Holger S Willenberg

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Corticotropin-releasing hormone receptor expression on normal and tumorous human adrenocortical cells
    Holger S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University of Dusseldorf, Dusseldorf, Germany
    Neuroendocrinology 82:274-81. 2005
  2. ncbi request reprint Comparison of the saline infusion test and the fludrocortisone suppression test for the diagnosis of primary aldosteronism
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 44:527-32. 2012
  3. pmc The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease
    Marissa Penna-Martinez
    Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Hospital Frankfurt, Frankfurt am Main, Germany
    BMC Med Genet 10:126. 2009
  4. pmc Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II
    Elizabeth Ramos-Lopez
    Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Hospital Frankfurt, Frankfurt am Main, Germany
    BMC Med Genet 9:65. 2008
  5. ncbi request reprint Helpful diagnostic markers of steroidogenesis for defining hyperandrogenemia in hirsute women
    Holger S Willenberg
    Department of Endocrinology, Diabetology and Rheumatology, University Hospital Duesseldorf, Moorenstr 5, D 40225 Dusseldorf, Germany
    Steroids 73:41-6. 2008
  6. doi request reprint Sporadic solitary aldosterone- and cortisol-co-secreting adenomas: endocrine, histological and genetic findings in a subtype of primary aldosteronism
    Holger S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Hypertens Res 33:467-72. 2010
  7. ncbi request reprint A case of catecholamine and glucocorticoid excess syndrome due to a corticotropin-secreting paraganglioma
    Holger S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstr 5, D 40225 Dusseldorf, Germany
    Ann N Y Acad Sci 1073:52-8. 2006
  8. doi request reprint The serum sodium to urinary sodium to (serum potassium)2 to urinary potassium (SUSPPUP) ratio in patients with primary aldosteronism
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Eur J Clin Invest 39:43-50. 2009
  9. ncbi request reprint The endothelium secretes interleukin-6 (IL-6) and induces IL-6 and aldosterone generation by adrenocortical cells
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:S70-4. 2008
  10. doi request reprint [Basics and management of glucocorticoid-induced osteoporosis]
    H S Willenberg
    Klinik fur Endokrinologie, Diabetologie und Rheumatologie, Universitatsklinikum Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
    Internist (Berl) 49:1186-90, 1192, 1194-6. 2008

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Corticotropin-releasing hormone receptor expression on normal and tumorous human adrenocortical cells
    Holger S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University of Dusseldorf, Dusseldorf, Germany
    Neuroendocrinology 82:274-81. 2005
    ..The data support the assertion of a direct action of CRH on human adrenocortical cells in addition to an intra-adrenal CRH receptor/adrenocorticotropin system. Enhanced CRH1R expression may be involved in adrenocortical tumorigenesis...
  2. ncbi request reprint Comparison of the saline infusion test and the fludrocortisone suppression test for the diagnosis of primary aldosteronism
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 44:527-32. 2012
    ..Long-term prospective studies are needed to address the question at what cutoff values patients benefit from subtype differentiation of PA. We discuss here possible explanations for divergent results obtained with both tests...
  3. pmc The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease
    Marissa Penna-Martinez
    Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Hospital Frankfurt, Frankfurt am Main, Germany
    BMC Med Genet 10:126. 2009
    ..Recent studies showed that a genetic variation within the interferon induced helicase domain 1 (IFIH1) locus (rs1990760 polymorphism) is an additional risk factor in type 1 diabetes and Graves' disease (GD)...
  4. pmc Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II
    Elizabeth Ramos-Lopez
    Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Hospital Frankfurt, Frankfurt am Main, Germany
    BMC Med Genet 9:65. 2008
    ....
  5. ncbi request reprint Helpful diagnostic markers of steroidogenesis for defining hyperandrogenemia in hirsute women
    Holger S Willenberg
    Department of Endocrinology, Diabetology and Rheumatology, University Hospital Duesseldorf, Moorenstr 5, D 40225 Dusseldorf, Germany
    Steroids 73:41-6. 2008
    ..Although testosterone and dehydroepiandrostendionesulfate (DHEAS) determination is considered useful in diagnostic workup, there is no laboratory definition that sufficiently describes androgen excess...
