Dan Ziegler

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint [Treatment of diabetic neuropathy]
    D Ziegler
    Institut für Klinische Diabetologie, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 132:1043-7. 2007
  2. doi request reprint Prevalence and risk factors of neuropathic pain in survivors of myocardial infarction with pre-diabetes and diabetes. The KORA Myocardial Infarction Registry
    Dan Ziegler
    Institute of Clinical Diabetes Research, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University, Dusseldorf, Germany
    Eur J Pain 13:582-7. 2009
  3. ncbi request reprint Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, GermanyDepartment of Endocrinology and Diabetology, University Hospital, Dusseldorf, Germany
    Diabetes 63:2454-63. 2014
  4. doi request reprint Evaluation of the Neuropad sudomotor function test as a screening tool for polyneuropathy in the elderly population with diabetes and pre-diabetes: the KORA F4 survey
    D Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabetes Metab Res Rev 28:692-7. 2012
  5. pmc High sensitive troponin T and heart fatty acid binding protein: novel biomarker in heart failure with normal ejection fraction? A cross-sectional study
    Wilfried Dinh
    Department of Cardiology, Witten Herdecke University, HELIOS Klinikum Wuppertal, Germany
    BMC Cardiovasc Disord 11:41. 2011
  6. pmc Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, and Department of Metabolic Diseases, University Hospital, Dusseldorf, Germany
    Diabetes Care 32:1479-84. 2009
  7. ncbi request reprint Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:464-9. 2008
  8. ncbi request reprint Impact of disease characteristics on the efficacy of duloxetine in diabetic peripheral neuropathic pain
    Dan Ziegler
    German Diabetes Center, Leibniz Institute at the Heinrich Heine University, 40225 Dusseldorf, Germany
    Diabetes Care 30:664-9. 2007
  9. ncbi request reprint Treatment of diabetic polyneuropathy: Update 2006
    Dan Ziegler
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, WHO Collaborating Center in Diabetes, European Training Center in Endocrinology and Metabolism, Dusseldorf, Germany
    Ann N Y Acad Sci 1084:250-66. 2006
  10. ncbi request reprint [Duloxetine, a new therapeutic option for diabetic peripheral neuropathic pain]
    D Ziegler
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum an der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany
    Dtsch Med Wochenschr 131:S284-8. 2006

Collaborators

Detail Information

Publications56

  1. ncbi request reprint [Treatment of diabetic neuropathy]
    D Ziegler
    Institut für Klinische Diabetologie, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 132:1043-7. 2007
  2. doi request reprint Prevalence and risk factors of neuropathic pain in survivors of myocardial infarction with pre-diabetes and diabetes. The KORA Myocardial Infarction Registry
    Dan Ziegler
    Institute of Clinical Diabetes Research, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University, Dusseldorf, Germany
    Eur J Pain 13:582-7. 2009
    ..Associated cardiovascular risk factors including abdominal obesity and low physical activity may constitute targets to prevent neuropathic pain in this population...
  3. ncbi request reprint Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, GermanyDepartment of Endocrinology and Diabetology, University Hospital, Dusseldorf, Germany
    Diabetes 63:2454-63. 2014
    ..Concomitant NCS impairment points to an early parallel involvement of small and large fibers, but the precise temporal sequence should be clarified in prospective studies. ..
  4. doi request reprint Evaluation of the Neuropad sudomotor function test as a screening tool for polyneuropathy in the elderly population with diabetes and pre-diabetes: the KORA F4 survey
    D Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabetes Metab Res Rev 28:692-7. 2012
    ..This study aimed to evaluate the utility of Neuropad as a screening tool for distal symmetric polyneuropathy among elderly subjects with diabetes and pre-diabetes in the general population...
  5. pmc High sensitive troponin T and heart fatty acid binding protein: novel biomarker in heart failure with normal ejection fraction? A cross-sectional study
    Wilfried Dinh
    Department of Cardiology, Witten Herdecke University, HELIOS Klinikum Wuppertal, Germany
    BMC Cardiovasc Disord 11:41. 2011
    ..We tested whether hsTnT and hFABP plasma levels are elevated in patients with heart failure with normal ejection fraction (HFnEF)...
