D Ziegler

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi [Treatment of diabetic neuropathy]
    D Ziegler
    Institut für Klinische Diabetologie, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 132:1043-7. 2007
  2. ncbi Selective contribution of diabetes and other cardiovascular risk factors to cardiac autonomic dysfunction in the general population
    D Ziegler
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, WHO Collaborating Center in Diabetes, European Training Center in Endocrinology and Metabolism, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 114:153-9. 2006
  3. ncbi Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy
    D Ziegler
    Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Diabetes Care 22:1296-301. 1999
  4. ncbi Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials
    D Ziegler
    Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 107:421-30. 1999
  5. ncbi Normal ranges and reproducibility of statistical, geometric, frequency domain, and non-linear measures of 24-hour heart rate variability
    D Ziegler
    Klinische Abteilung, Deutsches Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Horm Metab Res 31:672-9. 1999
  6. ncbi Management of erectile dysfunction in diabetic patients
    D Ziegler
    German Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabetes Nutr Metab 15:58-65. 2002
  7. doi Polyneuropathy in impaired glucose tolerance: is postprandial hyperglycemia the main culprit? A mini-review
    N Papanas
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Gerontology 59:193-8. 2013
  8. ncbi Assessment of cardiovascular autonomic function: age-related normal ranges and reproducibility of spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses
    D Ziegler
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 9:166-75. 1992
  9. doi Evaluation of the Neuropad sudomotor function test as a screening tool for polyneuropathy in the elderly population with diabetes and pre-diabetes: the KORA F4 survey
    D Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabetes Metab Res Rev 28:692-7. 2012
  10. ncbi Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis
    D Ziegler
    German Diabetes Research Institute, Leibriz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 21:114-21. 2004

