J Reifenberger

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint Cowden's disease: clinical and molecular genetic findings in a patient with a novel PTEN germline mutation
    J Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Br J Dermatol 148:1040-6. 2003
  2. ncbi request reprint [Basal cell carcinoma. Molecular genetics and unusual clinical features]
    J Reifenberger
    Hautklinik, Heinrich Heine Universitat, 40225, Dusseldorf
    Hautarzt 58:406-11. 2007
  3. ncbi request reprint [Hereditary tumor syndromes. Cutaneous manifestations and molecular pathogenesis of Gorlin and Cowden syndromes]
    J Reifenberger
    Hautklinik, Heinrich Heine Universitat, Dusseldorf
    Hautarzt 55:942-51. 2004
  4. ncbi request reprint Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas
    Julia Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Int J Cancer 109:377-84. 2004
  5. ncbi request reprint [Cutaneous epithelial tumors. Molecular biology and pathogenesis-based therapy]
    J Reifenberger
    Universitäts Hautklinik, Heinrich Heine Universitat, Dusseldorf
    Hautarzt 54:1164-70. 2003
  6. ncbi request reprint Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC
    Julia Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Int J Cancer 100:549-56. 2002
  7. ncbi request reprint Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
    J Reifenberger
    Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Br J Dermatol 152:43-51. 2005
  8. ncbi request reprint Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas
    J Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Virchows Arch 436:487-93. 2000
  9. ncbi request reprint Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    J Reifenberger
    Hautklinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Cancer Res 58:1798-803. 1998
  10. ncbi request reprint Multiple basal cell carcinomas associated with hairy cell leukaemia
    M P Schön
    Departments of Dermatology and Haematology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Br J Dermatol 140:150-3. 1999

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Cowden's disease: clinical and molecular genetic findings in a patient with a novel PTEN germline mutation
    J Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Br J Dermatol 148:1040-6. 2003
    ....
  2. ncbi request reprint [Basal cell carcinoma. Molecular genetics and unusual clinical features]
    J Reifenberger
    Hautklinik, Heinrich Heine Universitat, 40225, Dusseldorf
    Hautarzt 58:406-11. 2007
    ..This review article summarizes the current state of the art concerning the etiology, predisposition and molecular genetics of basal cell carcinoma. In addition, examples of unusual clinical manifestations are illustrated...
  3. ncbi request reprint [Hereditary tumor syndromes. Cutaneous manifestations and molecular pathogenesis of Gorlin and Cowden syndromes]
    J Reifenberger
    Hautklinik, Heinrich Heine Universitat, Dusseldorf
    Hautarzt 55:942-51. 2004
    ..Furthermore, novel pathogenesis-based pharmacological strategies are being developed that promise to improve prevention and therapy...
  4. ncbi request reprint Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas
    Julia Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Int J Cancer 109:377-84. 2004
    ..In addition, 22% of the melanomas and 50% of the cell lines showed reduced RASSF1A transcript levels. Thus, alterations of Ras pathway genes are of paramount importance in the pathogenesis of sporadic melanomas...
  5. ncbi request reprint [Cutaneous epithelial tumors. Molecular biology and pathogenesis-based therapy]
    J Reifenberger
    Universitäts Hautklinik, Heinrich Heine Universitat, Dusseldorf
    Hautarzt 54:1164-70. 2003
    ..This drug can eradicate non-melanoma skin cancers by different mechanisms, including cytokine-mediated stimulation of the anti-tumor immune response, as well as the induction of tumor cell apoptosis...
  6. ncbi request reprint Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC
    Julia Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Int J Cancer 100:549-56. 2002
    ..Taken together, our results indicate that the Wnt pathway may be altered in malignant melanomas by different mechanisms, including rare somatic mutations in CTNNB1, APC or ICAT, as well as low or absent expression of ICAT transcripts...
  7. ncbi request reprint Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
    J Reifenberger
    Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Br J Dermatol 152:43-51. 2005
    ..Basal cell carcinoma (BCC) of the skin is the most common human cancer. The genetic alterations underlying BCC development are only partly understood...
  8. ncbi request reprint Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas
    J Reifenberger
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Virchows Arch 436:487-93. 2000
    ..Our findings corroborate that loss of heterozygosity on chromosome 10 is a frequent aberration in malignant melanomas and implicate PTEN as a tumour suppressor gene inactivated by somatic mutation in a fraction of these tumours...
  9. ncbi request reprint Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    J Reifenberger
    Hautklinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Cancer Res 58:1798-803. 1998
    ..In summary, our results indicate that both PTCH and SMOH represent important targets for genetic alterations in sporadic BCCs and PNETs...
