M Cristina Polidori

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. ncbi Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, Italy
    Neurosci Lett 272:53-6. 1999
  2. ncbi Conflict of evidence: carotenoids and other micronutrients in the prevention and treatment of cognitive impairment
    Maria Cristina Polidori
    Department of Geriatrics, Marienhospital Herne, Ruhr University Bochum, Herne, Germany
    Biofactors 38:167-71. 2012
  3. ncbi [Influence of vascular comorbidities on the antioxidant defense system in Alzheimer's disease]
    M C Polidori
    Klinik für Altersmedizin und Frührehabilitation, Medizinische Fakultät der Ruhr Universität Bochum, Marienhospital Herne
    Dtsch Med Wochenschr 137:305-8. 2012
  4. ncbi A brief update on dementia prevention
    M C Polidori
    Department of Geriatrics, Marienhospital Herne, Ruhr University of Bochum, Bochum, Herne, Deutschland
    Z Gerontol Geriatr 45:7-10. 2012
  5. ncbi Antioxidant micronutrients in the prevention of age-related diseases
    M C Polidori
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, Geb 22 03, D 40225 Dusseldorf, Germany
    J Postgrad Med 49:229-35. 2003
  6. ncbi Oxidative stress and risk factors for Alzheimer's disease: clues to prevention and therapy
    M Cristina Polidori
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
    J Alzheimers Dis 6:185-91. 2004
  7. ncbi Congestive heart failure and Alzheimer's disease
    M Cristina Polidori
    Unit of Cognitive Frailty, Neurology Outpatient Clinic Dr Nelles, Cologne, Germany
    Neurol Res 28:588-94. 2006
  8. ncbi Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels
    Maria Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    Nutr J 8:10. 2009
  9. ncbi High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    J Alzheimers Dis 17:921-7. 2009
  10. ncbi Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, PO Box 101007, D 40001 Dusseldorf, Germany
    Br J Nutr 90:147-50. 2003

