Rolf Rau

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi request reprint The effect of HLA-DRB1 genes, rheumatoid factor, and treatment on radiographic disease progression in rheumatoid arthritis over 6 years
    R Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus Ratingen, Germany
    J Rheumatol 27:2566-75. 2000
  2. pmc Clinical and functional remission: even though biologics are superior to conventional DMARDs overall success rates remain low--results from RABBIT, the German biologics register
    Joachim Listing
    German Rheumatism Research Centre, Berlin, Germany
    Arthritis Res Ther 8:R66. 2006
  3. pmc Expert agreement confirms that negative changes in hand and foot radiographs are a surrogate for repair in patients with rheumatoid arthritis
    Desiree van der Heijde
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    Arthritis Res Ther 9:R62. 2007
  4. ncbi request reprint [Imaging techniques in rheumatology: scoring methods in rheumatoid arthritis]
    R Rau
    Rheumaklinik, Evangelisches Fachkrankenhaus, Rosenstr 2, 40882 Ratingen, Germany
    Z Rheumatol 62:555-65. 2003
  5. pmc Erosion healing in rheumatoid arthritis after anakinra treatment
    R Rau
    Evangelisches Fachkrankenhaus, Rosenstr 2, Ratingen, D 40882, Germany
    Ann Rheum Dis 62:671-3. 2003
  6. ncbi request reprint [Imaging techniques in rheumatology: conventional radiography in rheumatoid arthritis]
    R Rau
    Rheumaklinik, Evangelisches Fachkrankenhaus, 40882 Ratingen, Germany
    Z Rheumatol 64:473-87. 2005
  7. ncbi request reprint Rapid alleviation of signs and symptoms of rheumatoid arthritis with intravenous or subcutaneous administration of adalimumab in combination with methotrexate
    R Rau
    Rheumaklinik, Ratingen, Germany
    Scand J Rheumatol 33:145-53. 2004
  8. ncbi request reprint Have traditional DMARDs had their day? Effectiveness of parenteral gold compared to biologic agents
    Rolf Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus, Rosenstrasse 2, 40882, Ratingen, Germany
    Clin Rheumatol 24:189-202. 2005
  9. pmc Adalimumab (a fully human anti-tumour necrosis factor alpha monoclonal antibody) in the treatment of active rheumatoid arthritis: the initial results of five trials
    R Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus Ratingen, Ratingen, Germany
    Ann Rheum Dis 61:ii70-3. 2002
  10. ncbi request reprint Identification of radiologic healing phenomena in patients with rheumatoid arthritis
    R Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus Ratingen, Germany
    J Rheumatol 28:2608-15. 2001

Collaborators

Detail Information

Publications40

  1. ncbi request reprint The effect of HLA-DRB1 genes, rheumatoid factor, and treatment on radiographic disease progression in rheumatoid arthritis over 6 years
    R Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus Ratingen, Germany
    J Rheumatol 27:2566-75. 2000
    ....
  2. pmc Clinical and functional remission: even though biologics are superior to conventional DMARDs overall success rates remain low--results from RABBIT, the German biologics register
    Joachim Listing
    German Rheumatism Research Centre, Berlin, Germany
    Arthritis Res Ther 8:R66. 2006
    ..However, temporary or even sustained remission remain ambitious aims, which are achieved in a minority of patients only...
  3. pmc Expert agreement confirms that negative changes in hand and foot radiographs are a surrogate for repair in patients with rheumatoid arthritis
    Desiree van der Heijde
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    Arthritis Res Ther 9:R62. 2007
    ..The change in size of erosion was also picked up by independent readers applying the van der Heijde-modified Sharp scoring method and was reflected in their scores...
  4. ncbi request reprint [Imaging techniques in rheumatology: scoring methods in rheumatoid arthritis]
    R Rau
    Rheumaklinik, Evangelisches Fachkrankenhaus, Rosenstr 2, 40882 Ratingen, Germany
    Z Rheumatol 62:555-65. 2003
    ..A future task will be to include in scoring methods the rating of reparative changes which cannot be scored so far...