  6. pmc Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, and Department of Metabolic Diseases, University Hospital, Dusseldorf, Germany
    Diabetes Care 32:1479-84. 2009
    ..CONCLUSIONS Sequential intravenous and oral actovegin treatment over 160 days improved neuropathic symptoms, VPT, sensory function, and quality of life in type 2 diabetic patients with symptomatic polyneuropathy...
  7. ncbi request reprint Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:464-9. 2008
    ..The aim of this study was to determine the prevalence and risk factors of polyneuropathy in subjects with diabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or normal glucose tolerance (NGT)...
  8. ncbi request reprint Impact of disease characteristics on the efficacy of duloxetine in diabetic peripheral neuropathic pain
    Dan Ziegler
    German Diabetes Center, Leibniz Institute at the Heinrich Heine University, 40225 Dusseldorf, Germany
    Diabetes Care 30:664-9. 2007
    ..To evaluate the impact of baseline disease variables related to diabetes and diabetic neuropathy severity on efficacy and safety of duloxetine in the management of diabetic peripheral neuropathic pain...
  9. ncbi request reprint Treatment of diabetic polyneuropathy: Update 2006
    Dan Ziegler
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, WHO Collaborating Center in Diabetes, European Training Center in Endocrinology and Metabolism, Dusseldorf, Germany
    Ann N Y Acad Sci 1084:250-66. 2006
    ....
  10. ncbi request reprint [Duloxetine, a new therapeutic option for diabetic peripheral neuropathic pain]
    D Ziegler
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum an der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany
    Dtsch Med Wochenschr 131:S284-8. 2006
    ..The various drugs should be considered individually in any treatment algorithm, also taking into account their side effects. Psychotherapeutic methods serve to support the overcoming of pain...
  11. ncbi request reprint Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial
    Dan Ziegler
    FRCPE, Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:2365-70. 2006
    ..The aim of this trial was to evaluate the effects of alpha-lipoic acid (ALA) on positive sensory symptoms and neuropathic deficits in diabetic patients with distal symmetric polyneuropathy (DSP)...
  12. ncbi request reprint Prediction of mortality using measures of cardiac autonomic dysfunction in the diabetic and nondiabetic population: the MONICA/KORA Augsburg Cohort Study
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:556-61. 2008
    ..To evaluate whether reduced heart rate variability (HRV), prolonged corrected QT (QTc) interval, or increased QT dispersion (QTD) are predictors of mortality in the general diabetic and nondiabetic population...
  13. ncbi request reprint Management of painful diabetic neuropathy: what is new or in the pipeline for 2007?
    Dan Ziegler
    Institut für Klinische Diabetologie, Deutsches Diabetes Zentrum, Leibniz Zentrum an der Heinrich Heine Universität Düsseldorf, 40225 Dusseldorf, Germany
    Curr Diab Rep 7:409-15. 2007
    ..Among at least 50 new drugs for treatment of neuropathic pain in the pipelines, there are several promising candidates such as lacosamide. Individual tolerability remains a major aspect in any treatment decision...
  14. doi request reprint Painful diabetic neuropathy: treatment and future aspects
    Dan Ziegler
    Institute of Clinical Diabetes Research, German Diabetes Center, Leibniz Center at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Metab Res Rev 24:S52-7. 2008
    ..In future, drug combinations might also include those aimed at symptomatic pain relief and quality of life on one hand and improvement or slowing the progression of the underlying neuropathic process on the other hand...
  15. doi request reprint Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Pain Med 10:393-400. 2009
    ..The aim of this study was to determine the prevalence and risk factors of neuropathic pain in subjects with diabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or normal glucose tolerance (NGT)...
  16. pmc Efficacy and safety of lacosamide in painful diabetic neuropathy
    Dan Ziegler
    nstitute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, and the Department of Metabolic Diseases, University Hospital, Dusseldorf, Germany
    Diabetes Care 33:839-41. 2010
    ..To evaluate efficacy and safety of lacosamide compared with placebo in painful diabetic polyneuropathy...
