Alexander Strom

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: action LADA 6
    Alexander Strom
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Dusseldorf, Germany
    Cytokine 58:148-51. 2012
  2. ncbi Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial)
    Alexander Strom
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e33108. 2012
  3. ncbi Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Eur J Cell Biol 90:414-9. 2011
  4. ncbi Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, ON, Canada
    Lab Invest 87:139-49. 2007
  5. ncbi Impaired glucose tolerance in mice lacking cellular prion protein
    Alexander Strom
    Chronic Disease Program, Institute for Clinical Diabetology, German Diabetes Centre, Du sseldorf, Germany
    Pancreas 40:229-32. 2011
  6. ncbi Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163
    Brigitte Sonier
    Chronic Disease Program, Ottowa Hospital Research Institute, Ottowa, Ontario
    Can J Gastroenterol 25:327-9. 2011
  7. ncbi Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes
    Amanda J MacFarlane
    Nutrition Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON K1A0K9, Canada
    Mamm Genome 20:624-32. 2009
  8. ncbi Peripherin-reactive antibodies in mouse, rabbit, and human blood
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Proteome Res 9:1203-8. 2010
  9. ncbi Dietary proteins as environmental modifiers of type 1 diabetes mellitus
    David E Lefebvre
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6, Canada
    Annu Rev Nutr 26:175-202. 2006
  10. ncbi Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Lab N1, Box 221, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Proteomics 6:26-34. 2006

Collaborators

Detail Information

Publications10

  1. ncbi Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: action LADA 6
    Alexander Strom
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, Dusseldorf, Germany
    Cytokine 58:148-51. 2012
    ..This study aimed to compare the pro-inflammatory (interferon-γ, IFN-γ) and anti-inflammatory (interleukin-13, IL-13) T-cell responses in humans with LADA and type 1 diabetes...
  2. ncbi Improved preservation of residual beta cell function by atorvastatin in patients with recent onset type 1 diabetes and high CRP levels (DIATOR trial)
    Alexander Strom
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    PLoS ONE 7:e33108. 2012
    ..Aim of this secondary analysis was to identify patient subgroups which differ in the decline of beta cell function during treatment with atorvastatin...
  3. ncbi Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Eur J Cell Biol 90:414-9. 2011
    ..This study reveals new avenues for the elucidation of the physiological function of PrP(C) in endocrine and neuronal cells as well as the molecular mechanisms leading to prion diseases...
  4. ncbi Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, ON, Canada
    Lab Invest 87:139-49. 2007
    ..These data suggest a potential dysfunction in beta-cells of diabetes-prone rats, and point to new avenues for the study of diabetes pathogenesis...
  5. ncbi Impaired glucose tolerance in mice lacking cellular prion protein
    Alexander Strom
    Chronic Disease Program, Institute for Clinical Diabetology, German Diabetes Centre, Du sseldorf, Germany
    Pancreas 40:229-32. 2011
    ..To further characterize the function of PrPC in glucose homeostasis, we studied glucoregulation in PrPC knockout (PrPC KO) mice...
  6. ncbi Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163
    Brigitte Sonier
    Chronic Disease Program, Ottowa Hospital Research Institute, Ottowa, Ontario
    Can J Gastroenterol 25:327-9. 2011
    ..The novel finding of putative autoantibodies against tolerogenic intestinal CD163⁺ macrophages suggests that regulatory macrophages were targeted in this patient with celiac disease and T1D...
  7. ncbi Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes
    Amanda J MacFarlane
    Nutrition Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON K1A0K9, Canada
    Mamm Genome 20:624-32. 2009
    ..Here we speculate on various candidate processes and molecules of the immune and endocrine systems that could modify risk for T1D through epigenetic regulation...
  8. ncbi Peripherin-reactive antibodies in mouse, rabbit, and human blood
    Alexander Strom
    Chronic Disease Program, Ottawa Hospital Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Proteome Res 9:1203-8. 2010
    ..These findings point to the need for a re-evaluation of PRPH as a T1D autoantigen in NOD mice and raise the question of the physiological relevance of such widespread immune reactivity against this peripheral nervous system protein...
  9. ncbi Dietary proteins as environmental modifiers of type 1 diabetes mellitus
    David E Lefebvre
    Molecular Medicine, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6, Canada
    Annu Rev Nutr 26:175-202. 2006
    ..The key to diabetes pathogenesis, its prevention, and the ultimate success of beta-cell replacement therapies lies in understanding how the environment controls disease expression. Dietary proteins could be one of these keys...
  10. ncbi Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry
    Alexander Strom
    Molecular Medicine, Ottawa Health Research Institute, Lab N1, Box 221, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Proteomics 6:26-34. 2006
    ..Especially the application of this technique to investigate other neurodegenerative diseases is promising...