  5. pmc Erosion healing in rheumatoid arthritis after anakinra treatment
    R Rau
    Evangelisches Fachkrankenhaus, Rosenstr 2, Ratingen, D 40882, Germany
    Ann Rheum Dis 62:671-3. 2003
  6. ncbi request reprint [Imaging techniques in rheumatology: conventional radiography in rheumatoid arthritis]
    R Rau
    Rheumaklinik, Evangelisches Fachkrankenhaus, 40882 Ratingen, Germany
    Z Rheumatol 64:473-87. 2005
    ..In addition, radiographic changes that can be expected in RA including destruction and repair are discussed briefly...
  7. ncbi request reprint Rapid alleviation of signs and symptoms of rheumatoid arthritis with intravenous or subcutaneous administration of adalimumab in combination with methotrexate
    R Rau
    Rheumaklinik, Ratingen, Germany
    Scand J Rheumatol 33:145-53. 2004
    ..v.) and subcutaneous (s.c.) adalimumab (Humira, Abbott Laboratories) combined with methotrexate (MTX) in patients with active rheumatoid arthritis (RA) despite previous MTX therapy...
  8. ncbi request reprint Have traditional DMARDs had their day? Effectiveness of parenteral gold compared to biologic agents
    Rolf Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus, Rosenstrasse 2, 40882, Ratingen, Germany
    Clin Rheumatol 24:189-202. 2005
    ..Therefore, a sufficient trial of conventional DMARDs should precede the introduction of treatment with the very expensive biologics...
  9. pmc Adalimumab (a fully human anti-tumour necrosis factor alpha monoclonal antibody) in the treatment of active rheumatoid arthritis: the initial results of five trials
    R Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus Ratingen, Ratingen, Germany
    Ann Rheum Dis 61:ii70-3. 2002
  10. ncbi request reprint Identification of radiologic healing phenomena in patients with rheumatoid arthritis
    R Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus Ratingen, Germany
    J Rheumatol 28:2608-15. 2001
    ..Healing may become increasingly important with the availability of more potent antirheumatic drugs. We investigated whether radiologic healing phenomena can be identified by different observers in a blinded fashion...
  11. ncbi request reprint Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicenter, double-blind, placebo-controlled trial
    Siegfried Wassenberg
    Evangelisches Fachkrankenhaus Ratingen, Ratingen, Germany
    Arthritis Rheum 52:3371-80. 2005
    ..To assess the effect of 5 mg/day prednisolone on disease progression in patients with early rheumatoid arthritis (RA) receiving standardized disease-modifying antirheumatic drug (DMARD) therapy...
  12. ncbi request reprint Intravenous human recombinant tumor necrosis factor receptor p55-Fc IgG1 fusion protein Ro 45-2081 (lenercept): a double blind, placebo controlled dose-finding study in rheumatoid arthritis
    Rolf Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus, Ratingen, Germany
    J Rheumatol 30:680-90. 2003
    ..To determine the optimal dose regimen for intravenous Ro 45-2081 (lenercept) in patients with rheumatoid arthritis (RA) by evaluating efficacy, safety, tolerability, and pharmacokinetic and pharmacodynamic characteristics...
  13. ncbi request reprint Radiographic outcome after three years of patients with early erosive rheumatoid arthritis treated with intramuscular methotrexate or parenteral gold. Extension of a one-year double-blind study in 174 patients
    R Rau
    Department of Rheumatology, Evangelisches Fachkrankenhaus, Ratingen, Germany
    Rheumatology (Oxford) 41:196-204. 2002
    ..To compare the radiographic outcomes after 36 months in patients with early erosive rheumatoid arthritis (RA) who were treated with methotrexate (MTX) or gold sodium thiomalate (GSTM)...
  14. ncbi request reprint Radiographic healing with sustained clinical remission in a patient with rheumatoid arthritis receiving methotrexate monotherapy
    Siegfried Wassenberg
    Department of Rheumatology, Evangelisches Fachkrankenhaus, Rosenstrasse 2, D 40882 Ratingen, Germany
    Arthritis Rheum 46:2804-7. 2002
  15. ncbi request reprint Is remission in rheumatoid arthritis associated with radiographic healing?
