S Schmidt

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc Cell therapy in bone healing disorders
    Marcus Jager
    Dept of Orthopaedics, University Hospital Dusseldorf, Heinrich Heine University Dusseldorf, Moorenstr Düsseldorf, Germany
    Orthop Rev (Pavia) 2:e20. 2010
  2. pmc Spinning around or stagnation - what do osteoblasts and chondroblasts really like?
    C Zilkens
    Department of Orthopaedics, Heinrich Heine University of Duesseldorf, 40225 Duesseldorf, Germany
    Eur J Med Res 15:35-43. 2010
  3. pmc Migration pattern of cementless press fit cups in the presence of stabilizing screws in total hip arthroplasty
    C Zilkens
    Deputy Chief, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, 40225 Duesseldorf, Germany
    Eur J Med Res 16:127-32. 2011
  4. ncbi Primary total hip replacement in childhood, adolescence and young patients: quality and outcome of clinical studies
    M Jager
    Department of Orthopaedics, Heinrich Heine University Medical School, Dusseldorf, Germany
    Technol Health Care 16:195-214. 2008
  5. ncbi Hyperthermia associated osteonecrosis in young patients with pelvic malignancies
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Duesseldorf, Moorenstr 5, D 40225 Duesseldorf, Germany
    Anticancer Agents Med Chem 8:571-5. 2008
  6. doi [Indications and results of corrective pelvic osteotomies in developmental dysplasia of the hip]
    M Jager
    Klinik und Poliklinik für Orthopädie und Orthopädische Chirurgie, Universitatsklinikum, Heinrich Heine Universitat, Moorenstrasse 5, 40225, Dusseldorf, Germany
    Orthopade 37:556-70, 572-4, 576. 2008
  7. doi Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro
    Marcus Jager
    Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Dusseldorf, Germany
    J Orthop Res 26:1440-8. 2008
  8. ncbi Osteoblast differentiation onto different biometals with an endoprosthetic surface topography in vitro
    M Jager
    Research Lab for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
    J Biomed Mater Res A 86:61-75. 2008
  9. pmc Rationale for prostaglandin I2 in bone marrow oedema--from theory to application
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    Arthritis Res Ther 10:R120. 2008
  10. ncbi Bone marrow concentrate: a novel strategy for bone defect treatment
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Duesseldorf, Moorenstrasse 5, Duesseldorf, Germany
    Curr Stem Cell Res Ther 4:34-43. 2009

Collaborators

Detail Information

Publications37

  1. pmc Cell therapy in bone healing disorders
    Marcus Jager
    Dept of Orthopaedics, University Hospital Dusseldorf, Heinrich Heine University Dusseldorf, Moorenstr Düsseldorf, Germany
    Orthop Rev (Pavia) 2:e20. 2010
    ..Autologous bone marrow cell therapy seems to be a promising treatment option which may reduce the amount of bone grafting in future...
  2. pmc Spinning around or stagnation - what do osteoblasts and chondroblasts really like?
    C Zilkens
    Department of Orthopaedics, Heinrich Heine University of Duesseldorf, 40225 Duesseldorf, Germany
    Eur J Med Res 15:35-43. 2010
    ..The influence of cytomechanical forces in cellular migration, proliferation and differentiation of mesenchymal stem cells (MSCs) is still poorly understood in detail...
  3. pmc Migration pattern of cementless press fit cups in the presence of stabilizing screws in total hip arthroplasty
    C Zilkens
    Deputy Chief, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, 40225 Duesseldorf, Germany
    Eur J Med Res 16:127-32. 2011
    ..Our findings suggest that the use of screw fixation for cementless porous-coated acetabular components for primary THA does not prevent cup migration...
  4. ncbi Primary total hip replacement in childhood, adolescence and young patients: quality and outcome of clinical studies
    M Jager
    Department of Orthopaedics, Heinrich Heine University Medical School, Dusseldorf, Germany
    Technol Health Care 16:195-214. 2008
    ..The present meta-analysis illustrates relevant information about hip replacement in young patients that has been published during the past 3 decades...
