Tankred Schewe

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Myeloperoxidase-induced lipid peroxidation of LDL in the presence of nitrite. Protection by cocoa flavanols
    Tankred Schewe
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Biofactors 24:49-58. 2005
  2. ncbi request reprint (-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, D 40001 Dusseldorf, Germany
    Biochem Biophys Res Commun 359:828-33. 2007
  3. ncbi request reprint Cocoa polyphenols and inflammatory mediators
    Helmut Sies
    Institute for Biochemistry and Molecular Biology I and the Department of Medicine, Division of Cardiology, Pulmonary Diseases, and Angiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Am J Clin Nutr 81:304S-312S. 2005
  4. ncbi request reprint Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: protection by (-)-epicatechin
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Free Radic Biol Med 42:955-70. 2007
  5. ncbi request reprint Myeloperoxidase-mediated LDL oxidation and endothelial cell toxicity of oxidized LDL: attenuation by (-)-epicatechin
    Yvonne Steffen
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University Duesseldorf, PO Box 101007, D 40001 Duesseldorf, Germany
    Free Radic Res 40:1076-85. 2006
  6. ncbi request reprint Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat, Postfach 101007, D 40001 Dusseldorf, Germany
    Free Radic Biol Med 41:1139-50. 2006
  7. ncbi request reprint Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase
    Tankred Schewe
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Germany
    J Nutr 132:1825-9. 2002
  8. ncbi request reprint Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase
    Yvonne Steffen
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University Duesseldorf, D 4000 Duesseldorf, Germany
    Arch Biochem Biophys 469:209-19. 2008
  9. ncbi request reprint Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat, Dusseldorf, Germany
    Biochem Biophys Res Commun 331:1277-83. 2005
  10. ncbi request reprint Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids
    Vladimir A Kostyuk
    Institut fur Physiologische Chemie I, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat, P O Box 10 10 07, Germany
    FEBS Lett 537:146-50. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Myeloperoxidase-induced lipid peroxidation of LDL in the presence of nitrite. Protection by cocoa flavanols
    Tankred Schewe
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Biofactors 24:49-58. 2005
    ..This article gives a survey on recent progress in this field with special reference to own recently published work...
  2. ncbi request reprint (-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, D 40001 Dusseldorf, Germany
    Biochem Biophys Res Commun 359:828-33. 2007
    ..These data indicate an (*)NO-preserving effect of (-)-epicatechin via suppression of O2(*-)-mediated loss of (*)NO...
  3. ncbi request reprint Cocoa polyphenols and inflammatory mediators
    Helmut Sies
    Institute for Biochemistry and Molecular Biology I and the Department of Medicine, Division of Cardiology, Pulmonary Diseases, and Angiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Am J Clin Nutr 81:304S-312S. 2005
    ..Adverse effects of NO metabolites, such as nitrite and peroxynitrite, were thus attenuated...
  4. ncbi request reprint Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: protection by (-)-epicatechin
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Free Radic Biol Med 42:955-70. 2007
    ..These oxLDL-elicited changes in vascular endothelial cells described were suppressed by (-)-epicatechin, a dietary polyphenol, which inhibited NADPH oxidase activity in these cells...
  5. ncbi request reprint Myeloperoxidase-mediated LDL oxidation and endothelial cell toxicity of oxidized LDL: attenuation by (-)-epicatechin
    Yvonne Steffen
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University Duesseldorf, PO Box 101007, D 40001 Duesseldorf, Germany
    Free Radic Res 40:1076-85. 2006
    ..These protective actions are only partially shared by other vasoprotective agents such as vitamins C and E or aspirin. Thus, ( - )-epicatechin appears to be a pleiotropic protectant for both LDL and endothelial cells...
  6. ncbi request reprint Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat, Postfach 101007, D 40001 Dusseldorf, Germany
    Free Radic Biol Med 41:1139-50. 2006
    ..The dietary polyphenol (-)-epicatechin inhibited not only formation but also cytotoxic actions of both oxLDL and oxysterols...
  7. ncbi request reprint Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase
    Tankred Schewe
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Germany
    J Nutr 132:1825-9. 2002
    ....
