Walter Stummer

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report
    Walter Stummer
    Department of Neurosurgery, Heinrich Heine University, Moorenstr 5, 40225, Duesseldorf, Germany
    J Neurooncol 87:103-9. 2008
  2. doi The importance of surgical resection in malignant glioma
    Walter Stummer
    Klinik für Neurochirurgie, Heinrich Heine Universitat, Dusseldorf, Germany
    Curr Opin Neurol 22:645-9. 2009
  3. ncbi Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial
    Walter Stummer
    Neurochirurgische Klinik, Heinrich Heine University, Dusseldorf, Germany
    Lancet Oncol 7:392-401. 2006
  4. doi Finding the anaplastic focus in diffuse gliomas: the value of Gd-DTPA enhanced MRI, FET-PET, and intraoperative, ALA-derived tissue fluorescence
    Christian Ewelt
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Clin Neurol Neurosurg 113:541-7. 2011
  5. doi Comparison of (18)F-FET PET and 5-ALA fluorescence in cerebral gliomas
    Frank Willi Floeth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Eur J Nucl Med Mol Imaging 38:731-41. 2011
  6. doi Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study. Clinical article
    Walter Stummer
    Neurochirurgische Klinik, Universitatsklinikum Munster, 48149 Munster, Germany
    J Neurosurg 114:613-23. 2011
  7. ncbi 18F-FET PET differentiation of ring-enhancing brain lesions
    Frank W Floeth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Nucl Med 47:776-82. 2006
  8. doi Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias
    Walter Stummer
    Neurochirurgische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosurgery 62:564-76; discussion 564-76. 2008
  9. doi Glioblastoma multiforme of the elderly: the prognostic effect of resection on survival
    Christian Ewelt
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurooncol 103:611-8. 2011
  10. doi The transorbital keyhole approach: early and long-term outcome analysis of approach-related morbidity and cosmetic results. Technical note
    Kerim Beseoglu
    Department of Neurosurgery, Universitätsklinik Düsseldorf, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurosurg 114:852-6. 2011

Detail Information

Publications37

  1. ncbi Long-sustaining response in a patient with non-resectable, distant recurrence of glioblastoma multiforme treated by interstitial photodynamic therapy using 5-ALA: case report
    Walter Stummer
    Department of Neurosurgery, Heinrich Heine University, Moorenstr 5, 40225, Duesseldorf, Germany
    J Neurooncol 87:103-9. 2008
    ..Edema resolved completely. The patient is still free of recurrence 56 months after treatment, demonstrating an impressive and long-lasting response to this novel mode of therapy...
  2. doi The importance of surgical resection in malignant glioma
    Walter Stummer
    Klinik für Neurochirurgie, Heinrich Heine Universitat, Dusseldorf, Germany
    Curr Opin Neurol 22:645-9. 2009
    ..Here we review recent data from prospective studies that provide novel arguments in support of surgery...
  3. ncbi Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial
    Walter Stummer
    Neurochirurgische Klinik, Heinrich Heine University, Dusseldorf, Germany
    Lancet Oncol 7:392-401. 2006
    ..We aimed to assess the effect of fluorescence-guided resection with 5-aminolevulinic acid on surgical radicality, progression-free survival, overall survival, and morbidity...
  4. doi Finding the anaplastic focus in diffuse gliomas: the value of Gd-DTPA enhanced MRI, FET-PET, and intraoperative, ALA-derived tissue fluorescence
    Christian Ewelt
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Clin Neurol Neurosurg 113:541-7. 2011
    ..The relationship between these modalities and their value for guiding biopsies during resection has not yet been elucidated in the group of diffuse gliomas...
  5. doi Comparison of (18)F-FET PET and 5-ALA fluorescence in cerebral gliomas
    Frank Willi Floeth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Eur J Nucl Med Mol Imaging 38:731-41. 2011
    ....