  6. doi request reprint Sporadic solitary aldosterone- and cortisol-co-secreting adenomas: endocrine, histological and genetic findings in a subtype of primary aldosteronism
    Holger S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Hypertens Res 33:467-72. 2010
    ..These two cases document the fact that sporadic A/CPA is a subtype of PA. The presence of an A/CPA should be considered if a patient has both PA and hypercortisolism...
  7. ncbi request reprint A case of catecholamine and glucocorticoid excess syndrome due to a corticotropin-secreting paraganglioma
    Holger S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstr 5, D 40225 Dusseldorf, Germany
    Ann N Y Acad Sci 1073:52-8. 2006
    ..In this article we discuss the hormonal findings in the patient and its consequences, the pitfalls of the endocrine workup, and the results of our immunohistological and molecular studies in more detail...
  8. doi request reprint The serum sodium to urinary sodium to (serum potassium)2 to urinary potassium (SUSPPUP) ratio in patients with primary aldosteronism
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Eur J Clin Invest 39:43-50. 2009
    ..However, hormonal determinations are time consuming and expensive. Therefore, we studied the effectiveness of the serum sodium to urinary sodium to (serum potassium)(2) to urinary potassium (SUSPPUP) ratio in the diagnosis of PA...
  9. ncbi request reprint The endothelium secretes interleukin-6 (IL-6) and induces IL-6 and aldosterone generation by adrenocortical cells
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:S70-4. 2008
    ..Our findings support the hypothesis that the endothelium and the adrenal gland may play a role in the development of some forms of hypertension and - more speculative - inflammation...
  10. doi request reprint [Basics and management of glucocorticoid-induced osteoporosis]
    H S Willenberg
    Klinik fur Endokrinologie, Diabetologie und Rheumatologie, Universitatsklinikum Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
    Internist (Berl) 49:1186-90, 1192, 1194-6. 2008
    ..Education of the patients and pharmacological prevention are very important, antiresorptive therapy has to be started earlier than in primary osteoporosis and osteoanabolic agents have also been proven to be effective...
  11. ncbi request reprint [Adrenal gland tumors]
    H S Willenberg
    Klinik fur Endokrinologie, Diabetologie und Rheumatologie, Universitatsklinikum Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
    Internist (Berl) 48:971-86. 2007
    ..Recent developments in molecular biology have provided tools for testing for hereditary tumor syndromes associated with adrenal tumorigenesis and to establish strategies for further treatment and follow-up...
  12. ncbi request reprint Indicators of mineralocorticoid excess in the evaluation of primary aldosteronism
    Melania Balaş
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Hypertens Res 33:850-6. 2010
    ..Antihypertensive drugs only marginally interfere with the SUSPPUP ratio, but they may influence the ARR, whereby the effects in PA patients seem to be negligible...
  13. ncbi request reprint Amino acid-modified calcitonin immunization induces tumor epitope-specific immunity in a transgenic mouse model for medullary thyroid carcinoma
    Margret Wuttke
    Endocrine Cancer Center, Department of Endocrinology, Diabetology and Rheumatology, University Hospital Duesseldorf, 40225 Duesseldorf, Germany
    Endocrinology 149:5627-34. 2008
    ..The results are of potential importance because they might be applicable to patients with metastatic spread of a MTC...
  14. doi request reprint Dendritic cell vaccination with xenogenic polypeptide hormone induces tumor rejection in neuroendocrine cancer
    Claudia Papewalis
    Endocrine Cancer Center, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Clin Cancer Res 14:4298-305. 2008
    ..The aim of this study was to proof the concept of dendritic cell immunization with a tumor cell-specific polypeptide hormone as a target molecule in a transgenic mouse model for medullary thyroid carcinoma (Ret/Cal mice)...
  15. doi request reprint Chromogranin A as potential target for immunotherapy of malignant pheochromocytoma
    Claudia Papewalis
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Germany
    Mol Cell Endocrinol 335:69-77. 2011
    ..Our data clearly demonstrate that CgA peptide-based immunotherapy induces a cytotoxic immune response in experimental pheochromocytoma, indicating potential for therapeutic applications in patients with malignant pheochromocytoma...
