Affiliation: Heinrich Heine University
- Weber K, Simon M, Strassburger K, Markgraf D, Buyken A, Szendroedi J, et al. Habitual Fructose Intake Relates to Insulin Sensitivity and Fatty Liver Index in Recent-Onset Type 2 Diabetes Patients and Individuals without Diabetes. Nutrients. 2018;10: pubmed publisher..033) among T2D. Moderate SSB-derived fructose intake may detrimentally affect peripheral insulin sensitivity, whereas fruit-derived fructose intake appeared beneficial for liver fat content. ..
- Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, et al. Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab. 2015;21:739-46 pubmed publisher..These data suggest adaptation of the liver ("hepatic mitochondrial flexibility") at early stages of obesity-related insulin resistance, which is subsequently lost in NASH. ..
- Roden M, Mariz S, Brazzale A, Pacini G. Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes. J Intern Med. 2009;265:476-87 pubmed publisher..05), but decreased for gliclazide + metformin (P<0.05). Long-term improvements in adipose tissue insulin sensitivity and reduction in fasting FFAs with pioglitazone may help to reduce lipotoxicity in Type 2 diabetes. ..
- Weber K, Nowotny B, Strassburger K, Pacini G, MÃ¼ssig K, Szendroedi J, et al. The Role of Markers of Low-Grade Inflammation for the Early Time Course of Glycemic Control, Glucose Disappearance Rate, and Î²-Cell Function in Recently Diagnosed Type 1 and Type 2 Diabetes. Diabetes Care. 2015;38:1758-67 pubmed publisher..05). These data indicate that with the clinical onset of diabetes, low-grade inflammation relates to worsening of glycemia and that endothelial activation may contribute to decreasing Î²-cell function. ..
- Roden M. Future of muscle research in diabetes: a look into the crystal ball. Diabetologia. 2015;58:1693-8 pubmed publisher..This is one of a series of commentaries under the banner '50 years forward', giving personal opinions on future perspectives in diabetes, to celebrate the 50th anniversary of Diabetologia (1965-2015). ..
- Apostolopoulou M, Menart Houtermans B, Ruetter R, Nowotny B, Gehrmann U, Markgraf D, et al. Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years after diabetes diagnosis. Acta Diabetol. 2018;55:723-731 pubmed publisher..CD8+ T-cells associate with worse glycemia, lipidemia and inflammation after 5 years of type 1 diabetes, whereas CD4+ T-cells associate with increased inflammation after 5 years upon onset of type 2 diabetes. ..
- Homuth G, Wahl S, MÃ¼ller C, Schurmann C, MÃ¤der U, Blankenberg S, et al. Extensive alterations of the whole-blood transcriptome are associated with body mass index: results of an mRNA profiling study involving two large population-based cohorts. BMC Med Genomics. 2015;8:65 pubmed publisher..BMI-associated negative transcriptional regulation of insulin signaling and oxidative stress management provide new insights into the pathogenesis of metabolic syndrome and T2D. ..
- Herder C, Fürstos J, Nowotny B, Begun A, Strassburger K, Müssig K, et al. Associations between inflammation-related biomarkers and depressive symptoms in individuals with recently diagnosed type 1 and type 2 diabetes. Brain Behav Immun. 2017;61:137-145 pubmed publisher..It also provides suggestive evidence that further biomarkers of subclinical inflammation and endothelial activation may be associated with depressive symptoms in individuals with recently diagnosed T1D and T2D. ..
- Roden M, Merker L, Christiansen A, Roux F, Salsali A, Kim G, et al. Safety, tolerability and effects on cardiometabolic risk factors of empagliflozin monotherapy in drug-naÃ¯ve patients with type 2 diabetes: a double-blind extension of a Phase III randomized controlled trial. Cardiovasc Diabetol. 2015;14:154 pubmed publisher..9 %) per treatment group. Empagliflozin monotherapy for â‰¥76 weeks was well tolerated and led to sustained reductions in HbA1c and weight compared with placebo. clinicaltrials.gov NCT01289990. ..