  6. doi Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study. Clinical article
    Walter Stummer
    Neurochirurgische Klinik, Universitatsklinikum Munster, 48149 Munster, Germany
    J Neurosurg 114:613-23. 2011
    ..Presently, the authors focus on the latter aspects in the final study population, and attempt to determine how safety might be affected by cytoreductive surgery...
  7. ncbi 18F-FET PET differentiation of ring-enhancing brain lesions
    Frank W Floeth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Nucl Med 47:776-82. 2006
    ....
  8. doi Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias
    Walter Stummer
    Neurochirurgische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosurgery 62:564-76; discussion 564-76. 2008
    ....
  9. doi Glioblastoma multiforme of the elderly: the prognostic effect of resection on survival
    Christian Ewelt
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurooncol 103:611-8. 2011
    ..To conclude, elderly GBM patients should not be per se excluded from intensive treatment procedures...
  10. doi The transorbital keyhole approach: early and long-term outcome analysis of approach-related morbidity and cosmetic results. Technical note
    Kerim Beseoglu
    Department of Neurosurgery, Universitätsklinik Düsseldorf, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurosurg 114:852-6. 2011
    ..The authors evaluated approach-related morbidity and cosmetic results in their patients to determine the rate of complications and compared this to published reports of similar approaches...
  11. doi Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients
    Jörg Felsberg
    Department of Neuropathology, Heinrich Heine University, Dusseldorf, Germany
    Clin Cancer Res 15:6683-93. 2009
    ..The clinical significance of other glioblastoma-associated molecular aberrations and their relationship to MGMT promoter hypermethylation is still poorly understood...
  12. doi Microscope-integrated quantitative analysis of intraoperative indocyanine green fluorescence angiography for blood flow assessment: first experience in 30 patients
    Marcel A Kamp
    Klinik für Neurochirurgie, Heinrich Heine Universitat, Dusseldorf, Germany
    Neurosurgery 70:65-73; discussion 73-4. 2012
    ..Near-infrared indocyanine green (ICG) fluorescence angiography was introduced for visualizing vessel patency intraoperatively. However, quantitative information has not been available...
  13. doi Cordectomy as final treatment option for diffuse intramedullary malignant glioma using 5-ALA fluorescence-guided resection
    Christian Ewelt
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    Clin Neurol Neurosurg 112:357-61. 2010
    ..MRI demonstrated intramedullar invasion from T12 to T9. To assess tumor invasion intraoperatively, we used tumor fluorescence derived from 5-aminolevulinic acid (5-ALA)...
  14. doi Modulation of migratory activity and invasiveness of human glioma spheroids following 5-aminolevulinic acid-based photodynamic treatment. Laboratory investigation
    Nima Etminan
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurosurg 115:281-8. 2011
    ..Besides direct phototoxicity, additional mechanisms may contribute. Therefore, the authors studied the influence of ALA/PDT on glioblastoma's migratory and invasive behavior in a human glioma cell spheroid model...
  15. ncbi The value of metabolic imaging in diagnosis and resection of cerebral gliomas
    Frank Willi Floeth
    Department of Neurosurgery, University of Dusseldorf, Dusseldorf, Germany
    Nat Clin Pract Neurol 1:62-3. 2005
  16. doi Factors predicting recurrence of chronic subdural haematoma: the influence of intraoperative irrigation and low-molecular-weight heparin thromboprophylaxis
    Yasemin Tahsim-Oglou
    Department of Neurosurgery, Heinrich Heine Universitat, Dusseldorf, Germany
    Acta Neurochir (Wien) 154:1063-7; discussion 1068. 2012
    ..The current analysis was initiated to determine management-related risk factors for recurrence, i.e. postoperative low-molecular-weight heparin thromboprophylaxis, and the importance of rinsing the subdural space...
  17. doi Can systematic analysis of morbidity and mortality reduce complication rates in neurosurgery?
