Dan Ziegler

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Validation of a novel screening device (NeuroQuick) for quantitative assessment of small nerve fiber dysfunction as an early feature of diabetic polyneuropathy
    Dan Ziegler
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum an der Heinrich Heine Universität, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 28:1169-74. 2005
  2. ncbi request reprint Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy
    Dan Ziegler
    German Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 27:2178-83. 2004
  3. ncbi request reprint Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis
    D Ziegler
    German Diabetes Research Institute, Leibriz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 21:114-21. 2004
  4. ncbi request reprint Diagnosis and treatment of diabetic autonomic neuropathy
    D Ziegler
    German Diabetes Research Institute, Heinrich Heine University, German Diabetes Clinic, Auf m Hennekamp 65, Dusseldorf 40225, Germany
    Curr Diab Rep 1:216-27. 2001
  5. ncbi request reprint [Autonomic neuropathies in diabetic patients. Heart involvement signals poor prognosis]
    D Ziegler
    Deutsches Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf
    MMW Fortschr Med 144:35-7. 2002
  6. ncbi request reprint Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review
    Dan Ziegler
    German Diabetes Clinic, German Diabetes Research Institute, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Treat Endocrinol 3:173-89. 2004
  7. pmc Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:680-2. 2009
  8. doi request reprint Prevalence and risk factors of neuropathic pain in survivors of myocardial infarction with pre-diabetes and diabetes. The KORA Myocardial Infarction Registry
    Dan Ziegler
    Institute of Clinical Diabetes Research, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University, Dusseldorf, Germany
    Eur J Pain 13:582-7. 2009
  9. doi request reprint Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Pain Med 10:393-400. 2009
  10. doi request reprint Prediabetic neuropathy: does it exist?
    Nikolaos Papanas
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Curr Diab Rep 12:376-83. 2012

Detail Information

Publications37

  1. ncbi request reprint Validation of a novel screening device (NeuroQuick) for quantitative assessment of small nerve fiber dysfunction as an early feature of diabetic polyneuropathy
    Dan Ziegler
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum an der Heinrich Heine Universität, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 28:1169-74. 2005
    ..To validate a handheld screening device (NeuroQuick) for an early detection of diabetic distal symmetric polyneuropathy (DSP) by quantitative testing of cold sensation based on the wind chill factor (NeuroQuick threshold [NQT])...
  2. ncbi request reprint Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy
    Dan Ziegler
    German Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 27:2178-83. 2004
    ..The objective of this study was to evaluate plasma levels of various biomarkers of oxidative stress in diabetic subjects in relation to the presence or absence of polyneuropathy (PN) and/or cardiovascular autonomic neuropathy (CAN)...
  3. ncbi request reprint Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis
    D Ziegler
    German Diabetes Research Institute, Leibriz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 21:114-21. 2004
    ..To determine the efficacy and safety of 600 mg of alpha-lipoic acid given intravenously over 3 weeks in diabetic patients with symptomatic polyneuropathy...
  4. ncbi request reprint Diagnosis and treatment of diabetic autonomic neuropathy
    D Ziegler
    German Diabetes Research Institute, Heinrich Heine University, German Diabetes Clinic, Auf m Hennekamp 65, Dusseldorf 40225, Germany
    Curr Diab Rep 1:216-27. 2001
    ..Prior to an adequate symptomatic treatment a thorough risk-benefit estimate, aimed at maintaining the patient's quality of life, is required...
  5. ncbi request reprint [Autonomic neuropathies in diabetic patients. Heart involvement signals poor prognosis]
    D Ziegler
    Deutsches Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf
    MMW Fortschr Med 144:35-7. 2002
  6. ncbi request reprint Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review
    Dan Ziegler
    German Diabetes Clinic, German Diabetes Research Institute, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Treat Endocrinol 3:173-89. 2004
    ....
  7. pmc Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:680-2. 2009
    ..Therefore, we investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy...
  8. doi request reprint Prevalence and risk factors of neuropathic pain in survivors of myocardial infarction with pre-diabetes and diabetes. The KORA Myocardial Infarction Registry
    Dan Ziegler
    Institute of Clinical Diabetes Research, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University, Dusseldorf, Germany
    Eur J Pain 13:582-7. 2009
    ..Associated cardiovascular risk factors including abdominal obesity and low physical activity may constitute targets to prevent neuropathic pain in this population...
  9. doi request reprint Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Pain Med 10:393-400. 2009
    ..The aim of this study was to determine the prevalence and risk factors of neuropathic pain in subjects with diabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or normal glucose tolerance (NGT)...