  17. ncbi request reprint Current concepts in the management of diabetic polyneuropathy
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Dusseldorf, Germany
    Curr Diabetes Rev 7:208-20. 2011
    ....
  18. doi request reprint Neuropad: evaluation of three cut-off points of sudomotor dysfunction for early detection of polyneuropathy in recently diagnosed diabetes
    D Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabet Med 28:1412-5. 2011
    ..To examine the sensitivity and specificity of three cut-off points of Neuropad for the diagnosis of distal symmetric polyneuropathy and small-fibre dysfunction in patients within the first year after diagnosis of diabetes...
  19. doi request reprint Treatment of diabetic neuropathy and neuropathic pain: how far have we come?
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:S255-61. 2008
    ....
  20. ncbi request reprint Selective contribution of diabetes and other cardiovascular risk factors to cardiac autonomic dysfunction in the general population
    D Ziegler
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, WHO Collaborating Center in Diabetes, European Training Center in Endocrinology and Metabolism, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 114:153-9. 2006
    ..However, obesity and smoking contribute to autonomic dysfunction in men but not women. Thus, a selectivity and sex-related differences exist among the various cardiovascular risk factors as to their influence on autonomic dysfunction...
  21. pmc Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Germany
    Diabetes Care 34:2054-60. 2011
    ..Primary end point was a composite score (Neuropathy Impairment Score [NIS]-Lower Limbs [NIS-LL] and seven neurophysiologic tests). Secondary outcome measures included NIS, NIS-LL, nerve conduction, and quantitative sensory tests (QSTs)...
  22. ncbi request reprint Type 2 diabetes as an inflammatory cardiovascular disorder
    D Ziegler
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, WHO Collaborating Center in Diabetes, European Training Center in Endocrinology and Metabolism, Dusseldorf, Germany
    Curr Mol Med 5:309-22. 2005
    ..Drugs exerting anti-inflammatory and vascular effects have future potential to be used within an array of interventions aimed at reducing the enormous cardiovascular burden associated with Type 2 diabetes...
  23. pmc Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:680-2. 2009
    ..Therefore, we investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy...
  24. pmc Older subjects with diabetes and prediabetes are frequently unaware of having distal sensorimotor polyneuropathy: the KORA F4 study
    Brenda W C Bongaerts
    Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Diabetes Care 36:1141-6. 2013
    ..Distal sensorimotor polyneuropathy (DSPN) is a severe complication of type 2 diabetes. This study aimed to assess the prevalence of unawareness of DSPN in prediabetes and diabetes in a sample of the older population of Augsburg, Germany...
  25. doi request reprint Prediabetic neuropathy: does it exist?
    Nikolaos Papanas
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Curr Diab Rep 12:376-83. 2012
    ..In practice, therapy of prediabetic neuropathy should be addressed towards normoglycemia and correction of cardiovascular risk factors. However, additional work is needed to establish the long-term results of this approach...
  26. doi request reprint Pronounced reduction of cutaneous Langerhans cell density in recently diagnosed type 2 diabetes
    Alexander Strom
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabetes 63:1148-53. 2014
    ....
  27. pmc Postchallenge hyperglycemia is positively associated with diabetic polyneuropathy: the KORA F4 study
    Brenda W C Bongaerts
    Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Diabetes Care 35:1891-3. 2012
    ..To assess the prevalence of distal sensorimotor polyneuropathy (DSPN) in an older population and to examine its relationship with prediabetes...
  28. pmc Immune mediators in patients with acute diabetic foot syndrome
    Christian Weigelt
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:1491-6. 2009
    ..Further studies should investigate whether an activation of the immune system precedes the development of foot ulcer and whether anti-inflammatory therapies might be effective...