  5. ncbi Hyperthermia associated osteonecrosis in young patients with pelvic malignancies
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Duesseldorf, Moorenstr 5, D 40225 Duesseldorf, Germany
    Anticancer Agents Med Chem 8:571-5. 2008
    ..In this study, we present our data on AVN following RHT in children with intra-pelvic malignancies...
  6. doi [Indications and results of corrective pelvic osteotomies in developmental dysplasia of the hip]
    M Jager
    Klinik und Poliklinik für Orthopädie und Orthopädische Chirurgie, Universitatsklinikum, Heinrich Heine Universitat, Moorenstrasse 5, 40225, Dusseldorf, Germany
    Orthopade 37:556-70, 572-4, 576. 2008
    ..The aim of these procedures is to prevent early secondary osteoarthritis. For patients and families as well as for the orthopaedist, risk-benefit analysis is of major interest...
  7. doi Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro
    Marcus Jager
    Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Dusseldorf, Germany
    J Orthop Res 26:1440-8. 2008
    ..In conclusion, BMP-2 enhances DAG-induced osteogenic differentiation in mesenchymal bone marrow cells. Both agents interact in various ways and can modify osteoblastic bone formation...
  8. ncbi Osteoblast differentiation onto different biometals with an endoprosthetic surface topography in vitro
    M Jager
    Research Lab for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
    J Biomed Mater Res A 86:61-75. 2008
    ..Cells increased the implant roughness with the exception of sandblasted Ti6Al4V. Our data show that surface topography and physicochemical properties of biometals influence osteoblast differentiation in vitro...
  9. pmc Rationale for prostaglandin I2 in bone marrow oedema--from theory to application
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    Arthritis Res Ther 10:R120. 2008
    ..The purpose of this study was to assess the curative and symptomatic efficacy of the prostacyclin analogue iloprost in BME and AVN patients...
  10. ncbi Bone marrow concentrate: a novel strategy for bone defect treatment
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Duesseldorf, Moorenstrasse 5, Duesseldorf, Germany
    Curr Stem Cell Res Ther 4:34-43. 2009
    ..Although strong efforts have been made over the last decade to introduce stem cell and tissue engineering treatment strategies to the field of orthopaedics, only few clinical applications are currently available...
  11. doi Cord blood--an alternative source for bone regeneration
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstrasse 5, 40225, Dusseldorf, Germany
    Stem Cell Rev 5:266-77. 2009
    ..Within the umbilical cord different MSC types have been characterized which are potent to differentiate into osteoblasts. In contrast to a large number of in vitro investigations there are only few in vivo studies available so far...
  12. ncbi Efficiency of iloprost treatment for chemotherapy-associated osteonecrosis after childhood cancer
    Marcus Jager
    Department of Orthopedic Surgery, Heinrich Heine University Medical School, D 40225 Dusseldorf, Germany
    Anticancer Res 29:3433-40. 2009
    ..The risk of developing avascular osteonecrosis (AVN) after chemotherapy is age related and, at up to 17% of all treated patients, relatively high...
  13. doi Initial increased wear debris of XLPE-Al₂O₃ bearing in total hip arthroplasties
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, 40225, Duesseldorf, Germany
    Arch Orthop Trauma Surg 130:1481-6. 2010
    ..Aseptic implant loosening caused by wear debris is a common reason for early implant failure after total hip replacement (THR)...
  14. doi [Cell therapy in bone-healing disorders]
    M Jager
    Orthopadische Klinik, Universitatsklinikum, Heinrich Heine Universitat Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
    Orthopade 39:449-62; quiz 463. 2010
    ..Most clinical trials report successful bone regeneration after the application of mixed cell populations from bone marrow...
  15. doi [Regeneration of osteochondral defects in the knee]
    M Jager
    Klinik fur Orthopadie und Orthopadische Chirurgie, Heinrich Heine Universitat Dusseldorf
    Z Orthop Unfall 149:37-44. 2011
    ..This review summarises the basic cellular principles as well as clinical results of cell therapeutics for the regeneration of osteochondral defects in the knee...
