S Schinner

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc A progressive increase in cardiovascular risk assessed by coronary angiography in non-diabetic patients at sub-diabetic glucose levels
    Sven Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Germany
    Cardiovasc Diabetol 10:56. 2011
  2. doi request reprint Pathophysiological aspects of Wnt-signaling in endocrine disease
    Sven Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Eur J Endocrinol 160:731-7. 2009
  3. ncbi request reprint Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt-signaling pathway
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Int J Obes (Lond) 31:864-70. 2007
  4. ncbi request reprint Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Diabetologia 51:147-54. 2008
  5. doi request reprint Wnt-signalling and the metabolic syndrome
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 41:159-63. 2009
  6. doi request reprint Association of impaired glucose metabolism in morbid obesity with hypoadiponectinaemia
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:S64-9. 2008
  7. doi request reprint The effects of the endothelium on adrenal steroidogenesis and growth are mainly mediated by proteins other than endothelin-1
    I Paramonova
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 42:840-5. 2010
  8. doi request reprint The endothelium secretes interleukin-6 (IL-6) and induces IL-6 and aldosterone generation by adrenocortical cells
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:S70-4. 2008
  9. doi request reprint The CB-1 receptor antagonist rimonabant modulates the interaction between adipocytes and pancreatic beta-cells in vitro
    F Ulgen
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 119:41-6. 2011
  10. doi request reprint Role of the novel mTOR inhibitor RAD001 (everolimus) in anaplastic thyroid cancer
    C Papewalis
    Endocrine Cancer Center, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 41:752-6. 2009

