Research Topics
| W StahlSummaryAffiliation: Heinrich Heine University Country: Germany Publications
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Detail Information
Publications
Carotenoids and UV protectionHelmut Sies
Institut fur Biochemie und Molekularbiologie I, Heinrich-Heine-Universitat Dusseldorf, P.O.Box 101007, D-40001 Dusseldorf, Germany
Photochem Photobiol Sci 3:749-52. 2004..For successful intervention, treatment with carotenoids is needed for a period of at least ten weeks. An increased consumption of carotenoids may contribute to life-long protection against UV-induced damage...- Bioactivity and protective effects of natural carotenoidsWilhelm Stahl
Heinrich Heine University Duesseldorf, Institute of Biochemistry and Molecular Biology I, P O Box 101007, D 40001 Duesseldorf, Germany
Biochim Biophys Acta 1740:101-7. 2005..Protective effects are also achieved with a diet rich in lycopene... - Vitamin E biotransformation in humansFrancesco Galli
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Italy
Vitam Horm 76:263-80. 2007..The hypothesis of a transformation-dependent bioactivation of vitamin E represents an intriguing and emerging aspect of research that deserves further investigation... 
Photoprotection by dietary carotenoids: concept, mechanisms, evidence and future developmentWilhelm Stahl
Institute of Biochemistry and Molecular Biology I, Faculty of Medicine, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
Mol Nutr Food Res 56:287-95. 2012..In vitro data show that also other carotenoids are efficient photoprotectors. Among them are lutein and structurally unusual phenolic polyenes like 3,3'-dihydroxyisorenieratene...
Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levelsMaria Cristina Polidori
Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
Nutr J 8:10. 2009..Thus, a nutritional counseling program is capable of improving plasma levels of antioxidants even in a health-conscious population. A decrease in biomarkers of oxidative stress, however, does not occur...- Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopeneW Stahl
Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Dusseldorf, D 40001, Germany
Arch Biochem Biophys 373:271-4. 2000..Therefore, we conclude that lycopene affects GJC independent of the formation of acyclo-retinoic acid... - Antioxidant activity of carotenoidsWilhelm Stahl
Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, PO Box 101007, D 40001 Dusseldorf, Germany
Mol Aspects Med 24:345-51. 2003..Filtering of blue light has been proposed as a mechanism protecting the macula lutea against photooxidative damage. There is increasing evidence from human studies that carotenoids protect the skin against photooxidative damage... - Macular carotenoids: lutein and zeaxanthinW Stahl
Heinrich Heine University Dusseldorf, Institute of Biochemistry and Molecular Biology I, Dusseldorf, Germany
Dev Ophthalmol 38:70-88. 2005.... - Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severityM Cristina Polidori
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, , Germany
J Card Fail 10:334-8. 2004..These findings support the rationale for intervention trials aiming at exploring beneficial effects of antioxidant micronutrients in this disease... - Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) StudyM Cristina Polidori
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, , Germany
Biofactors 24:265-74. 2005..Further studies are warranted to clarify whether the use of vitamin C may add clinical long-term beneficial effects in patients with stroke... - Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humansW Stahl
Institut für Physiologische Chemie I and Biologisch Medizinisches Forschungszentrum, Heinrich Heine Universitat Dusseldorf, Germany
Am J Clin Nutr 71:795-8. 2000..beta-Carotene is widely used as an oral sun protectant but studies on its protective effects are scarce... - Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlightWilhelm Stahl
Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Dusseldorf 40001, Germany
Mol Biotechnol 37:26-30. 2007..After about 10-12 weeks of dietary intervention, a decrease in the sensitivity toward UV-induced erythema was observed in volunteers. Dietary micronutrients may contribute to life-long protection against harmful UV radiation... - Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjectsTimur Anlasik
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, , Germany
Br J Nutr 94:639-42. 2005..Modification of nutritional habits among other lifestyle changes should be encouraged to lower prevalence of disease risk factors in later life... - Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and conditionK Neukam
Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
Skin Pharmacol Physiol 24:67-74. 2011..The present study was performed to evaluate the effect of daily supplementation with flaxseed oil and safflowerseed oil on healthy volunteers with sensitive skin... - Carotenoids and protection against solar UV radiationWilhelm Stahl
, , , Deutschland
Skin Pharmacol Appl Skin Physiol 15:291-6. 2002..Such protective effects of carotenoids were also demonstrated in cell culture. The in-vitro data indicate that there is an optimal level of protection for each carotenoid... - Plasma levels of vitamin E and carotenoids are decreased in patients with Nonalcoholic Steatohepatitis (NASH)Andreas Erhardt
Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
Eur J Med Res 16:76-8. 2011..Oxidative stress is suggested to play an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The present study was aimed to compare plasma levels of antioxidants in patients suffering from NASH and healthy controls... - Lycopene: antioxidant and biological effects and its bioavailability in the humanH Sies