- Szendroedi J, Saxena A, Weber K, Strassburger K, Herder C, Burkart V, et al. Cohort profile: the German Diabetes Study (GDS). Cardiovasc Diabetol. 2016;15:59 pubmed publisher..This study will recruit 3000 patients and a group of humans without familiy history of diabetes. 237 type 1 and 456 type 2 diabetes patients have been already included. ..
- Roden M. [Diabetes mellitus: definition, classification and diagnosis]. Wien Klin Wochenschr. 2016;128 Suppl 2:S37-40 pubmed publisher..These data form the basis of the recommendations of the Austrian Diabetes Association for the clinical praxis of diabetes treatment. ..
- Apostolopoulou M, Strassburger K, Herder C, Knebel B, Kotzka J, Szendroedi J, et al. Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes. Diabetologia. 2016;59:2203-7 pubmed publisher..Oxidative capacity and metabolic flexibility are independent determinants of insulin sensitivity but are influenced by circulating NEFA in recent-onset type 2 diabetes. ClinicalTrial.gov registration no: NCT01055093. ..
- Nowotny B, Kahl S, Klüppelholz B, Hoffmann B, Giani G, Livingstone R, et al. Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans. Metabolism. 2018;81:113-125 pubmed publisher..Similar results were obtained for the disposition index (DI). The association of serum lipids and adiponectin with beta-cell function may represent a compensatory response to adapt for lower insulin sensitivity in nondiabetic humans. ..
- Gancheva S, Bierwagen A, Kaul K, Herder C, Nowotny P, Kahl S, et al. Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes. Diabetes. 2016;65:1849-57 pubmed publisher..Variations in genes controlling oxidative metabolism contribute to a reduction in hepatic ATP in the absence of NAFLD, suggesting that alterations in hepatic mitochondrial function may precede diabetes-related liver diseases. ..
- Gancheva S, Bierwagen A, Markgraf D, Bönhof G, Murphy K, Hatziagelaki E, et al. Constant hepatic ATP concentrations during prolonged fasting and absence of effects of Cerbomed Nemos® on parasympathetic tone and hepatic energy metabolism. Mol Metab. 2018;7:71-79 pubmed publisher..This technique is therefore unable to mimic brain insulin-mediated effects on peripheral homeostasis in humans. ..
- Diederichs T, Herder C, RoÃŸbach S, Roden M, Wudy S, NÃ¶thlings U, et al. Carbohydrates from Sources with a Higher Glycemic Index during Adolescence: Is Evening Rather than Morning Intake Relevant for Risk Markers of Type 2 Diabetes in Young Adulthood?. Nutrients. 2017;9: pubmed publisher..1). Conclusion: Avoidance of large amounts of carbohydrates from higher-GI sources in the evening should be considered in preventive strategies to reduce the risk of type 2 diabetes in adulthood. ..
- Reinauer C, Rosenbauer J, Bächle C, Herder C, Roden M, Ellard S, et al. The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype. Genes (Basel). 2017;8: pubmed publisher..In this study, we saw no evidence for a different clinical course of early-onset T1D based on the HLA genotype within the first ten years after manifestation. ..
- Jelenik T, Kaul K, Séquaris G, Flogel U, Phielix E, Kotzka J, et al. Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver. Diabetes. 2017;66:2241-2253 pubmed publisher..Peripheral insulin resistance is prevented during increased hepatic lipogenesis only if adipose tissue lipid storage capacity is preserved. ..
- Pesta D, Roden M. The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise. Curr Diab Rep. 2017;17:41 pubmed publisher..The different metabolic effects are likely due to variability of reactive species and discrepancies in temporal (acute vs. chronic) and local (subcellular distribution) patterns of production. ..
- Gancheva S, Koliaki C, Bierwagen A, Nowotny P, Heni M, Fritsche A, et al. Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans. Diabetes. 2015;64:1966-75 pubmed publisher..In conclusion, intranasal insulin does not affect HIS but rapidly improves hepatic energy metabolism in healthy humans, which is independent of peripheral insulinemia. These effects are blunted in patients with type 2 diabetes. ..