  16. doi Bridging the gap: bone marrow aspiration concentrate reduces autologous bone grafting in osseous defects
    Marcus Jager
    Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
    J Orthop Res 29:173-80. 2011
    ..BMAC combined with HA can reduce the time needed for healing of bone defects when compared to BMAC in combination with collagen sponge...
  17. ncbi Clinical outcome and genotype in patients with hereditary multiple exostoses
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstr 5, D 40225 Duesseldorf, Germany
    J Orthop Res 25:1541-51. 2007
    ..c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1541-1551, 2007...
  18. ncbi Antigen expression of cord blood derived stem cells under osteogenic stimulation in vitro
    Marcus Jager
    Research Lab for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
    Cell Biol Int 31:950-7. 2007
    ..Future investigations should show the role of cytomechanical forces in the differentiation of cord blood derived progenitor cells and also if a cell-loaded collagen I/III scaffold is appropriate to stimulate bone regeneration in vivo...
  19. ncbi [Fracture analysis of a ceramic liner. Is in hip endoprosthesis replacement of ceramic on ceramic components with only one of the corresponding partners justified?]
    M Jager
    Orthopädische Universitätsklinik Düsseldorf, Moorenstrasse 5, D 40225 Dusseldorf
    Biomed Tech (Berl) 47:306-9. 2002
    ..We recommend careful inspection of ceramic-on-ceramic articulating components during total hip revision surgery and if there is any uncertainty, replacement of both so as to avoid premature failure...
  20. ncbi Influence of different culture solutions on osteoblastic differentiation in cord blood and bone marrow derived progenitor cells
    M Jager
    Department of Orthopedics, Heinrich Heine University Hospital Duesseldorf
    Biomed Tech (Berl) 48:241-4. 2003
    ....
  21. ncbi [Osteonecrosis and HELLP-Syndrome]
    M Jager
    Orthopadische Universitatsklinik, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Z Geburtshilfe Neonatol 207:213-9. 2003
    ..Because of anatomical and biomechanical reasons the highest incidence of pregnancy-associated osteonecrosis are the subchondral areas of the femoral epiphysial head...
  22. ncbi [Computer-assisted periacetabular triple osteotomy for treatment of dysplasia of the hip]
    M Jager
    Orthopadische Universitatsklinik, Heinrich Heine Universitat Dusseldorf
    Z Orthop Ihre Grenzgeb 142:51-9. 2004
    ..Therefore, intraoperative computer-assisted control of the pelvic fragment may allow for precise reorientation of the acetabulum in all planes...
  23. ncbi [Total hip replacement in childhood, adolescence and young patients: a review of the literature]
    M Jager
    Orthopadische Universitatsklinik, Heinrich Heine Universitat, Dusseldorf
    Z Orthop Ihre Grenzgeb 142:194-212. 2004
    ..Which implants and fixation techniques should be recommended in total hip replacements in children, adolescents and young adults?..
  24. ncbi [Variations of superficial nerves at the pelvis considering orthopaedic surgical approaches]
    M Jager
    Orthopadische Universitatsklinik, Heinrich Heine Universitat Dusseldorf
    Zentralbl Chir 129:408-12. 2004
    ..In this study we elucidated the variations of subcutaneous nerves by anatomic preparation exposure with regard to the anterior and posterior spines...
  25. ncbi [In vivo and in vitro bone regeneration from cord blood derived mesenchymal stem cells]
    M Jager
    Orthopadische Universitatsklinik, Heinrich Heine Universitat, Dusseldorf
    Orthopade 33:1361-72. 2004
    ..The following report describes the use of cord blood derived stem cells as an alternative to other stem cell populations for bone regenerating tissue engineering...
  26. ncbi Osteogenic progenitor cell potency after high-dose chemotherapy (COSS-96)
    M Jager
    Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, D 40225 Duesseldorf, Germany
    Anticancer Res 25:947-54. 2005
    ..The uniform treatment concept of a high-dose polychemotherapy pre- and postoperatively improved the survival rate of these patients significantly. One severe side-effect of COSS chemotherapy is multiple osteonecrosis...