    R Rau
    Department of Rheumatology, Evangel isches Fachkrankenhaus Ratingen, Ratingen, Germany
    Clin Exp Rheumatol 24:S-41-4. 2006
    ..In contrast, healing is unlikely to be detected in patients with persistent clinically active disease and/or moderate or strong radiographic progression...
  16. ncbi request reprint [Imaging techniques in rheumatology: magnetic resonance imaging in rheumatoid arthritis]
    B Ostendorf
    Klinik fur Nephrologie und Rheumatologie, Rheumazentrum Düsseldorf, Heinrich Heine Universitat Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Z Rheumatol 62:274-86. 2003
    ....
  17. ncbi request reprint [Imaging methods in rheumatology: imaging in psoriasis arthritis (PsA)]
    R Rau
    Rheumaklinik, Evangelisches Fachkrankenhaus, Ratingen
    Z Rheumatol 65:159-67. 2006
    ..While conventional radiography demonstrates the bony consequences of inflammation in the spine, MRI also shows the active inflammatory changes in sacroiliacal joints and vertebrae...
  18. ncbi request reprint [The influence of study results on therapeutic decisions - experience in 35years]
    Rolf Rau
    Ev Fachkrankenhaus Rheumatologische Klinik Rosenstr 2, 40882 Ratingen, Germany
    Z Rheumatol 61:504-15. 2002
    ..e. MTX). Open longterm observational studies are undispensable in the field of rheumatology and may render more important knowledge than randomised studies...
  19. ncbi request reprint [Rheumatologic manifestations of endocrine disorders]
    R Rau
    Evangelisches Fachkrankenhaus, Rheumatologische Klinik, Rosenstrasse 2, 40882 Ratingen, Germany
    Z Rheumatol 63:30-42. 2004
    ..Carcinoid arthropathy is also mentioned...
  20. ncbi request reprint [Pneumonitis as a complication of low-dose methotrexate therapy in chronic polyarthritis]
    T Karger
    Rheumaklinik, EVK, Ratingen
    Pneumologie 44:576-7. 1990
    ..In view of the fact that the literature does not seem to contain unequivocal definition, it is urgently recommended that unequivocal criteria be established...
  21. ncbi request reprint [Use of glucocorticoids in rheumatoid arthritis. Inhibition of disease progression versus risk of steroid osteoporosis]
    R Rau
    Evangelisches Fachkrankenhaus Rheumatologische Klinik Rosenstrasse 2, 40882 Ratingen, Germany
    Z Rheumatol 60:485-91. 2001
    ..Two randomized studies and a metaanalysis indicate the development of steroid osteoporosis in RA already with low doses. As with every treatment, benefit and risk have to be considered carefully...
  22. ncbi request reprint Healing of erosive changes in rheumatoid arthritis
    R Rau
    Rheumatologie, Evangelisches Fachkrankenhaus, Rosenstrasse 2, 40882 Ratingen, Germany
    Clin Exp Rheumatol 22:S44-9. 2004
    ..As healing indicates that inflammation has discontinued for several months in an individual joint, it might represent a good additional outcome measure in RA clinical trials...
  23. ncbi request reprint [Short report about OMERACT 6, 11-14 April, 2002 in Brisbane/Australia]
    R Rau
    Ev Fachfrankenhaus, Rheumatologische Klinik, Ratingen, Germany
    Z Rheumatol 62:190-2. 2003
  24. pmc Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study
    Antonio Naranjo
    Hospital de Gran Canaria Dr, Negrin, University of Las Palmas de Gran Canaria, Barranco de la Ballena s n 35011, Spain
    Arthritis Res Ther 10:R30. 2008
    ....
  25. pmc QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries
    Tuulikki Sokka
    Arkisto Tutkijat, Jyvaskyla Central Hospital, 40620 Jyvaskyla, Finland
    Ann Rheum Dis 66:1491-6. 2007
    ..To conduct a cross-sectional review of non-selected consecutive outpatients with rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of the characteristics of patients with RA...