  10. ncbi request reprint Multiple basal cell carcinomas associated with hairy cell leukaemia
    M P Schön
    Departments of Dermatology and Haematology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Br J Dermatol 140:150-3. 1999
    ..Given that HCL is characterized by a profound defect in T-cell function, it is conceivable that T-cell immune dysregulation can contribute to the pathogenesis of BCC, possibly enhancing the aetiological effect of ultraviolet irradiation...
  11. ncbi request reprint Multiple eruptive myxoid dermatofibromas: report of first case and review of literature
    A Antal
    Department of Dermatology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Br J Dermatol 157:382-5. 2007
    ..To our knowledge this is the first report of multiple eruptive myxoid dermatofibromas. We consider this case to be a unique presentation of multiple eruptive dermatofibroma showing massive deposition of mucin...
  12. ncbi request reprint Long-term survival of a patient with giant cell glioblastoma. Case report
    M Sabel
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurosurg 94:605-11. 2001
    ..This patient is exceptional because tumor resection, probably in conjunction with a marked antitumor immune response, apparently resulted in eradication of the lesion...
  13. doi request reprint [Hereditary cutaneous leiomyomatosis]
    S A Braun
    Hautklinik, Universitatsklinikum Dusseldorf, Dusseldorf, Deutschland
    Hautarzt 63:276-8. 2012
    ..Taking into consideration the aforementioned complications, close interdisciplinary management of these patients and regular screening examinations within affected families are mandatory...
  14. doi request reprint [Epithelioid sarcoma of the right hand]
    N P Hoff
    Hautklinik, Universitatsklinikum Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Deutschland
    Hautarzt 63:278-82. 2012
    ..ES represents a diagnostic challenge, with consequent delay in diagnosis and adequate treatment. The most important measure in the treatment of ES is early surgical excision with adjuvant radiotherapy if local metastases are present...
  15. ncbi request reprint Type 1 segmental cutaneous leiomyomatosis
    K Lang
    Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
    Clin Exp Dermatol 27:649-50. 2002
    ..In our patient the lesions were restricted to one segment and therefore she most probably has a type 1 segmental cutaneous leiomyomatosis...
  16. doi request reprint [Incontinentia pigmenti (Bloch-Sulzberger syndrome)]
    E Mühlenstädt
    Hautklinik des Universitätsklinikums Düsseldorf, Moorenstr 5, 40225, Dusseldorf
    Hautarzt 61:831-3. 2010
    ..We summarize important clinical and diagnostic aspects of incontinentia pigmenti as well as its genetic and molecular basis...
  17. doi request reprint [Radiation-induced Favre-Racouchot disease]
    N P Hoff
    Hautklinik des Universitätsklinikums Düsseldorf, Moorenstr 5, 40225, Dusseldorf, Deutschland
    Hautarzt 63:766-7. 2012
    ..Taking in account the exclusive affection of the irradiated skin, we diagnosed a radiation-induced Favre-Racouchot disease. We recommended topical treatment with vitamin A derivatives in combination with physical comedo extraction...
  18. ncbi request reprint [Multiple eruptive dermatofibroma]
    A Antal
    Hautklinik der Heinrich Heine Universität, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Hautarzt 58:294-5. 2007
  19. ncbi request reprint [Progressive cicatricial psoriatic alopecia in AIDS]
    M P Schön
    Hautklinik, Heinrich Heine Universitat Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf
    Hautarzt 51:935-8. 2000
    ..In addition, early and efficient antipsoriatic treatment is recommended to prevent the disfiguring complication of scarring alopecia...
  20. doi request reprint [Tuberous sclerosis: diagnostic criteria and new treatment approaches]
    S Grieb
    Hautklinik des Universitätsklinikums Düsseldorf, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
    Hautarzt 59:774-6. 2008
    ..Various studies provided evidence that the macrolide rapamycin decreases growth of brain and kidney tumors by specific inhibition of mTOR kinase. Synergistic effects were observed in combination therapy with the cytokine IFN-gamma...
  21. doi request reprint [Treatment of carcinoma in situ of erythema ab igne with photodynamic therapy]
    C Kochs
    Hautklinik des Universitätsklinikums Düsseldorf, Moorenstrasse 5, 40225, Dusseldorf, Deutschland
    Hautarzt 59:777-9. 2008
    ..In our case we achieved successful results with photodynamic therapy...
  22. doi request reprint [NK/T-cell lymphoma, nasal type with cutaneous dissemination]
    A M Baran
    Hautklinik, Universitätsklinikums Düsseldorf, Moorenstr 5, 40225, Dusseldorf, Deutschland
    Hautarzt 63:272-5. 2012
    ..In the case of an unspecific chronic inflammatory process in the nasopharyngeal space one should always consider the possibility of this rare lymphoma, even in Europe...