Institut für Physiologische Chemie I and Biologisch Medizinisches Forschungszentrum, Heinrich Heine Universitat Dusseldorf, Germany
Proc Soc Exp Biol Med 218:121-4. 1998..Little is known about the metabolism of lycopene. Potentially biologically active oxidation products of lycopene have been identified in human plasma... - [Functional food for the skin]J Krutmann
,
Hautarzt 57:280. 2006 - Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetesM C Polidori
Institute of Gerontology and Geriatrics, Perugia University Hospital, Perugia, Italy
Diabetes Metab Res Rev 16:15-9. 2000..This evidence is limited in elderly patients with non-insulin dependent diabetes, in which age- and disease-related production of reactive oxygen species might exert synergistic damaging effects on tissues and organs... - The 5-aminolevulinic acid-induced porphyrin biosynthesis in benign and malignant cells of the skinK Lang
Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany
J Photochem Photobiol B 65:29-34. 2001..In conclusion, by optimizing the treatment modalities, especially the light source, topical photodynamic therapy (PDT) could become a treatment alternative of melanoma metastases in progressive disease... - High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjectsM Cristina Polidori
Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
J Alzheimers Dis 17:921-7. 2009..Modification of nutritional habits aimed at increasing intake of fruits and vegetables should be encouraged to lower prevalence of cognitive impairment in later life... - Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythemaOlivier Aust
, , , Germany
Int J Vitam Nutr Res 75:54-60. 2005..Both of these carotenoids exhibit absorption maxima at wavelengths of UV light. Absorption of UV light protects skin from photodamage and might explain the differences observed between groups... - Spectroscopic properties of phenolic and quinoid carotenoids: a combined theoretical and experimental studyChristel M Marian
Institute of Theoretical and Computational Chemistry, Heinrich Heine University Dusseldorf, Universitatsstr 1, 40225, Dusseldorf, Germany
Photochem Photobiol Sci 8:270-8. 2009.... - Nutritional, dietary and postprandial oxidative stressHelmut Sies
Institut fur Biochemie und Molekularbiologie I, Universitat Dusseldorf, Postfach 101007, D 40001 Dusseldorf, Germany
J Nutr 135:969-72. 2005..g., from wine, cocoa, or tea, improves endothelial dysfunction and lowers the susceptibility of LDL lipids to oxidation. Polyphenols affect endothelial function not solely as antioxidants but also as modulatory signaling molecules... - Non-nutritive bioactive constituents of plants: lycopene, lutein and zeaxanthinHelmut Sies
Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, P O Box 10 10 07, D 40001 Dusseldorf, Germany
Int J Vitam Nutr Res 73:95-100. 2003..Epidemiological studies provide evidence that an increased consumption of lutein is associated with a lowered risk for age-related macular degeneration, a disease with increasing incidence in the elderly... - Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severityMaria Cristina Polidori
Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
Free Radic Biol Med 32:148-52. 2002..The present study supports the concept that an increased consumption of vitamin-rich fruits and vegetables might help in achieving cardiovascular health... - Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementiaM Cristina Polidori
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, , Germany
Dement Geriatr Cogn Disord 18:265-70. 2004..This might be relevant to the pathophysiology of dementing disorders, particularly in light of the recently suggested importance of the vascular component in AD development... - Nutritional protection against skin damage from sunlightHelmut Sies
Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, D 40001 Dusseldorf, Germany
Annu Rev Nutr 24:173-200. 2004..Dietary protection is provided by carotenoids, tocopherols, ascorbate, flavonoids, or n-3 fatty acids, contributing to maintenance resistance as part of lifelong protection... - Bioavailability and metabolismWilhelm Stahl
, , Germany
Mol Aspects Med 23:39-100. 2002 - Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challengeM Cristina Polidori
Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, PO Box 101007, D 40001 Dusseldorf, Germany
Br J Nutr 90:147-50. 2003.... - Incorporation of carotenoids from paprika oleoresin into human chylomicronsAntonio Pérez-Gálvez
Institute for Physiological Chemistry I, Henrich Heine University Düsseldorf, Dusseldorf, Germany
Br J Nutr 89:787-93. 2003..However, oleoresin is a suitable source for the provitamin A carotenoids beta-carotene and beta-cryptoxanthin and the macular pigment zeaxanthin... - Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcomeM Cristina Polidori
Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
Free Radic Res 36:265-8. 2002..Among the carotenoids, only lutein plasma changes are associated with a poor early-outcome... - In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metaboliteAlejandro Betancor-Fernandez
, , Germany
Free Radic Res 36:915-21. 2002..We conclude that alpha-CEHC is a molecule with good antioxidant activity, having the advantage over Trolox of being a naturally occurring compound. These properties might be useful for research or industrial purposes... - Lycopene-rich products and dietary photoprotectionWilhelm Stahl
, , P.O. Box 101007, , Germany