Collaborators

Detail Information

Publications31

  1. ncbi Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, Italy
    Neurosci Lett 272:53-6. 1999
    ..The present findings are consistent with regionally specific oxidative damage in HD, which may be a further evidence of a metabolic defect...
  2. ncbi Conflict of evidence: carotenoids and other micronutrients in the prevention and treatment of cognitive impairment
    Maria Cristina Polidori
    Department of Geriatrics, Marienhospital Herne, Ruhr University Bochum, Herne, Germany
    Biofactors 38:167-71. 2012
    ..A possible clinical benefit of these substances in AD is not disproved to date, thus further better designed studies are needed...
  3. ncbi [Influence of vascular comorbidities on the antioxidant defense system in Alzheimer's disease]
    M C Polidori
    Klinik für Altersmedizin und Frührehabilitation, Medizinische Fakultät der Ruhr Universität Bochum, Marienhospital Herne
    Dtsch Med Wochenschr 137:305-8. 2012
    ..The aim of this study was the identification of an association between vascular comorbidities/vascular risk factors and plasma levels of antioxidant micronutrients in patients with AD...
  4. ncbi A brief update on dementia prevention
    M C Polidori
    Department of Geriatrics, Marienhospital Herne, Ruhr University of Bochum, Bochum, Herne, Deutschland
    Z Gerontol Geriatr 45:7-10. 2012
    ....
  5. ncbi Antioxidant micronutrients in the prevention of age-related diseases
    M C Polidori
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, Geb 22 03, D 40225 Dusseldorf, Germany
    J Postgrad Med 49:229-35. 2003
    ..A balanced and regular nutrition with at least five portions of fruit and vegetables per day is a critical constituent of such a healthy lifestyle...
  6. ncbi Oxidative stress and risk factors for Alzheimer's disease: clues to prevention and therapy
    M Cristina Polidori
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
    J Alzheimers Dis 6:185-91. 2004
    ....
  7. ncbi Congestive heart failure and Alzheimer's disease
    M Cristina Polidori
    Unit of Cognitive Frailty, Neurology Outpatient Clinic Dr Nelles, Cologne, Germany
    Neurol Res 28:588-94. 2006
    ..Finally, management schemes should include exercise training programs as well as patient and caregiver education...
  8. ncbi Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels
    Maria Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    Nutr J 8:10. 2009
    ..Thus, a nutritional counseling program is capable of improving plasma levels of antioxidants even in a health-conscious population. A decrease in biomarkers of oxidative stress, however, does not occur...
  9. ncbi High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    J Alzheimers Dis 17:921-7. 2009
    ..Modification of nutritional habits aimed at increasing intake of fruits and vegetables should be encouraged to lower prevalence of cognitive impairment in later life...
  10. ncbi Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, PO Box 101007, D 40001 Dusseldorf, Germany
    Br J Nutr 90:147-50. 2003
    ....
  11. ncbi Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease
    M Cristina Polidori
    Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
    J Alzheimers Dis 4:517-22. 2002
    ..AD in advanced age is accompanied by a poor plasma antioxidant status and increased plasma lipid peroxidation, as well as by a low resistance to peroxyl radical exposure...
  12. ncbi Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, Perugia, Italy
    Diabetes Metab Res Rev 16:15-9. 2000
    ..This evidence is limited in elderly patients with non-insulin dependent diabetes, in which age- and disease-related production of reactive oxygen species might exert synergistic damaging effects on tissues and organs...
  13. ncbi Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome
    M Cristina Polidori
    Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
    Free Radic Res 36:265-8. 2002
    ..Among the carotenoids, only lutein plasma changes are associated with a poor early-outcome...
  14. ncbi Plasma vitamin C levels are decreased and correlated with brain damage in patients with intracranial hemorrhage or head trauma
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, Perugia, Italy
    Stroke 32:898-902. 2001
    ....
  15. ncbi Superficial siderosis of the central nervous system: a 70-year-old man with ataxia, depression and visual deficits
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, AO Perugia, Italy
    Gerontology 47:93-5. 2001
    ..Typical symptoms include ataxia, sensorineural deafness and dementia...
  16. ncbi Peripheral non-enzymatic antioxidant changes with human aging: a selective status report
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, Italy
    Biogerontology 2:99-104. 2001
    ....
  17. ncbi Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity
    Maria Cristina Polidori
    Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
    Free Radic Biol Med 32:148-52. 2002
    ..The present study supports the concept that an increased consumption of vitamin-rich fruits and vegetables might help in achieving cardiovascular health...
  18. ncbi Heart disease and vascular risk factors in the cognitively impaired elderly: implications for Alzheimer's dementia
    M C Polidori
    Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
    Aging (Milano) 13:231-9. 2001
    ....
  19. ncbi Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, , Germany
    Biofactors 24:265-74. 2005
    ..Further studies are warranted to clarify whether the use of vitamin C may add clinical long-term beneficial effects in patients with stroke...
  20. ncbi Potential markers of oxidative stress in stroke
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, University of Perugia Medical School, Policlinico Monteluce Pad E, Via Brunamonti 51, 06122 Perugia, Italy
    Free Radic Biol Med 39:841-52. 2005
    ....
  21. ncbi Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, , Germany
    J Card Fail 10:334-8. 2004
    ..These findings support the rationale for intervention trials aiming at exploring beneficial effects of antioxidant micronutrients in this disease...
  22. ncbi Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects
    Timur Anlasik
    Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, , Germany
    Br J Nutr 94:639-42. 2005
    ..Modification of nutritional habits among other lifestyle changes should be encouraged to lower prevalence of disease risk factors in later life...
  23. ncbi Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, , Germany
    Dement Geriatr Cogn Disord 18:265-70. 2004
    ..This might be relevant to the pathophysiology of dementing disorders, particularly in light of the recently suggested importance of the vascular component in AD development...
  24. ncbi Low levels of carotenoids and retinol in involutional osteoporosis
    Dario Maggio
    Institute of Gerontology and Geriatrics, University of Perugia, Policlinico Monteluce, Via Brunamonti, 06124 Perugia, Italy
    Bone 38:244-8. 2006
    ..Our study suggests a bone sparing effect of retinol, to which the provitamin A activity of some carotenoids might have contributed...
  25. ncbi Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment
    Francesca Mangialasche
    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Ageing Res Rev 8:285-305. 2009
    ..In this review we discuss the main results obtained in the field of biomarkers of oxidative/nitrosative stress in AD and MCI in humans, in addition to their potential role as a tool for diagnosis, prognosis and treatment efficacy in AD...
  26. ncbi Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease
    Tiziana Ingegni
    Department of Gerontology and Geriatrics, University of Perugia School of Medicine, Perugia, Italy
    Dement Geriatr Cogn Disord 16:151-5. 2003
    ..Our data indicate no significant association between this polymorphism and the risk of AD. Likewise there was no association between CTSD polymorphism and the apolipoprotein E genotype in the risk of developing AD...
  27. ncbi Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease
    Patrizia Mecocci
    Institute of Gerontology and Geriatrics, University of Perugia, Via Eugubina 42, 06122 Perugia, Italy
    Arch Neurol 59:794-8. 2002
    ..A large body of experimental evidence suggests that in Alzheimer disease (AD) pathogenesis an important role is played by oxidative stress, but there is still a lack of data on in vivo markers of free radical-induced damage...
  28. ncbi Short-term and long-term vitamin C supplementation in humans dose-dependently increases the resistance of plasma to ex vivo lipid peroxidation
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, Duesseldorf, Germany
    Arch Biochem Biophys 423:109-15. 2004
    ..Plasma and body saturation with vitamin C in humans appears desirable to maximize antioxidant protection and lower risk of oxidative damage...
  29. ncbi Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E
    Dragan Radosavac
    Institute of Physiological Chemistry I, Heinrich-Heine University, P. O. Box 101007, , Germany
    Eur J Nutr 41:119-24. 2002
    ..The appearance of the metabolite in blood parallels that of the parent compound. The gamma-tocopherol analog appears to be metabolized more efficiently than alpha-tocopherol...
  30. ncbi Bridging the pathophysiology of Alzheimer's disease with vascular pathology: the feed-back, the feed-forward, and oxidative stress
    M Cristina Polidori
    Department of Geriatrics, Marienhospital Herne, Ruhr University Bochum, Herne, Germany
    J Alzheimers Dis 28:1-9. 2012
    ..Looking over the literature on AD-related vascular pathology, the need also emerges to find the right location of oxidative stress...
  31. ncbi A review of the major vascular risk factors related to Alzheimer's disease
    M Cristina Polidori
    Department of Geriatrics, Marienhospital Herne, Ruhr University Bochum, Herne, Germany
    J Alzheimers Dis 32:521-30. 2012
    ..The relative strategies with this purpose cannot be separated from a thorough lifestyle anamnesis including nutrition, physical exercise, and cognitive and social activities...