Research Topics
Species | S SchmidtSummaryAffiliation: Heinrich Heine University Country: Germany Publications
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Publications
Spinning around or stagnation - what do osteoblasts and chondroblasts really like?C Zilkens
Department of Orthopaedics, Heinrich Heine University of Duesseldorf, 40225 Duesseldorf, Germany
Eur J Med Res 15:35-43. 2010..The influence of cytomechanical forces in cellular migration, proliferation and differentiation of mesenchymal stem cells (MSCs) is still poorly understood in detail...- Migration pattern of cementless press fit cups in the presence of stabilizing screws in total hip arthroplastyC Zilkens
Deputy Chief, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, 40225 Duesseldorf, Germany
Eur J Med Res 16:127-32. 2011..Our findings suggest that the use of screw fixation for cementless porous-coated acetabular components for primary THA does not prevent cup migration... 
Clinical outcome and genotype in patients with hereditary multiple exostosesMarcus Jager
Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstr 5, D 40225 Duesseldorf, Germany
J Orthop Res 25:1541-51. 2007..c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1541-1551, 2007...- Osteoblast differentiation onto different biometals with an endoprosthetic surface topography in vitroM Jager
Research Lab for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
J Biomed Mater Res A 86:61-75. 2008..Cells increased the implant roughness with the exception of sandblasted Ti6Al4V. Our data show that surface topography and physicochemical properties of biometals influence osteoblast differentiation in vitro... 
Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitroMarcus Jager
Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Dusseldorf, Germany
J Orthop Res 26:1440-8. 2008..In conclusion, BMP-2 enhances DAG-induced osteogenic differentiation in mesenchymal bone marrow cells. Both agents interact in various ways and can modify osteoblastic bone formation...- [Indications and results of corrective pelvic osteotomies in developmental dysplasia of the hip]M Jager
Klinik und Poliklinik für Orthopädie und Orthopädische Chirurgie, Universitatsklinikum, Heinrich Heine Universitat, Moorenstrasse 5, 40225, Dusseldorf, Germany
Orthopade 37:556-70, 572-4, 576. 2008..The aim of these procedures is to prevent early secondary osteoarthritis. For patients and families as well as for the orthopaedist, risk-benefit analysis is of major interest... - Hyperthermia associated osteonecrosis in young patients with pelvic malignanciesMarcus Jager
Department of Orthopaedics, Heinrich Heine University Duesseldorf, Moorenstr 5, D 40225 Duesseldorf, Germany
Anticancer Agents Med Chem 8:571-5. 2008..In this study, we present our data on AVN following RHT in children with intra-pelvic malignancies... - Primary total hip replacement in childhood, adolescence and young patients: quality and outcome of clinical studiesM Jager
Department of Orthopaedics, Heinrich Heine University Medical School, Dusseldorf, Germany
Technol Health Care 16:195-214. 2008..The present meta-analysis illustrates relevant information about hip replacement in young patients that has been published during the past 3 decades... - Rationale for prostaglandin I2 in bone marrow oedema--from theory to applicationMarcus Jager
Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany
Arthritis Res Ther 10:R120. 2008..The purpose of this study was to assess the curative and symptomatic efficacy of the prostacyclin analogue iloprost in BME and AVN patients... - Bone marrow concentrate: a novel strategy for bone defect treatmentMarcus Jager
Department of Orthopaedics, Heinrich Heine University Duesseldorf, Moorenstrasse 5, Duesseldorf, Germany
Curr Stem Cell Res Ther 4:34-43. 2009..Although strong efforts have been made over the last decade to introduce stem cell and tissue engineering treatment strategies to the field of orthopaedics, only few clinical applications are currently available... - Cord blood--an alternative source for bone regenerationMarcus Jager
Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstrasse 5, 40225, Dusseldorf, Germany
Stem Cell Rev 5:266-77. 2009..Within the umbilical cord different MSC types have been characterized which are potent to differentiate into osteoblasts. In contrast to a large number of in vitro investigations there are only few in vivo studies available so far... - Efficiency of iloprost treatment for chemotherapy-associated osteonecrosis after childhood cancerMarcus Jager