  16. doi request reprint Evidence for the involvement of endothelial cell products in adrenal CITED2 expression
    Matthias Haase
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Cell Tissue Res 336:337-43. 2009
    ....
  17. ncbi request reprint CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor
    Matthias Haase
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr 5, D 40225 Duesseldorf, Germany
    J Endocrinol 192:459-65. 2007
    ..It is connected to the signaling cascades of bFGF and its expression is modulated by mitogen-activated protein kinases. This suggests a novel role for CITED2 in human adrenal growth and possibly in adrenal tumorigenesis...
  18. doi request reprint Increased numbers of tumor-lysing monocytes in cancer patients
    Claudia Papewalis
    Endocrine Tumor Center, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Germany
    Mol Cell Endocrinol 337:52-61. 2011
    ..Functional analyses revealed an apoptosis inducing capacity in vitro after IFN-α re-stimulation. Our data indicate the importance of tumor-lysing monocytes in antitumor immunity...
  19. doi request reprint Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line
    Pascal Werminghaus
    Department of Endocrinology and Diabetology, Medical Faculty, University of Dusseldorf, D 40225 Duesseldorf, Germany Department of Oto Rhino Laryngology, Head and Neck Surgery, Medical Faculty, University of Dusseldorf, D 40225 Duesseldorf, Germany
    J Steroid Biochem Mol Biol 139:7-15. 2014
    ..This might explain the lower expression of the Hh components GLI1 and SMO in CPA in comparison to the higher expression in NPA. Hh-signaling might be involved in the tumorigenesis of NPA. ..
  20. doi request reprint Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone, dexamethasone, and spironolactone
    Sarah Vogt
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Clin Exp Hypertens 34:582-7. 2012
    ..After fludrocortisone, dexamethasone, or spironolactone treatment, both ET-1 and ADM did not change significantly. The data support the hypothesis that the RAAS is not directly linked with the ET-1/ADM system...
  21. ncbi request reprint Immunoregulatory natural killer cells suppress autoimmunity by down-regulating antigen-specific CD8+ T cells in mice
    Margret Ehlers
    Division of Endocrinology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Endocrinology 153:4367-79. 2012
    ..1(+)/c-Kit(+) NK cells within the islets. Our results demonstrate a direct link between innate and adaptive immunity in autoimmunity with newly identified immunoregulatory NK cells displaying a potential role as immunosuppressors...
  22. ncbi request reprint Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's thyroiditis
    Margret Ehlers
    Department of Endocrinology, Diabetes, and Rheumatology, University Hospital Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    J Clin Endocrinol Metab 97:1347-54. 2012
    ..Only rare data are available regarding the recognition of specific cellular antigens, e.g. of thyroperoxidase (TPO) and thyroglobulin (Tg)...
  23. doi request reprint Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation
    Markus C Kühn
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Mol Cell Endocrinol 349:180-8. 2012
    ..These in vitro findings reflect the higher bone mass in obese people and attribute it to effects of adipocyte-secreted factors on bone formation...
  24. doi request reprint Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation
    Charlotte Heller
    Department of Endocrinology, Diabetes, and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Am J Physiol Endocrinol Metab 301:E864-72. 2011
    ..Wnt-4 modulates canonical Wnt signaling and acts as regulator of β-cell proliferation and inflammatory cytokine release. This suggests a novel mechanism through which GLP-1 can regulate β-cell proliferation...
  25. doi request reprint A new mutation in the menin gene causes the multiple endocrine neoplasia type 1 syndrome with adrenocortical carcinoma
    M Haase
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Moorenstrasse 5, Germany
    Endocrine 39:153-9. 2011
    ..Ser443Tyr; c.1328C > A). [corrected] Also, we provide clinical data that may add to the genotype-phenotype discussion. We conclude that the novel mutation in the MEN1 gene described herein was clinically relevant...
  26. ncbi request reprint IFN-alpha skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo
    Claudia Papewalis
    Endocrine Cancer Center, Department of Endocrinology, Diabetes, and Rheumatology, University Hospital, Moorenstrasse 5, Duesseldorf, Germany
    J Immunol 180:1462-70. 2008
    ..These cells represent another mechanism of the antitumor effect induced by IFN-alpha...
