D T Schneider

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Acute myelogenous leukemia after treatment for malignant germ cell tumors in children
    D T Schneider
    Department of Pediatric Hematology and Oncology, Heinrich Heine University Dusseldorf, Medical Center, Dusseldorf, Germany
    J Clin Oncol 17:3226-33. 1999
  2. ncbi request reprint Ovarian sex cord-stromal tumors--a clinicopathological study of 72 cases from the Kiel Pediatric Tumor Registry
    Dominik T Schneider
    Clinic of Pediatric Oncology, Hematology and Immunology, Children s Hospital, University Hospital Dusseldorf, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Virchows Arch 443:549-60. 2003
  3. ncbi request reprint Diagnostic value of alpha 1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood
    D T Schneider
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Moorenstr 5, D 40225 Dusseldorf, Germany
    Pediatr Hematol Oncol 18:11-26. 2001
  4. ncbi request reprint Ovarian sex cord-stromal tumors in children and adolescents
    D T Schneider
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University Medical Center, Dusseldorf, Germany
    J Clin Oncol 21:2357-63. 2003
  5. ncbi request reprint Genetic analysis of childhood germ cell tumors with comparative genomic hybridization
    D T Schneider
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Klin Padiatr 213:204-11. 2001
  6. ncbi request reprint Therapy of advanced ovarian juvenile granulosa cell tumors
    D T Schneider
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Klin Padiatr 214:173-8. 2002
  7. ncbi request reprint Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96
    D T Schneider
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    J Clin Oncol 19:1951-60. 2001
  8. ncbi request reprint The malignant potential of teratomas in infancy and childhood: the MAKEI experiences in non-testicular teratoma and implications for a new protocol
    U Gobel
    Department of Pediatric Oncology, Hematology and Immunology, Children s Hospital, UKD, Heinrich Heine University, Dusseldorf
    Klin Padiatr 218:309-14. 2006
  9. ncbi request reprint An approach for cure: PEI-chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors
    R Wessalowski
    Clinik of Pediatric Oncology, Hematology and Immunology, Heinrich Heine Universitat Dusseldorf, Germany
    Klin Padiatr 215:303-9. 2003
  10. ncbi request reprint Multimodal treatment of malignant sacrococcygeal germ cell tumors: a prospective analysis of 66 patients of the German cooperative protocols MAKEI 83/86 and 89
    U Gobel
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    J Clin Oncol 19:1943-50. 2001

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Acute myelogenous leukemia after treatment for malignant germ cell tumors in children
    D T Schneider
    Department of Pediatric Hematology and Oncology, Heinrich Heine University Dusseldorf, Medical Center, Dusseldorf, Germany
    J Clin Oncol 17:3226-33. 1999
    ..To identify the long-term sequelae of therapy for malignant germ cell tumors (GCTs)...
  2. ncbi request reprint Ovarian sex cord-stromal tumors--a clinicopathological study of 72 cases from the Kiel Pediatric Tumor Registry
    Dominik T Schneider
    Clinic of Pediatric Oncology, Hematology and Immunology, Children s Hospital, University Hospital Dusseldorf, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Virchows Arch 443:549-60. 2003
    ..Therefore, histopathological evaluation substantially contributes to risk assessment in patients with OSCST and might be useful for therapy stratification in prospective therapeutic protocols...
  3. ncbi request reprint Diagnostic value of alpha 1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood
    D T Schneider
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Moorenstr 5, D 40225 Dusseldorf, Germany
    Pediatr Hematol Oncol 18:11-26. 2001
    ..Other childhood tumors are rarely associated with AFP or beta-hCG production, usually at only moderately elevated serum levels, and in most patients these tumors can be excluded by clinical and radiological examination...
  4. ncbi request reprint Ovarian sex cord-stromal tumors in children and adolescents
    D T Schneider
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University Medical Center, Dusseldorf, Germany
    J Clin Oncol 21:2357-63. 2003
    ..To develop diagnostic standards and a risk-adapted therapeutic strategy for ovarian sex cord-stromal tumors (OSCST)...
  5. ncbi request reprint Genetic analysis of childhood germ cell tumors with comparative genomic hybridization
    D T Schneider
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Klin Padiatr 213:204-11. 2001
    ..As CGH does not require tissue culture, it also allows analysing archival tissue samples...
  6. ncbi request reprint Therapy of advanced ovarian juvenile granulosa cell tumors
    D T Schneider
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Klin Padiatr 214:173-8. 2002
    ..The current literature provides only limited and inconclusive data regarding the value of adjuvant chemotherapy in such patients with advanced disease...
