Nina C Weber

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK
    Nina C Weber
    Department of Anesthesiology, University Hospital of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Br J Pharmacol 144:123-32. 2005
  2. ncbi request reprint The concept of anaesthetic-induced cardioprotection: mechanisms of action
    Nina C Weber
    Department of Anaesthesiology, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Best Pract Res Clin Anaesthesiol 19:429-43. 2005
  3. pmc Mechanisms of xenon- and isoflurane-induced preconditioning - a potential link to the cytoskeleton via the MAPKAPK-2/HSP27 pathway
    Nina C Weber
    Department of Anesthesiology, University Hospital of Dusseldorf, Germany
    Br J Pharmacol 146:445-55. 2005
  4. doi request reprint Hypoxia induces late preconditioning in the rat heart in vivo
    Marc M Berger
    Department of Anesthesiology, University Hospital of Heidelberg, Heidelberg, Germany
    Anesthesiology 113:1351-60. 2010
  5. ncbi request reprint Desflurane preconditioning induces time-dependent activation of protein kinase C epsilon and extracellular signal-regulated kinase 1 and 2 in the rat heart in vivo
    Octavian Toma
    Department of Anesthesiology, University Hospital Duesseldorf, Germany
    Anesthesiology 101:1372-80. 2004
  6. ncbi request reprint Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1
    Nina C Weber
    Department of Anaesthesiology, University Hospital of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Eur J Pharmacol 539:1-9. 2006
  7. ncbi request reprint Morphine induces late cardioprotection in rat hearts in vivo: the involvement of opioid receptors and nuclear transcription factor kappaB
    Jan Frässdorf
    Department of Anesthesiology, University Hospital of Dusseldorf, POB 10 10 07, 40001 Dusseldorf, Germany
    Anesth Analg 101:934-41, table of contents. 2005
  8. doi request reprint Age-related loss of cardiac preconditioning: impact of protein kinase A
    Ragnar Huhn
    Department of Anaesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Exp Gerontol 47:116-21. 2012
  9. ncbi request reprint The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent
    Andre Heinen
    Department of Anesthesiology, University of Dusseldorf, 40215 Düsseldorf, Germany
    Eur J Pharmacol 578:108-13. 2008
  10. ncbi request reprint Effects of nitrous oxide on the rat heart in vivo: another inhalational anesthetic that preconditions the heart?
    Nina C Weber
    Department of Anesthesiology, University Hospital of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Anesthesiology 103:1174-82. 2005