Department of Orthopedic Surgery, Heinrich Heine University Medical School, D 40225 Dusseldorf, Germany
Anticancer Res 29:3433-40. 2009..The risk of developing avascular osteonecrosis (AVN) after chemotherapy is age related and, at up to 17% of all treated patients, relatively high... - Initial increased wear debris of XLPE-Al₂O₃ bearing in total hip arthroplastiesMarcus Jager
Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, 40225, Duesseldorf, Germany
Arch Orthop Trauma Surg 130:1481-6. 2010..Aseptic implant loosening caused by wear debris is a common reason for early implant failure after total hip replacement (THR)... - [Cell therapy in bone-healing disorders]M Jager
Orthopadische Klinik, Universitatsklinikum, Heinrich Heine Universitat Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
Orthopade 39:449-62; quiz 463. 2010..Most clinical trials report successful bone regeneration after the application of mixed cell populations from bone marrow... - [Regeneration of osteochondral defects in the knee]M Jager
Klinik fur Orthopadie und Orthopadische Chirurgie, Heinrich Heine Universitat Dusseldorf
Z Orthop Unfall 149:37-44. 2011..This review summarises the basic cellular principles as well as clinical results of cell therapeutics for the regeneration of osteochondral defects in the knee... - Bridging the gap: bone marrow aspiration concentrate reduces autologous bone grafting in osseous defectsMarcus Jager
Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
J Orthop Res 29:173-80. 2011..BMAC combined with HA can reduce the time needed for healing of bone defects when compared to BMAC in combination with collagen sponge... - Antigen expression of cord blood derived stem cells under osteogenic stimulation in vitroMarcus Jager
Research Lab for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Moorenstr 5, D 40225 Duesseldorf, Germany
Cell Biol Int 31:950-7. 2007..Future investigations should show the role of cytomechanical forces in the differentiation of cord blood derived progenitor cells and also if a cell-loaded collagen I/III scaffold is appropriate to stimulate bone regeneration in vivo... - Bone healing and migration of cord blood-derived stem cells into a critical size femoral defect after xenotransplantationMarcus Jager
Research Laboratory for Regenerative Medicine and Biomaterials, Department of Orthopaedics, Heinrich Heine University Medical School, Duesseldorf, Germany
J Bone Miner Res 22:1224-33. 2007..This study supports the application of cord blood stem cells for bone regeneration... - [Fracture analysis of a ceramic liner. Is in hip endoprosthesis replacement of ceramic on ceramic components with only one of the corresponding partners justified?]M Jager
Orthopädische Universitätsklinik Düsseldorf, Moorenstrasse 5, D 40225 Dusseldorf
Biomed Tech (Berl) 47:306-9. 2002..We recommend careful inspection of ceramic-on-ceramic articulating components during total hip revision surgery and if there is any uncertainty, replacement of both so as to avoid premature failure... - Influence of different culture solutions on osteoblastic differentiation in cord blood and bone marrow derived progenitor cellsM Jager
Department of Orthopedics, Heinrich Heine University Hospital Duesseldorf
Biomed Tech (Berl) 48:241-4. 2003.... - [Osteonecrosis and HELLP-Syndrome]M Jager
Orthopadische Universitatsklinik, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
Z Geburtshilfe Neonatol 207:213-9. 2003..Because of anatomical and biomechanical reasons the highest incidence of pregnancy-associated osteonecrosis are the subchondral areas of the femoral epiphysial head... - [Computer-assisted periacetabular triple osteotomy for treatment of dysplasia of the hip]M Jager
Orthopadische Universitatsklinik, Heinrich Heine Universitat Dusseldorf
Z Orthop Ihre Grenzgeb 142:51-9. 2004..Therefore, intraoperative computer-assisted control of the pelvic fragment may allow for precise reorientation of the acetabulum in all planes... - [Total hip replacement in childhood, adolescence and young patients: a review of the literature]M Jager
Orthopadische Universitatsklinik, Heinrich Heine Universitat, Dusseldorf
Z Orthop Ihre Grenzgeb 142:194-212. 2004..Which implants and fixation techniques should be recommended in total hip replacements in children, adolescents and young adults?.. - [Variations of superficial nerves at the pelvis considering orthopaedic surgical approaches]M Jager
Orthopadische Universitatsklinik, Heinrich Heine Universitat Dusseldorf