  29. ncbi request reprint Diagnosis and treatment of diabetic autonomic neuropathy
    D Ziegler
    German Diabetes Research Institute, Heinrich Heine University, German Diabetes Clinic, Auf m Hennekamp 65, Dusseldorf 40225, Germany
    Curr Diab Rep 1:216-27. 2001
    ..Prior to an adequate symptomatic treatment a thorough risk-benefit estimate, aimed at maintaining the patient's quality of life, is required...
  30. ncbi request reprint Management of erectile dysfunction in diabetic patients
    D Ziegler
    German Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabetes Nutr Metab 15:58-65. 2002
  31. ncbi request reprint Normal ranges and reproducibility of statistical, geometric, frequency domain, and non-linear measures of 24-hour heart rate variability
    D Ziegler
    Klinische Abteilung, Deutsches Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Horm Metab Res 31:672-9. 1999
    ..The majority of the HRV measures, in particular the geometric parameters, show a relatively high intraindividual reproducibility which underlines their suitability for the use in prospective studies...
  32. ncbi request reprint Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials
    D Ziegler
    Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 107:421-30. 1999
    ....
  33. ncbi request reprint Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy
    D Ziegler
    Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Diabetes Care 22:1296-301. 1999
    ..To evaluate the efficacy and safety of alpha-lipoic acid given intravenously, followed by oral treatment in type 2 diabetic patients with symptomatic polyneuropathy...
  34. ncbi request reprint Application of isotope-selective nondispersive infrared spectrometry (IRIS) for evaluation of [13C]octanoic acid gastric-emptying breath tests: comparison with isotope ratio-mass spectrometry (IRMS)
    P Schadewaldt
    Diabetes Forschungsinstitut, Klinische Biochemie Auf m Hennekamp 65, Dusseldorf, Germany
    Clin Chem 43:518-22. 1997
    ..99x + 4.06, Sy[symbol: see text]x = +/- 6.3; tlag, breath: y = 0.97x + 0.96, Sy[symbol: see text]x = +/-3.4; GEC: y = 0.97x - 0.01, Sy[symbol: see text]x = +/-0.09)...
  35. ncbi request reprint Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis
    D Ziegler
    German Diabetes Research Institute, Leibriz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 21:114-21. 2004
    ..To determine the efficacy and safety of 600 mg of alpha-lipoic acid given intravenously over 3 weeks in diabetic patients with symptomatic polyneuropathy...
  36. ncbi request reprint [Autonomic neuropathies in diabetic patients. Heart involvement signals poor prognosis]
    D Ziegler
    Deutsches Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf
    MMW Fortschr Med 144:35-7. 2002
  37. ncbi request reprint Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine
    R Freynhagen
    Department of Anaesthesiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Int J Clin Pract 61:1989-96. 2007
    ..We aimed to investigate pregabalin, a gamma-aminobutyric acid (GABA)-analogue, in a wide range of pregabalin naive patients with treatment refractory NeP...
  38. ncbi request reprint Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review
    Dan Ziegler
    German Diabetes Clinic, German Diabetes Research Institute, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Treat Endocrinol 3:173-89. 2004
    ....
  39. ncbi request reprint Efficacy and safety of flexible-dose vardenafil in men with type 1 diabetes and erectile dysfunction
    Dan Ziegler
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Institut, Heinrich Heine Universitat, Dusseldorf, Germany
    J Sex Med 3:883-91. 2006
    ..Limited data are available on the efficacy and safety of the potent oral phosphodiesterase-5 inhibitor vardenafil in men with ED and type 1 diabetes...
  40. ncbi request reprint Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy
    Dan Ziegler
    German Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 27:2178-83. 2004
    ..The objective of this study was to evaluate plasma levels of various biomarkers of oxidative stress in diabetic subjects in relation to the presence or absence of polyneuropathy (PN) and/or cardiovascular autonomic neuropathy (CAN)...
  41. ncbi request reprint Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation
    L Reichstein
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute, Heinrich Heine University Dusseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetologia 48:824-8. 2005
    ..We performed a controlled, randomised pilot trial to compare the effects of high-frequency external muscle stimulation (HF) with those of TENS in patients with symptomatic DSP...