  7. ncbi request reprint Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96
    D T Schneider
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    J Clin Oncol 19:1951-60. 2001
    ..To evaluate therapeutic options for recurrent malignant sacrococcygeal germ cell tumors (GCT) following three-agent, cisplatinum-based, first-line chemotherapy and tumor resection...
  8. ncbi request reprint The malignant potential of teratomas in infancy and childhood: the MAKEI experiences in non-testicular teratoma and implications for a new protocol
    U Gobel
    Department of Pediatric Oncology, Hematology and Immunology, Children s Hospital, UKD, Heinrich Heine University, Dusseldorf
    Klin Padiatr 218:309-14. 2006
    ..For this comparison, 274 patients from MAKEI 83/86/89 and 261 patients from MAKEI 96 are evaluable...
  9. ncbi request reprint An approach for cure: PEI-chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors
    R Wessalowski
    Clinik of Pediatric Oncology, Hematology and Immunology, Heinrich Heine Universitat Dusseldorf, Germany
    Klin Padiatr 215:303-9. 2003
    ..In clinical usage thermochemotherapy (TCH) should facilitate surgical resection and ameliorate local tumor control...
  10. ncbi request reprint Multimodal treatment of malignant sacrococcygeal germ cell tumors: a prospective analysis of 66 patients of the German cooperative protocols MAKEI 83/86 and 89
    U Gobel
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    J Clin Oncol 19:1943-50. 2001
    ..To evaluate a multimodal approach including surgery and cisplatinum chemotherapy for treatment of children with malignant sacrococcygeal germ cell tumors (GCT) and to compare adjuvant and neoadjuvant strategies in advanced tumors...
  11. ncbi request reprint Teratoma with malignant transformation: experiences of the cooperative GPOH protocols MAKEI 83/86/89/96
    W Biskup
    Department of Pediatric Oncology, Hematology and Immunology, Children s Hospital, UKD, Heinrich Heine University, Dusseldorf
    Klin Padiatr 218:303-8. 2006
    ..While TMT is a rare but well recognised phenomenon in adult germ cell tumors (GCT), data on TMT in pediatric GCTs are lacking...
  12. ncbi request reprint Prognostic value of tumor size, metastases, extension into bone, and increased tumor marker in children with malignant sacrococcygeal germ cell tumors: a prospective evaluation of 71 patients treated in the German cooperative protocols Maligne Keimzelltum
    G Calaminus
    Department of Pediatric Hematology, Children s Hospital, University of Dusseldorf, Dusseldorf, Germany
    J Clin Oncol 21:781-6. 2003
    ....
  13. ncbi request reprint Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups
    U Gobel
    Department of Pediatric Hematology and Oncology, Children s Hospital, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Ann Oncol 11:263-71. 2000
    ..On the other hand the completeness of the primary tumor resection according to oncological standards has been established as the most powerful prognostic parameter superior to tumor marker levels or primary site of the tumor...
  14. doi request reprint Brain metastases in children and adolescents with extracranial germ cell tumor - data of the MAHO/MAKEI-registry
    U Gobel
    ESPED Geschäftsstelle, Koordinierungsstelle für Klinische Studien, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Klin Padiatr 222:140-4. 2010
    ..We analyzed 15 children and adolescents with extracranial germ cell tumor (GCT) and brain metastases reported to the MAHO/MAKEI registry...
  15. doi request reprint Molecular genetic analysis of bilateral ovarian germ cell tumors
    E Hennes
    Clinic of Pediatric Oncology, Hematology and Immunology, Heinrich Heine University, Dusseldorf, Germany
    Klin Padiatr 224:359-65. 2012
    ..At least 50 % of gonadoblastomas may develop into malignant oGCTs, mostly dysgerminomas. In this study, we evaluated bilateral oGCTs in clinically inapparent patients for sex chromosomal aberrations...
  16. ncbi request reprint Avascular osteonecrosis after hyperthermia in children and adolescents with pelvic malignancies: a retrospective analysis of potential risk factors
    S Balzer
    Clinic of Pediatric Oncology, Hematology and Immunology, Heinrich Heine University Dusseldorf, Germany
    Int J Hyperthermia 22:451-61. 2006
    ..During the years 1993-2004 one has observed avascular osteonecrosis (AON) of the femoral head after RHT in seven children with pelvic germ cell tumours or rhabdomyosarcomas...
