggressive behavior is little understood...
  44. ncbi request reprint Targeted expression of tetanus neurotoxin interferes with behavioral responses to sensory input in Drosophila
    Andreas Keller
    Institut für Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    J Neurobiol 50:221-33. 2002
    ..To increase the utility of the GAL4 system for such purposes, we have designed an inducible system that allows us to circumvent lethality caused by TNT expression during early development...
  45. ncbi request reprint Dissection of the peripheral motion channel in the visual system of Drosophila melanogaster
    Jens Rister
    Lehrstuhl für Genetik und Neurobiologie, Universitat Wurzburg, Am Hubland, 97074, Wurzburg, Germany
    Neuron 56:155-70. 2007
    ..At low contrast, L1 and L2 depend upon each other for motion processing. Of the two minor pathways, amc/T1 specifically enhances the L1 pathway at intermediate contrast. L3 appears not to contribute to motion but to orientation behavior...
  46. pmc Motion vision is independent of color in Drosophila
    Satoko Yamaguchi
    Department of Genetics and Neurobiology, Biozentrum, University of Wurzburg, 97074 Wurzburg, Germany
    Proc Natl Acad Sci U S A 105:4910-5. 2008
    ..We conclude that the color channel (R7/R8) does not contribute to motion detection as monitored by the optomotor response...
  47. ncbi request reprint Distinct memory traces for two visual features in the Drosophila brain
    Gang Liu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Nature 439:551-6. 2006
    ..These can be localized to two groups of neurons extending branches as parallel, horizontal strata in the fan-shaped body. The central location of this memory store is well suited to mediate translational invariance...
  48. pmc Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila
    Alexandre Bettencourt Da Cruz
    CROET Oregon Health and Science University, Portland, OR 97239, USA
    Mol Biol Cell 16:2433-42. 2005
    ..The futsch(olk) mutants exhibit several characteristics of human neurodegenerative diseases, providing an opportunity to study the role of MAPs in progressive neurodegeneration within an experimentally accessible, in vivo model system...
  49. pmc Identification of mushroom body miniature, a zinc-finger protein implicated in brain development of Drosophila
    Thomas Raabe
    Institut fur Medizinische Strahlenkunde und Zellforschung, University of Wurzburg, Versbacherstrasse 5, D 97078 Wurzburg, Germany
    Proc Natl Acad Sci U S A 101:14276-81. 2004
    ..Immunohistochemical analysis shows that expression of the Mbm protein is not restricted to the mushroom bodies. BrdUrd labeling experiments indicate a function of Mbm in neuronal precursor cell proliferation...
  50. ncbi request reprint Interview with Martin Heisenberg
    Martin Heisenberg
    Curr Biol 14:R637-8. 2004
  51. ncbi request reprint Visual pattern recognition in Drosophila is invariant for retinal position
    Shiming Tang
    Institute of Biophysics Academia Sinica, 15 Datun Road, Chaoyang, Beijing 100101, P R China
    Science 305:1020-2. 2004
    ..Here, we show that flies recognize patterns at retinal positions where the patterns had not been presented before...
  52. pmc The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster
    Edward Ryder
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Genetics 167:797-813. 2004
    ..In addition, a further 37,000 deletions, selectable by molecular screening, may be generated. We are now using the collection to generate a second-generation deficiency kit that is precisely mapped to the genome sequence...