  42. ncbi request reprint Assessment of cardiovascular autonomic function: age-related normal ranges and reproducibility of spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses
    D Ziegler
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 9:166-75. 1992
    ....
  43. ncbi request reprint Validation of a novel screening device (NeuroQuick) for quantitative assessment of small nerve fiber dysfunction as an early feature of diabetic polyneuropathy
    Dan Ziegler
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum an der Heinrich Heine Universität, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 28:1169-74. 2005
    ..To validate a handheld screening device (NeuroQuick) for an early detection of diabetic distal symmetric polyneuropathy (DSP) by quantitative testing of cold sensation based on the wind chill factor (NeuroQuick threshold [NQT])...
  44. ncbi request reprint Clinical trials for drugs against diabetic neuropathy: can we combine scientific needs with clinical practicalities?
    Dan Ziegler
    German Diabetes Research Institute at the Heinrich Heine University, German Diabetes Clinic, 40225 Dusseldorf, Germany
    Int Rev Neurobiol 50:431-63. 2002
    ....
  45. ncbi request reprint New perspectives on the management of diabetic peripheral neuropathic pain
    Troels S Jensen
    Department of Endocrinology, Diabetology and Nutrition, Hôpital Jean Verdier APHP Paris Nord University, Bondy, France
    Diab Vasc Dis Res 3:108-19. 2006
    ..Irrespective of which treatment is offered, only about one third of patients are likely to achieve more than 50% pain relief. Further research to improve the diagnosis and management of DPNP is needed...
  46. ncbi request reprint Impact of diabetic polyneuropathy and cardiovascular autonomic neuropathy on the excretion of urinary 8-epi-PGF2alpha and its metabolites (2, 3-dinor and 2, 3-dinor-5, 6-dihydro)
    Jaffar Nourooz-Zadeh
    Department of Medicine, Royal Free and University College London School of Medicine, London, UK
    Free Radic Res 40:723-9. 2006
    ..48; P < 0.001). In conclusion, these biomarkers should prove useful in studies evaluating the impact of therapeutic drugs or antioxidant interventions aimed at delaying the onset of diabetic complications...
  47. ncbi request reprint Diabetic cardiovascular autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institute, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Circulation 115:387-97. 2007
  48. ncbi request reprint Challenges in design of multicenter trials: end points assessed longitudinally for change and monotonicity
    Peter J Dyck
    Peripheral Neuropathy Research Laboratories, Mayo Clinic College of Medicine, 200 First St, SW, Rochester, MN 55905, USA
    Diabetes Care 30:2619-25. 2007
    ..Assessing clinimetric performance of diabetic sensorimotor polyneuropathy (DSPN) end points in single and multicenter trials...
  49. ncbi request reprint The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial
    Alexander S Ametov
    Russian Medical Academy for Advanced Studies, Moscow, Russia
    Diabetes Care 26:770-6. 2003
    ....
  50. doi request reprint Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies
    Daniel K Kajdasz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Clin Ther 29:2536-46. 2007
    ....
  51. ncbi request reprint Diabetic neuropathies: a statement by the American Diabetes Association
    Andrew J M Boulton
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U K
    Diabetes Care 28:956-62. 2005
  52. ncbi request reprint Polyneuropathy in the diabetic patient--update on pathogenesis and management
    Dan Ziegler
    Nephrol Dial Transplant 19:2170-5. 2004
  53. ncbi request reprint Diabetic autonomic neuropathy. Cardiac sympathetic "dysinnervation," QT interval prolongation, and mortality
    Dan Ziegler
    Clin Auton Res 12:349-52. 2002
  54. ncbi request reprint Stroke in patients with diabetes mellitus
    Boris N Mankovsky
    Institute of Endocrinology, Kiev, Ukraine
    Diabetes Metab Res Rev 20:268-87. 2004
    ..Aggressive control of arterial hypertension and dyslipidemia allows to decrease the risk of stroke in diabetic patients substantially, while the importance of glucose control for stroke prevention remains unproven...