Collaborators

Detail Information

Publications19

  1. pmc The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK
    Nina C Weber
    Department of Anesthesiology, University Hospital of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Br J Pharmacol 144:123-32. 2005
    ..Thus, the results of the present study may contribute to elucidate the beneficial cardioprotective effects of this anesthetic gas...
  2. ncbi request reprint The concept of anaesthetic-induced cardioprotection: mechanisms of action
    Nina C Weber
    Department of Anaesthesiology, University of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Best Pract Res Clin Anaesthesiol 19:429-43. 2005
    ..There are three time windows when a substance may interact with the ischaemia reperfusion injury process: (1) during ischaemia, (2) after ischaemia (i.e. during reperfusion), and (3) before ischaemia (preconditioning)...
  3. pmc Mechanisms of xenon- and isoflurane-induced preconditioning - a potential link to the cytoskeleton via the MAPKAPK-2/HSP27 pathway
    Nina C Weber
    Department of Anesthesiology, University Hospital of Dusseldorf, Germany
    Br J Pharmacol 146:445-55. 2005
    ..F-actin and pHSP27 were colocalized after Xe-PC. Xe-PC activates MAPKAPK-2 and HSP27 downstream of PKC and p38 MAPK. These data link Xe-PC to the cytoskeleton, revealing new insights into the mechanisms of Xe-PC in vivo...
  4. doi request reprint Hypoxia induces late preconditioning in the rat heart in vivo
    Marc M Berger
    Department of Anesthesiology, University Hospital of Heidelberg, Heidelberg, Germany
    Anesthesiology 113:1351-60. 2010
    ..Although hypoxic late preconditioning (LPC) limits ischemia-reperfusion injury in vitro, its cardioprotective effect is not established in vivo...
  5. ncbi request reprint Desflurane preconditioning induces time-dependent activation of protein kinase C epsilon and extracellular signal-regulated kinase 1 and 2 in the rat heart in vivo
    Octavian Toma
    Department of Anesthesiology, University Hospital Duesseldorf, Germany
    Anesthesiology 101:1372-80. 2004
    ..The present study investigated the time dependency of PKC-epsilon and ERK1/2 activation during desflurane-induced preconditioning in the rat heart...
  6. ncbi request reprint Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1
    Nina C Weber
    Department of Anaesthesiology, University Hospital of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Eur J Pharmacol 539:1-9. 2006
    ..5-hydroxydecanoate and Wortmannin blocked both effects. PKC-epsilon is activated downstream of mitochondrial K(ATP) channels and PDK-1. Both pathways are functionally involved in xenon preconditioning...
  7. ncbi request reprint Morphine induces late cardioprotection in rat hearts in vivo: the involvement of opioid receptors and nuclear transcription factor kappaB
    Jan Frässdorf
    Department of Anesthesiology, University Hospital of Dusseldorf, POB 10 10 07, 40001 Dusseldorf, Germany
    Anesth Analg 101:934-41, table of contents. 2005
    ..Opioid receptors are involved as mediators in both MO- and LPS-induced LPC but as triggers only in MO-induced LPC...
  8. doi request reprint Age-related loss of cardiac preconditioning: impact of protein kinase A
    Ragnar Huhn
    Department of Anaesthesiology, University Hospital Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany
    Exp Gerontol 47:116-21. 2012
    ..05). He-PC is mediated by activation of PKA. Alterations in PKA regulation might be an underlying mechanism for the age-dependent loss of preconditioning...
  9. ncbi request reprint The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent
    Andre Heinen
    Department of Anesthesiology, University of Dusseldorf, 40215 Düsseldorf, Germany
    Eur J Pharmacol 578:108-13. 2008
    ..0+/-0.13 vs. 3.2+/-0.11, n=12). Increasing age reduced the effects of mK(Ca) opening on mitochondrial respiration. This might be one underlying reason of the decreased protective potency of ischemic preconditioning in the aged myocardium...
  10. ncbi request reprint Effects of nitrous oxide on the rat heart in vivo: another inhalational anesthetic that preconditions the heart?
    Nina C Weber
    Department of Anesthesiology, University Hospital of Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Anesthesiology 103:1174-82. 2005
    ....
  11. doi request reprint Physiological levels of glutamine prevent morphine-induced preconditioning in the isolated rat heart
    Andre Heinen
    Laboratory of Experimental Intensive Care and Anaesthesiology L E I C A, Academic Medical Centre AMC, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Pharmacol 595:58-64. 2008
    ..Cardioprotection by morphine-induced preconditioning is model dependent: in the isolated rat heart, morphine preconditioning is prevented by a glutamine containing perfusate...
  12. doi request reprint Blockade of anaesthetic-induced preconditioning in the hyperglycaemic myocardium: the regulation of different mitogen-activated protein kinases
    Nina C Weber
    Laboratory of Experimental Intensive Care and Anaesthesiology L E I C A, Academic Medical Center AMC, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Pharmacol 592:48-54. 2008
    ..Therefore, it can be assumed that the hyperglycaemic induced blockade of Des-preconditioning is situated downstream or in parallel of these mitogen-activated protein kinases or involves different signal transduction pathways...
  13. ncbi request reprint Inhibition of p38 MAPK activation via induction of MKP-1: atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany Alexandra Kiemer cup uni muenchen de
    Circ Res 90:874-81. 2002
    ..These effects point to an antiinflammatory and antiatherogenic potential of this cardiovascular hormone...
  14. ncbi request reprint Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon
    Benedikt Preckel
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Anesthesiology 105:187-97. 2006
    ....
  15. ncbi request reprint ANP inhibits TNF-alpha-induced endothelial MCP-1 expression--involvement of p38 MAPK and MKP-1
    Nina C Weber
    Department of Pharmacy, University of Munich, Germany
    J Leukoc Biol 74:932-41. 2003
    ..As antisense experiments revealed a pivotal role for MKP-1 induction and therefore, p38 MAPK inhibition in ANP-mediated attenuation of MCP-1 expression, this action seems to be rather independent of NF-kappaB inhibition...
  16. doi request reprint Molecular biology in cardiovascular anaesthesia
    Nina C Weber
    Department of Anaesthesiology, Laboratory of Experimental Intensive Care and Anaesthesiology, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands
    Curr Opin Anaesthesiol 21:71-7. 2008
    ..A basic knowledge of these techniques becomes increasingly important for the clinically working anaesthesiologist in order to understand research publications and the molecular description of disease processes and their diagnosis...
  17. doi request reprint Helium-induced preconditioning in young and old rat heart: impact of mitochondrial Ca(2+) -sensitive potassium channel activation
    Andre Heinen
    Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 109:830-6. 2008
    ..The authors investigated whether He-PC (1) is mediated by activation of Ca(2+) -sensitive potassium channels, (2) results in mitochondrial uncoupling, and (3) is age dependent...
  18. ncbi request reprint Characterization of heme oxygenase 1 (heat shock protein 32) induction by atrial natriuretic peptide in human endothelial cells
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, 81377 Munich, Germany
    Endocrinology 144:802-12. 2003
    ..The aim of this study was to characterize induction of heme oxygenase (HO)-1 by ANP in human umbilical vein endothelial cells (HUVEC)...
  19. doi request reprint Intermitted pharmacologic pretreatment by xenon, isoflurane, nitrous oxide, and the opioid morphine prevents tumor necrosis factor alpha-induced adhesion molecule expression in human umbilical vein endothelial cells
    Nina C Weber
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 108:199-207. 2008
    ..The authors investigated the impact of different anesthetics and morphine on TNF-alpha-induced endothelial cell adhesion molecule expression...