Collaborators

Detail Information

Publications22

  1. pmc A progressive increase in cardiovascular risk assessed by coronary angiography in non-diabetic patients at sub-diabetic glucose levels
    Sven Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Germany
    Cardiovasc Diabetol 10:56. 2011
    ..Therefore, we investigated associations of FBG and 2h-BG values with the prevalence of CHD assessed by coronary angiography as the most sensitive diagnostic tool...
  2. doi request reprint Pathophysiological aspects of Wnt-signaling in endocrine disease
    Sven Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Eur J Endocrinol 160:731-7. 2009
    ....
  3. ncbi request reprint Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt-signaling pathway
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Int J Obes (Lond) 31:864-70. 2007
    ..However, the molecular mechanisms mediating this effect are not known...
  4. ncbi request reprint Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Diabetologia 51:147-54. 2008
    ..They also regulate insulin secretion in pancreatic beta cells and the cell cycle. The aim of this study was to investigate the effect of adipocyte-derived Wnt signalling molecules on insulin secretion and beta cell proliferation...
  5. doi request reprint Wnt-signalling and the metabolic syndrome
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 41:159-63. 2009
    ..This review will summarise recent aspects of Wnt-signalling in these pathophysiologic events and discuss the contributions of dysregulation in Wnt-signalling to features of the metabolic syndrome...
  6. doi request reprint Association of impaired glucose metabolism in morbid obesity with hypoadiponectinaemia
    S Schinner
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:S64-9. 2008
    ..As obesity is the major risk factor for T2DM it is not clear why many patients with morbid obesity remain normoglycaemic and if this protection can be attributed to a lower grade of inflammation or higher adiponectin levels...
  7. doi request reprint The effects of the endothelium on adrenal steroidogenesis and growth are mainly mediated by proteins other than endothelin-1
    I Paramonova
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 42:840-5. 2010
    ..In conclusion, the cultured endothelial cells secrete a protein that stimulates steroidogenesis in adrenal cells and their growth. It was also shown that the ET-1 does not mediate the effect of ECCM on the NCI-H295R cell line...
  8. doi request reprint The endothelium secretes interleukin-6 (IL-6) and induces IL-6 and aldosterone generation by adrenocortical cells
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Germany
    Exp Clin Endocrinol Diabetes 116:S70-4. 2008
    ..Our findings support the hypothesis that the endothelium and the adrenal gland may play a role in the development of some forms of hypertension and - more speculative - inflammation...
  9. doi request reprint The CB-1 receptor antagonist rimonabant modulates the interaction between adipocytes and pancreatic beta-cells in vitro
    F Ulgen
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Exp Clin Endocrinol Diabetes 119:41-6. 2011
    ..Rimonabant decreases insulin levels in vivo. This effect can either be explained by improving insulin sensitivity or by effects on beta-cells including the modulation of adipocyte - beta-cell interactions...
  10. doi request reprint Role of the novel mTOR inhibitor RAD001 (everolimus) in anaplastic thyroid cancer
    C Papewalis
    Endocrine Cancer Center, Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 41:752-6. 2009
    ..In parallel, quantitative PCR of PCNA displayed a reduced expression of PCNA within the responding cell lines, respectively. In summary, we found a good responding effect in a part of ATC cell lines, which may have a clinical impact...
  11. doi request reprint Intrapancreatic adipocyte deposition in a mouse model of the metabolic syndrome
    F Ulgen
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Germany
    Horm Metab Res 40:507-9. 2008
  12. ncbi request reprint Molecular mechanisms of insulin resistance
    S Schinner
    Klinik fur Endokrinologie, Diabetologie und Rheumatologie, Universitäts klinikum Düsseldorf, Dusseldorf, Germany
    Diabet Med 22:674-82. 2005
    ....
  13. doi request reprint A new mutation in the menin gene causes the multiple endocrine neoplasia type 1 syndrome with adrenocortical carcinoma
    M Haase
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Moorenstrasse 5, Germany
    Endocrine 39:153-9. 2011
    ..Ser443Tyr; c.1328C > A). [corrected] Also, we provide clinical data that may add to the genotype-phenotype discussion. We conclude that the novel mutation in the MEN1 gene described herein was clinically relevant...
  14. doi request reprint [Therapy of dyslipidemia in rheumatic diseases]
    S Vordenbäumen
    Klinik fur Endokrinologie, Diabetologie und Rheumatologie, Heinrich Heine Universitat Dusseldorf, Deutschland
    Z Rheumatol 69:689-92, 694-5. 2010
    ..The EULAR recently released recommendations for cardiovascular risk management in patients with inflammatory arthritis...
  15. doi request reprint HLA-A2 phenotype may be protective against Graves' disease but not against Hashimoto's thyroiditis in Caucasians
    C Bernecker
    Division for Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Horm Metab Res 45:74-7. 2013
    ..In contrast the nonsignificant results for HT indicate that this association may not apply to AITDs in general...
  16. doi request reprint Reproducibility of Elecsys anti-TSHR test results in a lot-to-lot comparison
    D Hermsen
    Institute for Clinical Chemistry and Laboratory Diagnostics, University Hospital Dusseldorf, Germany
    Horm Metab Res 42:295-7. 2010
    ..The overall mean of differences was -0.8+/-14%. The data clearly demonstrate that the automated TRAb assay has a high stability in regard to TSH receptor preparations...
  17. doi request reprint New mechanisms to control aldosterone synthesis
    H S Willenberg
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Horm Metab Res 40:435-41. 2008
    ..Further identification and characterization of these factors may help in the development of novel therapies for the treatment of arterial hypertension, various metabolic diseases, and other disorders...
  18. doi request reprint Characterization of monocyte-derived IFNalpha-generated dendritic cells
    B Jacobs
    Department of Endocrinology, Diabetes, and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Horm Metab Res 40:117-21. 2008
    ..Because of their high stimulating capacity and their direct cytolytic effects these cells represent a new promising tool for cellular anticancer therapy...
  19. doi request reprint Evidence for an exercise induced increase of TNF-α and IL-6 in marathon runners
    C Bernecker
    Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
    Scand J Med Sci Sports 23:207-14. 2013
    ..We found an up-regulation of TNF-α and IL-6 in the plasma during vigorous exercise. This increase is not attributable to BMNC. We assume a local production in, or release from, exercised tissues...
  20. doi request reprint In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469
    C Urban
    Pharmaceutical and Medicinal Chemistry, Heinrich Heine University, Universitatsstr 1, 40225, Dusseldorf, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:1021-30. 2013
    ..TUG-469 turned out as a promising candidate for further drug development of FFA1 agonists for treatment of type 2 diabetes mellitus...
  21. doi request reprint Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation
    Charlotte Heller
    Department of Endocrinology, Diabetes, and Rheumatology, University Hospital Dusseldorf, Dusseldorf, Germany
    Am J Physiol Endocrinol Metab 301:E864-72. 2011
    ..Wnt-4 modulates canonical Wnt signaling and acts as regulator of β-cell proliferation and inflammatory cytokine release. This suggests a novel mechanism through which GLP-1 can regulate β-cell proliferation...
  22. ncbi request reprint Human adipocytes induce an ERK1/2 MAP kinases-mediated upregulation of steroidogenic acute regulatory protein (StAR) and an angiotensin II-sensitization in human adrenocortical cells
    A W Krug
    Medical Clinic III, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, D 01309 Dresden, Germany
    Int J Obes (Lond) 31:1605-16. 2007
    ..In addition to a direct stimulation, a sensitization toward angiotensin II (AngII) might be involved. The second objective was to determine a possible adipokines-induced sensitization of human adrenocortical cells to AngII...