  8. ncbi request reprint Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase
    Yvonne Steffen
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University Duesseldorf, D 4000 Duesseldorf, Germany
    Arch Biochem Biophys 469:209-19. 2008
    ..Notably, HUVEC converted (-)-epicatechin to NADPH oxidase-inhibitory methyl ethers. These data identify endothelial NADPH oxidase as candidate target of dietary flavonoids and particularly of their metabolites...
  9. ncbi request reprint Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat, Dusseldorf, Germany
    Biochem Biophys Res Commun 331:1277-83. 2005
    ..We conclude that dietary flavanols contribute to protection of the integrity of endothelial cells not only by scavenging free radicals but also by maintaining endothelial NO synthase...
  10. ncbi request reprint Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids
    Vladimir A Kostyuk
    Institut fur Physiologische Chemie I, Universitatsklinikum Dusseldorf, Heinrich Heine Universitat, P O Box 10 10 07, Germany
    FEBS Lett 537:146-50. 2003
    ..The flavonoids served as substrates of MPO leading to products with distinct absorbance spectra. The MPO-catalyzed oxidation of flavonoids was accelerated in the presence of nitrite...
  11. ncbi request reprint Oxidative modification of low-density lipoprotein: lipid peroxidation by myeloperoxidase in the presence of nitrite
    Tilo Kraemer
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, P O Box 10 10 07, D 40001 Dusseldorf, Germany
    Biol Chem 385:809-18. 2004
    ..This multi-site protection by (-)-epicatechin or other flavan-3-ols against proatherogenic modification of LDL may contribute to the purported beneficial effects of dietary flavan-3-ols for the cardiovascular system...
  12. ncbi request reprint Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in humans
    Ingrid Wiswedel
    Institut fur Klinische Chemie und Pathobiochemie, Otto von Guericke Universitat Magdeburg, Germany
    Free Radic Biol Med 37:411-21. 2004
    ..01, ANOVA). We conclude that dietary flavanols, using cocoa drink as example, can lower the plasma level of F(2)-isoprostanes, indicators of in vivo lipid peroxidation...
  13. ncbi request reprint Vascular effects of cocoa rich in flavan-3-ols
    Christian Heiss
    JAMA 290:1030-1. 2003
  14. doi request reprint How do dietary flavanols improve vascular function? A position paper
    Tankred Schewe
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University Duesseldorf, D 40001 Duesseldorf, Germany
    Arch Biochem Biophys 476:102-6. 2008
    ..Implications for the interpretation of the role of dietary polyphenols for cardiovascular health are discussed...
  15. ncbi request reprint Nitrite, a naturally occurring precursor of nitric oxide that acts like a 'prodrug'
    Christoph V Suschek
    Institute of Biochemistry and Molecular Biology II, Heinrich Heine University Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
    Biol Chem 387:499-506. 2006
    ..In the skin, nitrite-derived NO* may contribute to skin tanning, as well as to protection against UV-induced cell damage. Current knowledge on nitrite acting like an NO* 'prodrug' is presented, emphasizing the role of nitrite in skin...
  16. ncbi request reprint 15-lipoxygenase-1: a prooxidant enzyme
    Tankred Schewe
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, Germany
    Biol Chem 383:365-74. 2002
    ..Reaction of reticulocyte-type lipoxygenases with low-density lipoprotein renders the latter atherogenic and appears to be involved in the formation of atherosclerotic lesions...
  17. ncbi request reprint Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action
    Christian David Sadik
    Institut fur Physiologische Chemie I, Heinrich Heine Universitat Dusseldorf, P O Box 101007, Germany
    Biochem Pharmacol 65:773-81. 2003
    ..The flavone luteolin turned out to be the most potent inhibitor of the mammalian enzyme with an IC(50) of 0.6 microM followed by baicalein (1 microM) and fisetin (1.5 microM)...
  18. doi request reprint Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase
    Holger Spalteholz
    Institute for Medical Physics and Biophysics, Medical Faculty, University of Leipzig, D 04107 Leipzig, Germany
    Biochem Biophys Res Commun 371:810-3. 2008
    ..9 x 10(7) and 4.5 x 10(6) M(-1)s(-1), respectively (pH 7, 25 degrees C). The data indicate that (-)-epicatechin is capable of undergoing fast MPO-mediated one-electron oxidation...