    Hans Jakob Steiger
    Department of Neurosurgery, Heinrich Heine Universitat, Dusseldorf, Germany
    Acta Neurochir (Wien) 152:2013-9. 2010
    ....
  18. doi Symptomatic intracystic hemorrhage in pineal cysts. Report of 3 cases
    Sevgi Sarikaya-Seiwert
    Department of Neurosurgery, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurosurg Pediatr 4:130-6. 2009
    ..The authors' cases confirm that MR imaging can identify intracystic hemorrhage by a characteristic fluid-fluid interface. Their experience suggests that microsurgical resection of cysts may be an effective and curative treatment option...
  19. ncbi Perspectives in central nervous system malignancies
    Walter Stummer
    Heinrich Heine University of Dusseldorf, Universitatsstrasse 1, 40595 Dusseldorf, Germany
    IDrugs 9:412-4. 2006
  20. doi Early fatal hemorrhage after endovascular cerebral aneurysm treatment with a flow diverter (SILK-Stent): do we need to rethink our concepts?
    Bernd Turowski
    Institute of Radiology Neuroradiology, University of Duesseldorf, Duesseldorf, Germany
    Neuroradiology 53:37-41. 2011
    ..All available data were reviewed and beside hemodynamic factors instability of the intra-aneurysmal thrombus is discussed as a possible cofactor leading to this disastrous event...
  21. pmc The use of local agents: Surgicel and Surgifoam
    Michael Sabel
    Department of Neurosurgery, Heinrich Heine University of Dusseldorf, Moorenstrsse 5, 40225 Dusseldorf, Germany
    Eur Spine J 13:S97-101. 2004
    ....
  22. doi Dependence of subarachnoid hemorrhage on climate conditions: a systematic meteorological analysis from the dusseldorf metropolitan area
    Kerim Beseoglu
    Department of Neurosurgery, University Hospital Dusseldorf, Dusseldorf, Germany
    Neurosurgery 62:1033-8; discussion 1038-9. 2008
    ..The present study was initiated to determine whether specific meteorological conditions are related to the occurrence of SAH in the mild climatic zone of North Rhine Westphalia...
  23. pmc Full-endoscopic cervical arcocristectomy for the treatment of spinal stenosis: results of a cadaver study
    Sven O Eicker
    Department of Neurosurgery, Heinrich Heine University, Moorenstraße 5, 40225 Dusseldorf, Germany
    Eur Spine J 21:2487-91. 2012
    ..A posterior approach is often recommended in patients with multilevel dorsal cervical compression. Aim of the present experimental study was to evaluate the feasibility of a full-endoscopic arcocristectomy in a cadaver study...
  24. doi Preoperative localization of spinal and peripheral pathologies for surgery by computed tomography-guided placement of a specialized needle system
    Philipp Slotty
    Neurosurgery Clinic, Heinrich Heine University, Dusseldorf, Germany
    Neurosurgery 66:784-7. 2010
    ..The goal was to reduce intraoperative localization error and radiation exposure to patients and operating room personnel...
  25. ncbi Custom-tailored transdural anterior transpetrosal approach to ventral pons and retroclival regions
    Hans Jakob Steiger
    Department of Neurosurgery, Heinrich Heine University Medical School, Dusseldorf, Germany
    J Neurosurg 104:38-46. 2006
    ..The use of a custom-tailored transdural anterior transpetrosal approach can potentially avoid these pitfalls...
  26. ncbi Recombinant factor VIIa for the prophylaxis of perioperative hemorrhage in a patient with congenital factor XI deficiency undergoing brain tumor neurosurgery
    Christoph Sucker
    Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Moorenstrasse 5, Dusseldorf, Germany
    Clin Appl Thromb Hemost 14:472-5. 2008
    ..In this setting, off-label use of recombinant activated factor VII appears to be a promising alternative for patients suffering from this rare hemostatic defect with hitherto limited therapeutic options...