  10. doi request reprint Prediabetic neuropathy: does it exist?
    Nikolaos Papanas
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Curr Diab Rep 12:376-83. 2012
    ..In practice, therapy of prediabetic neuropathy should be addressed towards normoglycemia and correction of cardiovascular risk factors. However, additional work is needed to establish the long-term results of this approach...
  11. pmc Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, and Department of Metabolic Diseases, University Hospital, Dusseldorf, Germany
    Diabetes Care 32:1479-84. 2009
    ..CONCLUSIONS Sequential intravenous and oral actovegin treatment over 160 days improved neuropathic symptoms, VPT, sensory function, and quality of life in type 2 diabetic patients with symptomatic polyneuropathy...
  12. pmc Older Subjects With Diabetes and Prediabetes Are Frequently Unaware of Having Distal Sensorimotor Polyneuropathy: The KORA F4 Study
    Brenda W C Bongaerts
    Corresponding author Wolfgang Rathmann
    Diabetes Care 36:1141-6. 2013
    ....
  13. doi request reprint Painful diabetic neuropathy: treatment and future aspects
    Dan Ziegler
    Institute of Clinical Diabetes Research, German Diabetes Center, Leibniz Center at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Metab Res Rev 24:S52-7. 2008
    ..In future, drug combinations might also include those aimed at symptomatic pain relief and quality of life on one hand and improvement or slowing the progression of the underlying neuropathic process on the other hand...
  14. ncbi request reprint Prediction of mortality using measures of cardiac autonomic dysfunction in the diabetic and nondiabetic population: the MONICA/KORA Augsburg Cohort Study
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:556-61. 2008
    ..To evaluate whether reduced heart rate variability (HRV), prolonged corrected QT (QTc) interval, or increased QT dispersion (QTD) are predictors of mortality in the general diabetic and nondiabetic population...
  15. pmc Postchallenge hyperglycemia is positively associated with diabetic polyneuropathy: the KORA F4 study
    Brenda W C Bongaerts
    Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Diabetes Care 35:1891-3. 2012
    ..To assess the prevalence of distal sensorimotor polyneuropathy (DSPN) in an older population and to examine its relationship with prediabetes...
  16. doi request reprint Neuropathy in prediabetes: does the clock start ticking early?
    Nikolaos Papanas
    Heinrich Heine University, Leibniz, Germany
    Nat Rev Endocrinol 7:682-90. 2011
    ..This Review summarizes the current evidence on the association between prediabetes and neuropathy...
  17. ncbi request reprint Current concepts in the management of diabetic polyneuropathy
    Dan Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Dusseldorf, Germany
    Curr Diabetes Rev 7:208-20. 2011
    ....
  18. pmc Immune mediators in patients with acute diabetic foot syndrome
    Christian Weigelt
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:1491-6. 2009
    ..Further studies should investigate whether an activation of the immune system precedes the development of foot ulcer and whether anti-inflammatory therapies might be effective...
  19. pmc Efficacy and safety of lacosamide in painful diabetic neuropathy
    Dan Ziegler
    nstitute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, and the Department of Metabolic Diseases, University Hospital, Dusseldorf, Germany
    Diabetes Care 33:839-41. 2010
    ..To evaluate efficacy and safety of lacosamide compared with placebo in painful diabetic polyneuropathy...
  20. ncbi request reprint Management of painful diabetic neuropathy: what is new or in the pipeline for 2007?
    Dan Ziegler
    Institut für Klinische Diabetologie, Deutsches Diabetes Zentrum, Leibniz Zentrum an der Heinrich Heine Universität Düsseldorf, 40225 Dusseldorf, Germany
    Curr Diab Rep 7:409-15. 2007
    ..Among at least 50 new drugs for treatment of neuropathic pain in the pipelines, there are several promising candidates such as lacosamide. Individual tolerability remains a major aspect in any treatment decision...
  21. doi request reprint Treatment of diabetic neuropathy and neuropathic pain: how far have we come?
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:S255-61. 2008
    ....
  22. ncbi request reprint Impact of disease characteristics on the efficacy of duloxetine in diabetic peripheral neuropathic pain
    Dan Ziegler
    German Diabetes Center, Leibniz Institute at the Heinrich Heine University, 40225 Dusseldorf, Germany
    Diabetes Care 30:664-9. 2007
    ..To evaluate the impact of baseline disease variables related to diabetes and diabetic neuropathy severity on efficacy and safety of duloxetine in the management of diabetic peripheral neuropathic pain...