Detail Information

Publications25

  1. ncbi [Treatment of diabetic neuropathy]
    D Ziegler
    Institut für Klinische Diabetologie, Deutsches Diabetes Zentrum, Leibniz Institut an der Heinrich Heine Universität Düsseldorf
    Dtsch Med Wochenschr 132:1043-7. 2007
  2. ncbi Selective contribution of diabetes and other cardiovascular risk factors to cardiac autonomic dysfunction in the general population
    D Ziegler
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, WHO Collaborating Center in Diabetes, European Training Center in Endocrinology and Metabolism, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 114:153-9. 2006
    ..However, obesity and smoking contribute to autonomic dysfunction in men but not women. Thus, a selectivity and sex-related differences exist among the various cardiovascular risk factors as to their influence on autonomic dysfunction...
  3. ncbi Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy
    D Ziegler
    Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Diabetes Care 22:1296-301. 1999
    ..To evaluate the efficacy and safety of alpha-lipoic acid given intravenously, followed by oral treatment in type 2 diabetic patients with symptomatic polyneuropathy...
  4. ncbi Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials
    D Ziegler
    Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 107:421-30. 1999
    ....
  5. ncbi Normal ranges and reproducibility of statistical, geometric, frequency domain, and non-linear measures of 24-hour heart rate variability
    D Ziegler
    Klinische Abteilung, Deutsches Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf, Germany
    Horm Metab Res 31:672-9. 1999
    ..The majority of the HRV measures, in particular the geometric parameters, show a relatively high intraindividual reproducibility which underlines their suitability for the use in prospective studies...
  6. ncbi Management of erectile dysfunction in diabetic patients
    D Ziegler
    German Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabetes Nutr Metab 15:58-65. 2002
  7. doi Polyneuropathy in impaired glucose tolerance: is postprandial hyperglycemia the main culprit? A mini-review
    N Papanas
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Gerontology 59:193-8. 2013
    ..The increasing awareness of peripheral neuropathy in IGT is expected to improve healthcare provision in subjects with this condition...
  8. ncbi Assessment of cardiovascular autonomic function: age-related normal ranges and reproducibility of spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses
    D Ziegler
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 9:166-75. 1992
    ....
  9. doi Evaluation of the Neuropad sudomotor function test as a screening tool for polyneuropathy in the elderly population with diabetes and pre-diabetes: the KORA F4 survey
    D Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabetes Metab Res Rev 28:692-7. 2012
    ..This study aimed to evaluate the utility of Neuropad as a screening tool for distal symmetric polyneuropathy among elderly subjects with diabetes and pre-diabetes in the general population...
  10. ncbi Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis
    D Ziegler
    German Diabetes Research Institute, Leibriz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 21:114-21. 2004
    ..To determine the efficacy and safety of 600 mg of alpha-lipoic acid given intravenously over 3 weeks in diabetic patients with symptomatic polyneuropathy...
  11. doi Corneal confocal microscopy: a new technique for early detection of diabetic neuropathy
    N Papanas
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Auf m Hennekamp 65, 40225, Dusseldorf, Germany
    Curr Diab Rep 13:488-99. 2013
    ..Moreover, there is a need for a larger normative database. Finally, technical progress is expected to enable visualization of larger corneal areas and improve nerve fiber quantification, increasing diagnostic accuracy. ..
  12. ncbi [Autonomic neuropathies in diabetic patients. Heart involvement signals poor prognosis]
    D Ziegler
    Deutsches Diabetes Forschungsinstitut an der Heinrich Heine Universität, Dusseldorf
    MMW Fortschr Med 144:35-7. 2002
  13. ncbi Type 2 diabetes as an inflammatory cardiovascular disorder
    D Ziegler
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, WHO Collaborating Center in Diabetes, European Training Center in Endocrinology and Metabolism, Dusseldorf, Germany
    Curr Mol Med 5:309-22. 2005
    ..Drugs exerting anti-inflammatory and vascular effects have future potential to be used within an array of interventions aimed at reducing the enormous cardiovascular burden associated with Type 2 diabetes...
  14. doi Neuropad: evaluation of three cut-off points of sudomotor dysfunction for early detection of polyneuropathy in recently diagnosed diabetes
    D Ziegler
    Institute for Clinical Diabetology, German Diabetes Center at the Heinrich Heine University, Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Diabet Med 28:1412-5. 2011
    ..To examine the sensitivity and specificity of three cut-off points of Neuropad for the diagnosis of distal symmetric polyneuropathy and small-fibre dysfunction in patients within the first year after diagnosis of diabetes...
  15. ncbi Platelet activation in diabetic cardiovascular autonomic neuropathy
    U Rauch
    Diabetes Research Institute, Heinrich Heine University, Duesseldorf, Germany
    Diabet Med 16:848-52. 1999
    ..The present study attempts to clarify whether diabetic cardiovascular autonomic neuropathy (CAN) is associated with intravascular platelet activation...
  16. ncbi Diagnosis and treatment of diabetic autonomic neuropathy
    D Ziegler
    German Diabetes Research Institute, Heinrich Heine University, German Diabetes Clinic, Auf m Hennekamp 65, Dusseldorf 40225, Germany
    Curr Diab Rep 1:216-27. 2001
    ..Prior to an adequate symptomatic treatment a thorough risk-benefit estimate, aimed at maintaining the patient's quality of life, is required...
  17. ncbi Application of isotope-selective nondispersive infrared spectrometry (IRIS) for evaluation of [13C]octanoic acid gastric-emptying breath tests: comparison with isotope ratio-mass spectrometry (IRMS)
    P Schadewaldt
    Diabetes Forschungsinstitut, Klinische Biochemie Auf m Hennekamp 65, Dusseldorf, Germany
    Clin Chem 43:518-22. 1997
    ..99x + 4.06, Sy[symbol: see text]x = +/- 6.3; tlag, breath: y = 0.97x + 0.96, Sy[symbol: see text]x = +/-3.4; GEC: y = 0.97x - 0.01, Sy[symbol: see text]x = +/-0.09)...
  18. ncbi Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine
    R Freynhagen
    Department of Anaesthesiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Int J Clin Pract 61:1989-96. 2007
    ..We aimed to investigate pregabalin, a gamma-aminobutyric acid (GABA)-analogue, in a wide range of pregabalin naive patients with treatment refractory NeP...
  19. ncbi [Duloxetine, a new therapeutic option for diabetic peripheral neuropathic pain]
    D Ziegler
    Deutsche Diabetes Klinik, Deutsches Diabetes Zentrum, Leibniz Zentrum an der Heinrich Heine Universität Düsseldorf, Dusseldorf, Germany
    Dtsch Med Wochenschr 131:S284-8. 2006
    ..The various drugs should be considered individually in any treatment algorithm, also taking into account their side effects. Psychotherapeutic methods serve to support the overcoming of pain...
  20. ncbi Altered cerebral regulation in type 2 diabetic patients with cardiac autonomic neuropathy
    H Marthol
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Diabetologia 49:2481-7. 2006
    ..We evaluated the technique of oscillatory neck suction at 0.1 Hz to quantify cerebral regulation in diabetic patients and healthy control subjects...
  21. ncbi Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation
    L Reichstein
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute, Heinrich Heine University Dusseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetologia 48:824-8. 2005
    ..We performed a controlled, randomised pilot trial to compare the effects of high-frequency external muscle stimulation (HF) with those of TENS in patients with symptomatic DSP...
  22. doi A simple deep breathing test reveals altered cerebral autoregulation in type 2 diabetic patients
    C M Brown
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Diabetologia 51:756-61. 2008
    ..The purpose of this study was to evaluate the autoregulation of cerebral blood flow in diabetic patients using a simple method that could easily be applied to the clinical routine screening of diabetic patients...
  23. ncbi Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate
    M W Agelink
    Institute of Biological Psychiatry and Neuroscience at the Evangelical Clinics Gelsenkirchen, Ruhr-University of Bochum, Germany
    Clin Auton Res 11:99-108. 2001
    ..The authors computed age- and gender-dependent normal values for each of the HRV indices studied here and discuss the clinical consequences arising from gender differences in HRV...
  24. ncbi Impairment of cerebral autoregulation in diabetic patients with cardiovascular autonomic neuropathy and orthostatic hypotension
    B N Mankovsky
    Institute of Endocrinology and Metabolism, Kiev, Ukraine
    Diabet Med 20:119-26. 2003
    ..The purpose of this study was to evaluate cerebral blood flow velocity in response to standing in patients with diabetes and cardiovascular autonomic neuropathy with or without orthostatic hypotension...
  25. ncbi Time- and frequency-domain estimation of early diabetic cardiovascular autonomic neuropathy
    D Ziegler
    German Diabetes Research Institute at the Heinrich Heine University,
    Clin Auton Res 11:369-76. 2001
    ..In conclusion, these estimates of baroreceptor-HR function may provide a powerful tool for assessing cardiovascular autonomic neuropathy at any stage, including the early stage, which is not detected by the conventional tests...