  27. ncbi request reprint Enhanced iodine supplementation alters the immune process in a transgenic mouse model for autoimmune thyroiditis
    Margret Ehlers
    1 Division for Specific Endocrinology, University of Duesseldorf, Duesseldorf, Germany
    Thyroid 24:888-96. 2014
    ..In the present study we investigated the impact of moderate and high iodine supplementation on the course of disease in these mice, which are immunologically prone to AIT...
  28. ncbi request reprint Role of interleukin-6 in stress response in normal and tumorous adrenal cells and during chronic inflammation
    Holger S Willenberg
    Department of Endocrinology at the University of Düsseldorf, Dusseldorf, Germany
    Ann N Y Acad Sci 966:304-14. 2002
    ..We infer that the loss of responsivity of tumorous adrenal cells to IL-6, and in part corticotropin, is an important step in the process of adrenal tumorigenesis by which regulation by differentiating proteins is bypassed...
  29. ncbi request reprint Expression of connexins in chromaffin cells of normal human adrenals and in benign and malignant pheochromocytomas
    Holger S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital, Duesseldorf, Germany
    Ann N Y Acad Sci 1073:578-83. 2006
    ..We conclude that there is a differential expression of Cx in human adrenals. Immunohistological testing for Cx expression does not however allow differentiation of benign from malignant pheochromocytomas...
  30. ncbi request reprint Cushing's disease in a patient with steroid 21-hydroxylase deficiency
    Matthias Haase
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Germany
    Endocr J 58:699-706. 2011
    ....
  31. ncbi request reprint Dendritic cells as potential adjuvant for immunotherapy in adrenocortical carcinoma
    Claudia Papewalis
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Clin Endocrinol (Oxf) 65:215-22. 2006
    ..The aim of this study was to elaborate two methods of antigen delivery to DCs and to evaluate an immunotherapy protocol in ACC patients...
  32. ncbi request reprint Serum selenium levels in patients with remission and relapse of graves' disease
    Tina Wertenbruch
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Med Chem 3:281-4. 2007
    ..The aim of this study was to investigate whether serum Se levels may influence the outcome of Graves' disease (GD)...
  33. ncbi request reprint Ectopic adrenocorticotropin (ACTH) and corticotropin-releasing hormone (CRH) production in the adrenal gland: basic and clinical aspects
    Ilias Vrezas
    Department of Endocrinology, University Hospital of Duesseldorf, 40225 Duesseldorf, Germany
    Microsc Res Tech 61:308-14. 2003
    ..Finally, ectopic production of ACTH causing Cushing's syndrome has also been demonstrated in adrenocortical cells. This suggests a marked plasticity within the HPA axis and the neuroendocrine cell system...
  34. doi request reprint Aldosterone- and cortisol-co-secreting adrenal tumors: the lost subtype of primary aldosteronism
    Martin Späth
    Department of Endocrinology, Diabetes and Rheumatology Clinic of Nuclear Medicine Institute of Pathology, University Hospital Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    Eur J Endocrinol 164:447-55. 2011
    ..5 cm, ii) cortisol that is non-suppressible with overnight low-dose dexamethasone, or iii) grossly elevated serum levels of hybrid steroids, such as 18-OH-F...
  35. doi request reprint Trends in adrenal surgery: institutional review of 528 consecutive adrenalectomies
    Anja Lachenmayer
    Department of General, Visceral and Pediatric Surgery, University Hospital, Moorenstraße 5, 40225 Dusseldorf, Germany
    Langenbecks Arch Surg 397:1099-107. 2012
    ..The aim of our study was to report a single institution's experience with adrenal surgery...
  36. doi request reprint Update on the corticomedullary interaction in the adrenal gland
    Matthias Haase
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstrasse 5, Duesseldorf, Germany
    Endocr Dev 20:28-37. 2011
    ..In the past decade, significant progress in the understanding of the cortical-chromaffin communication has been made. Here, we summarize the insights gained from in vitro studies, from animal models and from clinical observations...