  23. ncbi request reprint Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial
    Dan Ziegler
    FRCPE, Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:2365-70. 2006
    ..The aim of this trial was to evaluate the effects of alpha-lipoic acid (ALA) on positive sensory symptoms and neuropathic deficits in diabetic patients with distal symmetric polyneuropathy (DSP)...
  24. ncbi request reprint Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3
    Dan Ziegler
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 31:464-9. 2008
    ..The aim of this study was to determine the prevalence and risk factors of polyneuropathy in subjects with diabetes, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or normal glucose tolerance (NGT)...
  25. ncbi request reprint Efficacy and safety of flexible-dose vardenafil in men with type 1 diabetes and erectile dysfunction
    Dan Ziegler
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Institut, Heinrich Heine Universitat, Dusseldorf, Germany
    J Sex Med 3:883-91. 2006
    ..Limited data are available on the efficacy and safety of the potent oral phosphodiesterase-5 inhibitor vardenafil in men with ED and type 1 diabetes...
  26. ncbi request reprint Clinical trials for drugs against diabetic neuropathy: can we combine scientific needs with clinical practicalities?
    Dan Ziegler
    German Diabetes Research Institute at the Heinrich Heine University, German Diabetes Clinic, 40225 Dusseldorf, Germany
    Int Rev Neurobiol 50:431-63. 2002
    ....
  27. ncbi request reprint Treatment of diabetic polyneuropathy: Update 2006
    Dan Ziegler
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, WHO Collaborating Center in Diabetes, European Training Center in Endocrinology and Metabolism, Dusseldorf, Germany
    Ann N Y Acad Sci 1084:250-66. 2006
    ....
  28. ncbi request reprint Diabetic cardiovascular autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institute, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Circulation 115:387-97. 2007
  29. ncbi request reprint The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial
    Alexander S Ametov
    Russian Medical Academy for Advanced Studies, Moscow, Russia
    Diabetes Care 26:770-6. 2003
    ....
  30. ncbi request reprint Impact of diabetic polyneuropathy and cardiovascular autonomic neuropathy on the excretion of urinary 8-epi-PGF2alpha and its metabolites (2, 3-dinor and 2, 3-dinor-5, 6-dihydro)
    Jaffar Nourooz-Zadeh
    Department of Medicine, Royal Free and University College London School of Medicine, London, UK
    Free Radic Res 40:723-9. 2006
    ..48; P < 0.001). In conclusion, these biomarkers should prove useful in studies evaluating the impact of therapeutic drugs or antioxidant interventions aimed at delaying the onset of diabetic complications...
  31. doi request reprint Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies
    Daniel K Kajdasz
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Clin Ther 29:2536-46. 2007
    ....
  32. ncbi request reprint Challenges in design of multicenter trials: end points assessed longitudinally for change and monotonicity
    Peter J Dyck
    Peripheral Neuropathy Research Laboratories, Mayo Clinic College of Medicine, 200 First St, SW, Rochester, MN 55905, USA
    Diabetes Care 30:2619-25. 2007
    ..Assessing clinimetric performance of diabetic sensorimotor polyneuropathy (DSPN) end points in single and multicenter trials...
  33. ncbi request reprint New perspectives on the management of diabetic peripheral neuropathic pain
    Troels S Jensen
    Department of Endocrinology, Diabetology and Nutrition, Hôpital Jean Verdier APHP Paris Nord University, Bondy, France
    Diab Vasc Dis Res 3:108-19. 2006
    ..Irrespective of which treatment is offered, only about one third of patients are likely to achieve more than 50% pain relief. Further research to improve the diagnosis and management of DPNP is needed...
  34. ncbi request reprint Diabetic neuropathies: a statement by the American Diabetes Association
    Andrew J M Boulton
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U K
    Diabetes Care 28:956-62. 2005
  35. ncbi request reprint Stroke in patients with diabetes mellitus
    Boris N Mankovsky
    Institute of Endocrinology, Kiev, Ukraine
    Diabetes Metab Res Rev 20:268-87. 2004
    ..Aggressive control of arterial hypertension and dyslipidemia allows to decrease the risk of stroke in diabetic patients substantially, while the importance of glucose control for stroke prevention remains unproven...
  36. ncbi request reprint Diabetic autonomic neuropathy. Cardiac sympathetic "dysinnervation," QT interval prolongation, and mortality
    Dan Ziegler
    Clin Auton Res 12:349-52. 2002
  37. ncbi request reprint Polyneuropathy in the diabetic patient--update on pathogenesis and management
    Dan Ziegler
    Nephrol Dial Transplant 19:2170-5. 2004