  17. ncbi request reprint Management of germ cell tumors in children: approaches to cure
    U Gobel
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Onkologie 25:14-22. 2002
    ..As current biologic studies reveal distinct genetic patterns in childhood GCT, it can be expected that further combined clinical and genetic studies will be valuable for risk assessment of childhood GCT...
  18. ncbi request reprint Efficacy and outcome of intensive care in pediatric oncologic patients
    R Heying
    Department of Pediatric Hematology and Oncology, Children's Hospital, Heinrich-Heine University, Duesseldorf, Germany
    Crit Care Med 29:2276-80. 2001
    ..However, all patients with a PRISM score of >20 died. CONCLUSIONS: Diagnosis of cancer does not exclude potential benefit from intensive care medicine in these children, although severe complications might affect the prognosis...
  19. ncbi request reprint Trends in infections in children with malignant disease in 2000: comparison of data of 1980/81
    H J Laws
    Department of Pediatric Oncology, Hematology and Immunology, Heinrich Heine University, Dusseldorf, Germany
    Pediatr Hematol Oncol 24:343-54. 2007
    ..This observation may indicate a sufficient preemptive antibacterial therapy followed by better diagnostic tools and goal-oriented treatment...
  20. ncbi request reprint Seasonal variation and atypical presentation of idiopathic intracranial hypertension in pre-pubertal children
    F Distelmaier
    Department of General Paediatrics, University Children s Hospital, Heinrich Heine University, Dusseldorf, Germany
    Cephalalgia 27:1261-4. 2007
    ..Moreover, eight children presented only with ophthalmologic findings without any other obvious symptoms, raising questions regarding the incidence of undetected cases, particularly in this age group...
  21. ncbi request reprint Long-term haematopoietic reconstitution and survival without interleukin-7 in a murine syngeneic bone marrow transplantation model
    O Feyen
    Department of Pediatric Oncology, Hematology and Immunology, University Children s Hospital Düsseldorf, Dusseldorf, Germany
    Scand J Immunol 64:601-8. 2006
    ..Long-term survival and lymphocyte reconstitution after syngeneic BMT can occur despite the absence of IL-7...
  22. ncbi request reprint Long-term FVII substitution in a preterm infant with severe gastrointestinal bleeding and FVII deficiency due to a homozygous donor splice mutation IVS4+1G-->A
    U Hennewig
    Department for Pediatric Oncology, Hematology and Immunology, Heinrich Heine University, Dusseldorf, Germany
    Pediatr Hematol Oncol 23:129-33. 2006
    ..Severe bleeding events were prevented with prophylactic treatment. Early identification of the underlying mutation helps to assess the risk of hemorrhage and prevent severe bleeding by prophylactic FVII therapy...
  23. ncbi request reprint Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are caused by true allelic loss: a combined comparative genomic hybridization and microsatellite analysis
    Susanne Zahn
    Clinic of Pediatric Oncology, Haematology and Immunology, Heinrich Heine University, Dusseldorf, Germany
    Genes Chromosomes Cancer 45:995-1006. 2006
    ..However, since two postpubertal tumors with LOH at 1p progressed, a prognostic relevance in this age group seems possible, warranting a prospective evaluation...
  24. doi request reprint Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups
    Tobias M Dantonello
    Pediatrics 5 Oncology, Hematology, Immunology, Olgahospital, Klinikum Stuttgart, Stuttgart, Germany
    Cancer 112:2424-31. 2008
    ..As reports about MCS in young patients are scarce, treatment and outcomes of children/adolescents/young adults in the CWS and COSS studies were investigated...
  25. ncbi request reprint Improvement in the outcome of children with germ cell tumors
    Luiz Fernando Lopes
    Department of Pediatrics Centro de Tratamento e Pesquisa Hospital do Cancer, A C Camargo, Sao Paulo, Brazil
    Pediatr Blood Cancer 50:250-3. 2008
    ..To describe the clinical characteristics and estimate the survival of children and adolescents with germ cell tumors treated with cisplatin-based combination chemotherapy according to three different protocols in Brazil...
  26. ncbi request reprint Genotype and protein expression after bone marrow transplantation for adrenoleukodystrophy
    Stefan Schönberger
    Clinic for Pediatric Oncology, Hematology, and Immunology, University Children s Hospital, Heinrich Heine University, Dusseldorf, Germany
    Arch Neurol 64:651-7. 2007
    ..So far, hematopoietic stem cell transplantation (HSCT) constitutes the only curative approach able to prevent the progression of cerebral X-ALD. However, biological mechanisms of this beneficial approach are still unknown...