  26. ncbi request reprint Scoring methods
    Rolf Rau
    J Rheumatol 29:653-5. 2002
  27. ncbi request reprint Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis
    Harald Burkhardt
    Dept of Internal Medicine III, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Arthritis Rheum 54:82-9. 2006
    ....
  28. ncbi request reprint Infections in patients with rheumatoid arthritis treated with biologic agents
    Joachim Listing
    German Rheumatism Research Centre, Schumannstrasse 21 22, D 10117 Berlin, Germany
    Arthritis Rheum 52:3403-12. 2005
    ....
  29. ncbi request reprint Bioavailability of higher dose MTX comparing oral and subcutaneous administration in patients with RA
    Rolf Rau
    J Rheumatol 32:1412; author reply 1412-3. 2005
  30. pmc Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis
    Sylvia Dörr
    Institute of Human Genetics, University of Halle Saale, Germany
    Arthritis Res Ther 6:R199-207. 2004
    ..Our findings suggest that there are haplotypes in a MMP cluster region that modify the joint destruction in RA in a phasic manner...
  31. ncbi request reprint Methotrexate, hydroxychloroquine, and intramuscular gold in rheumatoid arthritis
    Sigfried Wassenberg
    J Rheumatol 30:1891; author reply 1891-2. 2003
  32. ncbi request reprint OMERACT workshop: repair of structural damage in rheumatoid arthritis
    Desiree van der Heijde
    University Hospital Maastricht, Maastricht, The Netherlands
    J Rheumatol 30:1108-9. 2003
    ....
  33. ncbi request reprint Radiographic joint damage in early rheumatoid arthritis is highly dependent on body mass index
    Gisela Westhoff
    German Rheumatism Research Centre, Berlin, Germany
    Arthritis Rheum 56:3575-82. 2007
    ..To investigate the association between body mass index (BMI) and radiographic joint damage (using the Ratingen Score [RS]) in early rheumatoid arthritis (RA)...
  34. ncbi request reprint Variability of precision in scoring radiographic abnormalities in rheumatoid arthritis by experienced readers
    John T Sharp
    University of Washington School of Medicine, Seattle, Washington, USA
    J Rheumatol 31:1062-72. 2004
    ..To determine the extent of precision and sources of variability among experts on scoring radiographic abnormalities in rheumatoid arthritis...
  35. ncbi request reprint Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis
    Iryna Prots
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Germany
    Arthritis Rheum 54:1491-500. 2006
    ..To examine whether single-nucleotide polymorphisms (SNPs) of the interleukin-4 receptor gene IL4R influence susceptibility to, or radiographic progression in, rheumatoid arthritis (RA)...
  36. ncbi request reprint How to report radiographic data in randomized clinical trials in rheumatoid arthritis: guidelines from a roundtable discussion
    Desiree van der Heijde
    Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Arthritis Rheum 47:215-8. 2002
  37. ncbi request reprint A single dose, placebo controlled study of the fully human anti-tumor necrosis factor-alpha antibody adalimumab (D2E7) in patients with rheumatoid arthritis
    Alfons den Broeder
    Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Rheumatol 29:2288-98. 2002
    ..To assess the pharmacokinetics, safety profile, and efficacy of the fully human anti-tumor necrosis factor-alpha (anti-TNF-alpha) monoclonal antibody adalimumab (D2E7) in patients with long-standing, active rheumatoid arthritis (RA)...
  38. ncbi request reprint Reliability of scoring methods to measure radiographic change in patients with rheumatoid arthritis
    Rolf Rau
    J Rheumatol 32:766-8. 2005
  39. ncbi request reprint Repair of erosions in rheumatoid arthritis does occur. Results from 2 studies by the OMERACT Subcommittee on Healing of Erosions
    John T Sharp
    University of Washington, Seattle, Washington, USA
    J Rheumatol 30:1102-7. 2003
    ..This study provides evidence that repair of bone damage in RA does occur, resulting in some degree of improvement, which was recognized by a majority of a panel of experts...
  40. ncbi request reprint Correlation between clinical response to treatment and radiographic progression: comment on the article by Strand and Sharp
    Rolf Rau
    Arthritis Rheum 48:2997-8; author reply 2998. 2003