Zentralbl Chir 129:408-12. 2004..In this study we elucidated the variations of subcutaneous nerves by anatomic preparation exposure with regard to the anterior and posterior spines... - [In vivo and in vitro bone regeneration from cord blood derived mesenchymal stem cells]M Jager
Orthopadische Universitatsklinik, Heinrich Heine Universitat, Dusseldorf
Orthopade 33:1361-72. 2004..The following report describes the use of cord blood derived stem cells as an alternative to other stem cell populations for bone regenerating tissue engineering... - Osteogenic progenitor cell potency after high-dose chemotherapy (COSS-96)M Jager
Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, D 40225 Duesseldorf, Germany
Anticancer Res 25:947-54. 2005..The uniform treatment concept of a high-dose polychemotherapy pre- and postoperatively improved the survival rate of these patients significantly. One severe side-effect of COSS chemotherapy is multiple osteonecrosis... - The critical size bony defect in a small animal for bone healing studies (I): Comparative anatomical study on rats' femurM Jager
Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany, FRG
Biomed Tech (Berl) 50:107-10. 2005..Cortical thickness, bone marrow cavity diameter and femur length were higher in WR. Wistar rat's femur anatomy shows more similarities to human anatomy than Sprague Dawley rats... - The critical size bony defect in a small animal for bone healing studies (II): implant evolution and surgical technique on a rat's femurM Jager
Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf, Moorenstr 5, D 40225 Duesseldorf, Germany
Biomed Tech (Berl) 50:137-42. 2005..0 mm CSD were investigated clinically and roentgenologically over 10 weeks. The external fixator showed only a small implant failure rate. A solid fusion of the bone fragments was not observed within the 10 weeks follow-up period... - In vitro osteogenic differentiation is affected in Wiedemann-Rautenstrauch-Syndrome (WRS)Marcus Jager
Orthopaedic Research Laboratory, Department of Orthopaedics, Heinrich Heine University Duesseldorf Moorenstr 5, D 40225 Duesseldorf, Germany
In Vivo 19:831-6. 2005..To date, there are no data about the differentiation capacity of WRS progenitor cells available in the literature... - Proliferation and osteogenic differentiation of mesenchymal stem cells cultured onto three different polymers in vitroM Jager
Orthopaedic Research Lab, Department of Orthopaedics, Heinrich Heine University Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany FRG
Ann Biomed Eng 33:1319-32. 2005..The results indicate significant differences for the proliferation, differentiation, adherence, and Ca(2+) accumulation between the tested polymers in a MSC culture... - Extensive H(+) release by bone substitutes affects biocompatibility in vitro testingM Jager
Department of Orthopedics, Heinrich Heine University Hospital Duesseldorf, Moorenstrasse 5, D 40225 Duesseldorf, Germany
J Biomed Mater Res A 76:310-22. 2006..DMEM culture solution supports cell survival for those bone substitutes that induce an alkaline reaction, whereas MesenCult media promotes cell vitality in biomaterials, which leads to an acidification of culture solution... - Ovine cord blood accommodates multipotent mesenchymal progenitor cellsMarcus Jager
Department of Orthopaedics, Heinrich Heine University Hospital Duesseldorf D 40225 Duesseldorf Germany
In Vivo 20:205-14. 2006.... - Partial hemi-resurfacing of the hip joint--a new approach to treat local osteochondral defects?Marcus Jager
Department of Orthopaedics, Heinrich Heine University Hospital Dusseldorf, Dusseldorf, Germany
Biomed Tech (Berl) 51:371-6. 2006.... - [Medical-legal aspects in fractured ceramic liners after implantation of a hip endoprosthesis]M Jager
Orthopädische Universitätsklinik Düsseldorf, Dusseldorf, Germany
Z Orthop Ihre Grenzgeb 140:533-7. 2002..A detailed preoperative consent of the patient combined with an exact documentation is necessary to prevent potential medical claims by the patient, and also increases the compliance and reduces the costs for the health system... - [Cement distribution in vertebroplasty pedicle screws with different designs]K Kafchitsas
Klinik fur Orthopadie und Orthopadische Chirurgie, Universitätsmedizin Mainz, Langenbeckstrasse 1, 55129, Mainz, Deutschland
Orthopade 39:679-86. 2010..Accordingly cement distribution can be affected by the selection of the side openings (size and position). Screws with conical core and distally situated side openings facilitate the development of uniform cement dough...