  37. ncbi request reprint Circulating chemokines in patients with autoimmune thyroid diseases
    J Domberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 40:416-21. 2008
    ..These data suggest that the expression patterns of chemokines in various thyroid diseases differ from each other, which may reflect the distinct immune responses in HT and GD...
  38. pmc Identification of occult metastases of medullary thyroid carcinoma by pentagastrin-stimulated intravenous calcitonin sampling followed by targeted surgery
    Matthias Schott
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusselsorf, Germany
    Clin Endocrinol (Oxf) 66:405-9. 2007
    ..In limited disease stages, however, morphological investigations including ultrasound, magnetic resonance imaging (MRI) and 18F-FDG positron emission tomography ([18F]FDG-PET) may often fail to identify exact tumour sites...
  39. doi request reprint Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients
    Fatma Ulgen
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstrasse 5, Dusseldorf, Germany
    Arch Physiol Biochem 116:57-62. 2010
    ..However, controversial data exist regarding the association of serum levels of RBP4 with insulin resistance in humans. Obesity confers a major risk to develop insulin resistance...
  40. ncbi request reprint The short synacthen test in the evaluation of adrenal masses in patients with malignancies
    H S Willenberg
    Department of Endocrinology, University of Duesseldorf, Germany
    Endocr Res 28:793-7. 2002
    ..We therefore think that the ACTH test is a valuable biochemical tool to distinguish primary adrenal tumors from adrenal metastasis derived from other malignancies...
  41. ncbi request reprint Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnostic and therapeutic management
    A Wolf
    Department of General and Visceral Surgery, University Hospital, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Horm Metab Res 37:391-5. 2005
    ....
  42. ncbi request reprint Relevance of TSH receptor stimulating and blocking autoantibody measurement for the prediction of relapse in Graves' disease
    M Schott
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Horm Metab Res 37:741-4. 2005
    ..Bioassays should be reserved for special clinical questions such as Graves' disease in pregnancy...
  43. ncbi request reprint Levels of autoantibodies against human TSH receptor predict relapse of hyperthyroidism in Graves' disease
    M Schott
    Department of Endocrinology, Heinrich Heine University Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Horm Metab Res 36:92-6. 2004
    ..In conclusion, our data clearly indicate that TRAb measurement is useful for identifying patients that will not benefit from long-term antithyroid drug treatment...
  44. pmc Human adipocytes secrete mineralocorticoid-releasing factors
    M Ehrhart-Bornstein
    German Diabetes Center, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 100:14211-6. 2003
    ..In conclusion, human adipocytes secrete potent mineralocorticoid-releasing factors, suggesting a direct link between obesity and hypertension...
  45. ncbi request reprint Association of impaired glucose metabolism in morbid obesity with hypoadiponectinaemia
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:S64-9. 2008
    ..As obesity is the major risk factor for T2DM it is not clear why many patients with morbid obesity remain normoglycaemic and if this protection can be attributed to a lower grade of inflammation or higher adiponectin levels...
  46. doi request reprint Role of the novel mTOR inhibitor RAD001 (everolimus) in anaplastic thyroid cancer
    C Papewalis
    Endocrine Cancer Center, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 41:752-6. 2009
    ..In parallel, quantitative PCR of PCNA displayed a reduced expression of PCNA within the responding cell lines, respectively. In summary, we found a good responding effect in a part of ATC cell lines, which may have a clinical impact...
  47. ncbi request reprint Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt-signaling pathway
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Int J Obes (Lond) 31:864-70. 2007
    ..However, the molecular mechanisms mediating this effect are not known...
  48. ncbi request reprint Improved prediction of relapse of Graves' thyrotoxicosis by combined determination of TSH receptor and thyroperoxidase antibodies
    M Schott
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Horm Metab Res 39:56-61. 2007
    ..Our objective was to extend the outcome of the prediction by combining TRAb with thyroperoxidase antibody (TPO-Ab) measurement...
  49. pmc A progressive increase in cardiovascular risk assessed by coronary angiography in non-diabetic patients at sub-diabetic glucose levels
    Sven Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Germany
    Cardiovasc Diabetol 10:56. 2011
    ..Therefore, we investigated associations of FBG and 2h-BG values with the prevalence of CHD assessed by coronary angiography as the most sensitive diagnostic tool...