  27. ncbi request reprint Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols
    Dominik T Schneider
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Duesseldorf, Germany
    Pediatr Blood Cancer 42:169-75. 2004
    ..The objective of this analysis was to analyze a large population-based pediatric cohort of GCTs and to evaluate the parameters age, sex, site of the tumor, histology, and potential correlations between these parameters...
  28. ncbi request reprint Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors
    Michael K Fritsch
    Department of Pathology, University of Wisconsin Madison, 53706, USA
    Pediatr Dev Pathol 9:115-31. 2006
    ..These results indicate that activation of Wnt/beta-catenin signaling plays an important role in the pathogenesis of 2 histologic subtypes of human GCTs...
  29. ncbi request reprint IGF2/H19 imprinting analysis of human germ cell tumors (GCTs) using the methylation-sensitive single-nucleotide primer extension method reflects the origin of GCTs in different stages of primordial germ cell development
    Sonja Sievers
    Clinic of Pediatric Oncology, Haematology and Immunology, Medical Center, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Genes Chromosomes Cancer 44:256-64. 2005
    ..c) 2005 Wiley-Liss, Inc...
  30. ncbi request reprint Fatal glioblastoma multiforme in a patient with neurofibromatosis type I: the dilemma of systematic medical follow-up
    Felix Distelmaier
    Department of General Pediatrics, University Children s Hospital, Heinrich Heine University Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Childs Nerv Syst 23:343-7. 2007
    ..Although the majority of NF1 patients are only mildly affected, the risk of developing malignancies is significantly increased in this population...
  31. ncbi request reprint Ovarian small cell carcinoma of the hypercalcemic type in children and adolescents: a prognostically unfavorable but curable disease
    Felix Distelmaier
    Clinic of Pediatric Oncology, Hematology, and Immunology, Heinrich Heine University, Duesseldorf, Germany
    Cancer 107:2298-306. 2006
    ..The objective of the current study was to investigate the clinicopathologic features of this tumor and to develop preliminary diagnostic and therapeutic guidelines...
  32. ncbi request reprint Ovarian sex cord-stromal tumors in children and adolescents
    Dominik T Schneider
    Clinic of Pediatric Oncology, Hematology and Immunology, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    J Reprod Med 50:439-46. 2005
    ..Based on this analysis, a prospective study on OSCST in children and adolescents began recruiting cases in 2005...
  33. doi request reprint Pediatric malignant germ cell tumors show characteristic transcriptome profiles
    Roger D Palmer
    MRC Cancer Cell Unit, Hutchison MRC Research Center, Cambridge, United Kingdom
    Cancer Res 68:4239-47. 2008
    ....
  34. doi request reprint Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy
    Karl Ludwig Schaefer
    Institute of Pathology, Heinrich Heine University, Moorenstrasse 5, Duesseldorf, Germany
    Eur J Cancer 44:699-709. 2008
    ..We conclude that expression signatures of initial tumour biopsies can help to identify ESFT patients at high risk to develop tumour metastasis or to suffer from a therapy refractory cancer...
  35. ncbi request reprint JKT-1 is not a human seminoma cell line
    Jeroen de Jong
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center
    Int J Androl 30:350-65. 2007
    ..All results indicate that the JKT-1 cell line is not representative of human seminoma. Although it can originate from an early germ cell, a non-germ cell derivation cannot be excluded...
  36. ncbi request reprint Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene
    Leendert H J Looijenga
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Cancer Res 66:290-302. 2006
    ....
  37. ncbi request reprint Genetic analysis of mediastinal nonseminomatous germ cell tumors in children and adolescents
    Dominik T Schneider
    Division of Pediatric Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Genes Chromosomes Cancer 34:115-25. 2002
    ..Cooperative group studies reveal a significantly better prognosis of malignant M-GCT arising in infants compared to that in adolescents, suggesting that these genetic differences are associated with differences in clinical behavior...
  38. ncbi request reprint Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis
    Holger Cario
    Dept of Pediatrics, University Hospital Ulm, Prittwitzstrasse 43 D 89075 Ulm, Germany
    Haematologica 90:19-24. 2005
    ..Subsequently this and other mutations in the VHL gene were also detected in several patients of different ethnic origin. Haplotype analyses of the VHL gene suggested a common origin for the Chuvash-type mutation...