  27. ncbi The critical size bony defect in a small animal for bone healing studies (I): Comparative anatomical study on rats' femur
    M Jager
    Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany, FRG
    Biomed Tech (Berl) 50:107-10. 2005
    ..Cortical thickness, bone marrow cavity diameter and femur length were higher in WR. Wistar rat's femur anatomy shows more similarities to human anatomy than Sprague Dawley rats...
  28. ncbi Bone healing and migration of cord blood-derived stem cells into a critical size femoral defect after xenotransplantation
    Marcus Jager
    Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Duesseldorf, Germany
    J Bone Miner Res 22:1224-33. 2007
    ..This study supports the application of cord blood stem cells for bone regeneration...
  29. ncbi Partial hemi-resurfacing of the hip joint--a new approach to treat local osteochondral defects?
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Hospital Dusseldorf, Dusseldorf, Germany
    Biomed Tech (Berl) 51:371-6. 2006
    ....
  30. ncbi Ovine cord blood accommodates multipotent mesenchymal progenitor cells
    Marcus Jager
    Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf D 40225 Duesseldorf Germany
    In Vivo 20:205-14. 2006
    ....
  31. ncbi Extensive H(+) release by bone substitutes affects biocompatibility in vitro testing
    M Jager
    Department of Orthopedics, Heinrich Heine University Hospital Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    J Biomed Mater Res A 76:310-22. 2006
    ..DMEM culture solution supports cell survival for those bone substitutes that induce an alkaline reaction, whereas MesenCult media promotes cell vitality in biomaterials, which leads to an acidification of culture solution...
  32. ncbi Proliferation and osteogenic differentiation of mesenchymal stem cells cultured onto three different polymers in vitro
    M Jager
    Orthopaedic Research Lab, Department of Orthopaedics, Heinrich Heine University Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany FRG
    Ann Biomed Eng 33:1319-32. 2005
    ..The results indicate significant differences for the proliferation, differentiation, adherence, and Ca(2+) accumulation between the tested polymers in a MSC culture...
  33. ncbi In vitro osteogenic differentiation is affected in Wiedemann-Rautenstrauch-Syndrome (WRS)
    Marcus Jager
    Orthopaedic Research Laboratory, Department of Orthopaedics, Heinrich Heine University Duesseldorf Moorenstr 5, D 40225 Duesseldorf, Germany
    In Vivo 19:831-6. 2005
    ..To date, there are no data about the differentiation capacity of WRS progenitor cells available in the literature...
  34. ncbi The critical size bony defect in a small animal for bone healing studies (II): implant evolution and surgical technique on a rat's femur
    M Jager
    Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstr 5, D 40225 Duesseldorf, Germany
    Biomed Tech (Berl) 50:137-42. 2005
    ..0 mm CSD were investigated clinically and roentgenologically over 10 weeks. The external fixator showed only a small implant failure rate. A solid fusion of the bone fragments was not observed within the 10 weeks follow-up period...
  35. ncbi [Medical-legal aspects in fractured ceramic liners after implantation of a hip endoprosthesis]
    M Jager
    Orthopädische Universitätsklinik Düsseldorf, Dusseldorf, Germany
    Z Orthop Ihre Grenzgeb 140:533-7. 2002
    ..A detailed preoperative consent of the patient combined with an exact documentation is necessary to prevent potential medical claims by the patient, and also increases the compliance and reduces the costs for the health system...
  36. doi [Cement distribution in vertebroplasty pedicle screws with different designs]
    K Kafchitsas
    Klinik fur Orthopadie und Orthopadische Chirurgie, Universitätsmedizin Mainz, Langenbeckstrasse 1, 55129, Mainz, Deutschland
    Orthopade 39:679-86. 2010
    ..Accordingly cement distribution can be affected by the selection of the side openings (size and position). Screws with conical core and distally situated side openings facilitate the development of uniform cement dough...