  50. doi request reprint Pathophysiological aspects of Wnt-signaling in endocrine disease
    Sven Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Eur J Endocrinol 160:731-7. 2009
    ....
  51. ncbi request reprint Carcinogenic hypergastrinemia: signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome
    Matthias Schott
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    J Clin Endocrinol Metab 92:3378-82. 2007
    ..Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families...
  52. ncbi request reprint Functional central hypothyroidism in the elderly
    Maren A Sell
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, D 40225 Duesseldorf, Germany
    Aging Clin Exp Res 20:207-10. 2008
    ..However, testing of pituitary reserves leads to contradictory results and has infrequently been evaluated in studies...
  53. doi request reprint New mechanisms to control aldosterone synthesis
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 40:435-41. 2008
    ..Further identification and characterization of these factors may help in the development of novel therapies for the treatment of arterial hypertension, various metabolic diseases, and other disorders...
  54. ncbi request reprint Use of laser microdissection in complex tissue
    Holger S Willenberg
    Department of Endocrinology, University of Dusseldorf, D 40225 Dusseldorf, Germany
    Methods Enzymol 356:216-23. 2002
    ....
  55. doi request reprint Nestin as a marker in the classification of adrenocortical tumors
    A Lachenmayer
    Department of General, Visceral and Pediatric Surgery, University Hospital Dusseldorf, Dusseldorf 40225, Germany
    Horm Metab Res 41:397-401. 2009
    ..We conclude that our findings provide further evidence that nestin, as a marker, is not restricted to neuronal stem cells and nestin expression is worth to be studied in adrenocortical tumors...
  56. ncbi request reprint Adrenal cortical tumors and multiple endocrine neoplasia-related syndromes
    M Haase
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Minerva Endocrinol 34:123-35. 2009
    ..This review explores the underlying genetic defects, diagnosis and therapy of the major heritable tumor syndromes associated with adrenocortical tumorigenesis...
  57. ncbi request reprint Reproducibility of Elecsys anti-TSHR test results in a lot-to-lot comparison
    D Hermsen
    Institute for Clinical Chemistry and Laboratory Diagnostics, University Hospital Dusseldorf, Germany
    Horm Metab Res 42:295-7. 2010
    ..The overall mean of differences was -0.8+/-14%. The data clearly demonstrate that the automated TRAb assay has a high stability in regard to TSH receptor preparations...
  58. doi request reprint Standard-radical vs. function-preserving surgery of benign nodular goiter: a sonographic and biochemical 10-year follow-up study
    N Lehwald
    Department of General, Visceral and Pediatric Surgery, University Hospital Duesseldorf, Duesseldorf, Germany
    Langenbecks Arch Surg 394:279-83. 2009
    ..The aim of our study was to compare the long-term outcome of different thyroid resection modes with special interest in the incidence of recurrent nodules and the use of oral thyroid hormone medication...
  59. ncbi request reprint Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla
    P Patak
    Department of Endocrinology, Diabetes, Rheumatology, Heinrich Heine University, Duesseldorf, Germany
    Endocr Res 30:871-5. 2004
    ....
  60. ncbi request reprint Corticotropin-releasing hormone system in human adipose tissue
    Janette Seres
    German Diabetes Center, Heinrich Heine University of Duesseldorf, Duesseldorf 65 40225, Germany
    J Clin Endocrinol Metab 89:965-70. 2004
    ..This system could be implicated in energy homeostasis and in mediating the anorexic effects of CRH at adipose level...
  61. ncbi request reprint Polycystic ovary syndrome and infertility
    Holger S Willenberg
    JAMA 297:2582-3; author reply 2583. 2007
  62. ncbi request reprint Hirsutism
    Holger S Willenberg
    N Engl J Med 354:1533-5; author reply 1533-5. 2006
  63. ncbi request reprint Endothelial cell-mediated regulation of aldosterone release from human adrenocortical cells
    Ishrath Ansurudeen
    Department of Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, 01307 Dresden, Germany
    Mol Cell Endocrinol 265:150-6. 2007
    ..In conclusion, human endothelial cells are important intra-adrenal regulators of human aldosterone synthesis and release...