Photochem Photobiol Sci 5:238-42. 2006..After 10-12 weeks of intervention a decrease in the sensitivity towards UV-induced erythema was observed in volunteers. Dietary carotenoids may contribute to life-long protection against harmful UV radiation... - 3,3'-Dihydroxyisorenieratene prevents UV-induced formation of reactive oxygen species and the release of protein-bound zinc ions in human skin fibroblastsKaya Lutter
Institute of Biochemistry and Molecular Biology I, Heinrich Heine University Dusseldorf, D 40001 Dusseldorf, Germany
Mol Nutr Food Res 54:285-91. 2010..g. cysteine) and that protection by DHIR is due to intracellular scavenging of reactive oxygen species generated in photo-oxidation... - Quantification of the alpha- and gamma-tocopherol metabolites 2,5,7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman and 2,7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman in human serumW Stahl
Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Germany
Anal Biochem 275:254-9. 1999..About one-third of the alpha-CEHC circulating in the blood is present as a glucuronide conjugate. Baseline levels of gamma-CEHC are about 50 to 85 pmol/ml... - Consumption of flavanol-rich cocoa acutely increases microcirculation in human skinKarin Neukam
Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, P O Box 101007, 40001 Dusseldorf, Germany
Eur J Nutr 46:53-6. 2007..Long term cocoa ingestion leads to an increased resistance against UV-induced erythema and a lowered transepidermal water loss... - Intervention with flaxseed and borage oil supplements modulates skin condition in womenSilke De Spirt
Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, P O Box 101007, D 40001 Dusseldorf, Germany
Br J Nutr 101:440-5. 2009..05). Except for hydration, none of the parameters was affected in the placebo group. The present data provide evidence that skin properties can be modulated by an intervention with dietary lipids... - Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacityAlejandro Betancor-Fernandez
Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Postfach 101007, D 40001 Dusseldorf, Germany
J Pharm Pharmacol 55:981-6. 2003..That of salmon oil was mainly attributed to vitamin E, which is added to the product for stabilization. In all test preparations, the antioxidant activity was significantly correlated with the content of total phenolic compounds... - Non-antioxidant properties of carotenoidsWilhelm Stahl
, , Germany
Biol Chem 383:553-8. 2002.... - Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblastsFelicitas Daubrawa
Institute of Biochemistry and Molecular Biology I, , , Germany
J Nutr 135:2507-11. 2005..We suggest that astaxanthin affects channel function by changing the phosphorylation pattern of connexin43... - Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin EDragan Radosavac
Institute of Physiological Chemistry I, Heinrich-Heine University, P. O. Box 101007, , Germany
Eur J Nutr 41:119-24. 2002..The appearance of the metabolite in blood parallels that of the parent compound. The gamma-tocopherol analog appears to be metabolized more efficiently than alpha-tocopherol... - Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythemaUlrike Heinrich
, , Germany
J Nutr 133:98-101. 2003.... - Elevated lipid peroxidation biomarkers and low antioxidant status in atherosclerotic patients with increased carotid or iliofemoral intima media thicknessM Cristina Polidori
Institute of Biochemistry and Molecular Biology 1, Heinrich Heine University Düsseldirf, Düsseldirf, Germany
J Investig Med 55:163-7. 2007..The aim of the study was to assess the association between the intima media thickness (IMT) of the major arteries as a clinical marker of atherosclerosis and markers of lipid peroxidation along with the antioxidant status in humans... - Dietary carotenoids contribute to normal human skin color and UV photosensitivitySimon Alaluf
Unilever Research, Colworth Laboratory, Sharnbrook, Bedford MK44 3UP, UK
J Nutr 132:399-403. 2002.... - Low levels of carotenoids and retinol in involutional osteoporosisDario Maggio
Institute of Gerontology and Geriatrics, University of Perugia, Policlinico Monteluce, Via Brunamonti, 06124 Perugia, Italy
Bone 38:244-8. 2006..Our study suggests a bone sparing effect of retinol, to which the provitamin A activity of some carotenoids might have contributed... - Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblaststOlaf Eichler
, , Germany
Photochem Photobiol 75:503-6. 2002..05, 0.40 and 0.30 nmol/mg protein for lycopene, beta-carotene and lutein, respectively. Beyond the optimum levels, further increases of carotenoid levels in cells led to prooxidant effects... - Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer diseasePatrizia Mecocci
Institute of Gerontology and Geriatrics, University of Perugia, Via Eugubina 42, 06122 Perugia, Italy
Arch Neurol 59:794-8. 2002..A large body of experimental evidence suggests that in Alzheimer disease (AD) pathogenesis an important role is played by oxidative stress, but there is still a lack of data on in vivo markers of free radical-induced damage... - PASSCLAIM - Diet-related cardiovascular diseaseRonald P Mensink
Maastricht University, Department of Human Biology, P. O. Box 616, 6200 MD Maastricht, The Netherlands
Eur J Nutr 42:I6-27. 2003..Therefore, studies to further validate generic predictors for the CVD risk should be initiated... - Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in womenUlrike Heinrich
, , Germany
J Nutr 136:1565-9. 2006..Dietary flavanols from cocoa contribute to endogenous photoprotection, improve dermal blood circulation, and affect cosmetically relevant skin surface and hydration variables... - Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial functionMalcolm J Jackson
Department of Medicine, University of Liverpool, UK
Mol Aspects Med 23:209-85. 2002