A Wodarz

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi Asymmetric cell division during neurogenesis in Drosophila and vertebrates
    Andreas Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Mech Dev 120:1297-309. 2003
  2. ncbi Mechanisms of Wnt signaling in development
    A Wodarz
    Institut fur Genetik, Universitat Dusseldorf, Germany
    Annu Rev Cell Dev Biol 14:59-88. 1998
  3. ncbi Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
    Nature 402:544-7. 1999
  4. ncbi Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    J Cell Biol 150:1361-74. 2000
  5. ncbi Tumor suppressors: linking cell polarity and growth control
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Curr Biol 10:R624-6. 2000
  6. ncbi Cell polarity: no need to reinvent the wheel
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Curr Biol 11:R975-8. 2001
  7. ncbi Establishing cell polarity in development
    Andreas Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Nat Cell Biol 4:E39-44. 2002
  8. ncbi Tumor suppressors: control of signaling by endocytosis
    Bernd Giebel
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Dusseldorf, Moorenstr 5, Geb 14 80, 40225 Dusseldorf, Germany
    Curr Biol 16:R91-2. 2006
  9. ncbi Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization
    Martina Schneider
    Department for Experimental Medical Science, Section for Developmental Biology, Lund University, Lund, Sweden
    Development 133:3805-15. 2006
  10. ncbi Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells
    Andreas Wodarz
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 119:2425-34. 2006

Collaborators

Detail Information

Publications18

  1. ncbi Asymmetric cell division during neurogenesis in Drosophila and vertebrates
    Andreas Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Mech Dev 120:1297-309. 2003
    ..In this review we will focus on recent findings dealing with asymmetric cell division during neurogenesis in Drosophila and vertebrates and will discuss common principles and apparent differences between both systems...
  2. ncbi Mechanisms of Wnt signaling in development
    A Wodarz
    Institut fur Genetik, Universitat Dusseldorf, Germany
    Annu Rev Cell Dev Biol 14:59-88. 1998
    ..Here we review recent data that have started to unravel the mechanisms of Wnt signaling...
  3. ncbi Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
    Nature 402:544-7. 1999
    ..As Bazooka is also responsible for the maintenance of apical-basal polarity in epithelial tissues, it may be the missing link between epithelial polarity and neuroblast polarity...
  4. ncbi Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    J Cell Biol 150:1361-74. 2000
    ..This study is the first functional analysis of an atypical protein kinase C isoform using a loss-of-function allele in a genetically tractable organism...
  5. ncbi Tumor suppressors: linking cell polarity and growth control
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Curr Biol 10:R624-6. 2000
    ..Mutations in any of these genes lead to loss of apical-basal cell polarity and overproliferation of epithelia, revealing a close connection between cytoarchitecture and growth control...
  6. ncbi Cell polarity: no need to reinvent the wheel
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Curr Biol 11:R975-8. 2001
    ..Recent studies have now shown that these two types of polarity are controlled by a common set of genes...
  7. ncbi Establishing cell polarity in development
    Andreas Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Nat Cell Biol 4:E39-44. 2002
    ..There is growing evidence that the proteins encoded by these genes interact with key regulators of both the actin and the microtubule cytoskeletons...
  8. ncbi Tumor suppressors: control of signaling by endocytosis
    Bernd Giebel
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Dusseldorf, Moorenstr 5, Geb 14 80, 40225 Dusseldorf, Germany
    Curr Biol 16:R91-2. 2006
    ..These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch...
  9. ncbi Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization
    Martina Schneider
    Department for Experimental Medical Science, Section for Developmental Biology, Lund University, Lund, Sweden
    Development 133:3805-15. 2006
    ..We suggest that the interaction of Pcan and Dg at the basal side of the epithelium promotes basal membrane differentiation and is required for maintenance of cell polarity in the FCE...
  10. ncbi Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells
    Andreas Wodarz
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 119:2425-34. 2006
    ....
  11. ncbi Connecting cancer to the asymmetric division of stem cells
    Andreas Wodarz
    Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain CMPB, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Cell 124:1121-3. 2006
    ..This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis...
  12. ncbi Cell polarity in development and cancer
    Andreas Wodarz
    Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain CMPB, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Nat Cell Biol 9:1016-24. 2007
    ..The strongest hints in this direction come from studies on tumour suppressor genes in the fruitfly Drosophila melanogaster, which have revealed their importance in the control of apical-basal cell polarity...
  13. ncbi Molecular control of cell polarity and asymmetric cell division in Drosophila neuroblasts
    Andreas Wodarz
    Abteilung Stammzellbiologie, Georg August Universitat Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Curr Opin Cell Biol 17:475-81. 2005
    ..It has emerged that most of the relevant proteins are assembled into three major protein complexes whose molecular interactions are conserved in evolution...
  14. ncbi Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
    Walter von Stein
    Abteilung Stammzellbiologie, CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Development 132:1675-86. 2005
    ..Pten mutant embryos also show severe defects during cellularization. Our data provide evidence for a link between the PAR/aPKC complex, the actin cytoskeleton and PI3-kinase signaling mediated by PTEN...
  15. ncbi PKA-R1 spatially restricts Oskar expression for Drosophila embryonic patterning
    Shoko Yoshida
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Development 131:1401-10. 2004
    ..These data demonstrate that PKA mediates the spatial restriction of Oskar for anteroposterior patterning of the Drosophila embryo and that control of PKA activity by PKA-R1 is crucial in this process...
  16. ncbi A genetic hierarchy controlling cell polarity
    Kevin Johnson
    Nat Cell Biol 5:12-4. 2003
  17. ncbi A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin
    Andrea Penton
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical School, Stanford, California 94305 5323, USA
    Genetics 161:747-62. 2002
    ..We also recovered second-site-suppressing mutations in axin, mapping at a region that may specifically interact with overexpressed Dsh...
  18. ncbi Extraction and immunoblotting of proteins from embryos
    Andreas Wodarz
    Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain CMPB, University of Gottingen, Gottingen, Germany
    Methods Mol Biol 420:335-45. 2008
    ..In this chapter, I describe methods to extract proteins under denaturing and nondenaturing conditions from embryos, and to perform sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunoblotting, and coimmunoprecipitation...