  23. ncbi request reprint [Bullous pemphigoid: first manifestation under a picture of prurigo simplex subacuta]
    N Hodzic-Avdagic
    Hautklinik der Heinrich Heine Universität, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Hautarzt 58:290-2. 2007
  24. doi request reprint The new polyomavirus (MCPyV) does not affect the clinical course in MCCs
    J Handschel
    Department for Cranio and Maxillofacial Surgery, Heinrich Heine University, Dusseldorf, Germany
    Int J Oral Maxillofac Surg 39:1086-90. 2010
    ..The survival time was statistically independent from the presence of MCPyV. There is a striking occurrence of MCPyV in MCC, but whether it affects the clinical course remains unclear...
  25. ncbi request reprint Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes
    M Wolter
    Department of Neuropathology, Heinrich-Heine-University, , Germany
    J Neuropathol Exp Neurol 60:1170-80. 2001
    ..Taken together, our results indicate that hypermethylation of CDKN2A, p14ARF, and CDKN2B is an important epigenetic mechanism by which oligodendroglial tumors may escape from p53- and pRb-dependent growth control...
  26. ncbi request reprint [Extracranial meningioma. Rare differential diagnosis of a subacute tumor]
    R Mang
    Hautklinik, Heinrich Heine Universitat, Dusseldorf
    Hautarzt 56:376-7. 2005
  27. ncbi request reprint [Ulcus terebrans. Therapy options and their limits]
    M Sonntag
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 55:983-5. 2004
    ..A 75-year old patient with the most destructive form of BCC, ulcus terebrans, involving the scalp and invading the frontal bone. We discuss the problems and therapeutic limitations for this unusual BCC variant...
  28. ncbi request reprint Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in Europe
    H J Schulze
    Clinique Dermatologique, Strasbourg, France
    Br J Dermatol 152:939-47. 2005
    ..Clinical studies have demonstrated clinical and histological clearance of superficial basal cell carcinoma (sBCC) after treatment with imiquimod 5% cream...
  29. ncbi request reprint [Neurocutaneous melanosis and malignant melanoma]
    U Tartler
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 55:971-4. 2004
    ..In spite of a variety of therapeutic attempts (surgery, radiation therapy and chemotherapy) he followed a rapidly progressive, lethal course with increased intracranial pressure, hydrocephalus and spinal metastases...
  30. ncbi request reprint Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors
    A Koch
    Department of Neuropathology, University of Bonn Medical Center; Bonn, Germany
    Int J Cancer 93:445-9. 2001
    ..Our data indicate that inappropriate activation of the WNT/wingless signaling pathway by mutations of its components may contribute to the pathogenesis of a subset of PNETs...
  31. ncbi request reprint Coincident PTCH and BRCA1 germline mutations in a patient with nevoid basal cell carcinoma syndrome and familial breast cancer
    J Reifenberger
    J Invest Dermatol 116:472-4. 2001
  32. ncbi request reprint [Photodynamic therapy for a nevoid basal cell carcinoma syndrome]
    S Hanneken
    Hautklinik der Heinrich Heine Universität Düsseldorf
    Hautarzt 56:363-4. 2005
  33. ncbi request reprint [Blue-rubber-bleb-nevus syndrome]
    U Tartler
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 56:369-70. 2005
  34. ncbi request reprint [Angiosarcoma after radiation therapy of a hemangioma]
    H Dräger
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 56:970-1. 2005
  35. doi request reprint [Classical Kaposi's sarcoma in a 78-year-old woman]
    A S Antal
    Hautklinik der Heinrich Heine Universität, Moorenstrasse 5, 40225 Dusseldorf
    Hautarzt 59:276-8. 2008
  36. ncbi request reprint [Ulcerous basal cell carcinoma on the lower leg. Differential diagnosis of ulcus cruris venosum: a report of 3 cases]
    O Kovnerystyy
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 56:959-61. 2005
  37. ncbi request reprint [Cylindromatosis]
    H Dräger
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 57:332-3. 2006
  38. ncbi request reprint [Sarcoidosis induced by therapy with pegylated interferon alfa-2a]
    D Bruch-Gerharz
    Universitätshautklinik Düsseldorf
    Hautarzt 57:317-35. 2006
  39. ncbi request reprint [Erythropoietic protoporphyria in childhood]
    S Hanneken
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 57:318-9. 2006
  40. ncbi request reprint [A severe course of bullous pemphigoid in a young man]
    S Eigelshoven
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 57:320-2. 2006
  41. ncbi request reprint [Scleromyxedema]
    G Kukova
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 57:326-7. 2006
  42. ncbi request reprint [Rickettsiosis subsequent to vacation in Swaziland]
    A S Büchau
    Hautklinik der Heinrich Heine Universität, Dusseldorf
    Hautarzt 57:328-30. 2006