  27. doi Cerebral perfusion changes in chronic subdural hematoma
    Philipp Jörg Slotty
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurotrauma 30:347-51. 2013
    ..Cerebral autoregulation is intact in cSDH. Neurologic deficits are likely induced by borderline perfusion...
  28. ncbi Mechanisms of tumor-related brain edema
    Walter Stummer
    Department of Neurosurgery, Dusseldorf, Germany
    Neurosurg Focus 22:E8. 2007
    ..In this review the author focuses on established and current concepts regarding the pathophysiology of cerebral edema and its treatment...
  29. ncbi Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy
    Frank Willi Floeth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurosurg 102:318-27. 2005
    ..The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas...
  30. ncbi Temporary aneurysm orifice balloon occlusion as an alternative to retrograde suction decompression for giant paraclinoid internal carotid artery aneurysms: technical note
    Hans Jakob Steiger
    Department of Neurological Surgery, Heinrich Heine Universitat, Moorenstrasse 5, Dusseldorf, Germany
    Neurosurgery 56:E442; discussion E442. 2005
    ..With a large collateral supply, the method is not effective enough. The advent of relatively long and maneuverable soft balloons allows temporary occlusion of the aneurysm orifice...
  31. ncbi Photoirradiation therapy of experimental malignant glioma with 5-aminolevulinic acid
    Bernhard Olzowy
    Department of Neurosurgery, Institute for Neuroradiology, Laser Research Laboratory, Institute for Neuropathology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Neurosurg 97:970-6. 2002
    ..Because PPIX is a potent photosensitizer, the authors sought to discover whether its accumulation might be exploited for use in photoirradiation therapy of experimental brain tumors, without injuring normal or edematous brain...
  32. ncbi Acute morphological sequelae of photodynamic therapy with 5-aminolevulinic acid in the C6 spheroid model
    Pitr Zelenkov
    Department of Neurosurgery, Ludwig Maximilians University, Munich, Germany
    J Neurooncol 82:49-60. 2007
    ..We used a three-dimensional cell culture system, the C6 glioma spheroid model, to study acute effects of PDT and how they might be influenced by treatment conditions...
  33. ncbi Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX
    Tobias J Beck
    Laser Research Laboratory, Ludwig Maximilians University, Marchioninistr 23, 81377 Munich, Germany
    Lasers Surg Med 39:386-93. 2007
    ....
  34. ncbi ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment
    Herbert Stepp
    Laser Forschungslabor, LIFE Center, University Clinic Munich Grosshadern, Marchioninistr 23, 81377 Munich, Germany
    J Environ Pathol Toxicol Oncol 26:157-64. 2007
    ..In the past few years, we have participated in several clinical studies designed to investigate fluorescence guided resection (FGR) and photodynamic therapy (PDT)...
  35. ncbi Resection of glioblastoma
    Walter Stummer
    J Neurosurg 96:809-10; author reply 810. 2002
  36. ncbi Dendritic cell vaccination in patients with malignant gliomas: current status and future directions
    Steven De Vleeschouwer
    Department of Neurosurgery, University Hospital Gasthuisberg, Leuven, Belgium
    Neurosurgery 59:988-99; discussioin 999-1000. 2006
    ..Despite recent advances in neurosurgical resection techniques, radiation therapy, and chemotherapy, malignant gliomas continue to have a dismal prognosis because relapses are unavoidable...
  37. ncbi Efficacy of gamma knife radiosurgery for nonfunctioning pituitary adenomas: a quantitative follow up with magnetic resonance imaging-based volumetric analysis
    Berndt Wowra
    Gamma Knife Praxis, Department of Neurosurgery, Ludwig Maximilians Universitat, Munchen, Germany
    J Neurosurg 97:429-32. 2002
    ..The authors assessed the efficacy of gamma knife radiosurgery (GKS) for nonfunctioning pituitary adenomas (NPAs) by sequential quantitative determinations of tumor volume and neurological and endocrinological follow-up examinations...